Matching Items (9)

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Exploring genetic associations with ceRNA regulation in the human genome

Description

Competing endogenous RNAs (ceRNAs) are RNA molecules that sequester shared microRNAs (miRNAs) thereby affecting the expression of other targets of the miRNAs. Whether genetic variants in ceRNA can affect its

Competing endogenous RNAs (ceRNAs) are RNA molecules that sequester shared microRNAs (miRNAs) thereby affecting the expression of other targets of the miRNAs. Whether genetic variants in ceRNA can affect its biological function and disease development is still an open question. Here we identified a large number of genetic variants that are associated with ceRNA's function using Geuvaids RNA-seq data for 462 individuals from the 1000 Genomes Project. We call these loci competing endogenous RNA expression quantitative trait loci or ‘cerQTL’, and found that a large number of them were unexplored in conventional eQTL mapping. We identified many cerQTLs that have undergone recent positive selection in different human populations, and showed that single nucleotide polymorphisms in gene 3΄UTRs at the miRNA seed binding regions can simultaneously regulate gene expression changes in both cis and trans by the ceRNA mechanism. We also discovered that cerQTLs are significantly enriched in traits/diseases associated variants reported from genome-wide association studies in the miRNA binding sites, suggesting that disease susceptibilities could be attributed to ceRNA regulation. Further in vitro functional experiments demonstrated that a cerQTL rs11540855 can regulate ceRNA function. These results provide a comprehensive catalog of functional non-coding regulatory variants that may be responsible for ceRNA crosstalk at the post-transcriptional level.

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Date Created
  • 2017-05-02

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An Analysis of the Diversity of Chinese Languages in the Phoenix Metropolitan Area

Description

This project analyzes the diversity of the various Chinese languages present in the Phoenix metropolitan area. The diversity and presence of these languages can be used to make inferences about

This project analyzes the diversity of the various Chinese languages present in the Phoenix metropolitan area. The diversity and presence of these languages can be used to make inferences about different aspects of the Chinese American community in the Phoenix area, and therefore the dialects and compared to other aspects of the Chinese American immigration experience, such as where immigrants are from, what areas of Phoenix they reside, and the Chinese language skills of both the participants and their children. The data is then presented with historical context of the Phoenix Chinese community as well as a brief discussion on the current Chinese community in Phoenix as well as the acculturation of Chinese American children.

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Created

Date Created
  • 2021-05

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The Rising Dragon: Chinese Versus Western Aid and Foreign Direct Investment in Africa, Seeking a Partner in Development

Description

This paper is based on a research undertaking to understand China's presence in Africa and how this relates to Western relations with the continent. The research attempts to determine which

This paper is based on a research undertaking to understand China's presence in Africa and how this relates to Western relations with the continent. The research attempts to determine which option, Europe/US or the Chinese, may be the most suitable partner in development for Africa, as well as discuss what can be done to maximize the benefits, and mitigate the negative aspects of that relationship. A comparative analysis approach is used to judge the viability of each partner, and each is assessed according to a set of criteria, including the following: 1. Equitable and Respectful Relations 2. Maintenance of Sovereignty 3. Ability and Willingness to Finance Sustainable Development in Africa 4. Shared Experience and Understanding 5. Historical Element Drawing on the collected research presented in this document, the major finding is that the Chinese have a fundamentally different approach to aid and investment, and harbor conceptually distinctive ideas regarding development than the West. Based on the outcome of the comparative study against the above criteria, it is suggested that Africa may benefit from selecting China as a partner in achieving its own sustainable development, and suggestions are offered to effectively leverage this partnership.

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Created

Date Created
  • 2014-05

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The Relationship between Internalization of the Model Minority Myth and Critical Consciousness among Asian American College Students

Description

Objective: This study examined how the belief (internalization) in the model minority myth of achievement orientation and of unrestricted mobility relates to one’s social awareness of racial inequity and inequality

Objective: This study examined how the belief (internalization) in the model minority myth of achievement orientation and of unrestricted mobility relates to one’s social awareness of racial inequity and inequality in society (critical consciousness) amongst Asian American college students. Methods: Participants (N = 275, 67.7% female, M_age = 22.35) were recruited from Asian American ethnic studies classes, clubs and organizations and completed an online cross-sectional survey. Results: Results indicated that internalization of achievement orientation significantly correlated with levels of racial critical consciousness while unrestricted mobility did not. Conclusion: These findings extend research exploring the correlates of critical consciousness on internalization of racial stereotypes for Asian Americans.

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Created

Date Created
  • 2019-05

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Production, transmission, and consumption of Red Tourism in China: a model of the circuit of red heritage and tourism

Description

Because of its ability to harbor social values, norms, and beliefs, heritage has always been utilized as an ideological vehicle. One prominent example of politicizing heritage is Chinese red tourism,

Because of its ability to harbor social values, norms, and beliefs, heritage has always been utilized as an ideological vehicle. One prominent example of politicizing heritage is Chinese red tourism, comprised of state-promoted tours to revolutionary memorial sites. It is expected to generate political, economic, and social benefits, particularly to reinforce the legitimate leadership of the Chinese Communist Party. Statistics show that dramatic market growth in red tourism has occurred over the past decade. Yet it is still heavily driven by the government and thus whether long-term sustainability can be achieved is still questionable.

This dissertation explores the dynamics of red tourism from the perspective of a meaning-making process, where tourism discourses circulate among the processes of production, transmission, and consumption. The results reveal that higher-level government primarily assumes the leading role, whereas local government is largely excluded from strategy making processes and primarily responsible for implementation and operation. Some dissonance exists between higher and lower-level governments in their goals and involvement in red tourism development. Second, intermediaries are not altruistic and attempt to maximize their own benefits. While site interpreters may provide officially authorized narratives, their primary focus is hosting higher-up administrative visitors. On the contrary, tour guides are more customer-oriented, which may lead to officially undesirable interpretations. Third, driven by multiple motives, tourists have increasingly diverse attitudes towards red heritage and participate in various political and non-political activities. A considerable degree of congruence was found between tourists' participation, motivation, memories, and perception. Quantitative results indicate that the majority of tourists have learned about the political significance and/or content of red heritage, and developed more positive attitudes towards, and support for, the CCP and the government, to a certain extent.

This dissertation contributes to current research by adopting a systematic and emic perspective to explore the dynamics of red tourism. Several conceptual frameworks were developed inductively to describe the meaning-making process. Mixed methods were used to learn about tourists' consumption and perceptions of red heritage. Implications regarding enhancing the effectiveness of the meaning-making process, limitations of the study, and potential directions for future research are also discussed.

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Agent

Created

Date Created
  • 2014

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Chinese student migrants in the transition period in the United States: from human capital to social and cultural capitals

Description

Since the 1990s, the United States has been increasingly hosting large numbers of foreign students in its higher education sector and continues to accommodate these skilled college graduates in its

Since the 1990s, the United States has been increasingly hosting large numbers of foreign students in its higher education sector and continues to accommodate these skilled college graduates in its job market. When international students graduate, they can transition from an international student to a skilled migrant. Yet their decision-making process to stay in the receiving country (the United States), to return to sending countries, or to move on to another country, at different stages of such transition period, is not presently understood. This dissertation examines the experiences of these “migrants in transition period” when they face the “to return or to stay” choices under structural and institutional forces from the sending and receiving countries. This research adopts the conceptual framework of human capital, social capital, and cultural capital, to investigate how social capital and cultural capital impact the economic outcomes of migrants’ human capital under different societal contexts, and how migrants in the transition period cope with such situations and develop their stay or return plans accordingly. It further analyzes their decision-making process for return during this transition period. The empirical study of this dissertation investigates contemporary Chinese student migrants and skilled migrants from People’s Republic of China to the United States, as well as Chinese returnees who returned to China after graduation with a US educational degree. Findings reveal the impact of social and cultural capitals in shaping career experiences of skilled Chinese migrants, and also explore their mobility and the decision-makings of such movement of talent.

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Agent

Created

Date Created
  • 2016

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Programmed DNA self-assembly and logic circuits

Description

DNA is a unique, highly programmable and addressable biomolecule. Due to its reliable and predictable base recognition behavior, uniform structural properties, and extraordinary stability, DNA molecules are desirable substrates for

DNA is a unique, highly programmable and addressable biomolecule. Due to its reliable and predictable base recognition behavior, uniform structural properties, and extraordinary stability, DNA molecules are desirable substrates for biological computation and nanotechnology. The field of DNA computation has gained considerable attention due to the possibility of exploiting the massive parallelism that is inherent in natural systems to solve computational problems. This dissertation focuses on building novel types of computational DNA systems based on both DNA reaction networks and DNA nanotechnology. A series of related research projects are presented here. First, a novel, three-input majority logic gate based on DNA strand displacement reactions was constructed. Here, the three inputs in the majority gate have equal priority, and the output will be true if any two of the inputs are true. We subsequently designed and realized a complex, 5-input majority logic gate. By controlling two of the five inputs, the complex gate is capable of realizing every combination of OR and AND gates of the other 3 inputs. Next, we constructed a half adder, which is a basic arithmetic unit, from DNA strand operated XOR and AND gates. The aim of these two projects was to develop novel types of DNA logic gates to enrich the DNA computation toolbox, and to examine plausible ways to implement large scale DNA logic circuits. The third project utilized a two dimensional DNA origami frame shaped structure with a hollow interior where DNA hybridization seeds were selectively positioned to control the assembly of small DNA tile building blocks. The small DNA tiles were directed to fill the hollow interior of the DNA origami frame, guided through sticky end interactions at prescribed positions. This research shed light on the fundamental behavior of DNA based self-assembling systems, and provided the information necessary to build programmed nanodisplays based on the self-assembly of DNA.

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Agent

Created

Date Created
  • 2014

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Understanding housekeeper's perceived labor mobility and job satisfaction within the hospitality industry in metropolitan Phoenix, Arizona, U.S.A

Description

The objective of this study was to understand domestic and foreign-born housekeeper's individual perceptions of labor mobility and job satisfaction related to their jobs within the hospitality industry. Literature regarding

The objective of this study was to understand domestic and foreign-born housekeeper's individual perceptions of labor mobility and job satisfaction related to their jobs within the hospitality industry. Literature regarding the bridging of tourism, immigration, and labor supply was addressed to expose broad conceptual frameworks that lead to the development of this study. More specifically, literature regarding labor mobility within tourism industries, migrant decision making, and barriers to mobility and immigration helped to construct a narrowed conceptual framework specific to hospitality labor in Phoenix, Arizona. Similar and previous studies focused on perceived labor mobility during significant economic or industry shifts. This study included the addition of a policy factor to help determine to what degree state policy change effected hospitality workers' perceived labor mobility. Arizona's recently passed and implemented legislative act SB1070 regards immigrant identification and employment, and enforcement of the act in the state of Arizona; this serves as the implicated policy change. Data were collected via on-site survey administered February to May 2011. An overall score was created for the five motivational dimensions: 1 — Status; 2 — Economic; 3 — Refugee; 4 — Entrepreneurial; and, 5 — Political using principle component factor analysis using a varimax rotation with Kaiser normalization. Theory and literature suggest that the economic advancement, status advancement, and the refugee orientation are effective explanatory variables for motivating a career move into the tourism industry. A total of 82 questionnaires were delivered and completed (N = 82), and none were eliminated. The statistically-determined Economic Dimension was characterized by eleven statements explained 51% of the variation and was the overwhelming motivational force. The average coded response for change in job satisfaction was very positive at .75. Ten features of changes in job satisfaction were used as the basis of the second measure of change in job satisfaction. The first Principle Component of the ten features of job satisfaction change explained 45% of the variation in these features and loadings were positive near or above 0.60 for all items. The relationship between variations in each of the measurements of change in job satisfaction and motivating factors was explored using regression analysis. The two dependent variables were Overall Change and First Principle Component, and the independent variables for both regressions included the four motivating factors as measured by the rotated factors scores to represent dimensions of Economic, Status, Refugee and Entrepreneurial. In addition to the motivational factors, four demographic variables were included as independent variables to account for personal and situational differences. None of the regression coefficients were significant at even the 10% level. Although this result was expected, the positive sign of regression coefficients suggest that expectations of working as a housekeepers results in a positive outcome. Understanding this relationship further is necessary, and seeking larger sample sizes over a longer period of time would be most beneficial to this field of research.

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Created

Date Created
  • 2011

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Social Capital: Two Case Studies of Chinese Small Business in the Greater Phoenix and Los Angeles Areas

Description

As immigrants in the United States, Chinese small business entrepreneurs often encountered social and cultural barriers in the areas of finance, language, and employment in their new environment. This dissertation

As immigrants in the United States, Chinese small business entrepreneurs often encountered social and cultural barriers in the areas of finance, language, and employment in their new environment. This dissertation investigated how they utilized social capital to surmount the embedded disadvantages of an unequal market in their adopted country. The findings presented in this qualitative descriptive multi-case analysis, conducted in the greater metropolitan regions of Phoenix and Los Angeles, demonstrated the importance of social and transnational ties created in the United States within the local Chinese community as well as their social connections brought from China.

Drawing upon the data from in-depth interviews and informal observations, this dissertation was guided by three research questions: (a) What barriers do immigrant small business owners encounter? (b) What social connections provide help for immigrant small business owners to overcome those barriers or intensify their disadvantaged situations? (c) How do social networks influence immigrant small business development? The findings revealed many provocative facts on how social capital stimulated Chinese immigrant small business owners.

The influence of local and strong ties especially provided essential start-up funds, an affordable labor force. Those ties also provided authentication for business information provided by weak ties. Although the governments’ Small Business Administration empowers small business by various programs because it is an important social and economic element in the U.S. market, the Chinese community rarely utilized this support.

Transnational connections played an important role in the relatively mature market found in Los Angeles, but indeed all respondents in both case studies exhibited great interest in utilizing transnational connections to explore business opportunities. Regional connections provided a powerful resource for Chinese small business to create business alliance and increase their market competitiveness. Social capital embeds in a complexity of political, economic, social and personal backgrounds. In summary, social capital was an essential resource for Chinese small business when they encountered the barriers in the local market. From the findings, this dissertation’s scholarly contribution adds to the field of social capital studies by combining the investigation of social capital, embeddedness, intersectionality and transnational connections in respect to study immigrant entrepreneurship.

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Created

Date Created
  • 2019