Matching Items (19)
Description
Past research has shown that students have difficulty developing a robust conception of function. However, little prior research has been performed dealing with student knowledge of function composition, a potentially powerful mathematical concept. This dissertation reports the results of an investigation into student understanding and use of function composition, set against the backdrop of a precalculus class that emphasized quantification and covariational reasoning. The data were collected using task-based, semi-structured clinical interviews with individual students outside the classroom. Findings from this study revealed that factors such as the student's quantitative reasoning, covariational reasoning, problem solving behaviors, and view of function influence how a student understands and uses function composition. The results of the study characterize some of the subtle ways in which these factors impact students' ability to understand and use function composition to solve problems. Findings also revealed that other factors such as a students' persistence, disposition towards "meaning making" for the purpose of conceptualizing quantitative relationships, familiarity with the context of a problem, procedural fluency, and student knowledge of rules of "order of operations" impact a students' progress in advancing her/his solution approach.
ContributorsBowling, Stacey (Author) / Carlson, Marilyn P (Thesis advisor) / Thompson, Patrick W (Committee member) / Moore, Kevin C (Committee member) / Milner, Fabio (Committee member) / Van de Sande, Carla (Committee member) / Arizona State University (Publisher)
Created2014
Description
The phycologist, M. R. Droop, studied vitamin B12 limitation in the flagellate Monochrysis lutheri and concluded that its specific growth rate depended on the concentration of the vitamin within the cell; i.e. the cell quota of the vitamin B12. The Droop model provides a mathematical expression to link growth rate to the intracellular concentration of a limiting nutrient. Although the Droop model has been an important modeling tool in ecology, it has only recently been applied to study cancer biology. Cancer cells live in an ecological setting, interacting and competing with normal and other cancerous cells for nutrients and space, and evolving and adapting to their environment. Here, the Droop equation is used to model three cancers.
First, prostate cancer is modeled, where androgen is considered the limiting nutrient since most tumors depend on androgen for proliferation and survival. The model's accuracy for predicting the biomarker for patients on intermittent androgen deprivation therapy is tested by comparing the simulation results to clinical data as well as to an existing simpler model. The results suggest that a simpler model may be more beneficial for a predictive use, although further research is needed in this field prior to implementing mathematical models as a predictive method in a clinical setting.
Next, two chronic myeloid leukemia models are compared that consider Imatinib treatment, a drug that inhibits the constitutively active tyrosine kinase BCR-ABL. Both models describe the competition of leukemic and normal cells, however the first model also describes intracellular dynamics by considering BCR-ABL as the limiting nutrient. Using clinical data, the differences in estimated parameters between the models and the capacity for each model to predict drug resistance are analyzed.
Last, a simple model is presented that considers ovarian tumor growth and tumor induced angiogenesis, subject to on and off anti-angiogenesis treatment. In this environment, the cell quota represents the intracellular concentration of necessary nutrients provided through blood supply. Mathematical analysis of the model is presented and model simulation results are compared to pre-clinical data. This simple model is able to fit both on- and off-treatment data using the same biologically relevant parameters.
First, prostate cancer is modeled, where androgen is considered the limiting nutrient since most tumors depend on androgen for proliferation and survival. The model's accuracy for predicting the biomarker for patients on intermittent androgen deprivation therapy is tested by comparing the simulation results to clinical data as well as to an existing simpler model. The results suggest that a simpler model may be more beneficial for a predictive use, although further research is needed in this field prior to implementing mathematical models as a predictive method in a clinical setting.
Next, two chronic myeloid leukemia models are compared that consider Imatinib treatment, a drug that inhibits the constitutively active tyrosine kinase BCR-ABL. Both models describe the competition of leukemic and normal cells, however the first model also describes intracellular dynamics by considering BCR-ABL as the limiting nutrient. Using clinical data, the differences in estimated parameters between the models and the capacity for each model to predict drug resistance are analyzed.
Last, a simple model is presented that considers ovarian tumor growth and tumor induced angiogenesis, subject to on and off anti-angiogenesis treatment. In this environment, the cell quota represents the intracellular concentration of necessary nutrients provided through blood supply. Mathematical analysis of the model is presented and model simulation results are compared to pre-clinical data. This simple model is able to fit both on- and off-treatment data using the same biologically relevant parameters.
ContributorsEverett, Rebecca Anne (Author) / Kuang, Yang (Thesis advisor) / Nagy, John (Committee member) / Milner, Fabio (Committee member) / Crook, Sharon (Committee member) / Jackiewicz, Zdzislaw (Committee member) / Arizona State University (Publisher)
Created2015
Description
Since Duffin and Schaeffer's introduction of frames in 1952, the concept of a frame has received much attention in the mathematical community and has inspired several generalizations. The focus of this thesis is on the concept of an operator-valued frame (OVF) and a more general concept called herein an operator-valued frame associated with a measure space (MS-OVF), which is sometimes called a continuous g-frame. The first of two main topics explored in this thesis is the relationship between MS-OVFs and objects prominent in quantum information theory called positive operator-valued measures (POVMs). It has been observed that every MS-OVF gives rise to a POVM with invertible total variation in a natural way. The first main result of this thesis is a characterization of which POVMs arise in this way, a result obtained by extending certain existing Radon-Nikodym theorems for POVMs. The second main topic investigated in this thesis is the role of the theory of unitary representations of a Lie group G in the construction of OVFs for the L^2-space of a relatively compact subset of G. For G=R, Duffin and Schaeffer have given general conditions that ensure a sequence of (one-dimensional) representations of G, restricted to (-1/2,1/2), forms a frame for L^{2}(-1/2,1/2), and similar conditions exist for G=R^n. The second main result of this thesis expresses conditions related to Duffin and Schaeffer's for two more particular Lie groups: the Euclidean motion group on R^2 and the (2n+1)-dimensional Heisenberg group. This proceeds in two steps. First, for a Lie group admitting a uniform lattice and an appropriate relatively compact subset E of G, the Selberg Trace Formula is used to obtain a Parseval OVF for L^{2}(E) that is expressed in terms of irreducible representations of G. Second, for the two particular Lie groups an appropriate set E is found, and it is shown that for each of these groups, with suitably parametrized unitary duals, the Parseval OVF remains an OVF when perturbations are made to the parameters of the included representations.
ContributorsRobinson, Benjamin (Author) / Cochran, Douglas (Thesis advisor) / Moran, William (Thesis advisor) / Boggess, Albert (Committee member) / Milner, Fabio (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2014
Description
Persistence theory provides a mathematically rigorous answer to the question of population survival by establishing an initial-condition- independent positive lower bound for the long-term value of the population size. This study focuses on the persistence of discrete semiflows in infinite-dimensional state spaces that model the year-to-year dynamics of structured populations. The map which encapsulates the population development from one year to the next is approximated at the origin (the extinction state) by a linear or homogeneous map. The (cone) spectral radius of this approximating map is the threshold between extinction and persistence. General persistence results are applied to three particular models: a size-structured plant population model, a diffusion model (with both Neumann and Dirichlet boundary conditions) for a dispersing population of males and females that only mate and reproduce once during a very short season, and a rank-structured model for a population of males and females.
ContributorsJin, Wen (Author) / Thieme, Horst (Thesis advisor) / Milner, Fabio (Committee member) / Quigg, John (Committee member) / Smith, Hal (Committee member) / Spielberg, John (Committee member) / Arizona State University (Publisher)
Created2014
Description
This study contributes to the ongoing discussion of Mathematical Knowledge for Teaching (MKT). It investigates the case of Rico, a high school mathematics teacher who had become known to his colleagues and his students as a superbly effective mathematics teacher. His students not only developed excellent mathematical skills, they also developed deep understanding of the mathematics they learned. Moreover, Rico redesigned his curricula and instruction completely so that they provided a means of support for his students to learn mathematics the way he intended. The purpose of this study was to understand the sources of Rico's effectiveness. The data for this study was generated in three phases. Phase I included videos of Rico's lessons during one semester of an Algebra II course, post-lesson reflections, and Rico's self-constructed instructional materials. An analysis of Phase I data led to Phase II, which consisted of eight extensive stimulated-reflection interviews with Rico. Phase III consisted of a conceptual analysis of the prior phases with the aim of creating models of Rico's mathematical conceptions, his conceptions of his students' mathematical understandings, and his images of instruction and instructional design. Findings revealed that Rico had developed profound personal understandings, grounded in quantitative reasoning, of the mathematics that he taught, and profound pedagogical understandings that supported these very same ways of thinking in his students. Rico's redesign was driven by three factors: (1) the particular way in which Rico himself understood the mathematics he taught, (2) his reflective awareness of those ways of thinking, and (3) his ability to envision what students might learn from different instructional approaches. Rico always considered what someone might already need to understand in order to understand "this" in the way he was thinking of it, and how understanding "this" might help students understand related ideas or methods. Rico's continual reflection on the mathematics he knew so as to make it more coherent, and his continual orientation to imagining how these meanings might work for students' learning, made Rico's mathematics become a mathematics of students--impacting how he assessed his practice and engaging him in a continual process of developing MKT.
ContributorsLage Ramírez, Ana Elisa (Author) / Thompson, Patrick W. (Thesis advisor) / Carlson, Marilyn P. (Committee member) / Castillo-Chavez, Carlos (Committee member) / Saldanha, Luis (Committee member) / Middleton, James A. (Committee member) / Arizona State University (Publisher)
Created2011
Description
This dissertation describes an investigation of four students' ways of thinking about functions of two variables and rate of change of those two-variable functions. Most secondary, introductory algebra, pre-calculus, and first and second semester calculus courses do not require students to think about functions of more than one variable. Yet vector calculus, calculus on manifolds, linear algebra, and differential equations all rest upon the idea of functions of two (or more) variables. This dissertation contributes to understanding productive ways of thinking that can support students in thinking about functions of two or more variables as they describe complex systems with multiple variables interacting. This dissertation focuses on modeling the way of thinking of four students who participated in a specific instructional sequence designed to explore the limits of their ways of thinking and in turn, develop a robust model that could explain, describe, and predict students' actions relative to specific tasks. The data was collected using a teaching experiment methodology, and the tasks within the teaching experiment leveraged quantitative reasoning and covariation as foundations of students developing a coherent understanding of two-variable functions and their rates of change. The findings of this study indicated that I could characterize students' ways of thinking about two-variable functions by focusing on their use of novice and/or expert shape thinking, and the students' ways of thinking about rate of change by focusing on their quantitative reasoning. The findings suggested that quantitative and covariational reasoning were foundational to a student's ability to generalize their understanding of a single-variable function to two or more variables, and their conception of rate of change to rate of change at a point in space. These results created a need to better understand how experts in the field, such as mathematicians and mathematics educators, thinking about multivariable functions and their rates of change.
ContributorsWeber, Eric David (Author) / Thompson, Patrick (Thesis advisor) / Middleton, James (Committee member) / Carlson, Marilyn (Committee member) / Saldanha, Luis (Committee member) / Milner, Fabio (Committee member) / Van de Sande, Carla (Committee member) / Arizona State University (Publisher)
Created2012
Description
There have been a number of studies that have examined students’ difficulties in understanding the idea of logarithm and the effectiveness of non-traditional interventions. However, there have been few studies that have examined the understandings students develop and need to develop when completing conceptually oriented logarithmic lessons. In this document, I present the three papers of my dissertation study. The first paper examines two students’ development of concepts foundational to the idea of logarithm. This paper discusses two essential understandings that were revealed to be problematic and essential for students’ development of productive meanings for exponents, logarithms and logarithmic properties. The findings of this study informed my later work to support students in understanding logarithms, their properties and logarithmic functions. The second paper examines two students’ development of the idea of logarithm. This paper describes the reasoning abilities two students exhibited as they engaged with tasks designed to foster their construction of more productive meanings for the idea of logarithm. The findings of this study provide novel insights for supporting students in understanding the idea of logarithm meaningfully. Finally, the third paper begins with an examination of the historical development of the idea of logarithm. I then leveraged the insights of this literature review and the first two papers to perform a conceptual analysis of what is involved in learning and understanding the idea of logarithm. The literature review and conceptual analysis contributes novel and useful information for curriculum developers, instructors, and other researchers studying student learning of this idea.
ContributorsKuper Flores, Emily Ginamarie (Author) / Carlson, Marilyn (Thesis advisor) / Thompson, Patrick (Committee member) / Milner, Fabio (Committee member) / Zazkis, Dov (Committee member) / Czocher, Jennifer (Committee member) / Arizona State University (Publisher)
Created2018
Description
The advancement of technology has substantively changed the practices of numerous professions, including teaching. When an instructor first adopts a new technology, established classroom practices are perturbed. These perturbations can have positive and negative, large or small, and long- or short-term effects on instructors’ abilities to teach mathematical concepts with the new technology. Therefore, in order to better understand teaching with technology, we need to take a closer look at the adoption of new technology in a mathematics classroom. Using interviews and classroom observations, I explored perturbations in mathematical classroom practices as an instructor implemented virtual manipulatives as novel didactic objects in rational function instruction. In particular, the instructor used didactic objects that were designed to lay the foundation for developing a conceptual understanding of rational functions through the coordination of relative size of the value of the numerator in terms of the value of the denominator. The results are organized according to a taxonomy that captures leader actions, communication, expectations of technology, roles, timing, student engagement, and mathematical conceptions.
ContributorsPampel, Krysten (Author) / Currin van de Sande, Carla (Thesis advisor) / Thompson, Patrick W (Committee member) / Carlson, Marilyn (Committee member) / Milner, Fabio (Committee member) / Strom, April (Committee member) / Arizona State University (Publisher)
Created2017
Description
This dissertation report follows a three-paper format, with each paper having a different but related focus. In Paper 1 I discuss conceptual analysis of mathematical ideas relative to its place within cognitive learning theories and research studies. In particular, I highlight specific ways mathematics education research uses conceptual analysis and discuss the implications of these uses for interpreting and leveraging results to produce empirically tested learning trajectories. From my summary and analysis I develop two recommendations for the cognitive researchers developing empirically supported learning trajectories. (1) A researcher should frame his/her work, and analyze others’ work, within the researcher’s image of a broadly coherent trajectory for student learning and (2) that the field should work towards a common understanding for the meaning of a hypothetical learning trajectory.
In Paper 2 I argue that prior research in online learning has tested the impact of online courses on measures such as student retention rates, satisfaction scores, and GPA but that research is needed to describe the meanings students construct for mathematical ideas researchers have identified as critical to their success in future math courses and other STEM fields. This paper discusses the need for a new focus in studying online mathematics learning and calls for cognitive researchers to begin developing a productive methodology for examining the meanings students construct while engaged in online lessons.
Paper 3 describes the online Precalculus course intervention we designed around measurement imagery and quantitative reasoning as themes that unite topics across units. I report results relative to the meanings students developed for exponential functions and related ideas (such as percent change and growth factors) while working through lessons in the intervention. I provide a conceptual analysis guiding its design and discuss pre-test and pre-interview results, post-test and post-interview results, and observations from student behaviors while interacting with lessons. I demonstrate that the targeted meanings can be productive for students, show common unproductive meanings students possess as they enter Precalculus, highlight challenges and opportunities in teaching and learning in the online environment, and discuss needed adaptations to the intervention and future research opportunities informed by my results.
In Paper 2 I argue that prior research in online learning has tested the impact of online courses on measures such as student retention rates, satisfaction scores, and GPA but that research is needed to describe the meanings students construct for mathematical ideas researchers have identified as critical to their success in future math courses and other STEM fields. This paper discusses the need for a new focus in studying online mathematics learning and calls for cognitive researchers to begin developing a productive methodology for examining the meanings students construct while engaged in online lessons.
Paper 3 describes the online Precalculus course intervention we designed around measurement imagery and quantitative reasoning as themes that unite topics across units. I report results relative to the meanings students developed for exponential functions and related ideas (such as percent change and growth factors) while working through lessons in the intervention. I provide a conceptual analysis guiding its design and discuss pre-test and pre-interview results, post-test and post-interview results, and observations from student behaviors while interacting with lessons. I demonstrate that the targeted meanings can be productive for students, show common unproductive meanings students possess as they enter Precalculus, highlight challenges and opportunities in teaching and learning in the online environment, and discuss needed adaptations to the intervention and future research opportunities informed by my results.
ContributorsO'Bryan, Alan Eugene (Author) / Carlson, Marilyn P (Thesis advisor) / Thompson, Patrick W (Committee member) / Milner, Fabio (Committee member) / Roh, Kyeong Hah (Committee member) / Tallman, Michael (Committee member) / Arizona State University (Publisher)
Created2018
Description
A teacher’s mathematical knowledge for teaching impacts the teacher’s pedagogical actions and goals (Marfai & Carlson, 2012; Moore, Teuscher, & Carlson, 2011), and a teacher’s instructional goals (Webb, 2011) influences the development of the teacher’s content knowledge for teaching. This study aimed to characterize the reciprocal relationship between a teacher’s mathematical knowledge for teaching and pedagogical goals.
Two exploratory studies produced a framework to characterize a teacher’s mathematical goals for student learning. A case study was then conducted to investigate the effect of a professional developmental intervention designed to impact a teacher’s mathematical goals. The guiding research questions for this study were: (a) what is the effect of a professional development intervention, designed to perturb a teacher’s pedagogical goals for student learning to be more attentive to students’ thinking and learning, on a teacher’s views of teaching, stated goals for student learning, and overarching goals for students’ success in mathematics, and (b) what role does a teacher's mathematical teaching orientation and mathematical knowledge for teaching have on a teacher’s stated and overarching goals for student learning?
Analysis of the data from this investigation revealed that a conceptual curriculum supported the advancement of a teacher’s thinking regarding the key ideas of mathematics of lessons, but without time to reflect and plan, the teacher made limited connections between the key mathematical ideas within and across lessons. The teacher’s overarching goals for supporting student learning and views of teaching mathematics also had a significant influence on her curricular choices and pedagogical moves when teaching. The findings further revealed that a teacher’s limited meanings for proportionality contributed to the teacher struggling during teaching to support students’ learning of concepts that relied on understanding proportionality. After experiencing this struggle the teacher reverted back to using skill-based lessons she had used before.
The findings suggest a need for further research on the impact of professional development of teachers, both in building meanings of key mathematical ideas of a teacher’s lessons, and in professional support and time for teachers to build stronger mathematical meanings, reflect on student thinking and learning, and reconsider one’s instructional goals.
Two exploratory studies produced a framework to characterize a teacher’s mathematical goals for student learning. A case study was then conducted to investigate the effect of a professional developmental intervention designed to impact a teacher’s mathematical goals. The guiding research questions for this study were: (a) what is the effect of a professional development intervention, designed to perturb a teacher’s pedagogical goals for student learning to be more attentive to students’ thinking and learning, on a teacher’s views of teaching, stated goals for student learning, and overarching goals for students’ success in mathematics, and (b) what role does a teacher's mathematical teaching orientation and mathematical knowledge for teaching have on a teacher’s stated and overarching goals for student learning?
Analysis of the data from this investigation revealed that a conceptual curriculum supported the advancement of a teacher’s thinking regarding the key ideas of mathematics of lessons, but without time to reflect and plan, the teacher made limited connections between the key mathematical ideas within and across lessons. The teacher’s overarching goals for supporting student learning and views of teaching mathematics also had a significant influence on her curricular choices and pedagogical moves when teaching. The findings further revealed that a teacher’s limited meanings for proportionality contributed to the teacher struggling during teaching to support students’ learning of concepts that relied on understanding proportionality. After experiencing this struggle the teacher reverted back to using skill-based lessons she had used before.
The findings suggest a need for further research on the impact of professional development of teachers, both in building meanings of key mathematical ideas of a teacher’s lessons, and in professional support and time for teachers to build stronger mathematical meanings, reflect on student thinking and learning, and reconsider one’s instructional goals.
ContributorsMarfai, Frank Stephen (Author) / Carlson, Marilyn P. (Thesis advisor) / Ström, April D. (Committee member) / Thompson, Patrick W. (Committee member) / Middleton, James A. (Committee member) / Zandieh, Michelle J. (Committee member) / Arizona State University (Publisher)
Created2016