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- Creators: Chopin, Frédéric, 1810-1849
ContributorsChopin, Frédéric, 1810-1849 (Composer)
Description
With the rising prevalence of obesity and diabetes, novel treatments to help mitigate or prevent symptoms of these conditions are warranted. Prior studies have shown that fossilized plant materials found in soil lowers blood sugar in a mouse model of diabetes. The goal of this study is to determine whether a similar organometallic complex (OMC) could prevent insulin resistance in the skeletal muscle brought on by chronic high fat intake by examining the protein expression of key enzymes in the insulin signaling pathway and examining glucoregulatory measures. Six-week-old periadolescent male Sprague-Dawley rats (n=42) were randomly chosen to be fed either a high fat diet (HFD) (20% protein, 20% carbohydrates [6.8% sucrose], 60% fat) or a standard chow diet (18.9% protein, 57.33% carbohydrates, 5% fat) for 10 weeks. Rats from each diet group were then randomly assigned to one of three doses of OMC (0, 0.6, 3.0 mg/mL), which was added to their drinking water and fasting blood glucose was measured at baseline and again at 10 weeks. After 10 weeks, rats were euthanized, and soleus muscle samples were isolated, snap-frozen, and stored at -80°C until analyses. Fasting plasma glucose was measured using a commercially available glucose oxidase kit. Following 6 and 10 weeks, HFD rats developed significant hyperglycemia (p<0.001 and p=0.025) compared to chow controls which was prevented by high dose OMC (p=0.021). After 10 weeks, there were significant differences in fasting serum insulin between diets (p=0.009) where levels were higher in HFD rats. No significant difference was seen in p-PI3K expression between groups. These results suggest that OMC could prevent insulin resistance by reducing hyperglycemia. Further studies are needed to characterize the effects of diet and OMC on the insulin signaling pathway in skeletal muscle, the main site of postprandial glucose disposal. This study was supported by a grant from Isagenix International LLC as well as funds from Barrett, the Honors College at Arizona State University, Tempe Campus.
ContributorsStarr, Ashlee (Author) / Sweazea, Karen (Thesis director) / Johnston, Carol (Committee member) / Hyatt, JP (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
The purpose of this study was to develop proposal lesson plans for 4th-6th graders based on active learning to integrate movement physical activity into the curriculum. The 4th-6th graders were chosen, as this is the age where teaching typically transitions from active learning to sedentary/lecture style teaching. Research compiled indicated positive effects of active based learning on children such as increased attention span, retention, and general focus. A survey was created to not only assess the perception of active versus didactic learners, but to also assess the effects of movement-based learning on the variables that research claimed to change. The lesson plans developed here should be transferable to a classroom lesson to evaluate the hypothesized results.
ContributorsTanna, Nimisha (Author) / Hyatt, JP (Thesis director) / Ainsworth, Barbara (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
ContributorsChopin, Frédéric, 1810-1849 (Composer)
Description
Muslim refugees and Muslim immigrants, and undocumented immigrants have been a prominent part of American culture and have been woven into the history of the United States. Both group's presence in the United States has elicited rhetoric from U.S citizens and U.S public officials. One may infer that the narrative of Muslim refugees and Muslim immigrants overlaps the narrative of undocumented immigrants living in the United States. Both Muslim refugees and immigrants as well as unauthorized immigrants, are criminalized in the United States, or are associated to crime by default of their faith and or their legal status. The association that Muslim refugees and Muslim immigrants, and undocumented immigrants have with crime, based on their rhetoric, has elicited a policy from the United States government as well. The United States government has responded to a presumed threat that both groups pose to U.S. citizens and the nation by means of aggressive legislation, both local and federal. In this research paper, past and present discourse on Muslim refugees and Muslim immigrants and undocumented immigrants was analyzed to determine each of the group's narrative; the mainstream media, newspapers and photographic images, was also considered to determine the narrative of both groups. Based on the discourse on Muslim refugees and Muslim immigrants and on undocumented immigrants, the media portrayal of both groups, and on the change of public policy one may assert that the narratives of both groups overlaps; as both Muslim refugees and immigrants and unauthorized immigrants are seen as a possible threat to the American people.
ContributorsGalvan, Brigitte Magdalena (Author) / Doty, Roxanne (Thesis director) / Magaña, Lisa (Committee member) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
ContributorsChopin, Frédéric, 1810-1849 (Composer)
ContributorsChopin, Frédéric, 1810-1849 (Composer)
ContributorsChopin, Frédéric, 1810-1849 (Composer)
ContributorsChopin, Frédéric, 1810-1849 (Composer)