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Description
Once perceived as an unimportant occurrence in living organisms, cell degeneration was reconfigured as an important biological phenomenon in development, aging, health, and diseases in the twentieth century. This dissertation tells a twentieth-century history of scientific investigations on cell degeneration, including cell death and aging. By describing four central developments in cell degeneration research with the four major chapters, I trace the emergence of the degenerating cell as a scientific object, describe the generations of a variety of concepts, interpretations and usages associated with cell death and aging, and analyze the transforming influences of the rising cell degeneration research. Particularly, the four chapters show how the changing scientific practices about cellular life in embryology, cell culture, aging research, and molecular biology of Caenorhabditis elegans shaped the interpretations about cell degeneration in the twentieth-century as life-shaping, limit-setting, complex, yet regulated. These events created and consolidated important concepts in life sciences such as programmed cell death, the Hayflick limit, apoptosis, and death genes. These cases also transformed the material and epistemic practices about the end of cellular life subsequently and led to the formations of new research communities. The four cases together show the ways cell degeneration became a shared subject between molecular cell biology, developmental biology, gerontology, oncology, and pathology of degenerative diseases. These practices and perspectives created a special kind of interconnectivity between different fields and led to a level of interdisciplinarity within cell degeneration research by the early 1990s.
ContributorsJiang, Lijing (Author) / Maienschein, Jane (Thesis advisor) / Laubichler, Manfred (Thesis advisor) / Hurlbut, James (Committee member) / Creath, Richard (Committee member) / White, Michael (Committee member) / Arizona State University (Publisher)
Created2013
Description
In 1890, the State of Nevada built the Stewart Indian School on a parcel of land three miles south of Carson City, Nevada, and then sold the campus to the federal government. The Stewart Indian School operated as the only non-reservation Indian boarding school in Nevada until 1980 when the federal government closed the campus. Faced with the challenge of assimilating Native peoples into Anglo society after the conclusion of the Indian wars and the confinement of Indian nations on reservations, the federal government created boarding schools. Policymakers believed that in one generation they could completely eliminate Indian culture by removing children from their homes and educating them in boarding schools. The history of the Stewart Indian School from 1890 to 1940 is the story of a dynamic and changing institution. Only Washoe, Northern Paiute, and Western Shoshone students attended Stewart for the first decade, but over the next forty years, children from over sixty tribal groups enrolled at the school. They arrived from three dozen reservations and 335 different hometowns across the West. During this period, Stewart evolved from a repressive and exploitive institution, into a school that embodied the reform agenda of the Indian New Deal in the 1930s. This dissertation uses archival and ethnographic material to explain how the federal government's agenda failed. Rather than destroying Native culture, Stewart students and Nevada's Indian communities used the skills taught at the school to their advantage and became tribal leaders during the 1930s. This dissertation explores the individual and collective bodies of Stewart students. The body is a social construction constantly being fashioned by the intersectional forces of race, class, and gender. Each chapter explores the different ways the Stewart Indian School and the federal government tried to transform the students' bodies through their physical appearance, the built environment, health education, vocational training, and extracurricular activities such as band and sports.
ContributorsThompson, Bonnie (Author) / Iverson, Peter (Thesis advisor) / Gray, Susan (Thesis advisor) / Green, Monica (Committee member) / Arizona State University (Publisher)
Created2013
Description
During the nineteenth century, children's physical health became a dominant theme in France and Great Britain, two of Europe's pediatric pioneers. This dissertation examines how British and French doctors, legislators, hospital administrators, and social reformers came to see the preservation of children's physical health as an object of national and international concern. Medical knowledge and practice shaped, and was shaped by, nineteenth-century child preservation activities in France and Great Britain, linking medicine, public health, and national public and private efforts to improve the health of nations, especially that of their future members. Children's hospitals played a significant role in this process by promoting child health; preventing and combating childhood diseases; fostering pediatric professionalization and specialization; and diffusing medical-based justifications for child welfare reforms in the second half of the century. This deeply contextualized tale of two hospitals, Great Ormond Street Hospital for Children in London (1852) and Sainte-Eugénie in Paris (1855), traces a crescendo in the interest, provision, and advocacy for children's medical care over time: from foundling homes and dispensaries to specialized hospitals with convalescent branches and large outpatient clinics. As a comparative study of the medicalization of children's bodies between 1820 and 1890, this dissertation also investigates the transnational exchange of medical ideas, institutions, and practices pertaining to child health between France and Great Britain during a period of nation-building. Specialized pediatric institutions in Paris and London built upon and solidified local, national, and international interests in improving and preserving child health. Despite great differences in their hospital systems, French and British children's hospital administrators and doctors looked to one another as partners, models, and competitors. Nineteenth-century French and British concerns for national public health, and child health in particular, had important distinctions and parallels, but medical, institutional, and legislative developments related to these concerns were not isolated activities, but rather, tied to transnational communication, cooperation, and competition.
ContributorsSchreiner, Stephanie (Author) / Fuchs, Rachel G. (Thesis advisor) / Green, Monica (Committee member) / Szuter, Christine (Committee member) / Thompson, Victoria (Committee member) / Arizona State University (Publisher)
Created2014
Description
Natural history is, and was, dependent upon the collection of specimens. In the nineteenth century, American naturalists and institutions of natural history cultivated and maintained extensive collection networks comprised of numerous collectors that provided objects of natural history for study. Effective networks were collaborative in nature, with naturalists such as Spencer Baird of the Smithsonian trading their time and expertise for specimens. The incorporation of Darwinian and Neo-Lamarckian evolutionary theory into natural history in the middle of the century led to dramatic changes in the relationship between naturalists and collectors, as naturalists sought to reconcile their observations within the new evolutionary context. This dissertation uses the careers of collectors Robert Kennicott, Frank Stephens, Edward W. Nelson, E.A. Goldman, and Edmund Heller as case studies in order to evaluate how the changes in the theoretical framework of late nineteenth century natural history led to advances in field practice by assessing how naturalists trained their collectors to meet new demands within the field. Research focused on the correspondence between naturalists and collectors, along with the field notes and applicable publications by collectors. I argue that the changes in natural history necessitated naturalists training their collectors in the basics of biogeography - the study of geographic distribution of organisms, and systematics - the study of the diversity of life - leading to a collaborative relationship in which collectors played an active role in the formation of new biological knowledge. The project concludes that the changes in natural history with regard to theory and practice gradually necessitated a more professional cadre of collectors. Collectors became active agents in the formation of biological knowledge, and instrumental in the formation of a truly systematic natural history. As a result, collectors became de facto field naturalists, the forerunners of the field biologists that dominated the practice of natural history in the early and middle twentieth century.
ContributorsLaubacher, Matthew (Author) / Green, Monica (Thesis advisor) / Laubichler, Manfred (Thesis advisor) / Wright, Johnson Kent (Committee member) / Arizona State University (Publisher)
Created2011
Description
Researchers in the twentieth and twenty-first centuries identify the study of the intrinsic and external factors that influence human aging as senescence. A commonly held belief in the year 2015 is that at least some kinds of cells can replicate over long periods or even indefinitely, thereby meaning the cell does not undergo senescence (also known as replicative senescence) and is considered immortal. This study aims to provide information to answer the following question: While some scientists claim they can indefinitely culture a stem cell line in vitro, what are the consequences of those culturing practices? An analysis of a cluster of articles from the Embryo Project Encyclopedia provides information to suggest possible solutions to some potential problems in cell culturing, recognition of benefits for existing or historical culturing practices, and identification of gaps in scientific knowledge that warrant further research. Recent research suggests that hESCs, and immortalized cell lines in general, do not escape the effects of senescence. While there exists a constant change in the practices of cell culturing, a large portion of scientists still rely on practices established before modern senescence research: research that seems to suggest that cultured hESCs, among other immortal cell lines, are not truly immortal.
ContributorsBartlett, Zane (Author) / Maienschein, Jane (Thesis advisor) / Ellison, Karin (Committee member) / Hurlbut, James (Committee member) / Arizona State University (Publisher)
Created2015
Description
Nearly seven decades ago, the US government established grants to the states for family planning and acknowledged the importance of enabling all women to plan and space their pregnancies, regardless of personal income. Since then, publicly-funded family planning services have empowered millions of women, men, and adolescents to achieve their childbearing goals. Despite the recognized importance of subsidized family planning, services remain funded in a piecemeal fashion. Since the 1940s there have been numerous federal funding sources for family planning, including the Title V Maternal and Child Health Services Program, Office of Economic Opportunity grants, Title XX Social Services Program, Title X Family Planning Program, Medicaid, and the State Children’s Health Insurance Program, alongside state and local support. Spending guidelines allow states varying degrees of flexibility regarding allocation, to best serve the local population. With nearly two billion dollars spent annually on subsidized family planning, criticism often arises surrounding effective local program spending and state politics influencing grant allocation. Political tension regarding the amount of control states should have in managing federal funding is exacerbated in the context of family planning, which has become increasingly controversial among social conservatives in the twenty-first century. This thesis examines how Arizona’s political, geographic, cultural, and ethnic landscape shaped the state management of federal family planning funding since the early twentieth century. Using an extensive literature review, archival research, and oral history interviews, this thesis demonstrates the unique way Arizona state agencies and nonprofits collaborated to maximize the use of federal family planning grants, effectively reaching the most residents possible. That partnership allowed Arizona providers to reduce geographic barriers to family planning in a rural, frontier state. The social and political history surrounding the use of federal family planning funds in Arizona demonstrates the important role states have in efficient, effective, and equitable state implementation of national resources in successfully reaching local populations. The contextualization of government funding of family planning provides insight into recent attempts to defund abortion providers like Planned Parenthood, cut the Title X Family Planning Program, and restructure Medicaid in the twenty-first century.
ContributorsNunez-Eddy, Claudia (Author) / Maienschein, Jane (Thesis advisor) / Hurlbut, James (Committee member) / O'Neil, Erica (Committee member) / Arizona State University (Publisher)
Created2018
Description
There is no doubt that globalization has been a force in history , and especially in the past one hundred years. This is extremely evident in the implications of global epidemics. The global response to Severe Acute Respiratory Syndrome (SARS) revealed tensions between nation states and international health organization such as the World Health Organization) collectively called "Global Health Governance"). The issue was sovereignty. SARS showed us that there was more state-centric resistance to the Post-Westphalian world than previously thought. Where infectious diseases are concerned, however, the eventual compliance of states with the WHO shows reluctant but tacit compliance with international intervention.
ContributorsLaw, Stephanie (Author) / Rush, James (Thesis director) / Green, Monica (Committee member) / Lundry, Christopher (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
The essay conducts a wide review of the existing modern scholarship on plague, caused by Yersinia pestis, during the second plague pandemic in the Islamicate Mediterranean. A historiographical approach was taken to analyze the terminology recorded in scholarly plague treatises across the timeline of the historical narrative, from the centuries before during and after the 1348 plague pandemic known as the Black Death. Focus is given to the medical and symptom-based terminology that was used by medieval scholars to describes plagues arrival, appearance, and effects. Modern authors writing about regions from Anatolia and the Ottoman lands in the eastern Mediterranean, to the Andalusian region in Spanish Granada have translated and discussed major medieval treatises by scholars who were contemporary to the disease epidemics and this essay explores the medieval terminology using modern scholarship. An analysis of the detailed modern plague scholarship in the eastern Islamicate Mediterranean explores the interpretations and discussions generated by the numerous sources who wrote historical and religious treatises on plague during the initial pandemic and subsequent epidemic events. In the western Islamicate Mediterranean a trio of detailed treatises describe the symptoms and treatments for an unprecedented pandemic, providing unparalleled descriptive confirmation of the presence of plague related mortality. This western record is limited, however, by its finite temporal range, as no plague treatise arise from the Islamicate scholars in the western Mediterranean kingdoms to describe the events before or after the famous 1348 pandemic. Between the kingdoms in the east and west is a wasteland in the medieval scholarship on plague, its plague experience largely explained only in comparison with the adjacent regions. With this background the essay will seek the patterns and notable features in scholarly terminology, in order to create a coherent picture of the plague experience across the Islamicate Mediterranean.
ContributorsHayton, Jacob Raymond (Author) / Green, Monica (Thesis director) / El Hamel, Chouki (Committee member) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This paper analyzes the epidemiology of the disease 'hysteria', once thought to be a uniquely female disorder affecting a woman's physical and mental states. As early as Ancient Egypt, a woman's reproductive system was a topic of pointed interest, later leading to conclusions on how the womb may 'wander' and how the mental state of any woman with hysteria must be treated with care. The progression of its diagnosis builds upon collective opinion, culminating in modern stigmas and stereotypes. I will define the parameters that transformed female hysteria from Ancient Egyptian gynecology to the modern day taboos of female sexuality, all through the lens that a woman's biology is radically different and perhaps inferior to that of a man's. I will trace this tragic domino effect within Ancient Egyptian and Greek societies, introduce the sway of Christianity during the Middle Ages, extrapolate on the social expectations of the Victorian Era, and finally culminate with the lasting effects that this classification of hysteria had on both 20th and 21st century women. I will then include a discussion on how, due to historical assurances of the fragility of a woman, there is now an implicit assumption that women are subject to being overwhelmed by their emotions more so than men. I will mention social studies which analyze gender norms in modern Western society to provide context for the apparent struggles of women attempting to break glass ceilings in politics, science, the arts, literature, and the military and frequently failing due to the expectations of their sex. Following this, I will speak on how derogatory speech directed at women, through interpersonal communication and mass media, conditions future generations to generalize women as being nothing more than an inherently "delicate sex". I will then speak on an implicit association survey that I created and distributed to my peers to measure whether or not there is still a strong association between women and immaturity, childishness, and an emotionally unpredictable pattern of behavior. The stereotypic labeling of women as suffering from hysteria, or any offshoot of insanity, has stained the manner by which women as a sex are appraised. Consequently, it has forged a defensive need to "prove" self-worth in almost all professional arenas if women are to be taken seriously in male dominated fields. I believe that the classification and influence of hysteria played a critical role in shaping modern gender bias and normalizing demeaning treatment of women due to their allegedly inherent female traits. I will conclude through highlighting the efforts of female activist groups and the surge of women's marches in the fall of 2016 and early 2017. The response demanded by women's marches today preaches equality of the sexes and a chance to right the wrongs of their hysterical history.
ContributorsBailey, Brianna Lyne (Author) / Green, Monica (Thesis director) / Barca, Lisa (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
This is a project about medicine and the history of a condition called premenstrual syndrome (PMS), its “discovery” and conceptual development at both scientific and socio-cultural levels. Since it was first mentioned in medical literature, PMS has been explored empirically as a medical condition and conceptually as non-somatic cultural phenomenon. Many attempts have been made to produce scientific, empirical evidence to bolster the theory of PMS as a biological disease. Some non-medical perspectives argue that invoking biology as the cause of PMS medicalizes a natural function of the female reproductive system and shallowly interrogates what is actually a complex bio-psycho-social phenomenon. This thesis questions both sides of this debate in order to reveal how criteria for PMS were categorized despite disagreement surrounding its etiology.
This thesis illustrates how the concept of PMS developed and was informed by the discovery of hormones and the resulting field of endocrinology that provided a framework for conceptualizing PMS. It displays how the development of the medical diagnostic category of PMS developed in tandem with the emergence of the field of endocrinology and was legitimized and effectively medicalized through this connection. The diagnosis of PMS became established though the diagnostic techniques like questionnaires in spite of persistent disagreement over its definition. The thesis shows how these medical concepts and practices legitimated the category of PMS, and how it has become ubiquitous in contemporary culture.
This thesis illustrates how the concept of PMS developed and was informed by the discovery of hormones and the resulting field of endocrinology that provided a framework for conceptualizing PMS. It displays how the development of the medical diagnostic category of PMS developed in tandem with the emergence of the field of endocrinology and was legitimized and effectively medicalized through this connection. The diagnosis of PMS became established though the diagnostic techniques like questionnaires in spite of persistent disagreement over its definition. The thesis shows how these medical concepts and practices legitimated the category of PMS, and how it has become ubiquitous in contemporary culture.
ContributorsZietal, Bianca (Author) / Hurlbut, James (Thesis advisor) / Robert, Jason (Committee member) / Brian, Jennifer (Committee member) / Arizona State University (Publisher)
Created2016