Matching Items (412)
Description
This dissertation research contributes to the advancement of activity-based travel forecasting models along two lines of inquiry. First, the dissertation aims to introduce a continuous-time representation of activity participation in tour-based model systems in practice. Activity-based travel demand forecasting model systems in practice today are largely tour-based model systems that simulate individual daily activity-travel patterns through the prediction of day-level and tour-level activity agendas. These tour level activity-based models adopt a discrete time representation of activities and sequence the activities within tours using rule-based heuristics. An alternate stream of activity-based model systems mostly confined to the research arena are activity scheduling systems that adopt an evolutionary continuous-time approach to model activity participation subject to time-space prism constraints. In this research, a tour characterization framework capable of simulating and sequencing activities in tours along the continuous time dimension is developed and implemented using readily available travel survey data. The proposed framework includes components for modeling the multitude of secondary activities (stops) undertaken as part of the tour, the time allocated to various activities in a tour, and the sequence in which the activities are pursued.
Second, the dissertation focuses on the implementation of a vehicle fleet composition model component that can be used not only to simulate the mix of vehicle types owned by households but also to identify the specific vehicle that will be used for a specific tour. Virtually all of the activity-based models in practice only model the choice of mode without due consideration of the type of vehicle used on a tour. In this research effort, a comprehensive vehicle fleet composition model system is developed and implemented. In addition, a primary driver allocation model and a tour-level vehicle type choice model are developed and estimated with a view to advancing the ability to track household vehicle usage through the course of a day within activity-based travel model systems. It is envisioned that these advances will enhance the fidelity of activity-based travel model systems in practice.
Second, the dissertation focuses on the implementation of a vehicle fleet composition model component that can be used not only to simulate the mix of vehicle types owned by households but also to identify the specific vehicle that will be used for a specific tour. Virtually all of the activity-based models in practice only model the choice of mode without due consideration of the type of vehicle used on a tour. In this research effort, a comprehensive vehicle fleet composition model system is developed and implemented. In addition, a primary driver allocation model and a tour-level vehicle type choice model are developed and estimated with a view to advancing the ability to track household vehicle usage through the course of a day within activity-based travel model systems. It is envisioned that these advances will enhance the fidelity of activity-based travel model systems in practice.
ContributorsGarikapati, Venu Madhav (Author) / Pendyala, Ram M. (Thesis advisor) / Zhou, Xuesong (Committee member) / Lou, Yingyan (Committee member) / Arizona State University (Publisher)
Created2014
Description
The accurate prediction of pavement network condition and performance is important for efficient management of the transportation infrastructure system. By reducing the error of the pavement deterioration prediction, agencies can save budgets significantly through timely intervention and accurate planning. The objective of this research study was to develop a methodology for calculating a pavement condition index (PCI) based on historical distress data collected in the databases from Long-Term Pavement Performance (LTPP) program and Minnesota Road Research (Mn/ROAD) project. Excel™ templates were developed and successfully used to import distress data from both databases and directly calculate PCIs for test sections. Pavement performance master curve construction and verification based on the PCIs were also developed as part of this research effort. The analysis and results of LTPP data for several case studies indicated that the study approach is rational and yielded good to excellent statistical measures of accuracy.
It is believed that the InfoPaveTM LTPP and Mn/ROAD database can benefit from the PCI templates developed in this study, by making them available for users to compute PCIs for specific road sections of interest. In addition, the PCI-based performance model development can be also incorporated in future versions of InfoPaveTM. This study explored and analyzed asphalt pavement sections. However, the process can be also extended to Portland cement concrete test sections. State agencies are encouraged to implement similar analysis and modeling approach for their specific road distress data to validate the findings.
ContributorsWu, Gan (Author) / Kaloush, Kamil (Thesis advisor) / Zhou, Xuesong (Committee member) / Underwood, Benjamin Shane (Committee member) / Arizona State University (Publisher)
Created2015
Description
This research develops heuristics to manage both mandatory and optional network capacity reductions to better serve the network flows. The main application discussed relates to transportation networks, and flow cost relates to travel cost of users of the network. Temporary mandatory capacity reductions are required by maintenance activities. The objective of managing maintenance activities and the attendant temporary network capacity reductions is to schedule the required segment closures so that all maintenance work can be completed on time, and the total flow cost over the maintenance period is minimized for different types of flows. The goal of optional network capacity reduction is to selectively reduce the capacity of some links to improve the overall efficiency of user-optimized flows, where each traveler takes the route that minimizes the traveler’s trip cost. In this dissertation, both managing mandatory and optional network capacity reductions are addressed with the consideration of network-wide flow diversions due to changed link capacities.
This research first investigates the maintenance scheduling in transportation networks with service vehicles (e.g., truck fleets and passenger transport fleets), where these vehicles are assumed to take the system-optimized routes that minimize the total travel cost of the fleet. This problem is solved with the randomized fixed-and-optimize heuristic developed. This research also investigates the maintenance scheduling in networks with multi-modal traffic that consists of (1) regular human-driven cars with user-optimized routing and (2) self-driving vehicles with system-optimized routing. An iterative mixed flow assignment algorithm is developed to obtain the multi-modal traffic assignment resulting from a maintenance schedule. The genetic algorithm with multi-point crossover is applied to obtain a good schedule.
Based on the Braess’ paradox that removing some links may alleviate the congestion of user-optimized flows, this research generalizes the Braess’ paradox to reduce the capacity of selected links to improve the efficiency of the resultant user-optimized flows. A heuristic is developed to identify links to reduce capacity, and the corresponding capacity reduction amounts, to get more efficient total flows. Experiments on real networks demonstrate the generalized Braess’ paradox exists in reality, and the heuristic developed solves real-world test cases even when commercial solvers fail.
This research first investigates the maintenance scheduling in transportation networks with service vehicles (e.g., truck fleets and passenger transport fleets), where these vehicles are assumed to take the system-optimized routes that minimize the total travel cost of the fleet. This problem is solved with the randomized fixed-and-optimize heuristic developed. This research also investigates the maintenance scheduling in networks with multi-modal traffic that consists of (1) regular human-driven cars with user-optimized routing and (2) self-driving vehicles with system-optimized routing. An iterative mixed flow assignment algorithm is developed to obtain the multi-modal traffic assignment resulting from a maintenance schedule. The genetic algorithm with multi-point crossover is applied to obtain a good schedule.
Based on the Braess’ paradox that removing some links may alleviate the congestion of user-optimized flows, this research generalizes the Braess’ paradox to reduce the capacity of selected links to improve the efficiency of the resultant user-optimized flows. A heuristic is developed to identify links to reduce capacity, and the corresponding capacity reduction amounts, to get more efficient total flows. Experiments on real networks demonstrate the generalized Braess’ paradox exists in reality, and the heuristic developed solves real-world test cases even when commercial solvers fail.
ContributorsPeng, Dening (Author) / Mirchandani, Pitu B. (Thesis advisor) / Sefair, Jorge (Committee member) / Wu, Teresa (Committee member) / Zhou, Xuesong (Committee member) / Arizona State University (Publisher)
Created2017
Description
Recently, automation, shared use, and electrification are proposed and viewed as the “three revolutions” in the future transportation sector to significantly relieve traffic congestion, reduce pollutant emissions, and increase transportation system sustainability. Motivated by the three revolutions, this research targets on the passenger-focused scheduled transportation systems, where (1) the public transit systems provide high-quality ridesharing schedules/services and (2) the upcoming optimal activity planning systems offer the best vehicle routing and assignment for household daily scheduled activities.
The high quality of system observability is the fundamental guarantee for accurately predicting and controlling the system. The rich information from the emerging heterogeneous data sources is making it possible. This research proposes a modeling framework to systemically account for the multi-source sensor information in urban transit systems to quantify the estimated state uncertainty. A system of linear equations and inequalities is proposed to generate the information space. Also, the observation errors are further considered by a least square model. Then, a number of projection functions are introduced to match the relation between the unique information space and different system states, and its corresponding state estimate uncertainties are further quantified by calculating its maximum state range.
In addition to optimizing daily operations, the continuing advances in information technology provide precious individual travel behavior data and trip information for operational planning in transit systems. This research also proposes a new alternative modeling framework to systemically account for boundedly rational decision rules of travelers in a dynamic transit service network with tight capacity constraints. An agent-based single-level integer linear formulation is proposed and can be effectively by the Lagrangian decomposition.
The recently emerging trend of self-driving vehicles and information sharing technologies starts creating a revolutionary paradigm shift for traveler mobility applications. By considering a deterministic traveler decision making framework, this research addresses the challenges of how to optimally schedule household members’ daily scheduled activities under the complex household-level activity constraints by proposing a set of integer linear programming models. Meanwhile, in the microscopic car-following level, the trajectory optimization of autonomous vehicles is also studied by proposing a binary integer programming model.
The high quality of system observability is the fundamental guarantee for accurately predicting and controlling the system. The rich information from the emerging heterogeneous data sources is making it possible. This research proposes a modeling framework to systemically account for the multi-source sensor information in urban transit systems to quantify the estimated state uncertainty. A system of linear equations and inequalities is proposed to generate the information space. Also, the observation errors are further considered by a least square model. Then, a number of projection functions are introduced to match the relation between the unique information space and different system states, and its corresponding state estimate uncertainties are further quantified by calculating its maximum state range.
In addition to optimizing daily operations, the continuing advances in information technology provide precious individual travel behavior data and trip information for operational planning in transit systems. This research also proposes a new alternative modeling framework to systemically account for boundedly rational decision rules of travelers in a dynamic transit service network with tight capacity constraints. An agent-based single-level integer linear formulation is proposed and can be effectively by the Lagrangian decomposition.
The recently emerging trend of self-driving vehicles and information sharing technologies starts creating a revolutionary paradigm shift for traveler mobility applications. By considering a deterministic traveler decision making framework, this research addresses the challenges of how to optimally schedule household members’ daily scheduled activities under the complex household-level activity constraints by proposing a set of integer linear programming models. Meanwhile, in the microscopic car-following level, the trajectory optimization of autonomous vehicles is also studied by proposing a binary integer programming model.
ContributorsLiu, Jiangtao (Author) / Zhou, Xuesong (Thesis advisor) / Pendyala, Ram (Committee member) / Mirchandani, Pitu (Committee member) / Lou, Yingyan (Committee member) / Arizona State University (Publisher)
Created2018
Description
Optimization of on-demand transportation systems and ride-sharing services involves solving a class of complex vehicle routing problems with pickup and delivery with time windows (VRPPDTW). Previous research has made a number of important contributions to the challenging pickup and delivery problem along different formulation or solution approaches. However, there are a number of modeling and algorithmic challenges for a large-scale deployment of a vehicle routing and scheduling algorithm, especially for regional networks with various road capacity and traffic delay constraints on freeway bottlenecks and signal timing on urban streets. The main thrust of this research is constructing hyper-networks to implicitly impose complicated constraints of a vehicle routing problem (VRP) into the model within the network construction. This research introduces a new methodology based on hyper-networks to solve the very important vehicle routing problem for the case of generic ride-sharing problem. Then, the idea of hyper-networks is applied for (1) solving the pickup and delivery problem with synchronized transfers, (2) computing resource hyper-prisms for sustainable transportation planning in the field of time-geography, and (3) providing an integrated framework that fully captures the interactions between supply and demand dimensions of travel to model the implications of advanced technologies and mobility services on traveler behavior.
ContributorsMahmoudi, Monirehalsadat (Author) / Zhou, Xuesong (Thesis advisor) / Mirchandani, Pitu B. (Committee member) / Miller, Harvey J. (Committee member) / Pendyala, Ram M. (Committee member) / Arizona State University (Publisher)
Created2018
Description
Priced Managed Lanes (MLs) have been increasingly advocated as one of the effective ways to mitigating congestion in recent years. This study explores a new and innovative pricing strategy for MLs called Travel Time Refund (TTR). The proposed TTR provides an additional option to paying drivers that insures their travel time by issuing a refund to the toll cost if they do not reach their destination within specified travel times due to accidents or other unforeseen circumstances. Perceived benefits of TTR include raised public acceptance towards priced MLs, utilization increase of HOV/HOT lanes, overall congestion mitigation, and additional funding for relevant transportation agencies. To gauge travelers’ interests of TTR and to analyse its possible impacts, a stated preference (SP) survey was performed. An exploratory and statistical analysis of the survey responses revealed negative interest towards HOT and TTR option in accordance with common wisdom and previous studies. However, it is found that travelers are less negative about TTR than HOT alone; supporting the idea, that TTR could make HOT facilities more appealing. The impact of travel time reliability and latent variables representing psychological constructs on travelers’ choices in response to this new pricing strategy was also analysed. The results indicate that along with travel time and reliability, the decision maker’s attitudes and the level of comprehension of the concept of HOT and TTR play a significant role in their choice making. While the refund option may be theoretically and analytically feasible, the practical implementation issues cannot be ignored. This study also provides a discussion of the potential implementation considerations that include information provision to connected and non-connected vehicles, distinction between toll-only and refund customers, measurement of actual travel time, refund calculation and processing and safety and human factors issues. As the market availability of Connected and Automated Vehicles (CAVs) is prognosticated by 2020, the potential impact of such technologies on effective demand management, especially on MLs is worth investigating. Simulation analysis was performed to evaluate the system performance of a hypothetical road network at varying market penetration of CAVs. The results indicate that Connected Vehicles (CVs) could potentially encourage and enhance the use of MLs.
ContributorsVadlamani, Sravani (Author) / Lou, Yingyan (Thesis advisor) / Pendyala, Ram (Committee member) / Zhou, Xuesong (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2018
Description
Many developing countries do not have health care systems that can afford technological biomedical devices or supplies to make such devices operational. To fill this void, nonprofit organizations, like Project C.U.R.E., recondition retired biomedical instrumentation so they can send medical supplies to help these developing countries. One of the issues with this is that sometimes the devices are unusable because components or expendable supplies are not available (Bhadelia). This issue has also been shown in the Impact Evaluations that Project C.U.R.E. receives from the clinics that explain the reasons why certain devices are no longer in use. That need underlies the idea on which this honors thesis has come into being. The purpose of this honors project was to create packing lists for biomedical instruments that Project C.U.R.E. recycles. This packing list would decrease the likelihood of important items being forgotten when sending devices. If an extra fuse, battery, light bulb, cuff or transducer is the difference between a functional or a nonfunctional medical device, such a list would be of benefit to Project C.U.R.E and these developing countries. In order to make this packing list, manuals for each device were used to determine what supplies were required, what was necessary for cleaning, and what supplies were desirable but functionally optional. This list was then added into a database that could be easily navigated and could help when packing up boxes for a shipment. The database also makes adding and editing the packing list simple and easy so that as Project C.U.R.E. gets more donated devices the packing list can grow.
ContributorsGraft, Kelsey Anne (Author) / Coursen, Jerry (Thesis director) / Walters, Danielle (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The Hippo signaling pathway is responsible for regulating organ size through cell proliferation, stemness, and apoptosis. Through targeting proteins Yes-associated kinase 1(YAP) and transcriptional co-activator with a PDZ-binding domain(TAZ), YAP/TAZ are unable to enter the nucleus and bind with coactivators to express target genes. To understand YAP/TAZ dynamics and its role in tumorigenesis, tissue regeneration, and tissue degeneration, a regulatory network was modeled by ordinary differential equations. Using MATLAB, the deterministic behavior of the network was observed to determine YAP/TAZ activity in different states. Performing the bifurcation analysis of the system through Oscill8, three states were identified: tumorigenic/regenerative, degenerative, and homeostatic states. Further analysis through parameter modification allowed a better understanding of which proteins can be targeted for cancer and degenerative disease.
ContributorsBarra Avila, Diego Rodrigo (Author) / Tian, Xiaojun (Thesis director) / Wang, Xiao (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Based on James Marcia's theory, identity development in youth is the degree to which one has explored and committed to a vocation [1], [2]. During the path to an engineering identity, students will experience a crisis, when one's values and choices are examined and reevaluated, and a commitment, when the outcome of the crisis leads the student to commit to becoming an engineer. During the crisis phase, students are offered a multitude of experiences to shape their values and choices to influence commitment to becoming an engineering student. Student's identities in engineering are fostered through mentoring from industry, alumni, and peer coaching [3], [4]; experiences that emphasize awareness of the importance of professional interactions [5]; and experiences that show creativity, collaboration, and communication as crucial components to engineering. Further strategies to increase students' persistence include support in their transition to becoming an engineering student, education about professional engineers and the workplace [6], and engagement in engineering activities beyond the classroom. Though these strategies are applied to all students, there are challenges students face in confronting their current identity and beliefs before they can understand their value to society and achieve personal satisfaction. To understand student's progression in developing their engineering identity, first year engineering students were surveyed at the beginning and end of their first semester. Students were asked to rate their level of agreement with 22 statements about their engineering experience. Data included 840 cases. Items with factor loading less than 0.6 suggesting no sufficient explanation were removed in successive factor analysis to identify the four factors. Factor analysis indicated that 60.69% of the total variance was explained by the successive factors. Survey questions were categorized into three factors: engineering identity as defined by sense of belonging and self-efficacy, doubts about becoming an engineer, and exploring engineering. Statements in exploring engineering indicated student awareness, interest and enjoyment within engineering. Students were asked to think about whether they spent time learning what engineers do and participating in engineering activities. Statements about doubts about engineering to engineering indicated whether students had formed opinions about their engineering experience and had understanding about their environment. Engineering identity required thought in belonging and self-efficacy. Belonging statements called for thought about one's opinion in the importance of being an engineer, the meaning of engineering, an attachment to engineering, and self-identification as an engineer. Statements about self-efficacy required students to contemplate their personal judgement of whether they would be able to succeed and their ability to become an engineer. Effort in engineering indicated student willingness to invest time and effort and their choices and effort in their engineering discipline.
ContributorsNguyen, Amanda (Author) / Ganesh, Tirupalavanam (Thesis director) / Robinson, Carrie (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Alzheimer’s Disease (AD) affects over 5 million individuals in the U.S. and has a direct cost estimated in excess of $200 billion per year. Broadly speaking, there are two forms of AD—early-onset, familial AD (FAD) and late-onset-sporadic AD (SAD). Animal models of AD, which rely on the overexpression of FAD-related mutations, have provided important insights into the disease. However, these models do not display important disease-related pathologies and have been limited in their ability to model the complex genetics associated with SAD.
Advances in cellular reprogramming, have enabled the generation of in vitro disease models that can be used to dissect disease mechanisms and evaluate potential therapeutics. To that end, efforts by many groups, including the Brafman laboratory, to generated patient-specific hiPSCs have demonstrated the promise of studying AD in a simplified and accessible system. However, neurons generated from these hiPSCs have shown some, but not all, of the early molecular and cellular hallmarks associated with the disease. Additionally, phenotypes and pathological hallmarks associated with later stages of the human disease have not been observed with current hiPSC-based systems. Further, disease relevant phenotypes in neurons generated from SAD hiPSCs have been highly variable or largely absent. Finally, the reprogramming process erases phenotypes associated with cellular aging and, as a result, iPSC-derived neurons more closely resemble fetal brain rather than adult brain.
It is well-established that in vivo cells reside within a complex 3-D microenvironment that plays a significant role in regulating cell behavior. Signaling and other cellular functions, such as gene expression and differentiation potential, differ in 3-D cultures compared with 2-D substrates. Nonetheless, previous studies using AD hiPSCs have relied on 2-D neuronal culture models that do not reflect the 3-D complexity of native brain tissue, and therefore, are unable to replicate all aspects of AD pathogenesis. Further, the reprogramming process erases cellular aging phenotypes. To address these limitations, this project aimed to develop bioengineering methods for the generation of 3-D organoid-based cultures that mimic in vivo cortical tissue, and to generate an inducible gene repression system to recapitulate cellular aging hallmarks.
Advances in cellular reprogramming, have enabled the generation of in vitro disease models that can be used to dissect disease mechanisms and evaluate potential therapeutics. To that end, efforts by many groups, including the Brafman laboratory, to generated patient-specific hiPSCs have demonstrated the promise of studying AD in a simplified and accessible system. However, neurons generated from these hiPSCs have shown some, but not all, of the early molecular and cellular hallmarks associated with the disease. Additionally, phenotypes and pathological hallmarks associated with later stages of the human disease have not been observed with current hiPSC-based systems. Further, disease relevant phenotypes in neurons generated from SAD hiPSCs have been highly variable or largely absent. Finally, the reprogramming process erases phenotypes associated with cellular aging and, as a result, iPSC-derived neurons more closely resemble fetal brain rather than adult brain.
It is well-established that in vivo cells reside within a complex 3-D microenvironment that plays a significant role in regulating cell behavior. Signaling and other cellular functions, such as gene expression and differentiation potential, differ in 3-D cultures compared with 2-D substrates. Nonetheless, previous studies using AD hiPSCs have relied on 2-D neuronal culture models that do not reflect the 3-D complexity of native brain tissue, and therefore, are unable to replicate all aspects of AD pathogenesis. Further, the reprogramming process erases cellular aging phenotypes. To address these limitations, this project aimed to develop bioengineering methods for the generation of 3-D organoid-based cultures that mimic in vivo cortical tissue, and to generate an inducible gene repression system to recapitulate cellular aging hallmarks.
ContributorsBounds, Lexi Rose (Author) / Brafman, David (Thesis director) / Wang, Xiao (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05