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- Creators: School of Life Sciences
- Creators: Department of Supply Chain Management
- Resource Type: Text
Both great civilizations achieved their empires due to their innovative supply chains, organizational tactics, and culture. Each, however, presented their own unique solutions to the problem of world conquest by capitalizing on their respective strengths. For the Romans, this meant placing an emphasis on infrastructure, adopting and modifying the technologies of other peoples, and instituting a culture that emphasized achievement and resilience among an aristocratic elite. The Mongol’s, however, focused on their force’s mobility rather than infrastructure, emphasized recruiting of outsiders to supplement their weakness, and developed a meritocratic system largely free of aristocratic structure. Both empires, however, emphasized the importance of each soldier as a self-sufficient unit to ease the strain of the overall supply chain.
These two civilizations therefore provide valuable insight for two diametrically opposed business environments. The first being manufacturing companies, with the need for rigid processes and investments in infrastructure not unlike the Romans. The second being startups with their need for speed and flexibility much like the Mongols. Thus, by examining the past modern companies gain valuable insights in how to structure their organizations for the future.
The combined use of methamphetamine and opioids has been reported to be on the rise throughout the United States (U.S.). However, our knowledge of this phenomenon is largely based upon reported overdoses and overdose-related deaths, law enforcement seizures, and drug treatment records; data that are often slow, restricted, and only track a portion of the population participating in drug consumption activities. As an alternative, wastewater-based epidemiology (WBE) has the capability to track licit and illicit drug trends within an entire community, at a low cost and in near real-time, while providing anonymity to those contributing to the sewer shed. In this study, wastewater was collected from two Midwestern U.S. cities (2017-2019) and analyzed for the prevalence of methamphetamine and the opioids oxycodone, codeine, fentanyl, tramadol, hydrocodone, and hydromorphone. Monthly 24-hour time-weighted composite samples (n = 48) from each city were analyzed using isotope dilution liquid chromatography tandem mass spectrometry. Results showed that methamphetamine and total opioid consumption (milligram morphine equivalents) in City 1 were strongly correlated only in 2017 (Spearman rank order correlation coefficient, ρ = 0.78), the relationship driven by fentanyl, hydrocodone, and hydromorphone. For City 2, methamphetamine and total opioid consumption were strongly positively correlated during the entire study (ρ = 0.54), with the correlations driven by hydrocodone and hydromorphone. In both cities, hydrocodone and hydromorphone mass loads were highly correlated, suggesting a parent and metabolite relationship. WBE provides important insights into licit and illicit drug consumption patterns in near real-time as they evolve; important information for community stakeholders in municipalities across the U.S.