Matching Items (106)

137136-Thumbnail Image.png

Company X Collaborative Thesis: Supplier Financial Health

Description

This thesis discusses methodology used to assess the financial health of Company X's suppliers. Each suppliers' industry characteristics and key risk exposures are identified using the Porter's Five Forces. Along

This thesis discusses methodology used to assess the financial health of Company X's suppliers. Each suppliers' industry characteristics and key risk exposures are identified using the Porter's Five Forces. Along with qualitative analysis, financial data is analyzed with the Altman Z-Scores, forecasted financial statements, and comparative ratio analysis. The focus is narrowed down throughout the process to enable further investigation on Supplier E and the semiconductor-memory industry.The procedure and results of the analysis lead to the final recommendation to Company X on how it should assess the financial health of suppliers in the semiconductor-memory industry, and possibly other industries, using our methodology.

Contributors

Agent

Created

Date Created
  • 2014-05

136708-Thumbnail Image.png

IMMUNE RESPONSE TO TISSUE DAMAGE IN DROSOPHILA MELANOGASTER

Description

In humans, infections, disease, inflammation, and other injuries to specific tissues have been shown to cause delays in the onset of puberty. It is known that steroid hormones and insulin

In humans, infections, disease, inflammation, and other injuries to specific tissues have been shown to cause delays in the onset of puberty. It is known that steroid hormones and insulin play a role in these delays, yet it is not understood what is happening with the immune system during this response. Similar results have been found in the fruit fly, Drosophila melanogaster, in which damage to adult precursor tissues triggers developmental delays. This project addresses the immune component of the injury response in Drosophila. The goal is to identify which immune response genes, if any, show a significant change in expression after injury. The general methodologies used were first inducing injury via a temperature- sensitive expression of cell death genes in wing precursor tissues, then examining changes in gene expression of immune response genes before and after injury using real-time PCR. The results show that injury increases the expression of genes Drs, CecA1, and Def while decreasing expression of Rel, Dpt, PGRP-LE, and Tl. The changes in immune gene expression following injury suggest the possibility of an immune component to the systemic injury response. These results can further be explored by using mutations of the immune genes to examine their direct effects on the systemic injury response. This research can eventually lead to preventative measures to protect against developmental delays due to infections and diseases in humans.

Contributors

Created

Date Created
  • 2014-12

137404-Thumbnail Image.png

Identification of Differentially Expressed Genes as Biomarkers for Diagnosis of Irritable Bowel Syndrome (IBS): A Pilot Gene Discovery Hypothesis Generating Study

Description

The diagnosis of irritable bowel syndrome (IBS) is currently based on symptomatic criteria that exclude other conditions affecting the gastrointestinal tract, such as celiac disease, food allergies, and infections. The

The diagnosis of irritable bowel syndrome (IBS) is currently based on symptomatic criteria that exclude other conditions affecting the gastrointestinal tract, such as celiac disease, food allergies, and infections. The absence of appropriate diagnostic and therapeutic approaches for IBS places a significant burden on the patient and the health care system due to direct and indirect costs of care. Limitations associated with the application of symptomatic criteria include inappropriate use and/or intrinsic limitations such as the population to which these criteria are applied. The lack of biomarkers specific for IBS, non-specific abdominal symptoms, and considerable variability in the disease course creates additional uncertainty during diagnosis. This project involved screening tissue samples from patients with verified IBS to identify gene expression-based biomarkers associated with IBS. Through validation of microarray gene chip data on the tissue samples using PCR, it was determined that a number of genes within the diseased IBS patient tissue samples were differentially expressed in comparison to the healthy subjects. These findings could potentially lead to the diagnosis of IBS on the basis of a genetic "fingerprint".

Contributors

Agent

Created

Date Created
  • 2013-12

134377-Thumbnail Image.png

The Effects of Serial Killers on FBI Policies & Investigations By: Joseph Muzupappa

Description

Serial killers have had a profound impact on the United States' most powerful law enforcement agency, the Federal Bureau of Investigation. Through a brief history of the FBI, the birth

Serial killers have had a profound impact on the United States' most powerful law enforcement agency, the Federal Bureau of Investigation. Through a brief history of the FBI, the birth of the Behavioral Analysis Unit is highlighted and criminal profiling is realized as a tool to apprehend these serial killers. Four serial killer cases are presented as important representations to illustrate the contributions that were made to the FBI's investigatory procedure. As serial killings make up only one percent of the murders in the U.S. each year, it is still evident that these cases have had a profound impact on the U.S.'s top law enforcement agency. The FBI has been able to react to each case more effectively than the last. Constant learning on the job, as each impactful case happens within a short time span from the last, has been a necessity for investigators and has been a prime strength of the FBI. There is no way to tell when an individual will begin to commit serial murder, so while the FBI's methods are not perfect, the Bureau has been able to respond in full to each challenge a new serial killer case has presented and arrest the guilty party. Through an analysis of the criminal profile, stereotypes attributed to serial killers, and the application of forensic evidence to serial killer investigations, the impact of the investigations of these cases by the FBI is examined. A real world application of the FBI's recommended procedure for a serial killer investigation is spotlighted and analyzed to determine its practicality in modern-day investigations.

Contributors

Created

Date Created
  • 2017-05

135679-Thumbnail Image.png

Treatment of Type II Diabetes: Synthesis and Analysis of Five Analogs of Compound NEt-4IB that Target the Retinoid-X-Receptor

Description

This project details the synthesis and analysis of five analogs of model compound NEt-4IB (6-[ethyl(4-isobutoxy-3-isopropylphenyl)amino]nicotinic acid), that target the retinoid-X-receptor (RXR). These molecules were synthesized by substituting, adding, or removing

This project details the synthesis and analysis of five analogs of model compound NEt-4IB (6-[ethyl(4-isobutoxy-3-isopropylphenyl)amino]nicotinic acid), that target the retinoid-X-receptor (RXR). These molecules were synthesized by substituting, adding, or removing substituents in the nitrogen-containing ring of NEt-4IB. The parent compound is a RXR partial agonist and has proven to be effective in the treatment of type II diabetes without the unwanted side effects seen with full agonists. Many of the current drugs used to treat type II diabetes are accompanied by adverse effects including increased triglyceride levels, weight gain, and hypoglycemia. Biological evaluation with KK-Ay (obese diabetic) model mice indicates that NEt-4IB may even be more effective than current drugs on the market, like pioglitazone. As a result, it is predicted that due to such structural similarity, the analogs synthesized for this work will perform equally, if not better than, NEt-4IB.

Contributors

Agent

Created

Date Created
  • 2016-05

135967-Thumbnail Image.png

Child Abuse and Neglect Handbook: Victim Identification for School Aged Children

Description

Child abuse is a hard topic to talk about, and even harder to diagnose without proper training. Though there is a list of general characteristics that child abuse victim's exhibit,

Child abuse is a hard topic to talk about, and even harder to diagnose without proper training. Though there is a list of general characteristics that child abuse victim's exhibit, it could be difficult to diagnose because everyone reacts to maltreatment differently. Teachers are required by law to report any case where they believe a child is in an abusive environment. Unfortunately, teachers are given the tools to report the abuse, but they lack the knowledge of what to look for. The results are two fold; one is there is an overflow of false reporting, and two, the children who do not having obvious symptoms go unnoticed. This project aims to bridge the gap between these two extremes. It will lower the frequency of false reporting while increasing the chance that a child in need will be helped. The best way to achieve this is through education. The purpose of the study is to create an informational manual for teachers at the kindergarten and elementary level on how to identify child abuse and neglect victims. It will outline the behavioral and physical symptoms of physical abuse, sexual abuse, emotional abuse, and neglect. It will also highlight the importance of realizing that not all maltreatment victims react the same to abuse. It will then follow into advice on how to approach the situation and what questions to ask. The primary form of research was primary observation by volunteering at the Mesa Child Crisis Center (with IRB approval). Interviews were conducted with Child Crisis Center workers, child behavioral psychologists, and Special Victims Unit detectives. The goal of this research is to help teachers better identify children that are at risk of abuse
eglect, and to understand the theory behind their behavior. In the end, teachers will be more informed on the topic so they can better help their students and create a safe environment for them, and be more confident in reporting.

Contributors

Agent

Created

Date Created
  • 2015-12

135639-Thumbnail Image.png

Disease and Signaling: The Role of Vitamin D in Healthful Aging

Description

Vitamin D, a bioactive lipid and essential nutrient, is obtained by humans through either endogenous synthesis in response to UV light exposure or via nutritional intake. Once activated to its

Vitamin D, a bioactive lipid and essential nutrient, is obtained by humans through either endogenous synthesis in response to UV light exposure or via nutritional intake. Once activated to its hormonal form, vitamin D binds to and activates the nuclear vitamin D receptor (VDR). Activation of VDR is known to modulate gene transcription in vitamin D target tissues such as kidney, colon, and bone; however, less is known about the ability of VDR to respond to "nutritional modulators". One such potential VDR modulator is resveratrol, a plant-derived polyphenol and potent antioxidant nutrient that also functions as a chemopreventative. Resveratrol is known to activate sirtuin-1, a deacetylase enzyme with potential anti-aging properties. This study explores the potential for resveratrol, an anticancer nutraceutical, to upregulate VDR activity through its effector protein, sirtuin-1. Furthermore, due to its putative interactions with several intracellular signaling pathways, klotho has been proposed as an anti-aging protein and tumor suppressor gene, while the Wnt/β-catenin signaling pathway drives enhanced cellular proliferation leading to numerous types of cancers, especially colorectal neoplasia. Thus, the ability of klotho to cooperate with vitamin D to inhibit oncogenic β-catenin signaling was also analyzed. The experiments and resultant data presented in this thesis explore the potential role of VDR as a physiologically relevant nutritional sensor in human cells. This novel study reveals the importance of nutrient modulation of the VDR system by vitamin D and resveratrol and how this might represent a molecular mechanism that is responsible for the putative anti-cancer actions of vitamin D. Furthermore, this study enhances our understanding of how vitamin D/VDR and resveratrol interact with klotho and how this interaction affects β-catenin signaling to mitigate oncogenic growth and differentiation. This works demonstrates that the vitamin D hormone serves as a likely chemopreventive agent for various types of cancers through control of anti-oxidation and cellular proliferation pathways via its nuclear receptor. Our results also indicate the potential for resveratrol, an anticancer nutraceutical, to upregulate VDR activity through SIRT1. Furthermore, the novel data presented in this work illustrate that klotho, an anti-aging protein, cooperates with vitamin D to synergistically inhibit oncogenic β-catenin signaling. Ultimately, this study enhances our understating of the molecular pathways that underpin nutritional chemoprevention, and how modulation of these pathways via dietary intervention may lead to advances in public health strategies to eventually curb carcinogenesis.

Contributors

Agent

Created

Date Created
  • 2016-05

134552-Thumbnail Image.png

Standard mapping protocols misestimate sex-biased gene expression

Description

There are several challenges to accurately inferring levels of transcription using RNA-sequencing (RNA-seq) data, including detecting and correcting for reference genome mapping bias. One potential confounder of RNA-seq analysis results

There are several challenges to accurately inferring levels of transcription using RNA-sequencing (RNA-seq) data, including detecting and correcting for reference genome mapping bias. One potential confounder of RNA-seq analysis results from the application of a standardized pipeline to samples of different sexes in species with chromosomal sex determination. The homology between the human X and Y chromosomes will routinely cause mismapping to occur, artificially biasing estimates of sex-biased gene transcription. For this reason we tested sex-specific mapping scenarios in humans on RNA-seq samples from the brains of 5 genetic females and 5 genetic males to assess how inferences of differential gene expression patterns change depending on the reference genome. We first applied a mapping protocol where we mapped all individuals to the entire human reference genome (complete), including the X and Y chromosomes, and computed differential expression between the set of genetic male and genetic female samples. We next mapped the genetic female samples (46,XX) to the human reference genome with the Y chromosome removed (Y-excluded) and the genetic male samples (46, XY) to the human reference genome (including the Y chromosome), but with the pseudoautosomal regions of the Y chromosome hard-masked (YPARs-masked) for the two sex-specific mappings. Using the complete and sex-specific mapping protocols, we compared the differential expression measurements of genetic males and genetic females from cuffDiff outputs. The second strategy called 33 additional genes as being differentially expressed between the two sexes when compared to the complete mapping protocol. This research provides a framework for a new standard of reference genome mappings to correct for sex-biased gene expression estimates that can be used in future studies.

Contributors

Agent

Created

Date Created
  • 2017-05

134607-Thumbnail Image.png

Illness and Narrative Identity: Rewriting the Self

Description

Through this thesis, I intend to explore what sociologist Arthur Frank means when he describes illness as "a dangerous opportunity" (Frank, 1991, p. 1). It is my objective to more

Through this thesis, I intend to explore what sociologist Arthur Frank means when he describes illness as "a dangerous opportunity" (Frank, 1991, p. 1). It is my objective to more fully understand the lived experience of illness and how narrative can aid in transforming illness from tragic to transcendent. In doing so, it is first necessary to understand how illness differs from disease and how the medicalization of human health has displaced narrative from medical practice. Since illness is best understood as a lived experience, I will discuss how narrative is an exemplary means of communicating these experiences and restoring identity that is threatened by illness. Lastly, I will address how narrative might be more effectively utilized in the context of medicine, in respect to both patients and physicians. In this work, I propose that the opportunities posed by illness might be seized by actively exploring it by means of narrative expression. It is my hope that this thesis might contribute to extending the notion that narrative is a means of attributing greater meaning to illness and constructing a more complete, compassionate approach to medicine.

Contributors

Created

Date Created
  • 2017-05

134351-Thumbnail Image.png

Mathematical Analysis of Photoreceptor Degeneration in Retinal Detachment

Description

The retina is the lining in the back of the eye responsible for vision. When light photons hits the retina, the photoreceptors within the retina respond by sending impulses to

The retina is the lining in the back of the eye responsible for vision. When light photons hits the retina, the photoreceptors within the retina respond by sending impulses to the optic nerve, which connects to the brain. If there is injury to the eye or heredity retinal problems, this part can become detached. Detachment leads to loss of nutrients, such as oxygen and glucose, to the cells in the eye and causes cell death. Sometimes the retina is able to be surgically reattached. If the photoreceptor cells have not died and the reattachment is successful, then these cells are able to regenerate their outer segments (OS) which are essential for their functionality and vitality. In this work we will explore how the regrowth of the photoreceptor cells in a healthy eye after retinal detachment can lead to a deeper understanding of how eye cells take up nutrients and regenerate. This work uses a mathematical model for a healthy eye in conjunction with data for photoreceptors' regrowth and decay. The parameters for the healthy eye model are estimated from the data and the ranges of these parameter values are centered +/- 10\% away from these values are used for sensitivity analysis. Using parameter estimation and sensitivity analysis we can better understand how certain processes represented by these parameters change within the model as a result of retinal detachment. Having a deeper understanding for any sort of photoreceptor death and growth can be used by the greater scientific community to help with these currently irreversible conditions that lead to blindness, such as retinal detachment. The analysis in this work shows that maximizing the carrying capacity of the trophic pool and the rate of RDCVF, as well as minimizing nutrient withdrawal of the rods and the cones from the trophic pool results in both the most regrowth and least cell death in retinal detachment.

Contributors

Agent

Created

Date Created
  • 2017-05