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Description
This dissertation research contributes to the advancement of activity-based travel forecasting models along two lines of inquiry. First, the dissertation aims to introduce a continuous-time representation of activity participation in tour-based model systems in practice. Activity-based travel demand forecasting model systems in practice today are largely tour-based model systems that simulate individual daily activity-travel patterns through the prediction of day-level and tour-level activity agendas. These tour level activity-based models adopt a discrete time representation of activities and sequence the activities within tours using rule-based heuristics. An alternate stream of activity-based model systems mostly confined to the research arena are activity scheduling systems that adopt an evolutionary continuous-time approach to model activity participation subject to time-space prism constraints. In this research, a tour characterization framework capable of simulating and sequencing activities in tours along the continuous time dimension is developed and implemented using readily available travel survey data. The proposed framework includes components for modeling the multitude of secondary activities (stops) undertaken as part of the tour, the time allocated to various activities in a tour, and the sequence in which the activities are pursued.
Second, the dissertation focuses on the implementation of a vehicle fleet composition model component that can be used not only to simulate the mix of vehicle types owned by households but also to identify the specific vehicle that will be used for a specific tour. Virtually all of the activity-based models in practice only model the choice of mode without due consideration of the type of vehicle used on a tour. In this research effort, a comprehensive vehicle fleet composition model system is developed and implemented. In addition, a primary driver allocation model and a tour-level vehicle type choice model are developed and estimated with a view to advancing the ability to track household vehicle usage through the course of a day within activity-based travel model systems. It is envisioned that these advances will enhance the fidelity of activity-based travel model systems in practice.
Second, the dissertation focuses on the implementation of a vehicle fleet composition model component that can be used not only to simulate the mix of vehicle types owned by households but also to identify the specific vehicle that will be used for a specific tour. Virtually all of the activity-based models in practice only model the choice of mode without due consideration of the type of vehicle used on a tour. In this research effort, a comprehensive vehicle fleet composition model system is developed and implemented. In addition, a primary driver allocation model and a tour-level vehicle type choice model are developed and estimated with a view to advancing the ability to track household vehicle usage through the course of a day within activity-based travel model systems. It is envisioned that these advances will enhance the fidelity of activity-based travel model systems in practice.
ContributorsGarikapati, Venu Madhav (Author) / Pendyala, Ram M. (Thesis advisor) / Zhou, Xuesong (Committee member) / Lou, Yingyan (Committee member) / Arizona State University (Publisher)
Created2014
Description
Recently, automation, shared use, and electrification are proposed and viewed as the “three revolutions” in the future transportation sector to significantly relieve traffic congestion, reduce pollutant emissions, and increase transportation system sustainability. Motivated by the three revolutions, this research targets on the passenger-focused scheduled transportation systems, where (1) the public transit systems provide high-quality ridesharing schedules/services and (2) the upcoming optimal activity planning systems offer the best vehicle routing and assignment for household daily scheduled activities.
The high quality of system observability is the fundamental guarantee for accurately predicting and controlling the system. The rich information from the emerging heterogeneous data sources is making it possible. This research proposes a modeling framework to systemically account for the multi-source sensor information in urban transit systems to quantify the estimated state uncertainty. A system of linear equations and inequalities is proposed to generate the information space. Also, the observation errors are further considered by a least square model. Then, a number of projection functions are introduced to match the relation between the unique information space and different system states, and its corresponding state estimate uncertainties are further quantified by calculating its maximum state range.
In addition to optimizing daily operations, the continuing advances in information technology provide precious individual travel behavior data and trip information for operational planning in transit systems. This research also proposes a new alternative modeling framework to systemically account for boundedly rational decision rules of travelers in a dynamic transit service network with tight capacity constraints. An agent-based single-level integer linear formulation is proposed and can be effectively by the Lagrangian decomposition.
The recently emerging trend of self-driving vehicles and information sharing technologies starts creating a revolutionary paradigm shift for traveler mobility applications. By considering a deterministic traveler decision making framework, this research addresses the challenges of how to optimally schedule household members’ daily scheduled activities under the complex household-level activity constraints by proposing a set of integer linear programming models. Meanwhile, in the microscopic car-following level, the trajectory optimization of autonomous vehicles is also studied by proposing a binary integer programming model.
The high quality of system observability is the fundamental guarantee for accurately predicting and controlling the system. The rich information from the emerging heterogeneous data sources is making it possible. This research proposes a modeling framework to systemically account for the multi-source sensor information in urban transit systems to quantify the estimated state uncertainty. A system of linear equations and inequalities is proposed to generate the information space. Also, the observation errors are further considered by a least square model. Then, a number of projection functions are introduced to match the relation between the unique information space and different system states, and its corresponding state estimate uncertainties are further quantified by calculating its maximum state range.
In addition to optimizing daily operations, the continuing advances in information technology provide precious individual travel behavior data and trip information for operational planning in transit systems. This research also proposes a new alternative modeling framework to systemically account for boundedly rational decision rules of travelers in a dynamic transit service network with tight capacity constraints. An agent-based single-level integer linear formulation is proposed and can be effectively by the Lagrangian decomposition.
The recently emerging trend of self-driving vehicles and information sharing technologies starts creating a revolutionary paradigm shift for traveler mobility applications. By considering a deterministic traveler decision making framework, this research addresses the challenges of how to optimally schedule household members’ daily scheduled activities under the complex household-level activity constraints by proposing a set of integer linear programming models. Meanwhile, in the microscopic car-following level, the trajectory optimization of autonomous vehicles is also studied by proposing a binary integer programming model.
ContributorsLiu, Jiangtao (Author) / Zhou, Xuesong (Thesis advisor) / Pendyala, Ram (Committee member) / Mirchandani, Pitu (Committee member) / Lou, Yingyan (Committee member) / Arizona State University (Publisher)
Created2018
Description
Priced Managed Lanes (MLs) have been increasingly advocated as one of the effective ways to mitigating congestion in recent years. This study explores a new and innovative pricing strategy for MLs called Travel Time Refund (TTR). The proposed TTR provides an additional option to paying drivers that insures their travel time by issuing a refund to the toll cost if they do not reach their destination within specified travel times due to accidents or other unforeseen circumstances. Perceived benefits of TTR include raised public acceptance towards priced MLs, utilization increase of HOV/HOT lanes, overall congestion mitigation, and additional funding for relevant transportation agencies. To gauge travelers’ interests of TTR and to analyse its possible impacts, a stated preference (SP) survey was performed. An exploratory and statistical analysis of the survey responses revealed negative interest towards HOT and TTR option in accordance with common wisdom and previous studies. However, it is found that travelers are less negative about TTR than HOT alone; supporting the idea, that TTR could make HOT facilities more appealing. The impact of travel time reliability and latent variables representing psychological constructs on travelers’ choices in response to this new pricing strategy was also analysed. The results indicate that along with travel time and reliability, the decision maker’s attitudes and the level of comprehension of the concept of HOT and TTR play a significant role in their choice making. While the refund option may be theoretically and analytically feasible, the practical implementation issues cannot be ignored. This study also provides a discussion of the potential implementation considerations that include information provision to connected and non-connected vehicles, distinction between toll-only and refund customers, measurement of actual travel time, refund calculation and processing and safety and human factors issues. As the market availability of Connected and Automated Vehicles (CAVs) is prognosticated by 2020, the potential impact of such technologies on effective demand management, especially on MLs is worth investigating. Simulation analysis was performed to evaluate the system performance of a hypothetical road network at varying market penetration of CAVs. The results indicate that Connected Vehicles (CVs) could potentially encourage and enhance the use of MLs.
ContributorsVadlamani, Sravani (Author) / Lou, Yingyan (Thesis advisor) / Pendyala, Ram (Committee member) / Zhou, Xuesong (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2018
Description
The inherent risk in testing drugs has been hotly debated since the government first started regulating the drug industry in the early 1900s. Who can assume the risks associated with trying new pharmaceuticals is unclear when looked at through society's lens. In the mid twentieth century, the US Food and Drug Administration (FDA) published several guidance documents encouraging researchers to exclude women from early clinical drug research. The motivation to publish those documents and the subsequent guidance documents in which the FDA and other regulatory offices established their standpoints on women in drug research may have been connected to current events at the time. The problem of whether women should be involved in drug research is a question of who can assume risk and who is responsible for disseminating what specific kinds of information. The problem tends to be framed as one that juxtaposes the health of women and fetuses and sets their health as in opposition. That opposition, coupled with the inherent uncertainty in testing drugs, provides for a complex set of issues surrounding consent and access to information.
ContributorsMeek, Caroline Jane (Author) / Maienschein, Jane (Thesis director) / Brian, Jennifer (Committee member) / School of Life Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Social-emotional learning (SEL) methods are beginning to receive global attention in primary school education, yet the dominant emphasis on implementing these curricula is in high-income, urbanized areas. Consequently, the unique features of developing and integrating such methods in middle- or low-income rural areas are unclear. Past studies suggest that students exposed to SEL programs show an increase in academic performance, improved ability to cope with stress, and better attitudes about themselves, others, and school, but these curricula are designed with an urban focus. The purpose of this study was to conduct a needs-based analysis to investigate components specific to a SEL curriculum contextualized to rural primary schools. A promising organization committed to rural educational development is Barefoot College, located in Tilonia, Rajasthan, India. In partnership with Barefoot, we designed an ethnographic study to identify and describe what teachers and school leaders consider the highest needs related to their students' social and emotional education. To do so, we interviewed 14 teachers and school leaders individually or in a focus group to explore their present understanding of “social-emotional learning” and the perception of their students’ social and emotional intelligence. Analysis of this data uncovered common themes among classroom behaviors and prevalent opportunities to address social and emotional well-being among students. These themes translated into the three overarching topics and eight sub-topics explored throughout the curriculum, and these opportunities guided the creation of the 21 modules within it. Through a design-based research methodology, we developed a 40-hour curriculum by implementing its various modules within seven Barefoot classrooms alongside continuous reiteration based on teacher feedback and participant observation. Through this process, we found that student engagement increased during contextualized SEL lessons as opposed to traditional methods. In addition, we found that teachers and students preferred and performed better with an activities-based approach. These findings suggest that rural educators must employ particular teaching strategies when addressing SEL, including localized content and an experiential-learning approach. Teachers reported that as their approach to SEL shifted, they began to unlock the potential to build self-aware, globally-minded students. This study concludes that social and emotional education cannot be treated in a generalized manner, as curriculum development is central to the teaching-learning process.
ContributorsBucker, Delaney Sue (Author) / Carrese, Susan (Thesis director) / Barab, Sasha (Committee member) / School of Life Sciences (Contributor, Contributor) / School of Civic & Economic Thought and Leadership (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
As of 2019, 30 US states have adopted abortion-specific informed consent laws that require state health departments to develop and disseminate written informational materials to patients seeking an abortion. Abortion is the only medical procedure for which states dictate the content of informed consent counseling. State abortion counseling materials have been criticized for containing inaccurate and misleading information, but overall, informed consent laws for abortion do not often receive national attention. The objective of this project was to determine the importance of informed consent laws to achieving the larger goal of dismantling the right to abortion. I found that informed consent counseling materials in most states contain a full timeline of fetal development, along with information about the risks of abortion, the risks of childbirth, and alternatives to abortion. In addition, informed consent laws for abortion are based on model legislation called the “Women’s Right to Know Act” developed by Americans United for Life (AUL). AUL calls itself the legal architect of the pro-life movement and works to pass laws at the state level that incrementally restrict abortion access so that it gradually becomes more difficult to exercise the right to abortion established by Roe v. Wade. The “Women’s Right to Know Act” is part of a larger package of model legislation called the “Women’s Protection Project,” a cluster of laws that place restrictions on abortion providers, purportedly to protect women, but actually to decrease abortion access. “Women’s Right to Know” counseling laws do not directly deny access to abortion, but they do reinforce key ideas important to the anti-abortion movement, like the concept of fetal personhood, distrust in medical professionals, the belief that pregnant people cannot be fully autonomous individuals, and the belief that abortion is not an ordinary medical procedure and requires special government oversight. “Women’s Right to Know” laws use the language of informed consent and the purported goal of protecting women to legitimize those ideas, and in doing so, they significantly undermine the right to abortion. The threat to abortion rights posed by laws like the “Women’s Right to Know” laws indicates the need to reevaluate and strengthen our ethical defense of the right to abortion.
ContributorsVenkatraman, Richa (Author) / Maienschein, Jane (Thesis director) / Brian, Jennifer (Thesis director) / Abboud, Carolina (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Turbidity is a known problem for UV water treatment systems as suspended particles can shield contaminants from the UV radiation. UV systems that utilize a reflective radiation chamber may be able to decrease the impact of turbidity on the efficacy of the system. The purpose of this study was to determine how kaolin clay and gram flour turbidity affects inactivation of Escherichia coli (E. coli) when using a UV system with a reflective chamber. Both sources of turbidity were shown to reduce the inactivation of E. coli with increasing concentrations. Overall, it was shown that increasing kaolin clay turbidity had a consistent effect on reducing UV inactivation across UV doses. Log inactivation was reduced by 1.48 log for the low UV dose and it was reduced by at least 1.31 log for the low UV dose. Gram flour had a similar effect to the clay at the lower UV dose, reducing log inactivation by 1.58 log. At the high UV dose, there was no change in UV inactivation with an increase in turbidity. In conclusion, turbidity has a significant impact on the efficacy of UV disinfection. Therefore, removing turbidity from water is an essential process to enhance UV efficiency for the disinfection of microbial pathogens.
ContributorsMalladi, Rohith (Author) / Abbaszadegan, Morteza (Thesis director) / Alum, Absar (Committee member) / Fox, Peter (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Aquatic macroinvertebrates are important for many ecological processes within river ecosystems and, as a result, their abundance and diversity are considered indicators of water quality and ecosystem health. Macroinvertebrates can be classified into functional feeding groups (FFG) based on morphological-behavioral adaptations. FFG ratios can shift due to changes in normal disturbance patterns, such as changes in precipitation, and from human impact. Due to their increased sensitivity to environmental changes, it has become more important to protect and monitor aquatic and riparian communities in arid regions as climate change continues to intensify. Therefore, the diversity and richness of macroinvertebrate FFGs before and after monsoon and winter storm seasons were analyzed to determine the effect of flow-related disturbances. Ecosystem size was also considered, as watershed area has been shown to affect macroinvertebrate diversity. There was no strong support for flow-related disturbance or ecosystem size on macroinvertebrate diversity and richness. This may indicate a need to explore other parameters of macroinvertebrate community assembly. Establishing how disturbance affects aquatic macroinvertebrate communities will provide a key understanding as to what the stream communities will look like in the future, as anthropogenic impacts continue to affect more vulnerable ecosystems.
ContributorsSainz, Ruby (Author) / Sabo, John (Thesis director) / Grimm, Nancy (Committee member) / Lupoli, Christina (Committee member) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This study evaluates medical pluralism among 1.5 generation Indian American immigrants. 1.5 generation Indian Americans (N=16) were surveyed regarding their engagement in complementary and alternative medical systems (CAM), how immigration affected that, and reasons for and for not continuing the use of CAM. Results indicated most 1.5 Indian immigrants currently engage in CAM, given that their parents also engage in CAM. The top reasons respondents indicated continued engagement in CAM was that it has no side effects and is preventative. Reasons for not practicing CAM included feeling out of place, not living with parents or not believing in CAM. After immigration, most participants decreased or stopped their engagement in CAM. More women than men continued to practice CAM after immigration. From the results, it was concluded that CAM is still important to 1.5 generation Indian immigrants.
ContributorsMurugesh, Subhiksha (Author) / Stotts, Rhian (Thesis director) / Mubayi, Anuj (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Many factors are at play within the genome of an organism, contributing to much of the diversity and variation across the tree of life. While the genome is generally encoded by four nucleotides, A, C, T, and G, this code can be expanded. One particular mechanism that we examine in this thesis is modification of bases—more specifically, methylation of Adenine (m6A) within the GATC motif of Escherichia coli. These methylated adenines are especially important in a process called methyl-directed mismatch repair (MMR), a pathway responsible for repairing errors in the DNA sequence produced by replication. In this pathway, methylated adenines identify the parent strand and direct the repair proteins to correct the erroneous base in the daughter strand. While the primary role of methylated adenines at GATC sites is to direct the MMR pathway, this methylation has also been found to affect other processes, such as gene expression, the activity of transposable elements, and the timing of DNA replication. However, in the absence of MMR, the ability of these other processes to maintain adenine methylation and its targets is unknown.
To determine if the disruption of the MMR pathway results in the reduced conservation of methylated adenines as well as an increased tolerance for mutations that result in the loss or gain of new GATC sites, we surveyed individual clones isolated from experimentally evolving wild-type and MMR-deficient (mutL- ;conferring an 150x increase in mutation rate) populations of E. coli with whole-genome sequencing. Initial analysis revealed a lack of mutations affecting methylation sites (GATC tetranucleotides) in wild-type clones. However, the inherent low mutation rates conferred by the wild-type background render this result inconclusive, due to a lack of statistical power, and reveal a need for a more direct measure of changes in methylation status. Thus as a first step to comparative methylomics, we benchmarked four different methylation-calling pipelines on three biological replicates of the wildtype progenitor strain for our evolved populations.
While it is understood that these methylated sites play a role in the MMR pathway, it is not fully understood the full extent of their effect on the genome. Thus the goal of this thesis was to better understand the forces which maintain the genome, specifically concerning m6A within the GATC motif.
To determine if the disruption of the MMR pathway results in the reduced conservation of methylated adenines as well as an increased tolerance for mutations that result in the loss or gain of new GATC sites, we surveyed individual clones isolated from experimentally evolving wild-type and MMR-deficient (mutL- ;conferring an 150x increase in mutation rate) populations of E. coli with whole-genome sequencing. Initial analysis revealed a lack of mutations affecting methylation sites (GATC tetranucleotides) in wild-type clones. However, the inherent low mutation rates conferred by the wild-type background render this result inconclusive, due to a lack of statistical power, and reveal a need for a more direct measure of changes in methylation status. Thus as a first step to comparative methylomics, we benchmarked four different methylation-calling pipelines on three biological replicates of the wildtype progenitor strain for our evolved populations.
While it is understood that these methylated sites play a role in the MMR pathway, it is not fully understood the full extent of their effect on the genome. Thus the goal of this thesis was to better understand the forces which maintain the genome, specifically concerning m6A within the GATC motif.
ContributorsBoyer, Gwyneth (Author) / Lynch, Michael (Thesis director) / Behringer, Megan (Committee member) / Geiler-Samerotte, Kerry (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05