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It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

ContributorsKarmin, Monika (Author) / Saag, Lauri (Author) / Vicente, Mario (Author) / Wilson Sayres, Melissa (Author) / Jarve, Mari (Author) / Talas, Ulvi Gerst (Author) / Rootsi, Siiri (Author) / Ilumaee, Anne-Mai (Author) / Maegi, Reedik (Author) / Mitt, Mario (Author) / Pagani, Luca (Author) / Puurand, Tarmo (Author) / Faltyskova, Zuzana (Author) / Clemente, Florian (Author) / Cardona, Alexia (Author) / Metspalu, Ene (Author) / Sahakyan, Hovhannes (Author) / Yunusbayev, Bayazit (Author) / Hudjashov, Georgi (Author) / DeGiorgio, Michael (Author) / Loogvaeli, Eva-Liis (Author) / Eichstaedt, Christina (Author) / Eelmets, Mikk (Author) / Chaubey, Gyaneshwer (Author) / Tambets, Kristiina (Author) / Litvinov, Sergei (Author) / Mormina, Maru (Author) / Xue, Yali (Author) / Ayub, Qasim (Author) / Zoraqi, Grigor (Author) / Korneliussen, Thorfinn Sand (Author) / Akhatova, Farida (Author) / Lachance, Joseph (Author) / Tishkoff, Sarah (Author) / Momynaliev, Kuvat (Author) / Ricaut, Francois-Xavier (Author) / Kusuma, Pradiptajati (Author) / Razafindrazaka, Harilanto (Author) / Pierron, Denis (Author) / Cox, Murray P. (Author) / Sultana, Gazi Nurun Nahar (Author) / Willerslev, Rane (Author) / Muller, Craig (Author) / Westaway, Michael (Author) / Lambert, David (Author) / Skaro, Vedrana (Author) / Kovacevic, Lejla (Author) / Turdikulova, Shahlo (Author) / Dalimova, Dilbar (Author) / Khusainova, Rita (Author) / Trofimova, Natalya (Author) / Akhmetova, Vita (Author) / Khidiyatova, Irina (Author) / Lichman, Daria V. (Author) / Isakova, Jainagul (Author) / Pocheshkhova, Nymadawa (Author) / Mihailov, Evelin (Author) / Seng, Joseph Wee Tien (Author) / Evseeva, Irina (Author) / Migliano, Andrea Bamberg (Author) / Abdullah, Syafiq (Author) / Andriadze, George (Author) / Primorac, Dragan (Author) / Atramentova, Lubov (Author) / Utevska, Olga (Author) / Yepiskoposyan, Levon (Author) / Marjanovic, Damir (Author) / Kushniarevich, Alena (Author) / Behar, Doron M. (Author) / Gilissen, Christian (Author) / Vissers, Lisenka (Author) / Veltman, Joris (Author) / Balanovska, Elena (Author) / Derenko, Miroslava (Author) / Malyarchuk, Boris (Author) / Metspalu, Andres (Author) / Federova, Sardana (Author of afterword, colophon, etc.) / Eriksson, Anders (Author) / Manica, Andrea (Author) / Mendez, Fernando L. (Author) / Karafet, Tatiana M. (Author) / Veeramah, Krishna R. (Author) / Bradman, Neil (Author) / Hammer, Michael F. (Author) / Osipova, Ludmila P. (Author) / Balanovsky, Oleg (Author) / Khusnutdinova, Elza K. (Author) / Johnsen, Knut (Author) / Remm, Maido (Author) / Thomas, Mark G. (Author) / Tyler-Smith, Chris (Author) / Underhill, Peter A. (Author) / Willerslev, Eske (Author) / Nielsen, Rasmus (Author) / Metspalu, Mait (Author) / Villems, Richard (Author) / Kivisild, Toomas (Author) / College of Liberal Arts and Sciences (Contributor)
Created2015-04-01