Matching Items (549)
Filtering by
- Creators: Dean, W.P. Carey School of Business
- Resource Type: Text
Description
Hepatocellular carcinoma (HCC) is a type of liver cancer common in Sub-Saharan Africa and South East Asian countries. Each year more than 700,000 new cases and more than 600,000 deaths are recorded worldwide due to HCC. According to the American Cancer Society HCC is ranked the 5th most common cancer worldwide with a male:female susceptibility ratio ranging between 2:1 and 8:1. HCC risk factors include lifestyle behaviors, such as persistent alcohol abuse and smoking, prolonged exposure to aflatoxins, chronic viral hepatitis infections, inherited metabolic diseases and non-alcoholic fatty liver diseases. To understand the genetic effects underlying sex-bias in HCC, it is necessary to include the sex chromosomes in genomics analyses. X and Y chromosomes are often discluded in genomics studies because of the technical and analytical challenges: sequence homology. The purpose of this thesis is to analyze the effects of sex chromosome complement aware read mapping to germline variant calling. 10 male and 10 female tumor adjacent samples from The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA LIHC) cohort were processed using sex-aware and default reference and the concordance of the two approaches was examined. We detected a higher disconcordance of 0.69% on variants called on the X chromosome and a disconcordance of 0.51% on variants called on the Y chromosomes for the reference and alternative alleles respectively compared to autosomes. Variants called on the REF/ALT genotypes had a disconcordances of 1.00%, 1.05%, 1.35% and 12.34% for the autosomes, chromosome 7, the X, and the Y chromosome, respectively. At the end of the project we concluded that the generated datasets showed the effect of sex-aware read mapping on variant calling. Though the data did not show the sites that can be called as variants in one dataset but not in the other, rather the concordance looked at sites that were called as variants in both data sets.
ContributorsPhiri, Lovender Teresa (Co-author) / Phiri, Lovender (Co-author) / Wilson Sayres, Melissa (Thesis director) / Buetow, Kenneth (Committee member) / Natri, Heini (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
There are many parallels between human and equine sports medicine, including the roots of athletics, the development of specialized medicine, and injuries to the athletes. The most remarkable similarities are seen in tendinopathies. Because of the similarities between human and equine tendons, equine athletes serve as one of the best animal models to study tendon physiology and tendon injuries for application to human medicine. Because of this, many therapies have already successfully crossed from one realm of sports medicine to the other, the most notable of which are stem cell therapy, Interleukin-1 Receptor Antagonist (IRAP), and platelet rich plasma (PRP) therapies. There are also several therapies on the horizon that are very promising to potentially be successful in both human and equine athletes. However, some of these novel therapies are raising ethical questions. There are many regulations in place to protect against or address potential ethical conflicts in human medicine. The same trend is not seen in equine medicine. While there are rules enforced by many equestrian federations regarding ethical concerns and veterinary medicine, the information is not nearly as complete as it should be. Because they lack the autonomy that typical human patient possesses, equine athletes require significantly more advocacy from their veterinarians than human athletes do from their physicians. Additionally, there is a lack of large animal model studies secondary to cost and overall value of equine athletes to their owners, riders, and trainers. Ultimately it becomes an issue of veterinary ethics whether to pursue a novel or conventional treatment for an equine athlete. With biotechnology advancing as quickly as it is, new studies must be done and new regulations must be written in order to keep all fields of sports medicine operating safely and ethically for all athletes involved, regardless of species.
ContributorsWaslewski, Samantha Paige (Author) / Lynch, John (Thesis director) / Foley, James (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Usability in the Internet of Things (IOT) in the Smart Home is a new concept with limited current research, especially in user perception. User perception is an important aspect in the development of Smart Home Internet of Things systems, including smart home products and devices and in the design of the Smart Home experience. The aim of my thesis is to investigate user perceptions of Smart Home Internet of Things systems to understand how usable current Smart Home Internet of Things systems are from the perception of the user and how that impacts the Smart Home experience. By understanding the usability of Smart Home Internet of Things systems, we can better design Smart Home devices and products for a user-centered experience. My thesis informs the design of user-centered Smart Home Internet of Things systems and experiences.
This study includes a literature review and an empirical study. The empirical study is a usability testing survey that investigates user perceptions of Smart Home technology that make up the Internet of Things system in the Smart Home. Both closed-ended questions and open-ended questions are included in the survey for a comprehensive study. Main results showed that current smart home systems are somewhat usable. Results also showed that smart home users are satisfied with current smart home systems, believes that smart home technology adds value to their lifestyle, and will continue to use smart home technology. Main results showed that the strengths of current smart home systems design are efficiency, learnability, memorability, and enjoyability. Main results showed that there is a trend between age group and smart home user perceptions. These findings inform the design of user-centered smart home systems.
This study includes a literature review and an empirical study. The empirical study is a usability testing survey that investigates user perceptions of Smart Home technology that make up the Internet of Things system in the Smart Home. Both closed-ended questions and open-ended questions are included in the survey for a comprehensive study. Main results showed that current smart home systems are somewhat usable. Results also showed that smart home users are satisfied with current smart home systems, believes that smart home technology adds value to their lifestyle, and will continue to use smart home technology. Main results showed that the strengths of current smart home systems design are efficiency, learnability, memorability, and enjoyability. Main results showed that there is a trend between age group and smart home user perceptions. These findings inform the design of user-centered smart home systems.
ContributorsChuong, Samantha (Author) / Bowman, Diana (Thesis director) / Michael, Katina (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The classification of financially at-risk is an expansive term that fits the personal profile of most individuals when it comes to the conditioning of their attitude toward money management, particularly in the planning and investment of that money for the achievement of long-term goals. In the case of this thesis, we focus primarily on those who have made a career in professional athletics and entertainment. The behavioral finance tendencies of these two industry professions are widely regarded as insufficient and often damaging the to the longevity of achieved financial security. This ideology stems primarily from an environment where individuals enjoy rapid wealth accumulation in a highly competitive and constantly transitioning role within their respective crafts. The subjectively common behavioral shortcomings of these world-class athletes and performers and uncertain day-to-day security of the professions which these at-risk individuals possess make for highly unfavorable circumstances when striving to achieve a lifetime of income and a secure retirement. In examining individuals of these classes who have faced grave financial hardship, this thesis will serve as a basis for identifying measures to recondition problematic behavioral tendencies that ultimately cause disengagement from a prudent financial plan. Therefore, this thesis will also serve as a framework to determine what investment strategies will complement the behavioral modifications financial planners strive to instill in these individuals, so that professional athletes, celebrities, and financially at-risk professionals alike may achieve higher probability of creating financial freedom through the engaged execution of a goals-based financial plan.
ContributorsKeller, Charles Phillip (Author) / Licon, Wendell (Thesis director) / Budolfson, Arthur (Committee member) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Problem Statement
Company X does not currently have a proven hedging method that allows for forecasting flexibility and currency fluctuations, while still reducing the risk of de-designation in their international construction projects. To solve this issue, we will analyze historical currency fluctuations over the past 5 years, forecasting error rates, the impact of de-designation, and earnings per share impact.
Company X does not currently have a proven hedging method that allows for forecasting flexibility and currency fluctuations, while still reducing the risk of de-designation in their international construction projects. To solve this issue, we will analyze historical currency fluctuations over the past 5 years, forecasting error rates, the impact of de-designation, and earnings per share impact.
ContributorsBlackburn, Jamie Sue (Co-author) / Lopez, Ivan (Co-author) / Miller, Cole (Co-author) / Plocher, Jasmine (Co-author) / Sinacori, Anthony (Co-author) / Simonson, Mark (Thesis director) / Thomas, Jodi (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This thesis examines two electronic games, PlayerUnknown’s Battlegrounds (PUBG) and Fortnite, which rose to popularity as battle royale-style videogames, to question whether they are viable candidates for success as esports. In his 2018 Barrett Honors Thesis, Noah Hilliker developed a model for assessing electronic games as successful esports. His thesis, titled “Ambassador Communities, Hybrid Spectatorship, and Other Indicators of Success in eSports” applied his model of indicators of success to League of Legends, Overwatch and Hearthstone. In this thesis, I have applied his indicators to (PUBG) and Fortnite, which differ significantly from the games he previously analyzed, precisely as I argue here, because they are battle royale games. These indicators fall under three categories: the nature of fans, the overall design of the game and the relationship between game developers and fans. The data that was examined for this investigation included academic literature on esports, posts on online platforms, news articles, YouTube content and forums. The following indicators were analyzed in their application to the collected data for both games: self-organization, spectator-player hybridity, ambassadors, clear center of action, demonstration of skill, mechanical variance, game balance, character of fan/developer relationship and feedback to fans. Through this project, I apply a previous approach to analyzing esports success to two games, Fortnite and PUBG, in order to analyze how well the model fits battle royale-style games.
ContributorsSmith, Brenden (Author) / Ingram-Waters, Mary (Thesis director) / Schmidt, Peter (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Photovoltaic panels are commonly used for their versatility in on-site generation of clean electricity in urban environments, specifically on rooftops. However, their implementation on rooftops poses potential (positive and negative) impacts on the energy use of buildings, and urban climates. The negative impacts are compounded if PV is installed on top of a high-albedo rooftop. This study quantitively investigates these impacts from PV installation on top of a building with a white roof in Phoenix, AZ. We supplemented our measurements with EnergyPlus simulations to model the energy implications for archetypical residential and retail buildings and calculated the energy penalty to generation ratio as well as sensible heat flux for each combination of panel height and building type. Results indicate that the daily cooling energy penalty to due blockage of outgoing longwave radiation can be 4.9—11.2% of the PV generation. In addition, while we observed a small decrease in nighttime sensible heat flux to the ambient, PV cases increased the daytime heat flux by more than a factor of 10. This study highlights the potential unintended consequences of rooftop PV under certain conditions and provides a broader perspective for building designers and urban planners.
ContributorsBrown, Kyle (Author) / Sailor, David (Thesis director) / Phelan, Patrick (Committee member) / Department of Physics (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Sustainability (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Characterization of particulate process and product design is a difficult field because of the unique bulk properties and behaviors of particles that differ from gasses and liquids. The purpose of this research is to develop an equation to relate the angle of repose and flowability, the ability of the particle to flow as it pertains to particulate processes and product design. This research is important in multiple industries such as pharmaceuticals and food processes.
ContributorsNugent, Emily Rose (Author) / Emady, Heather (Thesis director) / Marvi, Hamidreza (Committee member) / Materials Science and Engineering Program (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
International refugees have continuously shaped the identity of modern London, England, creating a diverse cityscape. However, the referendum in June 2016 indicated a perceived desire of the majority of United Kingdom (UK) citizens to leave the European Union (EU) and the domination of far-right, anti-immigrant rhetoric in British politics. These elements have given rise to the question of how refugees will find belonging in a geographical space that continues to create borders at both a national and borough level. As the Brexit vote still stands, barriers to applying for refugee status and successful resettlement could increase - complicating the lives of refugees wanting to resettle in the UK. Urban spaces such as London, Manchester, and Birmingham have transformed into places where the lives of the British cross daily with the lives of those forcibly removed from their home state. With minimal current research on the relationship between international refugees in London and the current social and political identity of the city, post-Brexit vote, I believe there is a gap in understanding to be filled. This gap includes defining the relationship between place, people, and politics in the context of the city of London as well as the boroughs that comprise the city. In addition, this research explores the future of London as a place at a borough-level and aims to understand how the idea of borders and nationalism have been uncovered and subsequently amplified through the referendum. The following paper includes data collected from British refugee agencies and inhabitants of five London boroughs that will add to existing research in the form of academic and professional journals and published reports produced by refugee agencies and the British government in hopes to identify the current nature of the relationship between international refugees and Londoners and how this relationship might shift in the future.
ContributorsRichardson, Bari Dudley (Author) / Larson, Elizabeth (Thesis director) / Sivak, Henry (Committee member) / Dean, W.P. Carey School of Business (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Within the hotel industry, customers come first. Their satisfaction drives revenue and drives the industry forward. With the updates in technology, new Consumer Relationship Management (CRM) databases are being implemented to aggregate customer reviews into a single platform that is analyzed and creates policies to help increase overall satisfaction. Hotels are ranked within all customer review sites such as Trip Advisor and Yelp and the higher the scores and the rank, the more these review sites promote these establishments, and the more customers book at this hotel. Therefore, customer reviews directly affect the revenue of a hotel. A hotel with low scores and low customer satisfaction will not entice guests to book. This new era of technology and customer driven revenue is the motivator behind Hilton’s creation of the SALT database. This Satisfaction and Loyalty Tracking database helps improve loyalty within the Hilton brands.
This paper examines the overall use of CRM systems and then examines the property level satisfaction metrics that can be found on SALT. The two metrics that the individual property could have the most effect on with the lowest budget were determined to be Digital Key and Digital Check-In, which make up the Digital Platform. This Digital Platform is accessed through the Hilton Honors app, which is a loyalty program created by Hilton. There are four tiers of Honors Members within the loyalty program: Blue, Silver, Gold, and Diamond. Blue members make up most of the membership base in general, however, at the local property examined, 60% of all guests are Gold and Diamond. Therefore, the research done within this paper focuses on improving overall Digital Platform satisfaction of Gold and Diamond members who are key business travelers that bring in revenue to the specific property examine.
The research collected for this project was done through observations of guests from the perspective of a Front Desk Agent, interviews with guests, analysis of SALT scores and guest reviews, and firsthand experiences of using Digital Key at local competitors of the local property. Through these analyses, the main problems that were compiled were internet connectivity, confusing property layout, Digital Key allotment and activation, technological issues with the Digital Key and hardware at the property, Digital Check-In and room selection, and negative reception of Hilton Honors Members. The solutions that were suggested focus on excellent customer service, increased training of Front Desk Agents regarding Digital Platform and Hilton Honors recognition, adding wi-fi routers throughout the hotel, adding Hilton Honors stickers to entrances, adding digital reader maps, and having the Director of Front Office Operations ensure that they are updating the Digital Platform frequently with rooms for members to choose.
This paper examines the overall use of CRM systems and then examines the property level satisfaction metrics that can be found on SALT. The two metrics that the individual property could have the most effect on with the lowest budget were determined to be Digital Key and Digital Check-In, which make up the Digital Platform. This Digital Platform is accessed through the Hilton Honors app, which is a loyalty program created by Hilton. There are four tiers of Honors Members within the loyalty program: Blue, Silver, Gold, and Diamond. Blue members make up most of the membership base in general, however, at the local property examined, 60% of all guests are Gold and Diamond. Therefore, the research done within this paper focuses on improving overall Digital Platform satisfaction of Gold and Diamond members who are key business travelers that bring in revenue to the specific property examine.
The research collected for this project was done through observations of guests from the perspective of a Front Desk Agent, interviews with guests, analysis of SALT scores and guest reviews, and firsthand experiences of using Digital Key at local competitors of the local property. Through these analyses, the main problems that were compiled were internet connectivity, confusing property layout, Digital Key allotment and activation, technological issues with the Digital Key and hardware at the property, Digital Check-In and room selection, and negative reception of Hilton Honors Members. The solutions that were suggested focus on excellent customer service, increased training of Front Desk Agents regarding Digital Platform and Hilton Honors recognition, adding wi-fi routers throughout the hotel, adding Hilton Honors stickers to entrances, adding digital reader maps, and having the Director of Front Office Operations ensure that they are updating the Digital Platform frequently with rooms for members to choose.
ContributorsRezac, Cassandra Rose (Author) / Niebuhr, Robert (Thesis director) / McWilliams, Claire (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05