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- Creators: Harrington Bioengineering Program
- Member of: Theses and Dissertations
- Status: Published
Description
Preeclampsia is a condition which arises during pregnancy and can lead to serious, even fatal, complications for the mother and baby. Annually, preeclampsia is responsible for about 50,000 total deaths worldwide, and countless other complications for both the mother and fetus. While high blood pressure and protein in the urine are key features, symptoms vary widely, and thus understanding, diagnosing, and treating the condition is of paramount importance. Due to the correlation between preeclampsia and high blood pressure, multiple groups have studied the role of angiogenic growth factors and preeclampsia. We performed an advanced PubMed search to select studies with both preeclampsia and VEGF, a key growth factor for angiogenesis, in the title. The results of examining a total of 65 articles led to the formation of this review article to articulate the studies as a whole and state of the research on VEGF and preeclampsia to date.
ContributorsBoos, Kelsey (Author) / Burnsed, Olivia (Thesis director) / Vernon, Brent (Committee member) / Collins, Jason Mitchell (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Over the past 30 years the use of graphene has been increasing at a rapid rate. The reason why graphene has become more popular is because it is starting to be understood better, and researchers are starting to recognize graphene’s unique properties. Graphene is a single atomic layer of graphite, and graphite is a three-dimensional cube base structure of carbon. Graphite has a high conductivity rate, and graphene has an even higher conductivity, meaning that graphene makes for an excellent resistor in any hardware system. Graphene is flexible, has high durability, and can vary in resistance based on its shape (Sharon 2015). With graphene being able to change its resistivity, it can act as different types of sensors. These sensors include measuring pressure, resistance, force, strain, and angle. One problem across the globe is that patients have arthritis, decaying bone density, and injuries which can easily go mistreated or not treated at all. It can be hard to determine the severity of injuries in joints by observation of the patient. There are tools and equipment that will allow a doctor to track the force and degrees of motion of certain joints, but they are mostly limited to hospitals. With graphene acting as a sensor it can be embedded into casts, braces, and even clothing. With a mobile sensor that relays accurate and continuous data to a doctor they can more precisely determine a therapy or recovery time that will better suit the patients’ needs. In this project the graphene was used to measure the angle of a patient’s wrist while they were wearing a wrist brace. From the data collected, the graphene was able to track the user’s movement of their wrist as they moved it in a single direction. The data showed the angle of the wrist ranging from zero degrees to 90 degrees. This proves that graphene can shape the way biosensing is accomplished. Biodynamics is a growing field, and with more injuries everyday it is important to study graphene and how it can be used to diagnose and prevent injuries related to joints. Graphene can be used as a biosensor which can then be implemented into a brace to allow for accurate biodynamic tracking.
ContributorsSweeten, William (Author) / Lockhart, Thurmon (Thesis director) / Helms Tillery, Stephen (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
A major challenge with tissue samples used for biopsies is the inability to monitor their molecular quality before diagnostic testing. When tissue is resected from a patient, the cells are removed from their blood supply and normal temperature-controlled environment, which causes significant biological stress. As a result, the molecular composition and integrity undergo significant change. Currently, there is no method to track the effects of these artefactual stresses on the sample tissue to determine any deviations from the actual patient physiology. Without a way to track these changes, pathologists have to blindly trust that the tissue samples they are given are of high quality and fit for molecular analysis; physicians use the analysis to make diagnoses and treatment plans based on the assumption that the samples are valid. A possible way to track the quality of the tissue is by measuring volatile organic compounds (VOCs) released from the samples. VOCs are carbon-based chemicals with high vapor pressure at room temperature. There are over 1,800 known VOCs within humans and a number of these exist in every tissue sample. They are individualized and often indicative of a person’s metabolic condition. For this reason, VOCs are often used for diagnostic purposes. Their usefulness in diagnostics, reflectiveness of a person’s metabolic state, and accessibility lends them to being beneficial for tracking degradation. We hypothesize that there is a relationship between the change in concentration of the volatile organic compounds of a sample, and the molecular quality of a sample. This relationship is what would indicate the accuracy of the tissue quality used for a biopsy in relation to the tissue within the body.
ContributorsSharma, Nandini (Co-author) / Fragoso, Claudia (Co-author) / Grenier, Tyler (Co-author) / Hanson, Abigail (Co-author) / Compton, Carolyn (Thesis director) / Tao, Nongjian (Committee member) / Moakley, George (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This thesis explores the introduction of Virgil Ortiz’s traditional Cochiti pueblo ceramic techniques and iconic imagery into the world of contemporary atmospheric high fired ceramics. Virgil is a multidimensional artist who has been working in ceramics since the age of 12, practicing the traditional hand building and decoration methods of his ancestral pueblo (1 traditional work) . In recent years, Virgil has begun to explore the use of modern materials and firing techniques in order to further his work and break into the contemporary ceramics community (2 modern materials). Virgil’s style is very figurative, sculpting human and human-like figures, and illustrating large vessels in the Cochiti traditional style, while incorporating his own characters, story lines and social commentaries.
Virgil and I met in 2019 while Virgil was performing a ceramics demo at the ASU Ceramics facilities. We collaborated on Virgil’s first line of completely handmade functional wares for his collaborative show at the ReVOlt gallery for Indian Market, Santa Fe 2019. In 2020, Virgil came to ASU as a visiting artist faculty and began work on larger pieces using more sculptural clays and exploring internal support structures under the guidance of myself and artist Ben Jackel. Seeing this large work and the opportunity to build on this, renowned art critic and appraiser Peter Held brought myself and Virgil to Reitz Ranch Center for Ceramic Arts, the former studio and home of Don Reitz. Don was an American master, building huge vessels and sculptures and firing them in salt, soda and wood kilns built on his property. He built a particularly larger Anagama style kiln, deemed the Reitz-agama, which measures 60in tall and 30 feet deep, specifically to be able to wood fire his massive wares. Don’s work is visceral and emotional, made with a heavy hand and minimally glazed, allowing for the buildup of wood ash and salt from the atmospheric firings to complete their surfaces. The ranch still holds all of his kilns, and hundreds of his pieces from years of success and failures. The owner of the ranch Sheryl Leigh-Devault, and Don’s former assistant Ben Roti, invited Virgil and I up to work at the ranch any time we wanted during this visit, and due to the closures of ASU studios and a desire to push our work together further than we ever had before, we orchestrated a week visit. This week visit developed into two weeks, and had since developed further into a one and a half month short term quarantine residency.
Virgil and I met in 2019 while Virgil was performing a ceramics demo at the ASU Ceramics facilities. We collaborated on Virgil’s first line of completely handmade functional wares for his collaborative show at the ReVOlt gallery for Indian Market, Santa Fe 2019. In 2020, Virgil came to ASU as a visiting artist faculty and began work on larger pieces using more sculptural clays and exploring internal support structures under the guidance of myself and artist Ben Jackel. Seeing this large work and the opportunity to build on this, renowned art critic and appraiser Peter Held brought myself and Virgil to Reitz Ranch Center for Ceramic Arts, the former studio and home of Don Reitz. Don was an American master, building huge vessels and sculptures and firing them in salt, soda and wood kilns built on his property. He built a particularly larger Anagama style kiln, deemed the Reitz-agama, which measures 60in tall and 30 feet deep, specifically to be able to wood fire his massive wares. Don’s work is visceral and emotional, made with a heavy hand and minimally glazed, allowing for the buildup of wood ash and salt from the atmospheric firings to complete their surfaces. The ranch still holds all of his kilns, and hundreds of his pieces from years of success and failures. The owner of the ranch Sheryl Leigh-Devault, and Don’s former assistant Ben Roti, invited Virgil and I up to work at the ranch any time we wanted during this visit, and due to the closures of ASU studios and a desire to push our work together further than we ever had before, we orchestrated a week visit. This week visit developed into two weeks, and had since developed further into a one and a half month short term quarantine residency.
ContributorsSmith, Andrew Walton Lee (Author) / Chung, Samuel (Thesis director) / Ortiz, Virgil (Committee member) / Harrington Bioengineering Program (Contributor) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
In terms of overall athleticism, other than the obvious extremities that take on more skillful duties in performance (arms, legs, fingers ie.), the back, specifically lower, is pivotal in athletic movement. The main bolstering force in the lower back is the lumbar vertebrae, which on the upper end are connected to the thoracic portion of the spine, and on the lower end transform into the various processes of the sacrum. The lower back is highly involved in bending and stabilizing during athletic movement, while also being favorably responsible for not only producing but absorbing force as well. Men’s Football has the highest rate of occurrence in injuries compared to all other collegiate sports (Hassebrock 2019). This is a product of the various specificities of the game of football such as groundbreaking speed and strength, along with some psychological group-centered constructs. In survey findings, 83% healthcare professionals say that the best active treatment plan is strengthening the core muscles. While in terms of natural and technological treatments like acupuncture, contrast immersion, and electrical stimulation, there wasn’t a definitive methodology proven to be superior to the others. Allowing for the healthcare professional to be creative in their combination of treatments, as long as core strengthening is primarily targeted.
ContributorsWilliams, Kyle Ellis (Author) / Vernon, Brent (Thesis director) / Chhabra, Anikar (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Should choreographing a dance routine be completely subjective or should it include some objective assessment? Dance is a performing art with the purpose of expressing an emotion or idea. In literature, dance is approached from solely the artistic side, using principles of art like movement, pattern, and rhythm. Art and science are often pinned against one another; art is considered subjective while science considered objective. Art tries to express knowledge while science aims to acquire knowledge. However, the two disciplines relate in their effort to understand the world. Although their intended audiences are contrasting, their goals are essentially the same. Considering this relation, my thesis will use both art and science to quantify elements of pom routines to create objective data to be used in the subjective choreography process. My project will look at the collegiate dance world and assess routines that have placed well at UDA College Dance Team National Championships. This research investigates how inclusion of certain elements adds value to the pom routines performed. I will then take what I have analyzed and gathered from extensive research on these successful routines and choreograph my own routine for my college dance team to compete in the 2020 UDA College Dance Team National Championship. With proper preparation and inclusion of the correct elements that were found in other winning routines, the Arizona State University Dance Team will place well and better than last year’s eighth place.
ContributorsHolland, Haylee Aliyah (Author) / Hudson, James G. (Thesis director) / Caryl, Bianca (Committee member) / Harrington Bioengineering Program (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Advancements in healthcare and the emergence of an aging population has led to an increase in the number of prosthetic joint procedures in the United States. According to Healthcare Cost and Utilization Project, 660,876 and 348,970 total hip and knee arthroplasties were performed in 2014[1].The percentage of total hip or knee procedures that are revised due to an infection is 1.23% and 1.21% respectively[3], [4]. Although the percent of infections may be small, an infection can have a tremendous burden on the patient and healthcare system. It is expected that prosthetic joint infections (PJIs) will cost the healthcare system an estimated $1.62 billion by 2020[5]. PJIs are often difficult to treat due to the formation of biofilm at the site of the infection. A large majority of PJIs are the result of a bacterial biofilm, but around 1% of PJIs are due to fungal infections[3]. The current method of treatment is to surgically remove all infected tissue at the site of infection through a process called debridement and then insert a medicated bone cement spacer[7], [10]–[12]. One such medication that is loaded into the bone cement is caspofungin, a member of the echinocandin class of compounds that inhibit the synthesis of 1,3-β-D-glucan which is a crucial element of the cell wall of the target fungi[13]–[15]. For the studies reported herein, the caspofungin-loaded bone cement samples were made at 5 dosage strengths according to standard operating room practices. The elution of the drug was analyzed using ultraviolet spectrophotometry. The elution profiles were analyzed for 19 days consecutively, during which the 70 mg, 1 g, and 5 g dosage groups showed a prolonged, sustained release of the caspofungin. The 70 mg and 1 g dosage cumulative mass release profiles were not statistically significant, but it is unlikely that the difference would not have a clinical significance especially in the treatment of a fungal biofilm infection. The determination of the elution profile for caspofungin from loaded-bone cement can provide clinicians with a basis for how the drug will release into the infected joint.
ContributorsMoore, Rex C. (Author) / Vernon, Brent (Thesis director) / Overstreet, Derek (Committee member) / Industrial, Systems & Operations Engineering Prgm (Contributor) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Piloerection (known as goosebumps) is mediated by activation of alpha-adrenergic receptors within the sympathetic branch of the autonomic nervous system. The study of piloerection is important in multiple fields, from emotion studies to nervous system pathology. This makes piloerection particularly relevant to emotions research. Despite wide-ranging applications, current methods for measuring piloerection are laborious and qualitative. The goal of this study is to build a wearable piloerection sensor through the use of straight-line lasers and photoresistors. The study analyzed methods of detecting and measuring goosebumps, and applied the method of laser scattering as a detection method. This device was designed and tested against a population of seven Arizona State University students. Goosebumps were elicited through conditions of cold, and video clips meant to elicit emotions of awe and sadness. Piloerection was then quantified through two controls of self-identification and camera recording, as well as the new detection method. These were then compared together, and it was found that subjective methods of determining goosebumps did not correlate well with objective measurements, but that the two objective measurements correlated well with one another. This shows that the technique of laser scattering can be used to detect goosebumps and further developments on this new detection method will be made. Moreover, the presence of uncorrelated subjective measurements further shows the need for an objective measurement of piloerection, while also bringing into question other factors that may be confused with the feeling of piloerection, such as chills or shivers. This study further reaffirmed previous studies showing a positive correlation between intense emotions.
ContributorsHemesath, Angela (Author) / Muthuswamy, Jitendran (Thesis director) / Shiota, Michelle (Lani) (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This thesis aimed to develop a consistent protocol used to effectively image the apolipoprotein E (ApoE) ε4 allele, which is a known genetic risk factor for Alzheimer’s Disease (AD). The research team used methods to extract DNA from saliva samples, amplify the DNA using polymerase chain reaction (PCR), and image the results using gel electrophoresis and a transilluminator. Extensive literature review was used to optimize these techniques. Future studies will use these methods of characterizing the ApoE ε4 allele as preliminary work towards the goal of integrating this protocol into ongoing research in aging within the Motor Rehabilitation and Learning (MRL) Lab on Arizona State University’s campus.
ContributorsWorman, Drew (Author) / Schaefer, Sydney (Thesis director) / Lewis, Candace (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Tissue engineering is an emerging field focused on the repair, replacement, and regeneration of damaged tissue. Engineered tissue consists of three factors: cells, biomolecular signals, and a scaffold. Cell-free scaffolds present a unique opportunity to develop highly specific microenvironments with tunable properties. Norbornene-functionalized hyaluronic acid (NorHA) hydrogels provide spatial control over biomolecule binding through a photopolymerization process. With this, biomimetic gradients can be produced to model a variety of tissue interfaces. To produce these patterns, a gradient mechanism was developed to function in tandem with a syringe pump. A conversion equation was derived to calculate a panel speed from the volumetric flow rate setting on the pump. Seven speeds were used to produce fluorophore gradients on the surface of NorHA hydrogels to assess changes in the length and slope of the gradient. The results indicated a strong positive linear correlation between the speed of the panel and the length of the gradient as well as a strong negative correlation between the speed of the panel and the slope of the gradient. Additionally, the mechanism was able to successfully produce several other types of gradients including multiregional, dual, and triregional.
ContributorsSogge, Amber (Author) / Holloway, Julianne (Thesis director) / Stabenfeldt, Sarah (Committee member) / Fumasi, Fallon (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05