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Father Daniel Berrigan once said that "writing about prisoners is a little like writing about the dead." I think what he meant is that we treat prisoners as ghosts. They're unseen and unheard. It's easy to simply ignore them and it's even easier when the government goes to great lengths to keep them hidden.
Supermax prisons

Father Daniel Berrigan once said that "writing about prisoners is a little like writing about the dead." I think what he meant is that we treat prisoners as ghosts. They're unseen and unheard. It's easy to simply ignore them and it's even easier when the government goes to great lengths to keep them hidden.
Supermax prisons are used to hold those prisoners whom prison authorities regard as the most problematic in the prison system. These facilities merge the 19th-century practice of long-term solitary confinement with 21st-century technology in ways that subject prisoners to unparalleled levels of isolation, surveillance, and control, usually for long duration, with the potential to inflict significant amounts of psychological harm. Despite a range of academic studies documenting the serious and potentially long-lasting psychological harm it may inflict, and several judicial opinions criticizing the risks it entails and significantly limiting its use, supermax prisons are still in full effect today.
Although there have been no successful cases brought to the Supreme Court alleging the use of supermax prisons being in violation of the inmate’s Eighth Amendment right, one can look at isolated factors that distinguish supermax prisons in which judges at the Supreme Court level have shown to be unconstitutional in general population prisons. This thesis examines the Eighth Amendment implications of cruel and unusual punishment within supermax prisons, through isolated factors through judicial intervention.
ContributorsLucca, Veronica Cristina (Author) / Stanford, Michael (Thesis director) / Cavender, Gray (Committee member) / School of Social Transformation (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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Description
The objective of this research was to create a 3D in vitro model to mimic the native breast tumor microenvironment. Polydimethylsiloxane (PDMS) stamps and micromolding techniques were utilized to develop collagen based 3D tumor model. Geometrical design was optimized for the PDMS stamp to compartmentalize the tumor and stromal region

The objective of this research was to create a 3D in vitro model to mimic the native breast tumor microenvironment. Polydimethylsiloxane (PDMS) stamps and micromolding techniques were utilized to develop collagen based 3D tumor model. Geometrical design was optimized for the PDMS stamp to compartmentalize the tumor and stromal region of the 3D model. Addition of tumor and stromal cells into the platform further demonstrated the successful fabrication of the 3D model which will be used to investigate the role of stromal components on tumor growth and progression. Atomic force microscopy will also be utilized to access stromal remodeling during active invasion.
ContributorsAssefa, Eyerusalem Dibaba (Author) / Nikkhah, Mehdi (Thesis director) / Saini, Harpinder (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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Description
Cystic Fibrosis (CF) is a genetic disorder that disrupts the hydration of mucous of the lungs, which promotes opportunistic bacterial infections that begin in the affected person’s childhood, and persist into adulthood. One of the bacteria that infect the CF lung is Pseudomonas aeruginosa. This gram-negative bacterium is acquired from

Cystic Fibrosis (CF) is a genetic disorder that disrupts the hydration of mucous of the lungs, which promotes opportunistic bacterial infections that begin in the affected person’s childhood, and persist into adulthood. One of the bacteria that infect the CF lung is Pseudomonas aeruginosa. This gram-negative bacterium is acquired from the environment of the CF lung, changing the expression of phenotypes over the course of the infection. As P. aeruginosa infections become chronic, some phenotype changes are known to be linked with negative patient outcomes. An important exoproduct phenotype is rhamnolipid production, which is a glycolipid that P. aeruginosa produces as a surfactant for surface-mediated travel. Over time, the expression of this phenotype decreases in expression in the CF lung.
The objective of this investigation is to evaluate how environmental changes that are related to the growth environment in the CF lung alters rhamnolipid production. Thirty-five P. aeruginosa isolates from Dartmouth College and Seattle Children’s Hospital were selected to observe the impact of temperature, presence of Staphylococcus aureus metabolites, and oxygen availability on rhamnolipid production. It was found that the rhamnolipid production significantly decreased for 30C versus 37C, but not at 40C. The addition of S. aureus spent media, in any of the tested conditions, did not influence rhamnolipid production. Finally, the change in oxygen concentration from normoxia to hypoxia significantly reduced rhamnolipid production. These results were compared to swarming assay data to understand how changes in rhamnolipid production impact surface-mediated motility.
ContributorsKiermayr, Jonathan Patrick (Author) / Bean, Heather (Thesis director) / Misra, Rajeev (Committee member) / Haydel, Shelley (Committee member) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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Description
Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and

Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and adapt to a plethora of biochemical and biophysical signals from stromal cells and extracellular matrix (ECM) proteins. Due to these complexities, there is a critical need to understand molecular mechanisms underlying cancer metastasis to facilitate the discovery of more effective therapies. In the past few years, the integration of advanced biomaterials and microengineering approaches has initiated the development of innovative platform technologies for cancer research. These technologies enable the creation of biomimetic in vitro models with physiologically relevant (i.e. in vivo-like) characteristics to conduct studies ranging from fundamental cancer biology to high-throughput drug screening. In this review article, we discuss the biological significance of each step of the metastatic cascade and provide a broad overview on recent progress to recapitulate these stages using advanced biomaterials and microengineered technologies. In each section, we will highlight the advantages and shortcomings of each approach and provide our perspectives on future directions.
ContributorsPeela, Nitish (Author) / Nikkhah, Mehdi (Thesis director) / LaBaer, Joshua (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Hindustani classical music is an ancient art, where musicians perform ragas, or scales of notes with specific rules as to how one can move up/down the scales, which notes can be emphasized, what time of day they can be performed, what kinds of moods they evoke, and what phrases can

Hindustani classical music is an ancient art, where musicians perform ragas, or scales of notes with specific rules as to how one can move up/down the scales, which notes can be emphasized, what time of day they can be performed, what kinds of moods they evoke, and what phrases can and cannot be used. In this Honors thesis, I performed Raga Maru Bihag, an early night romantic raga. I performed three compositions within this raga, in slow, medium, and fast speeds. The majority of the performance was improvised, as is typical of Hindustani music. In addition to providing video footage of the performance, I have included an essay covering the history of Hindustani classical music, a stylistic analysis of my performance, and the cultural significance of the concert. The history section covers major developments in the art starting from its inception in 2500 BCE and details the contributions of important figures in Hindustani classical music. The stylistic analysis of the performance breaks down each and every element of the raga's presentation and development, with video links accompanying relevant descriptions. Lastly, the cultural significance section discusses the importance of the audience's behavior, artists' behavior, setting, invocation, gestures, etc. Collectively, the thesis will introduce the reader to Hindustani classical music and use a specific performance as a point of reference to showcase unique elements of the art style.
ContributorsSridhar, Swaroon (Author) / Little, Bliss (Thesis director) / Norton, Kay (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Each year, 30,000 patients obtain transplants. To prevent graft rejection, immunosuppressants such as tacrolimus are prescribed. Due to tacrolimus's narrow therapeutic range, a dose that is too low places patients at risk for transplant rejection, but too high of a dose leads to kidney failure. The de facto method for

Each year, 30,000 patients obtain transplants. To prevent graft rejection, immunosuppressants such as tacrolimus are prescribed. Due to tacrolimus's narrow therapeutic range, a dose that is too low places patients at risk for transplant rejection, but too high of a dose leads to kidney failure. The de facto method for monitoring of transplant patient health is bimonthly blood draws, which are cumbersome, painful, and difficult to translate into urgently needed dosage changes in a timely manner. To improve long-term transplant survival rates, we propose a finger-prick sensor that will provide patients and healthcare providers with a measurement of tacrolimus, immune health (through IL-12), and kidney damage (through cystatin C) levels 100 times more frequently than the status quo. Additionally, patient quality of life will be improved due to reduction in time and pain associated with blood draws. Optimal binding frequencies for each marker were found. However, due to limitations with EIS, the integration of the detection of the three markers into one multimarker sensing platform has not yet been realized. To this end, impedance-time tests were run on each marker along with different antibodies, and optimal times of each marker were determined to be 17s, 6s, and 2s, for tacrolimus, cystatin c, and IL-12, respectively (n=6). The integration of impedance-time analysis with traditional EIS methodologies has the potential to enable multi-marker analysis by analyzing binding kinetics on a single electrode with respect to time. Thus, our results provide unique insight into possibilities to improve and facilitate detection of multiple markers not only for the sensor for solid organ transplant patients, but for the monitoring of patients with disease that also entail the observation of multiple markers. Furthermore, the use of impedance-time testing also provides the ability for another way to optimize accuracy/precision of marker detection because it specifies a particular time, in addition to a particular optimal binding frequency, at which to measure concentration.
ContributorsDoshi, Meera Kshitij (Author) / LaBelle, Jeffrey (Thesis director) / Steidley, Eric (Committee member) / Harrington Bioengineering Program (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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Description
This thesis explores the intersection of religion, social class, and politics during the late nineteenth century in Imperial Germany. Specifically, the focus of this work is on the Workers' Association of Saint Paul's in Aachen and Burtscheid, a Catholic working-class organization in the 1870s located in the city of Aachen,

This thesis explores the intersection of religion, social class, and politics during the late nineteenth century in Imperial Germany. Specifically, the focus of this work is on the Workers' Association of Saint Paul's in Aachen and Burtscheid, a Catholic working-class organization in the 1870s located in the city of Aachen, a rapidly industrializing city in the majority Catholic Prussian Rhineland. This organization was the largest Catholic working-class association in Germany in the 1870s, reaching 5,000 members by the middle of the decade, and also espoused the politics of Christian Socialism. This thesis explores the intersection of the possibly competing social identities of these workers between being Catholics and workers. To start, the scholarly framework of studying society and politics in Imperial Germany is discussed, especially the concept of rigidly constructed social milieus into five groups, two of them being the Catholics and the working-class, and how this work may suggest a challenge to this concept. Next, the background information of how a Catholic working-class came into existence, as it was the product of simultaneous nineteenth century processes of industrialization and a religious revival among German Catholics. The Kulturkampf was the force that politicized Catholicism in Germany, as the persecution of Catholic institutions by Prussia forced Catholics into a social and political "ghetto." Then, the Association of St. Paul's itself is discussed. First, the workers espoused their Catholic identity and religious solidarity during a time of persecution, but also emphasized the Christian basis for their brand of Socialism. This lent into their identity as part of the working-class. While they steadfastly rejected the "godlessness" of Social Democracy, the Christian Socialists also shared many similar social and political goals. This intersection between identities eventually led to political conflict in Aachen throughout the 1870s with the mainstream, bourgeois Catholics of the city. To conclude, the legacy of Christian Socialism on modern Germany is discussed, as well as its contribution to the complex politics of Imperial Germany.
Created2016-05
Description
Optogenetics presents the ability to control membrane dynamics through the usage of transfected proteins (opsins) and light stimulation. However, as the field continues to grow, the original biological and stimulation tools used have become dated or limited in their uses. The usage of Organic Light Emitting Diodes (OLEDs) in optical

Optogenetics presents the ability to control membrane dynamics through the usage of transfected proteins (opsins) and light stimulation. However, as the field continues to grow, the original biological and stimulation tools used have become dated or limited in their uses. The usage of Organic Light Emitting Diodes (OLEDs) in optical stimulation offers greater resolution, finer control of pixel arrays, and the increased functionality of a flexible display at the cost of lower irradiance power density. This study was done to simulate methods using genetic and optical tools towards decreasing the threshold irradiance needed to initiate an action potential in a ChR2 expressing neuron. Simulations show that pulsatile stimulation can decrease threshold irradiances by increasing the overall duration of stimulus while keeping individual pulse durations below 5 ms. Furthermore, the redistribution of Channelrhodopsin-2 (ChR2) to the apical dendrites and a change in wavelength to 625 nm both result in lower threshold irradiances. However, the model used has many discrepancies and has room for improvement in areas such as the light distribution model and ChR2 dynamics. The simulations run with this model however still present valuable insight and knowledge towards the usage of new stimulation methods and revisions on existing protocols.
ContributorsKyeh, James (Author) / Muthuswamy, Jitendran (Thesis director) / Crook, Sharon (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Parkinson's disease is a neurodegenerative disorder in the central nervous system that affects a host of daily activities and involves a variety of symptoms; these include tremors, slurred speech, and rigid muscles. It is the second most common movement disorder globally. In Stage 3 of Parkinson's, afflicted individuals begin to

Parkinson's disease is a neurodegenerative disorder in the central nervous system that affects a host of daily activities and involves a variety of symptoms; these include tremors, slurred speech, and rigid muscles. It is the second most common movement disorder globally. In Stage 3 of Parkinson's, afflicted individuals begin to develop an abnormal gait pattern known as freezing of gait (FoG), which is characterized by decreased step length, shuffling, and eventually complete loss of movement; they are unable to move, and often results in a fall. Surface electromyography (sEMG) is a diagnostic tool to measure electrical activity in the muscles to assess overall muscle function. Most conventional EMG systems, however, are bulky, tethered to a single location, expensive, and primarily used in a lab or clinical setting. This project explores an affordable, open-source, and portable platform called Open Brain-Computer Interface (OpenBCI). The purpose of the proposed device is to detect gait patterns by leveraging the surface electromyography (EMG) signals from the OpenBCI and to help a patient overcome an episode using haptic feedback mechanisms. Previously designed devices with similar intended purposes utilize accelerometry as a method of detection as well as audio and visual feedback mechanisms in their design.
ContributorsAnantuni, Lekha (Author) / McDaniel, Troy (Thesis director) / Tadayon, Arash (Committee member) / Harrington Bioengineering Program (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Technology both stimulates and is simultaneously stimulated by people and society. As a classic example, games have shaped and have been shaped by people's preferences. Today, online computer games are roaming everywhere, attracting and connecting players all over the world. However, at the same time, a lesser form of technology

Technology both stimulates and is simultaneously stimulated by people and society. As a classic example, games have shaped and have been shaped by people's preferences. Today, online computer games are roaming everywhere, attracting and connecting players all over the world. However, at the same time, a lesser form of technology has emerged alongside of online computer games. It is known as trading card games (TCGs). Surprisingly, TCGs have been able to compete on same level as online computer games. Looking at my past experiences, I offered a theory that encompasses three forms of social interactions to explain for TCGs' success. The three types of interactions are: interaction of identities, interaction of interests, and interaction of influences. Interaction of identities is the constant interchange of player information and knowledge through different mediums. Interaction of interests involves the exchange and quality of the tangible and intangible. Interaction of influences deals with the fluid flow of communication and ideas that players use to change an outcome, however consciously or unconsciously done. Not one of these three factors of interactions act along; each is a part of a grand picture of interaction of interactions. Altogether, these factors explain, at least in part, the current popularity of trading card games as a relatively simple technology in a society with a plethora of technologically advanced entertainments and games such as virtual computer gaming. A web-based survey was devised to further examine the effects of the three forms of interactions have on online computer game and trading card game players. The results were consistent with the premises of the three-factor interaction theory.
ContributorsQin, Sheng (Author) / Eaton, John P. (Thesis director) / Olsen, G. Douglas (Committee member) / Department of Psychology (Contributor) / Department of Management (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05