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Language acquisition is a phenomenon we all experience, and though it is well studied many questions remain regarding the neural bases of language. Whether a hearing speaker or Deaf signer, spoken and signed language acquisition (with eventual proficiency) develop similarly and share common neural networks. While signed language and spoken

Language acquisition is a phenomenon we all experience, and though it is well studied many questions remain regarding the neural bases of language. Whether a hearing speaker or Deaf signer, spoken and signed language acquisition (with eventual proficiency) develop similarly and share common neural networks. While signed language and spoken language engage completely different sensory modalities (visual-manual versus the more common auditory-oromotor) both languages share grammatical structures and contain syntactic intricacies innate to all languages. Thus, studies of multi-modal bilingualism (e.g. a native English speaker learning American Sign Language) can lead to a better understanding of the neurobiology of second language acquisition, and of language more broadly. For example, can the well-developed visual-spatial processing networks in English speakers support grammatical processing in sign language, as it relies heavily on location and movement? The present study furthers the understanding of the neural correlates of second language acquisition by studying late L2 normal hearing learners of American Sign Language (ASL). Twenty English speaking ASU students enrolled in advanced American Sign Language coursework participated in our functional Magnetic Resonance Imaging (fMRI) study. The aim was to identify the brain networks engaged in syntactic processing of ASL sentences in late L2 ASL learners. While many studies have addressed the neurobiology of acquiring a second spoken language, no previous study to our knowledge has examined the brain networks supporting syntactic processing in bimodal bilinguals. We examined the brain networks engaged while perceiving ASL sentences compared to ASL word lists, as well as written English sentences and word lists. We hypothesized that our findings in late bimodal bilinguals would largely coincide with the unimodal bilingual literature, but with a few notable differences including additional attention networks being engaged by ASL processing. Our results suggest that there is a high degree of overlap in sentence processing networks for ASL and English. There also are important differences in regards to the recruitment of speech comprehension, visual-spatial and domain-general brain networks. Our findings suggest that well-known sentence comprehension and syntactic processing regions for spoken languages are flexible and modality-independent.
ContributorsMickelsen, Soren Brooks (Co-author) / Johnson, Lisa (Co-author) / Rogalsky, Corianne (Thesis director) / Azuma, Tamiko (Committee member) / Howard, Pamela (Committee member) / Department of Speech and Hearing Science (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
In this study, I aim to understand general knowledge of menstruation and reproductive health among women who live and work in Dakar, Senegal. While there is an established nationalized sex education curriculum and robust HIV prevention campaigns, there is nonetheless an unmet need for sexual health education in Senegal and

In this study, I aim to understand general knowledge of menstruation and reproductive health among women who live and work in Dakar, Senegal. While there is an established nationalized sex education curriculum and robust HIV prevention campaigns, there is nonetheless an unmet need for sexual health education in Senegal and limited access to family planning services in low-income communities. I examine data obtained from surveys conducted with participants selected using convenience sampling in five different neighborhoods in Dakar, as well as ethnographic observations during the four month period of study. Qualitative and quantitative analyses address women's comforts levels during menstruation, barriers to access of high quality menstrual care products, familiarity with different kinds of contraceptive methods, and information on where women receive information regarding puberty, sex, and menstruation. Results show that most participants seek out family members, female friends and other respected members in the community for reproductive development information. National programs and international organizations sponsor youth to become community educators, who offer an informal and more accessible method of education. Earlier research shows that informal methods of education can be extremely effective ; in the setting of Dakar, young health educators are also creating inclusive and safe spaces for meaningful discussions about sexuality to be held, combating the negative effects of the traditional patriarchal and conservative culture. Relationships with one's community are extremely important, and can be an invaluable resource in transmitting sexual and reproductive health information to women. Improved understanding of reproductive health among women in Senegal can encourage them to make informed decisions about family planning.
ContributorsShirazi, Afsoon Louise (Author) / Hayford, Sarah (Thesis director) / Suk, Mina (Committee member) / School of International Letters and Cultures (Contributor, Contributor) / School of Social Transformation (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Physician-assisted suicide occurs when a physician facilitates a patient's death by prescribing a lethal medication that they understand will be used for the purpose of ending the patient's life. It is a highly contentious subject and, with the recent addition of California to the list of states that allow physician-assisted

Physician-assisted suicide occurs when a physician facilitates a patient's death by prescribing a lethal medication that they understand will be used for the purpose of ending the patient's life. It is a highly contentious subject and, with the recent addition of California to the list of states that allow physician-assisted suicide, is an increasingly relevant subject. Physician-assisted suicide is rarely framed as a healthcare experience, despite being a choice in the process of end-of-life care. The research seeks to bring together the debates about physician-assisted suicide with conversations about health care experiences. The experiences and perspectives of young people are particularly valuable to evaluate now, as their voices will soon be the leaders in the debate over physician-assisted suicide. Within this research, there is an underlying theme of independence of individuals that is present through both the literature review and the body of data collected and analyzed. The study found that there was no significant relationship between the quality of a person's healthcare and their perspectives about physician-assisted suicide.
ContributorsMoeur, Katherine Elizabeth (Author) / Brian, Jennifer (Thesis director) / Graff, Sarah (Committee member) / Stevenson, Christine (Committee member) / School of Life Sciences (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Abstract
The aim of the research performed was to increase research potential in the field of cell stimulation by developing a method to adhere human neural progenitor cells (hNPC’s) to a sterilized stretchable microelectrode array (SMEA). The two primary objectives of our research were to develop methods of sterilizing the polydimethylsiloxane

Abstract
The aim of the research performed was to increase research potential in the field of cell stimulation by developing a method to adhere human neural progenitor cells (hNPC’s) to a sterilized stretchable microelectrode array (SMEA). The two primary objectives of our research were to develop methods of sterilizing the polydimethylsiloxane (PDMS) substrate being used for the SMEA, and to derive a functional procedure for adhering hNPC’s to the PDMS. The proven method of sterilization was to plasma treat the sample and then soak it in 70% ethanol for one hour. The most successful method for cell adhesion was plasma treating the PDMS, followed by treating the surface of the PDMS with 0.01 mg/mL poly-l-lysine (PLL) and 3 µg/cm2 laminin. The development of these methods was an iterative process; as the methods were tested, any problems found with the method were corrected for the next round of testing until a final method was confirmed. Moving forward, the findings will allow for cell behavior to be researched in a unique fashion to better understand the response of adherent cells to physical stimulation by measuring changes in their electrical activity.
ContributorsBridgers, Carson (Co-author) / Peterson, Mara (Co-author) / Stabenfeldt, Sarah (Thesis director) / Graudejus, Oliver (Committee member) / Harrington Bioengineering Program (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
This study investigates how the patient-provider relationship between lesbian, gay, and bisexual women and their healthcare providers influences their access to, utilization of, and experiences within healthcare environments. Nineteen participants, ages 18 to 34, were recruited using convenience and snowball sampling. Interviews were conducted inquiring about their health history and

This study investigates how the patient-provider relationship between lesbian, gay, and bisexual women and their healthcare providers influences their access to, utilization of, and experiences within healthcare environments. Nineteen participants, ages 18 to 34, were recruited using convenience and snowball sampling. Interviews were conducted inquiring about their health history and their experiences within the healthcare system in the context of their sexual orientation. The data collected from these interviews was used to create an analysis of the healthcare experiences of those who identify as queer. Although the original intention of the project was to chronicle the experiences of LGB women specifically, there were four non-binary gender respondents who contributed interviews. In an effort to not privilege any orientation over another, the respondents were collectively referred to as queer, given the inclusive and an encompassing nature of the term. The general conclusion of this study is that respondents most often experienced heterosexism rather than outright homophobia when accessing healthcare. If heterosexism was present within the healthcare setting, it made respondents feel uncomfortable with their providers and less likely to inform them of their sexuality even if it was medically relevant to their health outcomes. Gender, race, and,socioeconomic differences also had an effect on the patient-provider relationship. Non-binary respondents acknowledged the need for inclusion of more gender options outside of male or female on the reporting forms often seen in medical offices. By doing so, medical professionals are acknowledging their awareness and knowledge of people outside of the binary gender system, thus improving the experience of these patients. While race and socioeconomic status were less relevant to the context of this study, it was found that these factors have an affect on the patient-provider relationship. There are many suggestions for providers to improve the experiences of queer patients within the healthcare setting. This includes nonverbal indications of acknowledgement and acceptance, such as signs in the office that indicate it to be a queer friendly space. This will help in eliminating the fear and miscommunication that can often happen when a queer patient sees a practitioner for the first time. In addition, better education on medically relevant topics to queer patients, is necessary in order to eliminate disparities in health outcomes. This is particularly evident in trans health, where specialized education is necessary in order to decrease poor health outcomes in trans patients. Future directions of this study necessitate a closer look on how race and socioeconomic status have an effect on a queer patient's relationship with their provider.
Created2016-05
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This study explores the topic of the birth control use of college women, and the factors that influence their decision of whether or not to use contraception consistently. A literature review was performed on Academic Search Premier, SocIndex, Women's Studies International, Pubmed, CINAHL, and ICRW. Interviews were conducted with 7

This study explores the topic of the birth control use of college women, and the factors that influence their decision of whether or not to use contraception consistently. A literature review was performed on Academic Search Premier, SocIndex, Women's Studies International, Pubmed, CINAHL, and ICRW. Interviews were conducted with 7 participants recruited through convenience sampling. The results suggest that low perception of risk, lack of access, and alcohol use are all major influences on women's decisions regarding birth control. A review of current policy was also completed, and potential policy changes are suggested in order to improve college women's consistent contraceptive use.
ContributorsMorehouse, Brittany Anne (Author) / Weitz, Rose (Thesis director) / Durfee, Alesha (Committee member) / School of Politics and Global Studies (Contributor) / School of Social Transformation (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Epigenetic mechanisms such as DNA methylation have been found to affect metabolic processes, which leads to conditions like type 2 diabetes and obesity. The aim of this project was to validate differentially methylated cytosines (DMCs) identified in skeletal muscle from seven obese, non-diabetic women pre- and 3 months post- Roux-en-Y

Epigenetic mechanisms such as DNA methylation have been found to affect metabolic processes, which leads to conditions like type 2 diabetes and obesity. The aim of this project was to validate differentially methylated cytosines (DMCs) identified in skeletal muscle from seven obese, non-diabetic women pre- and 3 months post- Roux-en-Y gastric bypass surgery. DNA samples extracted from skeletal muscle were sent to the Mayo Genotyping Core to undergo reduced representation bisulfite sequencing (RRBS). Differentially methylated cytosines at chr14.105353824 of the gene CEP170B, chr19.16437949 of the KLF2 gene, chr7.130126082 of MEST, and chr15.62457572 of C2CD4B were captured from the RRBS analysis using MethylSig. Bisulfite sequencing PCR (BSP) was performed on all DMCs listed above which resulted in no significant changes in methylation post-surgery. It was concluded that an alternate, more precise method should be used for validation of the RRBS, such as pyrosequencing.
ContributorsKelley, Conley Lane (Author) / Coletta, Dawn K. (Thesis director) / Roust, Lori R. (Committee member) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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This work challenges the conventional perceptions surrounding the utility and use of the CMS Open Payments data. I suggest unconsidered methodologies for extracting meaningful information from these data following an exploratory analysis of the 2014 research dataset that, in turn, enhance its value as a public good. This dataset is

This work challenges the conventional perceptions surrounding the utility and use of the CMS Open Payments data. I suggest unconsidered methodologies for extracting meaningful information from these data following an exploratory analysis of the 2014 research dataset that, in turn, enhance its value as a public good. This dataset is favored for analysis over the general payments dataset as it is believed that generating transparency in the pharmaceutical and medical device R&D process would be of the greatest benefit to public health. The research dataset has been largely ignored by analysts and this may be one of the few works that have accomplished a comprehensive exploratory analysis of these data. If we are to extract valuable information from this dataset, we must alter both our approach as well as focus our attention towards re-conceptualizing the questions that we ask. Adopting the theoretical framework of complex systems serves as the foundation for our interpretation of the research dataset. This framework, in conjunction with a methodological toolkit for network analysis, may set a precedent for the development of alternative perspectives that allow for novel interpretations of the information that big data attempts to convey. By thus proposing a novel perspective in interpreting the information that this dataset contains, it is possible to gain insight into the emergent dynamics of the collaborative relationships that are established during the pharmaceutical and medical device R&D process.
Created2016-05
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Description
Popular culture tends to downplay strong female characters to favor a plethora of male figures that children look up to as heroes. This creates a gender imbalance in exposure to inspirational characters that children can look up to as role models. For our team's creative project, we chose to write

Popular culture tends to downplay strong female characters to favor a plethora of male figures that children look up to as heroes. This creates a gender imbalance in exposure to inspirational characters that children can look up to as role models. For our team's creative project, we chose to write and illustrate a children's book mainly targeted at young girls, ages eight to twelve that focuses on the stories of selected female figures of Norse mythology. The five stories in our collection focus on the figures Frigg, Skadi, Elli, Idunn, and Freya and are inspired by the mythology contained in the Prose Edda by Snorri Sturluson and selected medieval texts on the Germanic Lombard tribe. Through our book, Women of Norse Myth: For Little Goddesses, we wanted to introduce children to Norse mythology, a branch of myth that is often overshadowed by more popular mythologies such as Roman and Greek. Additionally, our goal was to bring light to the female figures within Norse myth that are generally given less attention than their male counterparts. Keeping in mind these goals, the stories were adapted from the original myths in a manner that would be suitable for a young audience as well as our aim for female empowerment. The final manuscript contains an introduction to Norse cosmology, introductions to the figures, a glossary of Norse terms used, and the illustrated stories themselves. Together with our combined talents, interests, and goals, Women of Norse Myth: For Little Goddesses was completed, and we hope that someday it can be published and serve as a fun and inspiring storybook for children to read and learn from.
ContributorsFarine, Brittany (Co-author) / Muth, Margaret (Co-author) / Youngjohn, Trystan (Co-author) / Alexander, John (Thesis director) / Wells, Cornelia (Committee member) / Department of English (Contributor) / Department of Psychology (Contributor) / School of Human Evolution and Social Change (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Because children do not have the same decision-making powers as adults in matters affecting their health, their opinions have often been underrepresented in research (Bradding & Horstman, 1999). However, there is growing interest in the way that children view health because this knowledge elicits the development of more child-centered and

Because children do not have the same decision-making powers as adults in matters affecting their health, their opinions have often been underrepresented in research (Bradding & Horstman, 1999). However, there is growing interest in the way that children view health because this knowledge elicits the development of more child-centered and effective approaches to health education and intervention (Bradding & Horstman, 1999). Professionals have often utilized the write-and-draw technique in school settings to gain a better understanding of how to best implement health education programs. The "bottom-up" approach of the write-and-draw method encourages participation and has been shown to elicit thoughtful responses about how children conceptualize health (Pridmore & Bendelow, 1995). This study uses the write-and-draw method to perform a cross- cultural comparison of child perspectives of health in the United States and Guatemala, countries that represent contrasting paradigms for child health. The results of this study are consistent with previous research, especially the emergent health themes. Children from the United States and Guatemala predominantly depicted health in terms of food. Guatemalan students were more likely to refer to hygienic practices and environmental conditions, while US children mentioned vegetables, water, and exercise as being healthy. For the unhealthy category, themes of poor hygiene, chips, fat/grease, fruit, carbohydrates, and environment were mentioned more often in Guatemala, while U.S. students listed sweets and fast food more frequently. Results support claims made in other literature that children's concepts of health are shaped by life experience and social context. Potential applications of the research include exposing areas (themes) where children are less likely to understand health implications and developing educational curriculum to increase a more comprehensive understanding of health.
ContributorsRenslow, Jillian Marie (Author) / Maupin, Jonathan (Thesis director) / BurnSilver, Shauna (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of International Letters and Cultures (Contributor)
Created2015-05