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Evaluating STAT5 Signature in Recurrent Glioblastoma

Description

Background: Recurrent glioblastoma (GBM) is resistant to available treatments and continued growth of the tumor is inevitable; this process is facilitated by the expression of genes regulated by the Signal Transducer and Activator of Transcription (STAT) family of transcription factors, namely STAT5, active in the invasive rim of GBM tumors. Currently, there are no targeted therapies for recurrent GBM that increase the overall patient survival rate. This study aims to analyze the differential expression of genes regulated by STAT5 between primary and recurrent GBM.<br/>Methods: Analysis of whole exome and RNA sequencing were performed on matched bulk primary and multiple recurrent tumor samples from GBM patients who received the current standard care to determine significant changes in gene expression of STAT3/5 targets. <br/>Results: Statistical analysis reveals a decrease in Synaptotagmin 2 (SYT2) and Pleckstrin Homology Domain Containing A3 (PLEKHA3) at recurrence, previously identified as potential STAT5 targets. <br/>Conclusions: To get a better understanding of the roles of STAT5 in GBM recurrence, their downstream effects need to be better understood. The transcriptomic program initiated by STAT5 activation is distinct from that of STAT3 activation. The roles of STAT5 target genes in GBM are poorly characterized, so further research should focus on understanding the effects of altered expression of these genes as they relate to STAT3/5 in GBM recurrence.

ContributorsPennett, Maya E (Author) / Martin, Thomas W. (Thesis director) / Tran, Nhan L. (Committee member) / Blomquist, Mylan (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)

Created2021-05

Close Encounters of the First Kind: On Cultural Representations of Extraterrestrials, First Contact, & the Mythology of the Alien Other

Description

Western culture has oversimplified and mythologized the possibility of first contact with extraterrestrial intelligence. Whether through anthropocentrism, lack of contextual literature and/or available knowledge, or simple misunderstanding, humanity has failed to fully consider the impacts of seeking out alien life. Instead, humanity’s cultural and political representations of extraterrestrials tell us a great deal about the people behind the stories—all of us stuck together on our pale blue dot. This thesis explores the mythological character that is ever-present in the extraterrestrial conversation, and how past and current cultural creators in the global West have perpetuated and changed that paradigm. This thesis is also an exploration of the ways we envision our ability to contact and interact with an unknown extraterrestrial other—in many ways mythological, and in some ways as powerful symbols for struggles against oppression. I argue for a more nuanced, creative, and scientifically driven representation and consideration of first contact with extraterrestrial intelligence.

ContributorsDean, Jake William (Author) / Martin, Thomas W. (Thesis director) / Walker, Sara (Committee member) / Finn, Ed (Committee member) / Historical, Philosophical & Religious Studies (Contributor, Contributor) / School of Earth and Space Exploration (Contributor) / School of Sustainability (Contributor, Contributor, Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)

Created2020-12