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Investigating the Role of the Las and Rhl Quorum Sensing Systems in the Pathogenesis of Pseudomonas aeruginosa

Description

Pseudomonas aeruginosa is an opportunistic bacterial pathogen commonly associated with increased morbidity and mortality in cystic fibrosis (CF) patients. To adapt to the CF lung environment, P. aeruginosa undergoes multiple genetic changes as it moves from an acute to a

Pseudomonas aeruginosa is an opportunistic bacterial pathogen commonly associated with increased morbidity and mortality in cystic fibrosis (CF) patients. To adapt to the CF lung environment, P. aeruginosa undergoes multiple genetic changes as it moves from an acute to a chronic infection. The resultant phenotypes have been associated with chronic infection and can provide important information to track the patient’s individualized disease progression. This study examines the link between the accumulation of QS genetic mutations and phenotypic expression in P. aeruginosa laboratory strains and clinical isolates. We utilized several plate-based and colorimetric assays to quantify the production of pyocyanin, rhamnolipids, and protease from paired clinical early- and late-stage chronic infection isolates across 16 patients. Exoproduct production of each isolate was compared to the mean production of pooled isolates to classify high producing (QS-sufficient) and low producing (QS-deficient) isolates. We found that over time P. aeruginosa isolates exhibit a reduction in QS-related phenotypes during chronic infections. Future research of the QS regulatory networks will identify whether reversion of genotype will result in corresponding phenotypic changes in QS-deficient chronic infection isolates.

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2020-05

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The Development of Marketing with Respect to Retro-Acculturation

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With the United States' diverse group of people, diverse set of beliefs and diverse cultural backgrounds, it’s no wonder that over the last few decades there has been a 51 percent increase in second-generation Americans in the United States (Child

With the United States' diverse group of people, diverse set of beliefs and diverse cultural backgrounds, it’s no wonder that over the last few decades there has been a 51 percent increase in second-generation Americans in the United States (Child Trends, 2018). Though each of these second- and third-generation Americans experience life in the U.S. vastly different, the common steps of self-identity, acculturation and assimilation persist. However, what is often missed with this seemingly linear process is the delineating step: retro acculturation. Their sense of disconnect sparks a feeling of blurred identity, introducing the phenomenon of retro- acculturation, or an individual’s conscious efforts to connect to their heritage in new ways. Understanding the “why” behind this revelation is essential in understanding the “how”- or the actions taken by the individual to connect with their withdrawn culture. A deeper understanding of retro-acculturation and its processes is essential to leveraging a successful marketing effort in order to reach this demographic. As this population steadily reaches a larger population and quickly gains consumer buying power, it is important to be taking note of new and innovative ways of making lasting impressions on this demographic. This study focuses on exploring and discovering why individuals experience retro-acculturation and their triggers, as well as what approaches they use to connect to their heritage culture. Additionally, the insights gained were leveraged to provide recommendations as to how business can more effectively market to reach this demographic.

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2020-05

Obscenity: The Quick and Dirty

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Zines have made space for queer, intersectional feminists to bring together academic and artistic knowledge in order to produce a message and inspire readers. In order to criticize the legal definition and practical execution of obscenity in the US, a

Zines have made space for queer, intersectional feminists to bring together academic and artistic knowledge in order to produce a message and inspire readers. In order to criticize the legal definition and practical execution of obscenity in the US, a visual component was a necessity. The use of a Zine allowed for a critical and humorous exploration of obscenity in US law and media. The Zine provides a visual analysis while the companion essay provides a critique of the zine and additional analysis. The Zine brings awareness to ways in which the legal historical objectification of black and native bodies contributed to the creation of modern obscenity laws. These laws are based on racist and sexist ideals of morality and create inherently flawed definitions of obscenity through personal bias. The flaws within the laws allow for exceptions in the legal definition of obscenity which normalizes the commodification of women's bodies. These laws and the exceptions present contribute to the dehumanization of and violence towards women as usefulness is deemed the most important factor when considering the use of women’s bodies in potentially obscene images and films.

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2020-05

A Reflection on Translating a Thesis on Soil Pollution in Jiangsu

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This project took thesis written in Mandarin researching heavy metal pollution in the Jiangsu region of province and translated it to English. Then the reflection process was discussed, considering the translation challenges between Mandarin and English and how the scientific nature of the piece played into that process.

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2020-12

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Automation in a Progressive Economy: The Race between Humans and Technology

Description

For as long as humans have been working, they have been looking for ways to get that work done better, faster, and more efficient. Over the course of human history, mankind has created innumerable spectacular inventions, all with the goal

For as long as humans have been working, they have been looking for ways to get that work done better, faster, and more efficient. Over the course of human history, mankind has created innumerable spectacular inventions, all with the goal of making the economy and daily life more efficient. Today, innovations and technological advancements are happening at a pace like never seen before, and technology like automation and artificial intelligence are poised to once again fundamentally alter the way people live and work in society. Whether society is prepared or not, robots are coming to replace human labor, and they are coming fast. In many areas artificial intelligence has disrupted entire industries of the economy. As people continue to make advancements in artificial intelligence, more industries will be disturbed, more jobs will be lost, and entirely new industries and professions will be created in their wake. The future of the economy and society will be determined by how humans adapt to the rapid innovations that are taking place every single day. In this paper I will examine the extent to which automation will take the place of human labor in the future, project the potential effect of automation to future unemployment, and what individuals and society will need to do to adapt to keep pace with rapidly advancing technology. I will also look at the history of automation in the economy. For centuries humans have been advancing technology to make their everyday work more productive and efficient, and for centuries this has forced humans to adapt to the modern technology through things like training and education. The thesis will additionally examine the ways in which the U.S. education system will have to adapt to meet the demands of the advancing economy, and how job retraining programs must be modernized to prepare workers for the changing economy.

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2018-05

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The Effects of Sleep Efficiency on Serum Osteocalcin in College-Aged Individuals

Description

Osteoporosis is a medical condition that leads to decreased bone mineral density, resulting in increased fracture risk.1 Research regarding the relationship between sleep and bone mass is limited and has primarily been studied in elderly adults. While this population is

Osteoporosis is a medical condition that leads to decreased bone mineral density, resulting in increased fracture risk.1 Research regarding the relationship between sleep and bone mass is limited and has primarily been studied in elderly adults. While this population is most affected by osteoporosis, adolescents are the most proactive population in terms of prevention. The purpose of this study was to evaluate the relationship between sleep efficiency and serum osteocalcin in college-aged individuals as a means of osteoporosis prevention. Thirty participants ages 18-25 years (22 females, 8 males) at Arizona State University were involved in this cross-sectional study. Data were collected during one week via self-recorded sleep diaries, quantitative ActiWatch, DEXA imaging, and serum blood draws to measure the bone biomarker osteocalcin. Three participants were excluded from the study as outliers. The median (IQR) for osteocalcin measured by ELISA was 11.6 (9.7, 14.5) ng/mL. The average sleep efficiency measured by actigraphy was 88.3% ± 3.0%. Regression models of sleep efficiency and osteocalcin concentration were not statistically significant. While the addition of covariates helped explain more of the variation in serum osteocalcin concentration, the results remained insignificant. There was a trend between osteocalcin and age, suggesting that as age increases, osteocalcin decreases. This was a limited study, and further investigation regarding the relationship between sleep efficiency and osteocalcin is warranted.

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2018-05

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Bariatric Surgery: The Good, Bad, & Questionable

Description

Obesity has developed into a worldwide health problem that is associated with many risks. The elements causing obesity are complex and numerous including behavioral, psychological, and physiological. Traditional methods of weight loss have demonstrated short-lived positive health benefits and minimal

Obesity has developed into a worldwide health problem that is associated with many risks. The elements causing obesity are complex and numerous including behavioral, psychological, and physiological. Traditional methods of weight loss have demonstrated short-lived positive health benefits and minimal long-term weight loss, which has led to the prevalence of bariatric surgery as an answer to long-term weight loss for Class III obesity. Gastric bypass surgery has become especially popular for its numerous benefits including successful weight loss, improvements in obesity-related diseases, and increased lifespan. Bariatric surgery is still not a perfect solution. Negative effects after surgery range from surgical complications and vitamin deficiencies to altered hormonal levels and metabolic rates. Many questions regarding bariatric surgery still remain including the impact of adolescent bariatric surgery, long-term bone effects, and long-term psychosocial and lifestyle components of bariatric patients. Understanding the good, the bad, and several of the remaining questions regarding bariatric surgery, will help health professionals be more appreciative of the complexity of treating their obese patients.

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2018-05

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Computational Modeling and Experimentation of Pervaporation Membrane Processes for Brackish Water Recovery

Description

Fresh water is essential to the human population and is an integral component in global economics for its multiple uses, and population growth/development cause concern for the possible exhaustion of the limited supply of freshwater. A combined computational and experimental

Fresh water is essential to the human population and is an integral component in global economics for its multiple uses, and population growth/development cause concern for the possible exhaustion of the limited supply of freshwater. A combined computational and experimental approach to observe and evaluate pervaporation membrane performance for brackish water recovery was done to assess its efficiency and practicality for real world application. Results from modeling conveyed accuracy to reported parameter values from literature as well as strong dependence of performance on input parameters such as temperature. Experimentation results showed improved performance in flux by 34%-42% with radiative effect and then additional performance improvement (9%-33%) with the photothermal effect from carbon black application. Future work will include improvements to the model to include scaling propensity and energy consumption as well as continued experimentation to assess quality of pervaporation in water recovery.

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2018-05

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Comparing behavioral activities of male and female adolescent macaques

Description

Behavior of males and females may be mediated by their biological differences and, among cercopithecines, their divergent reproductive strategies. In order to have high reproductive success, individuals need to produce high quality offspring. Through pregnancy, lactation, and maternal care, females

Behavior of males and females may be mediated by their biological differences and, among cercopithecines, their divergent reproductive strategies. In order to have high reproductive success, individuals need to produce high quality offspring. Through pregnancy, lactation, and maternal care, females have a strong influence on the quality of their offspring. Within the cercopithecine mating system, males are limited in direct influence on offspring outcomes within the Cercopithecines, and are adapted to more typically maximize mating opportunities. In general, female reproductive strategies involve securing the most food while male reproductive strategies are geared towards helping them secure the most fertile females both somatically and behaviorally. In this paper, I investigated how the behaviors observed among female adolescent rhesus macaque monkeys would differ from the males as their divergent reproductive trajectories begin to manifest. I made predictions based off of four questions: who would be more affiliative with whom, who would be more aggressive and with whom, who would be more variable in their behaviors, and who would be lonelier. I predicted that females would be more affiliative with other females, due to the importance of social connectivity, and males would be more affiliative with males, due to the social bonds male adolescents form with each other. I predicted that males would be overall more aggressive than males because they were found to be by Bernstein et al. (1993). I predicted that males would show more variation in behavior since they may have to be more flexible to capitalize on all conditions to obtain mates. Finally, I predicted that males would be lonelier as an effect of social rank on males and female choice. In order to further understand these differences, 36 adolescent Macaca mulatta, N = 20 female and N=16 male, from the California Primate Center at University of California at Davis, CA were observed. The observer used a standardized method to score the subjects on a variety of behaviors like locomotion, aggression, grooming and more. Each individual underwent around 6 trials and the observations lasted 15 minutes. The data supported the first hypothesis that females are affiliative with each other and males are affiliative with each other. The date also showed that females are more aggressive than males and their aggression is generally targeted towards females. The third prediction was not supported by the data and females were actually more variable in their behaviors than males. Lastly, the data did not support the prediction that males are lonely moneys, however, it did support the alternative hypothesis that they are truly low sociable, low in sociability and low social connectivity.

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2018-05

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The History, Evolution, and Development of Wedding Cakes

Description

A key component to American weddings is the wedding cake and the number of customs associated with it. The History, Evolution, and Development of Wedding Cakes is a creative project that hopes to answer why the wedding cake is such

A key component to American weddings is the wedding cake and the number of customs associated with it. The History, Evolution, and Development of Wedding Cakes is a creative project that hopes to answer why the wedding cake is such an iconic item and what it represents. A historical study details the evolution from its origin to present day while a comparison of wedding cakes (or wedding cake analogs) from other cultures explores their role(s) across the globe. It was found that while little regard is given to the symbolism of the wedding cake today, its presence persists in some shape or form as it continues to evolve. Cultural variations were recreated to reflect personal interpretations of contemporary designs in addition to an original design of a contemporary-rustic American wedding cake.

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2018-05