Shakespeare’s Case for Vulnerability: Giving Voice to Pain and Suffering is a combination of two pieces of work. The research centers around understanding the communication of pain and suffering and how this factors into our everyday lives, in combination with an interview and video project called Evolution of Woman. This project sought to determine the different facets of pain and suffering and how, specifically, Shakespeare communicates these concepts in his work. This work also explores how the representation of pain and suffering was different between male and female roles in Shakespeare’s writing. From this research, questions were developed to interview Shakespearean experts and actors. These interviews explore the details of portraying Shakespeare’s characters and how gender plays a role in the characters’ expression of pain and suffering, as well as what it means to be a female actor in plays that are dominated by male characters.

For my honors thesis, I chose a creative project that would incorporate expertise and skills from both of my undergraduate degrees at Arizona State University: Music Performance and Music Theory and Composition. The main goal for this project was to design and experience an artistic process of musical production and create a professional musical work to release on digital platforms. The musical process included five main components: Listening, Transcribing, Composing, Recording, and Post Production. The final product is a full album, titled This is Jam Music, that consists of eight pieces and a run time of 33 minutes.

I conducted a literature review of articles pertaining to the history and treatment of rats. After outlining all of the relevant connections, I argue that as a result of people's conceptions about rats, rats do not receive the same respect and protections afforded other animals, such as cats and dogs, in the laboratory and beyond. I present both negative and positive conceptions about rats and the realities of these conceptions. Finally, I talk about the changes that need to take place in laboratory research, why animals are still used in research today, and the alternatives that exist to animal models.

Managed Aquifer Recharge is an increasingly prevalent solution to sustain water availability in arid regions. Recharge of groundwater resources using treated wastewater effluent is one type of managed aquifer recharge that offers long-term sustainable water management. However, there are some concerns regarding the reuse of wastewater and its potential to increase exposures to antibiotic resistant bacteria and antibiotic resistance genes that could affect human health. Antibiotic resistance genes can confer the ability for bacteria to resist antibacterial treatment, rendering their presence in water supplies as an area of research needed to evaluate where environmental “hot spots” of potential antibiotic resistance disseminate. To evaluate the occurrence of antibiotic resistant bacteria and antibiotic resistance genes, sampling of an Arizona managed aquifer recharge facility was performed, with target antibiotic resistance genes measured using quantitative polymerase chain reaction. The occurrence of antibiotic resistance genes was evaluated at several sampling wells and in sediments to examine trade-offs between water quantity benefits and water quality issues. The goal of this work is to inform management operations for secure water quality in the face of climate change.

This thesis examines the theological significance and use of chant in the Divine Liturgy of Saint Chrysostom, in both Eastern Orthodoxy and Eastern Catholicism. An overview of the Liturgy and its chant is given while examining contemporary and historical practices. Finally, this paper also offers an overview of trends and practices used by Eastern Christian faithful in the United States.

For my creative project, I explored using natural sound to create a sound score or song. I used contrasting natural sounds to create the sound scores. Most of the sound recordings are from the New York City subways as well as other recordings around different cities in the United States. I created new sounds using sound manipulation techniques. I explored the use of electronic music production to translate the natural noise into the patterns, repetition and other elemental musical techniques to create a song. I used Ableton as the music production platform to develop the three songs.

In this thesis paper, the mental health consequences of the COVID-19 pandemic are discussed. Chapter 1 discusses what inspired me to write this thesis and follows with a discussion of social isolation during the COVID-19 pandemic. Chapter 2 takes a step back and discusses biological effects of social isolation in general. Chapter 3 discusses the psychological effects of social isolation. Finally, this thesis concludes with a discussion of what can be done to help those experiencing social isolation during the pandemic.

In my undergraduate honors thesis, I strive to convey my idea that dance is more than just movement, it’s one of the many artistic tools used to express emotions; which therefore has the power to storytell without words. It is my hope to create a captivating form of art that you not only view, but can interact and interpret.

Every season from September to March in Taiji, Japan, around 23,000 dolphins, and other small cetaceans are slaughtered or sold to dolphinariums in the name of a 400-year-old tradition. The word ‘tradition’ is often used to rationalize and justify the terrible acts of animal cruelty, as seen in many countries such as bullfighting in Spain, fox hunting in Britain, Thanksgiving in America, and drive hunting in Japan. However, just because something is deemed as a tradition, does not mean it should not be challenged and judged against the standards of morality. Whale and dolphin hunting has stopped becoming a proud cultural tradition of small-scale subsistence whaling and has become a business run on wholesale slaughter and the exploitation of another species. The disconnect between the past and present has led to an evil distortion of the past.
However, this event cannot simply be explained by blaming solely greed and selfishness for driving this long-lasting tradition. By analyzing poems by Misuzu Kaneko, early hunting methods, memorial services, and graves built in the past and comparing them to the current hunting methods, dolphin shows, and the Taiji Whale Museum, one can determine the variety of factors driving these actions and find the point in time when the intentions of these practices shifted. By having a better understanding of the past and the present, one can follow a once-proud tradition becoming a source to justify unethical and cruel behavior.

TSPO was discovered in 1977 and it’s function is still currently unknown. Significant research has suggested that TSPO functions in steroidogenesis to import cholesterol from the mitochondrial outer membrane (MOM) to the mitochondrial inner membrane (MIM) where it is converted into steroids. There were two indications that this is TSPOs main function: its elevated levels in steroidogenic tissue and its primary location in the MOM. There is evidence of TSPO binding cholesterol with high affinity, however there is not currently evidence of TSPO transporting cholesterol. STAR, ACBD1, and ACBD3 are proteins thought to be associated with TSPO and steroidogenesis. However, the distribution of these proteins in various eukaryotes show little similarity suggesting that TSPO functions independently. The function of TSPO in steroid synthesis has been called into question because a well-cited research paper claimed that TSPO knockdown resulted in embryonic lethal mice, however there was no evidence presented from their study and this experiment did not produce the same results when repeated in later studies. There are also studies that show TSPO may not be involved in regulation of sterols, but instead may regulate cell stress. The elevated levels of TSPO during inflammation suggest a role for TSPO in cellular stress. Binding interactions with porphyrins and heme also support that TSPO may modulate stress levels. We used the phylogeny of TSPO in order to gain greater insight into the evolutionary function of TSPO. NCBI BLAST searches revealed that TSPO was present in bacteria and had a widespread but patchy distribution in a small set of eukaryotes. From these initial results, we were prompted to search a larger set of eukaryotes for TSPO. All of the prokaryotic and eukaryotic TSPO sequences were used to create a phylogenetic tree that would provide greater insight into the evolution and function of TSPO. If TSPO was from a common ancestor, it is probable that its function is related to sterol regulation whereas if gained in eukaryotes by horizontal gene transfer from bacteria its function is related to stress regulation. The phylogenetic tree was most consistent with an ancestral origin of TSPO with an evolutionary function related to steroid synthesis regulation. However, there is not sufficient research to confirm the function of TSPO.