Today in the U.S. the narrative of the “bad drug” has become quite a familiar account. There is an ever-growing collection of pharmaceutical products whose safety and efficacy has been debunked through the scandalous exposure of violations of integrity on the part of researchers, lapses in procedure and judgment on the part of the FDA, and reckless profiteering on the part of big pharma. However, a closer look reveals that the oversights and loopholes depicted in the bad drug narrative are not incidental failures of an otherwise intact, effective system. Rather, bad drugs, like good drugs, are a product of normal operations of the system; the same processes, actors, and influences manifest in both. The aim of this project is to shed light on these processes, actors, and influences at work in drug normalization by interrogating the peculiar case of the drug Lupron. Lupron exhibits all of the controversial features of the “bad drug” narrative but has remained an endorsed and embraced staple of the infertility industry. This contradiction situates Lupron to expose a number of the contingencies on which drug normalization rests more generally. In order to put forth an explanatory model for drug normalization, three such contingencies are described in detail for the case at hand: the nature of drug regulation, the structures and value that underpin the medical categorization of diseases, and the inextricability of post-medicine from the forces of industry. These contingencies provide some explanatory power for understanding not only the retention of Lupron but the ways in which all drugs are produced, validated, and perpetuated in a society.

This is a project about medicine and the history of a condition called premenstrual syndrome (PMS), its “discovery” and conceptual development at both scientific and socio-cultural levels. Since it was first mentioned in medical literature, PMS has been explored empirically as a medical condition and conceptually as non-somatic cultural phenomenon. Many attempts have been made to produce scientific, empirical evidence to bolster the theory of PMS as a biological disease. Some non-medical perspectives argue that invoking biology as the cause of PMS medicalizes a natural function of the female reproductive system and shallowly interrogates what is actually a complex bio-psycho-social phenomenon. This thesis questions both sides of this debate in order to reveal how criteria for PMS were categorized despite disagreement surrounding its etiology.

This thesis illustrates how the concept of PMS developed and was informed by the discovery of hormones and the resulting field of endocrinology that provided a framework for conceptualizing PMS. It displays how the development of the medical diagnostic category of PMS developed in tandem with the emergence of the field of endocrinology and was legitimized and effectively medicalized through this connection. The diagnosis of PMS became established though the diagnostic techniques like questionnaires in spite of persistent disagreement over its definition. The thesis shows how these medical concepts and practices legitimated the category of PMS, and how it has become ubiquitous in contemporary culture.

2023 has been a record-breaking year for legislation aimed at restricting and even criminalizing access to gender affirming care for minors. In response to these legislative efforts, many advocates rely on invocations of medical authority to defend the right of individuals to access gender affirming care. However, this reliance on the pathologization of transgender identity both reaffirms stigmatization of transgender identity as mental illness as well as forecloses on opportunities to affirm access to gender affirming care otherwise. The purpose of this research is to use disability justice scholarship, predominantly crip theory, to analyze these legislative efforts in-depth beyond the predominant critique offered by the medical-model. I demonstrate that these legislative moves to ban access to gender affirming care are part of a larger effort to prevent a trans future more broadly. Trans childhood has become a particularly fruitful site for this political action due to the ways in which normativities relating to time, biological plasticity, and capacity shape the way that their bodies are understood. I term those individual bodies which have such characteristics of non-normative temporalities, plasticity, and capacity/incapacity grafted onto them become “bodies of normative intervention” and explore how they become the laboratory sites for producing population-wide normative interventions. This legislative effort to restrict access to gender affirming care for minors represents a broader effort to legislate a trans future out of existence through the strategic targeting of trans children. This robs society of valuable trans knowledge and experience.

Corporations in biomedicine hold significant power and influence, in both political and personal spheres. The decisions these companies make about ethics are critically important, as they help determine what products are developed, how they are developed, how they are promoted, and potentially even how they are regulated. In the last fifteen years, for-profit private companies have been assembling bioethics committees to help resolve dilemmas that require informed deliberation about ethical, legal, scientific, and economic considerations. Private sector bioethics committees represent an important innovation in the governance of emerging technologies, with corporations taking a lead role in deciding what is ethically appropriate or problematic. And yet, we know very little about these committees, including their structures, memberships, mandates, authority, and impact. Drawing on an extensive literature review and qualitative analysis of semi-structured interviews with executives, scientists and board members, this dissertation provides an in-depth analysis of the Ethics and Public Policy Board at SmithKline Beecham, the Ethics Advisory Board at Advanced Cell Technology, and the Bioethics Committee at Eli Lilly and offers insights about how ideas of bioethics and governance are currently imagined and enacted within corporations. The SmithKline Beecham board was the first private sector bioethics committee; its mandate was to explore, in a comprehensive and balanced analysis, the ethics of macro trends in science and technology. The Advanced Cell Technology board was created to be like a watchdog for the company, to prevent them from making major errors. The Eli Lilly board is different than the others in that it is made up mostly of internal employees and does research ethics consultations within the company. These private sector bioethics committees evaluate and construct new boundaries between their private interests and the public values they claim to promote. Findings from this dissertation show that criticisms of private sector bioethics that focus narrowly on financial conflicts of interest and a lack of transparency obscure analysis of the ideas about governance (about expertise, credibility and authority) that emerge from these structures and hamper serious debate about the possible impacts of moving ethical deliberation from the public to the private sector.

The Undoing Project is an ongoing educational feminist YouTube channel that serves as an introduction to feminism and feminist theory. The objective for this project is to present feminist theory and feminist ideology in an accessible and entertaining way. Through this project I sought to accomplish three goals: to challenge the negative image of feminism, bridge the gap between the language of academia and the public, and to acknowledge and unlearn ingrained prejudices. The videos focus on theory, history, legislation, current events, and pop culture. The initial project consists of ten videos addressing the feminist wave models, a brief history of the feminist movement, and discussions of concepts like hegemony, intersectionality, masculinity, femininity, and race.

Physician-assisted suicide occurs when a physician facilitates a patient's death by prescribing a lethal medication that they understand will be used for the purpose of ending the patient's life. It is a highly contentious subject and, with the recent addition of California to the list of states that allow physician-assisted suicide, is an increasingly relevant subject. Physician-assisted suicide is rarely framed as a healthcare experience, despite being a choice in the process of end-of-life care. The research seeks to bring together the debates about physician-assisted suicide with conversations about health care experiences. The experiences and perspectives of young people are particularly valuable to evaluate now, as their voices will soon be the leaders in the debate over physician-assisted suicide. Within this research, there is an underlying theme of independence of individuals that is present through both the literature review and the body of data collected and analyzed. The study found that there was no significant relationship between the quality of a person's healthcare and their perspectives about physician-assisted suicide.

The first global estimate of maternal mortality in 1985 revealed that over half a million women die each year due to pregnancy related causes. Although a relatively small figure compared to the deaths attributed to such diseases as malaria and HIV, this was new data. New data meant attraction from powerful international agency leaders, which eventually led to the formation of a global effort called the Safe Motherhood Initiative (SMI). In turn, the global SMI provided the framework for the World Health Organization's (WHO) Millennium Development Goal 5 (MDG 5). Both of these global campaigns, which were largely implemented through advocacy efforts, adopted time sensitive goals aimed specifically to decrease maternal mortality. Although the placement of maternal health on the public health agenda was an extraordinary accomplishment for women's health advocates, a historical examination of safe motherhood efforts will reveal that these advocacy techniques would not keep maternal health on the public health agenda. Over two decades of unsuccessful efforts to reduce maternal mortality have shown that advocacy efforts are not the answer to actually decreasing maternal mortality ratios. Due to the intrinsic difficulties in measuring maternal mortality, and the public health sector's emphasis in prioritizing the political agenda based on such measurements, maternal health has arguably fallen in last place on the agenda. This thesis will explore how the concern for mothers influenced the formation of MDG 5, and how MDG 5 has been translated into local practices. A case study of the Pan American Health Organization's advocacy effort also called the Safe Motherhood Initiative explores the underlying, culturally complex problems that are hindering progress of MDG 5. The results show that the lack of comprehensive reproductive health services for women is not only due to poor health systems in place, which is what many safe motherhood 5 efforts have attempted to address, but also due to cultural traditions and laws on sexual and reproductive health forbidding women to obtain the care they need to survive.

The nonmedical use of prescription ADHD medications by American college students for the purpose of enhancing academic performance has been well-documented for more than a decade. A closer look at this trend through the lens of biomedicalization theory shows us that this behavior, which is often dismissed as a simple abuse of the system by deviant young people, is consistent with broader trends in post-modern medicine and health. The goal of this project was to describe the biomedicalization of studying by illustrating the historical, sociocultural, and politico-economic roots of nonmedical stimulant use by college students in the United States. An online survey was administered to students at ASU and responses from students studying in the College of Liberal Arts and Sciences (n=233) were analyzed. A 12.4% lifetime prevalence of illicit stimulant use was found among the sample population. Thematic analysis was performed on students' open-ended commentary and several themes related to the biomedicalization framework were uncovered including Necessity, Identity, Inextricability from academia, and Trust in the system. Through these themes it was found that many of the theorized transitions of biomedicalization were visible in the data set, confirming the idea that nonmedical stimulant use is embedded in the complex network of processes that represents post-modern medicine today.

A fundamental component of Transhumanism, radical life extension is the process of utilizing ever increasing technologies to further extend the average life span of humans. This iterative process has continued to increase in speed since the digital age. As society develops a larger knowledge base, and scientific fields combine their knowledge bases, the capability of medical professionals continues to increase at an exponential rate. Through an understanding of these technological trends the social, legal, logistical and economic implications can be better understood. Scenarios can be used to better categorize these implications based on the evolution of these technologies. By considering biological, non-biological and linear life extension technologies a broad analysis of the varied implications can be constructed. Based on these scenarios one can conclude radical life extension technologies will have significant impacts on the current social definitions of what it means to be human and how society organizes itself. Continued research towards radical life extension technologies comes with high social implications which must be considered in tandem.

This paper encompasses part of the complex topic of relationships between consumers, organic products, and advertising in America with a particular focus on Tempe, Arizona. Background research included in this paper includes how the term "organic" was developed and regulated to fit the federal standards that are implied through the use of the USDA organic label that was introduced in October of 2002. Further research considers the factors that have empirically and overwhelmingly contributed to motivations of attitude development and purchasing behaviors of the average organic consumer in America, tracking changes and potential causes over the past several decades. A large proportion of this paper analyzes the results of a survey conducted in Tempe between late 2014 and early 2015. This survey, shown in the appendices, includes responses from 310 Tempe consumers regarding questions of demographics, knowledge and perception of organic products, perceived access to organic products, consumer values, and purchasing behaviors. The results of the survey reflect the values displayed in previous studies on national surveys, with some discrepancies that appear to set Tempe apart from the national average. However, the results of the survey are limited by their exclusion and limited parsing of multiple confounds. Additionally, the respondents of the survey were not proportionate to the actually population of Tempe and therefore cannot be accurately generalized to the Tempe population as a whole. The third and final section of this paper deals with the relationship between advertisers and consumers. This considers how advertising helps to develop product values and perceptions through various methods. Future directions for advertising of organic products is also addressed, as advertisers can potentially become a source of developing scientific information if properly utilized. Further directives and gaps in research are addressed in the final portion of the paper and include how to increase consumer knowledge, the problems faced by organic advocates, what is important about what we already know, and where to go from here.