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Description
This paper discusses the impact of substance use disorder (SUD) stigma on individuals with substance use disorders and details the development of a SUD Stigma Reduction pilot module for the Student Health Outreach for Wellness (SHOW) affiliated course (HCR 494 Complex Health - Immersion) offered at Arizona State University. This course was designed to educate pre-health professional and health professional students on complex health topics in an interprofessional, experiential-learning environment. The SUD and Stigma module developed in this thesis project provided students with information on SUDs and the opportunity to confront stigma, improving their perceptions on individuals with SUD.
The pilot module on SUD Stigma Reduction was researched, designed, and implemented in the HCR 494 course. After students completed the module, a retrospective pre-post survey was administered to evaluate the effectiveness of the module in two areas: content knowledge and personal perceptions. Only one student responded to the survey, placing limitations on analysis. The student’s response showed a general increase in understanding of the module material, matching the stated objectives, and positive changes in perceptions on people with SUDs. Due to the positive evaluation of the course, the pilot module was deemed successful and has been integrated into the HCR 494 course. Further research is necessary to determine the long term impact of stigma reduction modules in experiential learning courses.
The pilot module on SUD Stigma Reduction was researched, designed, and implemented in the HCR 494 course. After students completed the module, a retrospective pre-post survey was administered to evaluate the effectiveness of the module in two areas: content knowledge and personal perceptions. Only one student responded to the survey, placing limitations on analysis. The student’s response showed a general increase in understanding of the module material, matching the stated objectives, and positive changes in perceptions on people with SUDs. Due to the positive evaluation of the course, the pilot module was deemed successful and has been integrated into the HCR 494 course. Further research is necessary to determine the long term impact of stigma reduction modules in experiential learning courses.
ContributorsYee, Anna (Author) / Harrell, Susan (Thesis director) / Saewert, Karen (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Morphological variation among individuals has the potential to influence multiple life history characteristics such as dispersal, migration, reproductive success, and survival (Wilder et al., 2016). Research has shown that individuals that are in better "condition" can disperse or migrate further or more successfully, have greater reproductive success, and survive for longer (Wilder et al., 2016; Heidinger et al., 2010; Liao et al., 2011), particularly in years where environmental conditions are harsh (Milenkaya et al., 2014). An individual's body condition can be defined in various ways, but is most often considered an individual's energetic or immune state (Milenkaya et al., 2014). Since these traits are hard to measure directly, researchers have instead used a variety of morphological proxy variables to quantify condition such as fat score (Kaiser, 1993), weight, ratio of weight to tarsus length (Labocha et al., 2014), a scaled mass index (Peig and Green, 2009), as well as hematological indices for immune system function (Fleskes et al., 2017, Kraft et al., 2019). However, there is mixed support regarding whether these condition indices relate to life history characteristics (Wilder et al., 2016; Labocha et al., 2014), and whether the relationship is linear (Mcnamara et al., 2005; Milenkaya et al., 2014). Additionally, although some researchers use multiple morphological proxy variables for condition (e.g. Warnock and Bishop, 1998), rarely have there been direct comparisons among proxies to validate that they measure the same trait. In this investigation, we define condition as an energetic state and we attempt to measure it by comparing two indices (fat score and the scaled mass index) to validate whether they measure the same trait in our study system, the great-tailed grackle (Quiscalus mexicanus). We found that the morphological proxy variables did not correlate with each other, indicating that they were not measuring the same trait. Further, the proxy variables did not correlate with reproductive success, measured as whether a female had a fledgling and whether a male held a territory containing nests. These results improve our understanding of measures of condition in grackles, and birds in general, and the importance of condition for reproductive success - a necessary component for selection to act.
ContributorsBerens, Jennifer (Author) / Langergraber, Kevin (Thesis director) / McCune, Kelsey (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The rate of vaccinations has been consistently decreasing in the past years in children of ages 0-18. Multiple factors and barriers contribute to these low rates. This comparative case study investigated the accessibility of information regarding childhood vaccinations to parents in areas with differing poverty levels in the greater Phoenix region, specifically in the West Valley, Downtown Phoenix, and the East Valley. Pediatric clinics, public elementary schools, and public libraries were visited in each area to assess how much information was available where. The analysis produced unexpected results: the West Valley, which had the highest poverty level, contained the most amount of accessible information for parents in many languages, while the East Valley, with a low poverty level, had almost no information accessible to parents of these children. Implications for future research, policy, and practice are discussed. Based on these unexpected results, one recommendation is to develop a pamphlet that could be distributed to these public places to raise awareness of the importance of vaccinations in children to parents.
ContributorsShah, Veedhi (Author) / Bates, Denise (Thesis director) / Castillo, Elizabeth (Committee member) / College of Health Solutions (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The rise in community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections and the ability of the organism to develop resistance to antibiotics necessitate new treatment methods for MRSA. Geopolymers (GPs) are cheap, porous materials that have demonstrated adsorptive capabilities. In this study, GPs were investigated for their ability to adsorb whole MRSA cells and MRSA secreted proteins [culture filtrate proteins (CFPs)] as a complementary method of controlling MRSA infections. GPs have been synthesized with variable pore sizes (meso/macro scale) and further modified with stearic acid (SA) to increase surface hydrophobicity. Four GPs (SA-macroGP, macroGP, SA-mesoGP, and mesoGP) were incubated with whole cells and with CFPs to quantify GP adsorption capabilities. Following MRSA culture incubation with GPs, unbound MRSA cells were filtered and plated to determine cell counts. Following CFP incubation with GPs, unbound CFPs were separated via SDS-PAGE, stained with SYPRO Ruby, and analyzed using densitometry. Results indicate that macroGP was the most effective at adsorbing whole MRSA cells. Visual banding patterns and densitometry quantitation indicate that SA-mesoGP was the most effective at adsorbing CFP. Ultimately, GP-based products may be further developed as nonselective or selective adsorbents and integrated into fibrous materials for topical applications.
ContributorsGanser, Collin (Co-author, Co-author) / Haydel, Shelley E. (Thesis director) / Seo, Don (Committee member) / Borges, Chad (Committee member) / School of Earth and Space Exploration (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Evolution is a powerful process that acts on features as organisms adapt to fill a variety of niches. It is visible in the emergence of the beak in the fossil record, through a number of small changes over time. To explain and convey these changes to a general audience, I produced an art book combining my review of bird beak evolution with art. The intent was to present evolution in an informative, visual, and engaging manner that a general audience would be able to understand.
ContributorsWalls, Sarah Camille (Author) / Collins, James (Thesis director) / Hodgen, Heidi (Committee member) / School of Life Sciences (Contributor, Contributor) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Background: The hippocampus is a critical brain structure for memory formation and other aspects of cognition. The hippocampus and the white matter tracts connecting it to other parts of the brain are known to lose volume and integrity with aging. For populations with prior compromised hippocampal integrity, such as those with autism spectrum disorder (ASD), it is less well known how the hippocampus and its connections will respond to aging. In children with ASD, there may be an initial period of enlarged hippocampi, after which there is a trajectory of faster decline in volume compared to neurotypicals (NT). We have previously identified reduced hippocampal volumes and fornix white matter integrity in middle-age and older adults with ASD compared to matched NT adults. However, freewater (FW) may be a more sensitive structural integrity measure of the hippocampal complex. FW is present in the brain as cerebrospinal fluid but also accumulates within the extracellular spaces indicative of reduced gray matter density and increased axon degeneration. FW shows promise as a more sensitive biomarker for Parkinson’s and Alzheimer’s disease. This study evaluated age-related hippocampal complex FW differences in adults with and without ASD across the adult lifespan. We hypothesized that adults with ASD would demonstrate a larger age association with increasing FW in the hippocampus and fornix, compared to NT adults, and that FW would be a more sensitive brain measure than traditional fractional anisotropy (FA).
Methods: The study consisted of 79 participants with ASD (59 male, 20 female; ages 18-70, mean=40.27 [±17] years) and 77 NT participants (46 male, 31 female; ages 18-71, mean=40.33 [±16] years). Hippocampal and fornix FW and FA values were generated from diffusion tensor images obtained along 32 directions using a b-value of 2500 s/mm2 in the axial direction with 3 mm slice resolution. These images were then processed for eddy current, distortion, b-vec and motion correction, skull stripped, and non-linear registered using Advanced Normalization Tools (ANTs) to the subject’s T1 image. FW and FA maps were calculated using custom written MatLab code and standard atlases containing the hippocampus and fornix were applied.
Results: The right hippocampus showed a significant diagnosis by age interaction (p=0.018), such that the increase in FW with age was greater for adults with ASD. The left hippocampus diagnosis by age interaction approached significance (p=0.055). Similarly, the right fornix showed a significant diagnosis by age interaction (p=0.044), with increases in FW with age as greater for adults with ASD, and the left fornix diagnosis by age interaction approached significance (p=0.053). FA values showed no significant diagnosis by age interactions.
Conclusion: In the hippocampus and fornix, the association between increasing FW and increasing age was more pronounced for adults with ASD than matched NT adults. This may mean that as adults with ASD age, these regions will degenerate faster than their NT peers, which could have implications for accelerated age-related memory decline. However, a notable limitation is the cross-sectional nature of the study. Our ongoing longitudinal study will inform a more definitive picture of brain aging with ASD.
Methods: The study consisted of 79 participants with ASD (59 male, 20 female; ages 18-70, mean=40.27 [±17] years) and 77 NT participants (46 male, 31 female; ages 18-71, mean=40.33 [±16] years). Hippocampal and fornix FW and FA values were generated from diffusion tensor images obtained along 32 directions using a b-value of 2500 s/mm2 in the axial direction with 3 mm slice resolution. These images were then processed for eddy current, distortion, b-vec and motion correction, skull stripped, and non-linear registered using Advanced Normalization Tools (ANTs) to the subject’s T1 image. FW and FA maps were calculated using custom written MatLab code and standard atlases containing the hippocampus and fornix were applied.
Results: The right hippocampus showed a significant diagnosis by age interaction (p=0.018), such that the increase in FW with age was greater for adults with ASD. The left hippocampus diagnosis by age interaction approached significance (p=0.055). Similarly, the right fornix showed a significant diagnosis by age interaction (p=0.044), with increases in FW with age as greater for adults with ASD, and the left fornix diagnosis by age interaction approached significance (p=0.053). FA values showed no significant diagnosis by age interactions.
Conclusion: In the hippocampus and fornix, the association between increasing FW and increasing age was more pronounced for adults with ASD than matched NT adults. This may mean that as adults with ASD age, these regions will degenerate faster than their NT peers, which could have implications for accelerated age-related memory decline. However, a notable limitation is the cross-sectional nature of the study. Our ongoing longitudinal study will inform a more definitive picture of brain aging with ASD.
ContributorsAlvar, Jocelyn R (Author) / Braden, Brittany Blair (Thesis director) / Ofori, Edward (Committee member) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
I was a curious child who grew up to be a curious adult. Ever since I learned how to read, I have had a passion for science and learning new things. I chose to watch the Discovery channel over any other network on TV, and I was drawn to the non-fiction section of the Phoenix Public Library. My parents encouraged my curiosity and helped me learn in any way they could. My mom took me to Juniper Library every weekend while my dad sat through countless episodes of Mythbusters, How It’s Made, and Shark Week specials. Eventually, there came a time when they could no longer answer the endless questions I would throw their way. My mom likes to remind me of one question in particular that I would ask that she was unable to form any kind of answer to. This question ended up shaping my scientific interests and became the basis for my chosen college major. The question was “why are people people?”
ContributorsMaiorella, Madeline Jo (Author) / Meissinger, Ellen (Thesis director) / Lawrence, Julie (Committee member) / School of Life Sciences (Contributor) / School of Geographical Sciences and Urban Planning (Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Prior studies of Mourning Doves have observed no changed in glucose in response to either a high fat “chow” diet or a white bread diet. In the current feeding study, we fed doves an urban diet, high in carbohydrates, fat, and sodium, which is representative of typical American nutrition accessible to the avian population in an urbanized environment. Based on studies of other avian species that examined the effects of an urban diet on physiology, I hypothesized that doves fed an urban diet would have increased plasma glucose and sodium, which would promote an increase in plasma osmolality. This hypothesis was based on preliminary data that found birds fed an urban diet developed impaired vasodilation compared to seed diet control birds. Therefore, differences in plasma glucose, sodium, and osmolality were examined as increases may contribute to the impairment. Adult doves of both sexes were captured on the Arizona State University, Tempe campus. Doves were placed in two dietary groups: an urban diet consisting of a 50/50 ratio of French fries and nutritionally-balanced bird seed (n=7) and a control group of only the seed diet (n=6). Following the four-week diets, birds were euthanized, and cardiac plasma samples were collected from birds to measure glucose, sodium, and osmolality. There were no significant differences between the two study groups in plasma glucose concentration (p=0.445), sodium concentration (p=0.731), or osmolality (p=0.692). Sodium concentrations were signficantly more variable in birds consuming a seed diet than those that were provided the mixed French fry and seed diet (p=0.014). These results suggest that glucose, sodium, and osmolality likely do not contribute to the altered vasodilation of doves fed an urban diet and that such a diet may not be as detrimental to the doves health given their phenotypic flexibility.
ContributorsKayata, Lana (Author) / Sweazea, Karen (Thesis director) / Deviche, Pierre (Committee member) / Basile, Anthony (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
In the United States, cardiovascular disease remains the number one cause of death. The most prevalent risk factor for cardiovascular disease is poor nutrition and thus, proper nutrition is often used as a preventative measure. With the expensive and often ineffective medications and procedures currently being used to treat cardiovascular disease, we need to find a better solution. One promising solution is nutrition therapy, which is the implementation of proper nutrition guidelines into the treatment plan of patients with cardiovascular disease. After close research and analysis of four popular diets, a vegan (plant-based) diet, vegetarian diet, and Mediterranean diet could offer improvement of cardiovascular disease risk factors and chances of cardiovascular disease mortality. Different ways to start implementing nutrition therapy in medicine include emphasizing nutrition education in medical school and/or including registered dietitians in the treatment process for cardiovascular disease patients.
ContributorsMorris, Madison Marie (Author) / Don, Rachael (Thesis director) / Morse, Lisa (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
I am evaluating the genomic basis of a model of heat tolerance in which organisms succumb to warming when their demand for oxygen exceeds their supply. This model predicts that tolerance of hypoxia should correlate genetically with tolerance of heat. To evaluate this prediction, I tested heat and hypoxia tolerance in several genetic lines of Drosophila melanogaster. I hypothesized that genotypes that can fly better at high temperatures are also able to fly well at hypoxia. Genotypes from the Drosophila Genetic Reference Panel (DGRP) were assessed for flight at hypoxia and normal temperature (12% O2 and 25°C) as well as normoxia and high temperature (21% O2 and 39°C). After testing 66 lines from the DGRP, the oxygen- and capacity-limited thermal tolerance theory is supported; hypoxia-resistant lines are more likely to be heat-resistant. This supports previous research, which suggested an interaction between the tolerance of the two environmental variables. I used this data to perform a genome-wide association study to find specific single-nucleotide polymorphisms associated with heat tolerance and hypoxia tolerance but found no specific genomic markers. Understanding factors that limit an organism’s stress tolerance as well as the regions of the genome that dictate this phenotype should enable us to predict how organisms may respond to the growing threat of climate change.
ContributorsFredette-Roman, Jacob Daniel (Author) / Angilletta, Michael (Thesis director) / VandenBrooks, John (Committee member) / Youngblood, Jacob (Committee member) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05