Matching Items (31)
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Description
Modern, advanced statistical tools from data mining and machine learning have become commonplace in molecular biology in large part because of the “big data” demands of various kinds of “-omics” (e.g., genomics, transcriptomics, metabolomics, etc.). However, in other fields of biology where empirical data sets are conventionally smaller, more

Modern, advanced statistical tools from data mining and machine learning have become commonplace in molecular biology in large part because of the “big data” demands of various kinds of “-omics” (e.g., genomics, transcriptomics, metabolomics, etc.). However, in other fields of biology where empirical data sets are conventionally smaller, more traditional statistical methods of inference are still very effective and widely used. Nevertheless, with the decrease in cost of high-performance computing, these fields are starting to employ simulation models to generate insights into questions that have been elusive in the laboratory and field. Although these computational models allow for exquisite control over large numbers of parameters, they also generate data at a qualitatively different scale than most experts in these fields are accustomed to. Thus, more sophisticated methods from big-data statistics have an opportunity to better facilitate the often-forgotten area of bioinformatics that might be called “in-silicomics”.

As a case study, this thesis develops methods for the analysis of large amounts of data generated from a simulated ecosystem designed to understand how mammalian biomechanics interact with environmental complexity to modulate the outcomes of predator–prey interactions. These simulations investigate how other biomechanical parameters relating to the agility of animals in predator–prey pairs are better predictors of pursuit outcomes. Traditional modelling techniques such as forward, backward, and stepwise variable selection are initially used to study these data, but the number of parameters and potentially relevant interaction effects render these methods impractical. Consequently, new modelling techniques such as LASSO regularization are used and compared to the traditional techniques in terms of accuracy and computational complexity. Finally, the splitting rules and instances in the leaves of classification trees provide the basis for future simulation with an economical number of additional runs. In general, this thesis shows the increased utility of these sophisticated statistical techniques with simulated ecological data compared to the approaches traditionally used in these fields. These techniques combined with methods from industrial Design of Experiments will help ecologists extract novel insights from simulations that combine habitat complexity, population structure, and biomechanics.
ContributorsSeto, Christian (Author) / Pavlic, Theodore (Thesis advisor) / Li, Jing (Committee member) / Yan, Hao (Committee member) / Arizona State University (Publisher)
Created2018
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Description

Ultimate Frisbee or "Ultimate," is a fast growing field sport that is being played competitively at universities across the country. Many mid-tier college teams have the goal of winning as many games as possible, however they also need to grow their program by training and retaining new players. The purpose

Ultimate Frisbee or "Ultimate," is a fast growing field sport that is being played competitively at universities across the country. Many mid-tier college teams have the goal of winning as many games as possible, however they also need to grow their program by training and retaining new players. The purpose of this project was to create a prototype statistical tool that maximizes a player line-up's probability of scoring the next point, while having as equal playing time across all experienced and novice players as possible. Game, player, and team data was collected for 25 different games played over the course of 4 tournaments during Fall 2017 and early Spring 2018 using the UltiAnalytics iPad application. "Amount of Top 1/3 Players" was the measure of equal playing time, and "Line Efficiency" and "Line Interaction" represented a line's probability of scoring. After running a logistic regression, Line Efficiency was found to be the more accurate predictor of scoring outcome than Line Interaction. An "Equal PT Measure vs. Line Efficiency" graph was then created and the plot showed what the optimal lines were depending on what the user's preferences were at that point in time. Possible next steps include testing the model and refining it as needed.

ContributorsSpence, Andrea Nicole (Author) / McCarville, Daniel R. (Thesis director) / Pavlic, Theodore (Committee member) / Industrial, Systems and Operations Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
This paper outlines the development of a software application that explores the plausibility and potential of interacting with three-dimensional sound sources within a virtual environment. The intention of the software application is to allow a user to become engaged with a collection of sound sources that can be perceived both

This paper outlines the development of a software application that explores the plausibility and potential of interacting with three-dimensional sound sources within a virtual environment. The intention of the software application is to allow a user to become engaged with a collection of sound sources that can be perceived both graphically and audibly within a spatial, three-dimensional context. The three-dimensional sound perception is driven primarily by a binaural implementation of a higher order ambisonics framework while graphics and other data are processed by openFrameworks, an interactive media framework for C++. Within the application, sound sources have been given behavioral functions such as flocking or orbit patterns, animating their positions within the environment. The author will summarize the design process and rationale for creating such a system and the chosen approach to implement the software application. The paper will also provide background approaches to spatial audio, gesture and virtual reality embodiment, and future possibilities for the existing project.
ContributorsBurnett, Garrett (Author) / Paine, Garth (Thesis director) / Pavlic, Theodore (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Arts, Media and Engineering (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Simulation games are widely used in engineering education, especially for industrial engineering and operations management. A well-made simulation game aids in achieving learning objectives for students and minimal additional teaching by an instructor. Many simulation games exist for engineering education, but newer technologies now exist that improve the overall experience

Simulation games are widely used in engineering education, especially for industrial engineering and operations management. A well-made simulation game aids in achieving learning objectives for students and minimal additional teaching by an instructor. Many simulation games exist for engineering education, but newer technologies now exist that improve the overall experience of developing and using these games. Although current solutions teach concepts adequately, poorly-maintained platforms distract from the key learning objectives, detracting from the value of the activities. A backend framework was created to facilitate an educational, competitive, participatory simulation of a manufacturing system that is intended to be easy to maintain, deploy, and expand.
ContributorsChandler, Robert Keith (Author) / Clough, Michael (Thesis director) / Pavlic, Theodore (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
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Description
Temnothorax ants are a model species for studying collective decision-making. When presented with multiple nest sites, they are able to collectively select the best one and move the colony there. When a scout encounters a nest site, she will spend some time exploring it. In theory she should explore the

Temnothorax ants are a model species for studying collective decision-making. When presented with multiple nest sites, they are able to collectively select the best one and move the colony there. When a scout encounters a nest site, she will spend some time exploring it. In theory she should explore the site for long enough to determine both its quality and an estimate of the number of ants there. This ensures that she selects a good nest site and that there are enough scouts who know about the new nest site to aid her in relocating the colony. It also helps to ensure that the colony reaches a consensus rather than dividing between nest sites. When a nest site reaches a certain threshold of ants, a quorum has been reached and the colony is committed to that nest site. If a scout visits a good nest site where a quorum has not been reached, she will lead a tandem run to bring another scout there so that they can learn the way and later aid in recruitment. At a site where a quorum has been reached, scouts will instead perform transports to carry ants and brood there from the old nest. One piece that is missing in all of this is the mechanism. How is a quorum sensed? One hypothesis is that the encounter rate (average number of encounters with nest mates per second) that an ant experiences at a nest site allows her to estimate the population at that site and determine whether a quorum has been reached. In this study, encounter rate and entrance time were both shown to play a role in whether an ant decided to lead a tandem run or perform a transport. Encounter rate was shown to have a significant impact on how much time an ant spent at a nest site before making her decision, and encounter rates significantly increased as migrations progressed. It was also shown to individual ants did not differ from each other in their encounter rates, visit lengths, or entrance times preceding their first transports or tandem runs, studied across four different migrations. Ants were found to spend longer on certain types of encounters, but excluding certain types of encounters from the encounter rate was not found to change the correlations that were observed. It was also found that as the colony performed more migrations, it became significantly faster at moving to the new nest.
ContributorsJohnson, Christal Marie (Author) / Pratt, Stephen (Thesis director) / Pavlic, Theodore (Committee member) / Shaffer, Zachary (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description

The first step in process improvement is to scope the problem, next is measure the current process, but if data is not readily available and cannot be manually collected, then a measurement system must be implemented. General Dynamics Mission Systems (GDMS) is a lean company that is always seeking to

The first step in process improvement is to scope the problem, next is measure the current process, but if data is not readily available and cannot be manually collected, then a measurement system must be implemented. General Dynamics Mission Systems (GDMS) is a lean company that is always seeking to improve. One of their current bottlenecks is the incoming inspection department. This department is responsible for finding defects on parts purchased and is critical to the high reliability product produced by GDMS. To stay competitive and hold their market share, a decision was made to optimize incoming inspection. This proved difficult because no data is being collected. Early steps in many process improvement methodologies, such as Define, Measure, Analyze, Improve and Control (DMAIC), include data collection; however, no measurement system was in place, resulting in no available data for improvement. The solution to this problem was to design and implement a Management Information System (MIS) that will track a variety of data. This will provide the company with data that will be used for analysis and improvement. The first stage of the MIS was developed in Microsoft Excel with Visual Basic for Applications because of the low cost and overall effectiveness of the software. Excel allows update to be made quickly, and allows GDMS to collect data immediately. Stage two would be moving the MIS to a more practicable software, such as Access or MySQL. This thesis is only focuses on stage one of the MIS, and GDMS will proceed with stage two.

ContributorsDiaz, Angel (Author) / McCarville, Daniel R. (Thesis director) / Pavlic, Theodore (Committee member) / Industrial, Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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Description
Commuting is a significant cost in time and in travel expenses for working individuals and a major contributor to emissions in the United States. This project focuses on increasing the efficiency of an intersection through the use of "light metering." Light metering involves a series of lights leading up to

Commuting is a significant cost in time and in travel expenses for working individuals and a major contributor to emissions in the United States. This project focuses on increasing the efficiency of an intersection through the use of "light metering." Light metering involves a series of lights leading up to an intersection forcing cars to stop further away from the final intersection in smaller queues instead of congregating in a large queue before the final intersection. The simulation software package AnyLogic was used to model a simple two-lane intersection with and without light metering. It was found that light metering almost eliminates start-up delay by preventing a long queue to form in front of the modeled intersection. Shorter queue lengths and reduction in the start-up delays prevents cycle failure and significantly reduces the overall delay for the intersection. However, frequent deceleration and acceleration for a few of the cars occurs before each light meter. This solution significantly reduces the traffic density before the intersection and the overall delay but does not appear to be a better emission alternative due to an increase in acceleration. Further research would need to quantify the difference in emissions for this model compared to a standard intersection.
ContributorsGlavin, Erin (Author) / Pavlic, Theodore (Thesis director) / Sefair, Jorge (Committee member) / Industrial, Systems and Operations Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description

Optimal foraging theory provides a suite of tools that model the best way that an animal will <br/>structure its searching and processing decisions in uncertain environments. It has been <br/>successful characterizing real patterns of animal decision making, thereby providing insights<br/>into why animals behave the way they do. However, it does

Optimal foraging theory provides a suite of tools that model the best way that an animal will <br/>structure its searching and processing decisions in uncertain environments. It has been <br/>successful characterizing real patterns of animal decision making, thereby providing insights<br/>into why animals behave the way they do. However, it does not speak to how animals make<br/>decisions that tend to be adaptive. Using simulation studies, prior work has shown empirically<br/>that a simple decision-making heuristic tends to produce prey-choice behaviors that, on <br/>average, match the predicted behaviors of optimal foraging theory. That heuristic chooses<br/>to spend time processing an encountered prey item if that prey item's marginal rate of<br/>caloric gain (in calories per unit of processing time) is greater than the forager's<br/>current long-term rate of accumulated caloric gain (in calories per unit of total searching<br/>and processing time). Although this heuristic may seem intuitive, a rigorous mathematical<br/>argument for why it tends to produce the theorized optimal foraging theory behavior has<br/>not been developed. In this thesis, an analytical argument is given for why this<br/>simple decision-making heuristic is expected to realize the optimal performance<br/>predicted by optimal foraging theory. This theoretical guarantee not only provides support<br/>for why such a heuristic might be favored by natural selection, but it also provides<br/>support for why such a heuristic might a reliable tool for decision-making in autonomous<br/>engineered agents moving through theatres of uncertain rewards. Ultimately, this simple<br/>decision-making heuristic may provide a recipe for reinforcement learning in small robots<br/>with little computational capabilities.

ContributorsCothren, Liliaokeawawa Kiyoko (Author) / Pavlic, Theodore (Thesis director) / Brewer, Naala (Committee member) / School of Mathematical and Statistical Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Robots are often used in long-duration scenarios, such as on the surface of Mars,where they may need to adapt to environmental changes. Typically, robots have been built specifically for single tasks, such as moving boxes in a warehouse

Robots are often used in long-duration scenarios, such as on the surface of Mars,where they may need to adapt to environmental changes. Typically, robots have been built specifically for single tasks, such as moving boxes in a warehouse or surveying construction sites. However, there is a modern trend away from human hand-engineering and toward robot learning. To this end, the ideal robot is not engineered,but automatically designed for a specific task. This thesis focuses on robots which learn path-planning algorithms for specific environments. Learning is accomplished via genetic programming. Path-planners are represented as Python code, which is optimized via Pareto evolution. These planners are encouraged to explore curiously and efficiently. This research asks the questions: “How can robots exhibit life-long learning where they adapt to changing environments in a robust way?”, and “How can robots learn to be curious?”.

ContributorsSaldyt, Lucas P (Author) / Ben Amor, Heni (Thesis director) / Pavlic, Theodore (Committee member) / Computer Science and Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Enantiomers are pairs of non-superimposable mirror-image molecules. One molecule in the pair is the clockwise version (+) while the other is the counterclockwise version (-). Some pairs have divergent odor qualities, e.g. L-carvone (“spearmint”) vs. D-carvone (“caraway”), while other pairs do not. Existing theory about the origin of such differences

Enantiomers are pairs of non-superimposable mirror-image molecules. One molecule in the pair is the clockwise version (+) while the other is the counterclockwise version (-). Some pairs have divergent odor qualities, e.g. L-carvone (“spearmint”) vs. D-carvone (“caraway”), while other pairs do not. Existing theory about the origin of such differences is largely qualitative (Friedman and Miller, 1971; Bentley, 2006; Brookes et al., 2008). While quantitative models based on intrinsic molecular features predict some structure–odor relationships (Keller et al., 2017), they cannot identify, e.g. the more intense enantiomer in a pair; the mathematical operations underlying such features are invariant under symmetry (Shadmany et al., 2018). Only the olfactory receptor (OR) can break this symmetry because each molecule within an enantiomeric pair will have a different binding configuration with a receptor. However, features that predict odor divergence within a pair may be identifiable; for example, six-membered ring flexibility has been offered as a candidate (Brookes et al., 2008). To address this problem, we collected detection threshold data for >400 molecules (organized into enantiomeric pairs) from a variety of public data sources and academic literature. From each pair, we computed the within-pair divergence in odor detection threshold, as well as Mordred descriptors (molecular features derived from the structure of a molecule) and Morgan fingerprints (mathematical representations of molecule structure). While these molecular features are identical within-pair (due to symmetry), they remain distinct across pairs. The resulting structure+perception dataset was used to build a predictive model of odor detection threshold divergence. It predicted a modest fraction of variance in odor detection threshold divergence (r 2 ~ 0.3 in cross-validation). We speculate that most of the remaining variance could be explained by a better understanding of the ligand-receptor binding process.

ContributorsColeman, Liyah (Author) / Pavlic, Theodore (Thesis director) / Gerkin, Richard (Committee member) / Barrett, The Honors College (Contributor) / Computer Science - BS (Contributor)
Created2023-05