Many of us regularly make decisions with the intention of living longer, healthier lives. We try to eat right, exercise, take vitamins, get checkups, and keep our bodies in general good shape. Some of the enhancements we make that are meant to increase the length or quality of life go even further: organ or joint replacement surgeries, cosmetic surgeries, cancer treatments, etc. These kinds of enhancements and attempts at increasing one's life, or, in some cases, the feeling or look of youth, are not the focus of this essay. These adjustments are too minor. Here I focus on the potential for significant lifespan extension (SLE), with "significant" being the operative word. For the purposes of this article, I shall define SLE as an extension to the human lifespan that is at least 100 years greater than humans 'current lifespan, which now maxes-out at about 120 years. Lifespan extension of merely a few years, say if people could live to 130 or so, would not likely result in vast personal and social differences. However, SLE promises to have more interesting and impactful potential results.