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My passion on the importance of oral health began when I was four years old with the traumatic experience of witnessing my grandmother, my idol, with a toothless smile without her dentures in. At present, I have been a dental assistant for five years, and have heard of similar stories

My passion on the importance of oral health began when I was four years old with the traumatic experience of witnessing my grandmother, my idol, with a toothless smile without her dentures in. At present, I have been a dental assistant for five years, and have heard of similar stories of people struggling with maintaining oral hygiene and having access to oral health care, including: family members, friends, patients, coworkers, and even Arizona State University faculty. Since the abolishment of emergency dental services in Arizona's Health Care Cost Containment System, dental related oral health care rates have jumped incrementally. In addition Arizona has created a dental desert, because dentists are not setting up their practices in the rural areas of the Valley, due to wanting to generate the most amount of income. Studies have also shown that dentists feel inept at treating ethnically diverse patients as well as patients from lower socioeconomic classes. These problems create a myriad of mental effects and physical ailments on the patient that are not limited to the oral cavity. In this paper, these issues in oral health care were studied along with their effects, including recommendations for resolutions.
ContributorsTaylor, Janine Marie (Author) / Ingram-Waters, Mary (Thesis director) / Ili, Joan (Committee member) / School for the Future of Innovation in Society (Contributor) / School of Film, Dance and Theatre (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Sex trafficking is an issue that is prevalent in the United States, including in Arizona. The Catholic Charities Diversion Program in Phoenix seeks to rehabilitate adults who have been involved in prostitution. The aim of this paper was to test three pilot interventions to address stress experienced by the program

Sex trafficking is an issue that is prevalent in the United States, including in Arizona. The Catholic Charities Diversion Program in Phoenix seeks to rehabilitate adults who have been involved in prostitution. The aim of this paper was to test three pilot interventions to address stress experienced by the program clients through three different techniques which was given in a workshop format. Cognitive Behavior Therapy (CBT), Dance Movement Therapy (DMT), and yoga and meditation are the three types of stress reduction techniques that have been studied in previous research and were pilot tested with adult sex-trafficked victims. This particular sections discusses the benefits of DMT and the results obtained after teaching sex-trafficked victims this therapy. The results of the pilot studies found that all three techniques reduced levels of stress significantly, and that they want further testing.
ContributorsKhanal, Garima (Co-author) / Somayaji, Vallari (Co-author) / Satapathy, Nikita (Co-author) / Sepowitz, Dominique Roe (Thesis director) / Graff, Sarah (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Sex trafficking is an issue that is prevalent in the United States, including in Arizona. The Catholic Charities Diversion Program in Phoenix seeks to rehabilitate adults who have been involved in prostitution. The aim of this paper was to test three pilot interventions to address stress experienced by the program

Sex trafficking is an issue that is prevalent in the United States, including in Arizona. The Catholic Charities Diversion Program in Phoenix seeks to rehabilitate adults who have been involved in prostitution. The aim of this paper was to test three pilot interventions to address stress experienced by the program clients through three different techniques that were given in workshop format. Cognitive Behavior Therapy (CBT), Dance Movement Therapy, and yoga and meditation are the three types of stress reduction techniques that have been studied in previous research and were pilot tested with adult sex trafficking victims. The results of the pilot studies and all three techniques reduced levels of stress significantly, and they warrant future testing.
ContributorsSatapathy, Nikita (Co-author) / Khanal, Garima (Co-author) / Somayaji, Vallari (Co-author) / Roe-Sepowitz, Dominique (Thesis director) / Graff, Sarah (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Sex trafficking is an issue that is prevalent in the United States, including in Arizona. The Catholic Charities Diversion Program in Phoenix seeks to rehabilitate women who were involved in prostitution. The aim of this paper was to treat Post Traumatic Stress Disorder (PTSD) through three different techniques, which will

Sex trafficking is an issue that is prevalent in the United States, including in Arizona. The Catholic Charities Diversion Program in Phoenix seeks to rehabilitate women who were involved in prostitution. The aim of this paper was to treat Post Traumatic Stress Disorder (PTSD) through three different techniques, which will be given in the format of workshops. Cognitive Behavior Therapy (CBT), Dance Movement Therapy (DMT), and yoga and meditation are the three types of stress reduction techniques that have been studied in previous papers and will be used for sex-trafficked victims. It is important to combat stress and find stress reducing techniques to improve health and quality of life in an individual. This specific section of the study focuses on yoga and meditation therapy and how it helps to reduce stress. The results showed that all three techniques, including yoga and meditation, reduced levels of stress significantly, thereby giving them a tool to use on their own to improve their health, and that they can be further tested in a longitudinal study to examine the reduction of PTSD symptoms over time.
ContributorsSomayaji, Vallari (Co-author) / Khanal, Garima (Co-author) / Satapathy, Nikita (Co-author) / Roe-Sepowitz, Dominique (Thesis director) / Graff, Sarah (Committee member) / School of Life Sciences (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
The Community Action Research Experiences (CARE) Program collaborated with a local non-profit organization called Arizona Facts of Life to design a program evaluation for their Youth Leadership Development Training Program, FACTS Curriculum. The purpose of this study was to identify targeted program outcomes, design an assessment to address these outcomes,

The Community Action Research Experiences (CARE) Program collaborated with a local non-profit organization called Arizona Facts of Life to design a program evaluation for their Youth Leadership Development Training Program, FACTS Curriculum. The purpose of this study was to identify targeted program outcomes, design an assessment to address these outcomes, and recommend possible evaluation designs. Arizona Facts of Life will implement the assessment using one of the recommended evaluation designs, and use the results to measure their Youth Leadership Development Training Program's outcomes and demonstrate efficacy.
Created2016-05
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Description
The purpose of this study is to analyze the stereotypes surrounding four wind instruments (flutes, oboes, clarinets, and saxophones), and the ways in which those stereotypes propagate through various levels of musical professionalism in Western culture. In order to determine what these stereotypes might entail, several thousand social media and

The purpose of this study is to analyze the stereotypes surrounding four wind instruments (flutes, oboes, clarinets, and saxophones), and the ways in which those stereotypes propagate through various levels of musical professionalism in Western culture. In order to determine what these stereotypes might entail, several thousand social media and blog posts were analyzed, and direct quotations detailing the perceived stereotypical personality profiles for each of the four instruments were collected. From these, the three most commonly mentioned characteristics were isolated for each of the instrument groups as follows: female gender, femininity, and giggliness for flutists, intelligence, studiousness, and demographics (specifically being an Asian male) for clarinetists, quirkiness, eccentricity, and being seen as a misfit for oboists, and overconfidence, attention-seeking behavior, and coolness for saxophonists. From these traits, a survey was drafted which asked participating college-aged musicians various multiple choice, opinion scale, and short-answer questions that gathered how much they agree or disagree with each trait describing the instrument from which it was derived. Their responses were then analyzed to determine how much correlation existed between the researched characteristics and the opinions of modern musicians. From these results, it was determined that 75% of the traits that were isolated for a particular instrument were, in fact, recognized as being true in the survey data, demonstrating that the stereotypes do exist and seem to be widely recognizable across many age groups, locations, and levels of musical skill. Further, 89% of participants admitted that the instrument they play has a certain stereotype associated with it, but only 38% of people identify with that profile. Overall, it was concluded that stereotypes, which are overwhelmingly negative and gendered by nature, are indeed propagated, but musicians do not appear to want to identify with them, and they reflect a more archaic and immature sense that does not correlate to the trends observed in modern, professional music.
ContributorsAllison, Lauren Nicole (Author) / Bhattacharjya, Nilanjana (Thesis director) / Ankeny, Casey (Committee member) / School of Life Sciences (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Memory CD8+ T-cells can persist in the absence of antigen, primed for immediate activation and proliferation if later exposed to the same antigen. These cytotoxic lymphocytes provide long-term immunity following an acute infection. Studies have observed that intermediate levels of general T cell transfer prior to infection may cause an

Memory CD8+ T-cells can persist in the absence of antigen, primed for immediate activation and proliferation if later exposed to the same antigen. These cytotoxic lymphocytes provide long-term immunity following an acute infection. Studies have observed that intermediate levels of general T cell transfer prior to infection may cause an inappropriate response resulting in increased pathology rather than prevention. Therefore, our study focused on a memory CD8 T-cell therapy using lymphocytic choriomeningitis virus (LCMV) specific splenocytes, which activate and proliferate at an accelerated pace compared to that of naive T-cells. LCMV is a natural murine pathogen which also poses a zoonotic infection threat to humans, and the effect of immune cell vaccination therapies for LCMV is not fully understood. We observed the effect of multiple memory CD8 T cell dosage levels on overall disease and memory CD8 T-cell response to the virus. Infection by exposure to a carrier was shown to have a reduced impact on mice receiving higher doses of memory T cells prior to infection compared to mice receiving less or no memory cells. Higher presence of activated memory cells were shown to correlate with less disease-related weight loss and accelerated recovery times. Survival rate after exposure to carriers was not shown to be affected by dosage level, warranting further research regarding the prevalence of the immunopathology observed in other studies in natural murine transmission models.
ContributorsMiller, Charles (Author) / Blattman, Joseph (Thesis director) / Holechek, Susan (Committee member) / Carmen, Joshua (Committee member) / W. P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
The stress response facilitates our ability to deal effectively with threatening situations, but exposure to severe or chronic stressors can lead to undesirable neural, physiological, and behavioral outcomes. Chronic stress is associated with structural changes in the rat hippocampus, with corresponding deficits in learning and memory. Recent studies have uncovered

The stress response facilitates our ability to deal effectively with threatening situations, but exposure to severe or chronic stressors can lead to undesirable neural, physiological, and behavioral outcomes. Chronic stress is associated with structural changes in the rat hippocampus, with corresponding deficits in learning and memory. Recent studies have uncovered an inherent neuroplasticity that allows the hippocampus to recover from these stress-induced neural changes. Underlying mechanisms likely involve several different cellular and molecular pathways. In order to gain a more comprehensive understanding of these pathways, we investigated differences in protein expression throughout the timeline of chronic stress and recovery. Male Sprague-Dawley rats were randomly assigned to chronic restraint stress for 6hr/d/10d or 6hr/d/21d, stress for 6hr/d/21d followed by a recovery period of no stress for 10 or 21 days, or a control group. The proteome from the hippocampus of these rats was sequenced using liquid chromatography tandem mass spectrometry (LC-MS/MS) and analyzed. We hypothesized that chronic stress alters interneuronal signaling in the hippocampus by enhancing or attenuating the expression of proteins responsible for synaptic plasticity (functional) and neuronal structure (morphology). So far we have found that structural proteins, such as alpha-internexin, homer protein homolog 3, neurofilament light, and vimentin were significantly altered by chronic stress and recovery. In contrast, proteins necessary for or associated with myelination such as 2',3'-cyclic-nucleotide 3'-phosphodiesterase, myelin-associated glycoprotein, myelin basic protein S, and myelin proteolipid protein were significantly downregulated by chronic stress. Collectively, these results will provide a resource for further investigations into the mechanisms of the brain's recovery from chronic stress.
ContributorsKachemov, Marketta Marilyn (Author) / Orchinik, Miles (Thesis director) / Pirrotte, Patrick (Committee member) / Conrad, Cheryl (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Historically, studies of condition-dependent signals in animals have been male-centric, but recent work suggests that female ornaments can also communicate individual quality (e.g., disease state, fecundity). There has been a surge of interest in how urbanization alters signaling traits, but we know little about if and how cities affect signal

Historically, studies of condition-dependent signals in animals have been male-centric, but recent work suggests that female ornaments can also communicate individual quality (e.g., disease state, fecundity). There has been a surge of interest in how urbanization alters signaling traits, but we know little about if and how cities affect signal expression in female animals. We measured carotenoid-based plumage coloration and coccidian (Isospora spp) parasite burden in desert and city populations of house finches to examine urban impacts on male and female health and attractiveness. In earlier work, we showed that male house finches are less colorful and more parasitized in the city, and we again detected that pattern in this study for males. However, though city females are also less colorful than their rural counterparts, we found that rural females were more parasitized. Also, regardless of sex and unlike rural birds, more colorful birds in the city were more heavily infected with coccidia. These results show that urban environments can disrupt signal honesty in female animals and highlight the need for more studies on how cities affect disease and condition-dependent traits in both male and female animals.
ContributorsSykes, Brooke Emma (Author) / McGraw, Kevin (Thesis director) / Sweazea, Karen (Committee member) / Hutton, Pierce (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Background: Noninvasive MRI methods that can accurately detect subtle brain changes are highly desirable when studying disease-modifying interventions. Texture analysis is a novel imaging technique which utilizes the extraction of a large number of image features with high specificity and predictive power. In this investigation, we use texture analysis to

Background: Noninvasive MRI methods that can accurately detect subtle brain changes are highly desirable when studying disease-modifying interventions. Texture analysis is a novel imaging technique which utilizes the extraction of a large number of image features with high specificity and predictive power. In this investigation, we use texture analysis to assess and classify age-related changes in the right and left hippocampal regions, the areas known to show some of the earliest change in Alzheimer's disease (AD). Apolipoprotein E (APOE)'s e4 allele confers an increased risk for AD, so studying differences in APOE e4 carriers may help to ascertain subtle brain changes before there has been an obvious change in behavior. We examined texture analysis measures that predict age-related changes, which reflect atrophy in a group of cognitively normal individuals. We hypothesized that the APOE e4 carriers would exhibit significant age-related differences in texture features compared to non-carriers, so that the predictive texture features hold promise for early assessment of AD. Methods: 120 normal adults between the ages of 32 and 90 were recruited for this neuroimaging study from a larger parent study at Mayo Clinic Arizona studying longitudinal cognitive functioning (Caselli et al., 2009). As part of the parent study, the participants were genotyped for APOE genetic polymorphisms and received comprehensive cognitive testing every two years, on average. Neuroimaging was done at Barrow Neurological Institute and a 3D T1-weighted magnetic resonance image was obtained during scanning that allowed for subsequent texture analysis processing. Voxel-based features of the appearance, structure, and arrangement of these regions of interest were extracted utilizing the Mayo Clinic Python Texture Analysis Pipeline (pyTAP). Algorithms applied in feature extraction included Grey-Level Co-Occurrence Matrix (GLCM), Gabor Filter Banks (GFB), Local Binary Patterns (LBP), Discrete Orthogonal Stockwell Transform (DOST), and Laplacian-of-Gaussian Histograms (LoGH). Principal component (PC) analysis was used to reduce the dimensionality of the algorithmically selected features to 13 PCs. A stepwise forward regression model was used to determine the effect of APOE status (APOE e4 carriers vs. noncarriers), and the texture feature principal components on age (as a continuous variable). After identification of 5 significant predictors of age in the model, the individual feature coefficients of those principal components were examined to determine which features contributed most significantly to the prediction of an aging brain. Results: 70 texture features were extracted for the two regions of interest in each participant's scan. The texture features were coded as 70 initial components andwere rotated to generate 13 principal components (PC) that contributed 75% of the variance in the dataset by scree plot analysis. The forward stepwise regression model used in this exploratory study significantly predicted age, accounting for approximately 40% of the variance in the data. The regression model revealed 5 significant regressors (2 right PC's, APOE status, and 2 left PC by APOE interactions). Finally, the specific texture features that contributed to each significant PCs were identified. Conclusion: Analysis of image texture features resulted in a statistical model that was able to detect subtle changes in brain integrity associated with age in a group of participants who are cognitively normal, but have an increased risk of developing AD based on the presence of the APOE e4 phenotype. This is an important finding, given that detecting subtle changes in regions vulnerable to the effects of AD in patients could allow certain texture features to serve as noninvasive, sensitive biomarkers predictive of AD. Even with only a small number of patients, the ability for us to determine sensitive imaging biomarkers could facilitate great improvement in speed of detection and effectiveness of AD interventions..
ContributorsSilva, Annelise Michelle (Author) / Baxter, Leslie (Thesis director) / McBeath, Michael (Committee member) / Presson, Clark (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05