Matching Items (81)
Description
The hypothalamus pituitary adrenal (HPA) axis and the human genome are important components of the biological etiology of externalizing disorders. By studying the associations between specific genetic variants, diurnal cortisol, and externalizing symptoms we can begin to unpack this complex etiology. It was hypothesized that genetic variants from the corticotropine releasing hormone receptor 1 (CRHR1), FK506 binding protein 51 (FKBP5), catechol-O-methyl transferase (COMT), and dopamine transporter (DAT1) genes and diurnal cortisol intercepts and slopes would separately predict externalizing symptoms. It was also hypothesized that genetic variants would moderate the association between cortisol and externalizing. Participants were 800 twins (51% boys), 88.5% Caucasian, M=7.93 years (SD=0.87) participating in the Wisconsin Twin Project. Hierarchical Linear Modeling (HLM) was used to separate the variance associated with state and trait cortisol measured across three consecutive days and trait cortisol measures were used. There were no main effects of genes on externalizing symptoms. The evening cortisol intercept, the morning cortisol slope and the evening cortisol slope predicted externalizing, but only in boys, such that boys with higher cortisol and flatter slopes across the day also had more externalizing symptoms. The morning cortisol intercept and CRHR1 rs242924 interacted to predict externalizing in both boys and girls, with GG carriers significantly higher compared to TT carriers at one standard deviation below the mean of morning cortisol. For boys only there was a significant interaction between the DAT1 variable number tandem repeat (VNTR) and the afternoon slope and a significant slope for 9/9 carriers and 9/10 carriers such that when the slope was more steep, boys carrying a nine had fewer externalizing symptoms but when the slope was less steep, they had more. Results confirm a link between diurnal trait cortisol and externalizing in boys, as well as moderation of that association by genetic polymorphisms. This is the first study to empirically examine this association and should encourage further research on the biological etiology of externalizing disorder symptoms.
ContributorsSwann, Gregory (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Chassin, Laurie (Committee member) / Doane-Sampey, Leah (Committee member) / Arizona State University (Publisher)
Created2012
Description
Using data from an eight-year longitudinal study of 214 children's social and emotional development, I conducted three studies to (1) examine patterns of agreement for internalizing (INT) and externalizing (EXT) symptomatology among different informants (mothers, fathers, teachers, and adolescents) using a recently developed structural equation modeling approach for multi-trait, multi-method data; (2) examine the developmental trajectories for INT and EXT and predict individual differences in symptom development using temperament and parenting variables; and (3) describe patterns of INT and EXT co-occurrence and predict these patterns from temperament and parenting. In Study 1, longitudinal invariance was established for mothers', fathers' and teachers' reports over a six-year period. Sex, age, and SES did not substantially moderate agreement among informants, although both sex and age were differentially related to symptomatology depending on the informant. Agreement among teachers and mothers, but not among mothers and fathers, differed by domain of symptomatology, and was greater for EXT than for INT. In Study 2, latent profile analysis, a person-centered analytic approach, did not provide easily interpretable patterns of symptom development, a failure that is likely the result of the relatively modest sample size. Latent growth curve models, an alternative analytic approach, did provide good fit to the data. Temperament and parenting variables were examined as predictors of the latent growth parameters in these models. Although there was little prediction of the slope, effortful control was negatively related to overall levels of EXT, whereas impulsivity and anger were positively related. Mutually responsive orientation, a measure of the parent-child relationship, was a more consistent predictor of EXT than was parental warmth. Furthermore, the relation between mutually responsive orientation and EXT was partially mediated by inhibitory control. Across informants, there were few consistent predictors of INT. In Study 3, latent profile analysis was used to classify individuals into different patterns of INT and EXT co-occurrence. In these models, a similar class structure was identified for mothers and for teachers. When temperament and parenting were examined as predictors of co-occurring symptomatology, few significant interactions were found and results largely replicated prior findings from this data set using arbitrary symptom groups.
ContributorsSulik, Michael John (Author) / Eisenberg, Nancy (Thesis advisor) / Spinrad, Tracy L (Thesis advisor) / Lemery-Chalfant, Kathryn (Committee member) / Wolchik, Sharlene A (Committee member) / Arizona State University (Publisher)
Created2013
Description
Over the last three decades there has been a rise in the number of workers employed during nonstandard (evening and overnight) hours; accompanying this trend has been a renewed interest in documenting workers, their families, and outcomes associated with nonstandard-hour employment. However, there are important gaps in the current literature. Few have considered how parents who work nonstandard hours care for their children when parental care is unavailable; little is known about who participates in nonparental child care during nonstandard hours, or the characteristics of those who participate. Most pressingly from a policy perspective, it is unclear how participation in nonparental child care during nonstandard hours influences child well-being. This study aims to fill these gaps. This dissertation paints a descriptive portrait of children and parents who use nonstandard child care, explores the relationship between nonstandard hours of nonparental child care participation and various measures of child well-being, and identifies longitudinal patterns of participation in nonstandard-hour child care. I find that children who participate in nonstandard-hours of nonparental child care look significantly different from those who do not participate. In particular, children are more likely to be older, identify as black or Hispanic, and reside with younger, unmarried parents who have lower levels of education. Estimates also suggest a negative relationship between participation in nonstandard-hour child care and child well-being. Specifically, children who participate in nonstandard-hour care show decreased school engagement and school readiness, increased behavioral problems, decreased social competency, and lower levels of physical health. These findings have serious implications for social and education policy.
ContributorsBoyd-Swan, Casey Helen (Author) / Herbst, Chris M. (Thesis advisor) / Bradley, Robert H (Committee member) / Segal, Elizabeth A. (Committee member) / Lucio, Joanna D. (Committee member) / Arizona State University (Publisher)
Created2015
Description
Siblings are a salient part of family life; however, few studies have explored the role of siblings on youths' cultural development and educational expectations. In the current dissertation, two studies address this gap in the literature by using longitudinal data from 246 Mexican-origin sibling pairs and their mothers and fathers. The first study examined how older siblings' cultural orientations and values uniquely contribute to younger siblings' cultural orientations and values from late adolescence to young adulthood, after accounting for mothers' and fathers' cultural orientations and values; further, it was explored the role of sibling modeling and sibling characteristics as moderators of these associations. Findings revealed that older siblings' cultural orientations and values contribute to younger siblings' cultural orientations and values from late adolescence into young adulthood. Specifically, under conditions of high sibling modeling, younger siblings reported higher levels of Anglo orientation and familism values. Whereas, fathers' orientations were positively associated with younger siblings' Anglo and Mexican orientations and mothers' values were predictive of younger siblings' familism values. Together, the findings suggest that siblings and parents play different roles in youths' cultural development.
The second study explored the reciprocal associations between older and younger siblings' educational expectations from early/middle adolescence to middle/late adolescence and from middle/late adolescence to young adulthood. In this study it was tested the moderating role of family immigrant context and sibling characteristics in the association between older and younger siblings' educational expectations. Findings revealed that older siblings' educational expectations at T1 predicted younger siblings' educational expectations at T2. Further, older siblings' educational expectations at T2 continued to influence younger siblings' educational expectations at T3, and younger siblings' educational expectations at T2 also predicted older siblings' educational expectations at T3. Family immigrant context moderated the association from older siblings' educational expectations at T2 to younger siblings' educational expectations at T3, such that the association was significant for immigrant-born families, but not for U.S.-born/Mixed-status families. Our study highlights the value of siblings' roles, particularly in immigrant families, as youth make important decisions about their educational pursuits.
The second study explored the reciprocal associations between older and younger siblings' educational expectations from early/middle adolescence to middle/late adolescence and from middle/late adolescence to young adulthood. In this study it was tested the moderating role of family immigrant context and sibling characteristics in the association between older and younger siblings' educational expectations. Findings revealed that older siblings' educational expectations at T1 predicted younger siblings' educational expectations at T2. Further, older siblings' educational expectations at T2 continued to influence younger siblings' educational expectations at T3, and younger siblings' educational expectations at T2 also predicted older siblings' educational expectations at T3. Family immigrant context moderated the association from older siblings' educational expectations at T2 to younger siblings' educational expectations at T3, such that the association was significant for immigrant-born families, but not for U.S.-born/Mixed-status families. Our study highlights the value of siblings' roles, particularly in immigrant families, as youth make important decisions about their educational pursuits.
ContributorsRodríguez De Jesús, Sue Annie (Author) / Updegraff, Kimberly A (Thesis advisor) / Bradley, Robert H (Committee member) / Iida, Masumi (Committee member) / Umaña-Taylor, Adriana J. (Committee member) / Arizona State University (Publisher)
Created2015
Description
Low-income Mexican American women face significant risk for poor health during the postpartum period. Chronic stressors are theorized to negatively impact mental and physical health outcomes. However, physiological factors associated with increased self-regulatory capacity, such as resting heart rate variability, may buffer the impact of stress. In a sample of 322 low-income Mexican American women (mother age 18-42; 84% Spanish-speaking; modal family income $10,000-$15,000), the interactive influence of resting heart rate variability and three chronic prenatal stressors (daily hassles, negative life events, economic stress) on maternal cortisol output, depressive symptoms, and self-rated health at 12 weeks postpartum was assessed. The hypothesized interactive effects between resting heart rate variability and the chronic prenatal stressors on the health outcomes were not supported by the data. However, results showed that a higher number of prenatal daily hassles was associated with increased postpartum depressive symptoms, and a higher number of prenatal negative life events was associated with lower postpartum cortisol output. These results suggest that elevated chronic stress during the prenatal period may increase risk for poor health during the postpartum period.
ContributorsJewell, Shannon Linda (Author) / Luecken, Linda J. (Thesis advisor) / Lemery-Chalfant, Kathryn (Committee member) / Perez, Marisol (Committee member) / Arizona State University (Publisher)
Created2015
Description
The current study delineated the developmental trajectories of early childhood externalizing and internalizing symptoms reported by mothers and fathers, and examined the role of the 18-month observed parenting quality × Respiratory Sinus Arrhythmia
(RSA) interaction in predicting these trajectories. Child sex was tested as a covariate and moderator. It was found that children's low baseline RSA or high RSA reactivity , in comparison to high baseline RSA or low RSA reactivity , was more reactive as a function
of early parenting quality when predicting the development of early childhood problem symptoms. Differential patterns of the interaction between parenting quality and RSA were detected for mothers' and fathers' reports. Mother-reported models showed a diathesis-stress pattern, whereas the father-reported model showed a vantage-sensitivity pattern, especially for internalizing symptoms. This may imply the potential benefit of fathers' active engagement in children's early development. In addition, the effect of the parenting quality × RSA interaction in predicting the mother-reported models was found
to be further moderated by child sex. Specifically, the parenting quality × baseline RSA interaction was significantly predictive of girls' 54-month internalizing, and the parenting quality × RSA reactivity interaction significantly predicted boys' internalizing slope. Girls with low baseline RSA or boys with high RSA reactivity were vulnerable to the less positive parenting, exhibiting high levels of 54-month internalizing symptoms or slow decline in internalizing over time, respectively. Future research directions were discussed in terms of integrating the measures of SNS and PNS in psychopathology study,
exploring the mechanisms underlying the sex difference in parenting quality × RSA interaction, and comparing the findings of children's typical and atypical development.
(RSA) interaction in predicting these trajectories. Child sex was tested as a covariate and moderator. It was found that children's low baseline RSA or high RSA reactivity , in comparison to high baseline RSA or low RSA reactivity , was more reactive as a function
of early parenting quality when predicting the development of early childhood problem symptoms. Differential patterns of the interaction between parenting quality and RSA were detected for mothers' and fathers' reports. Mother-reported models showed a diathesis-stress pattern, whereas the father-reported model showed a vantage-sensitivity pattern, especially for internalizing symptoms. This may imply the potential benefit of fathers' active engagement in children's early development. In addition, the effect of the parenting quality × RSA interaction in predicting the mother-reported models was found
to be further moderated by child sex. Specifically, the parenting quality × baseline RSA interaction was significantly predictive of girls' 54-month internalizing, and the parenting quality × RSA reactivity interaction significantly predicted boys' internalizing slope. Girls with low baseline RSA or boys with high RSA reactivity were vulnerable to the less positive parenting, exhibiting high levels of 54-month internalizing symptoms or slow decline in internalizing over time, respectively. Future research directions were discussed in terms of integrating the measures of SNS and PNS in psychopathology study,
exploring the mechanisms underlying the sex difference in parenting quality × RSA interaction, and comparing the findings of children's typical and atypical development.
ContributorsLi, Yi (Author) / Eisenberg, Nancy (Thesis advisor) / Spinrad, Tracy (Thesis advisor) / Lemery-Chalfant, Kathryn (Committee member) / Wilkens, Natalie (Committee member) / Arizona State University (Publisher)
Created2014
Description
Children's academic experiences during first grade have substantial implications for their academic performance both concurrently and longitudinally. Using two complementary studies, this dissertation utilizing data from the National Institute of Child Development Study of Early Child Care and Youth Development helps create a better understanding of the importance of first-grade experiences for children's academic performance. The first study expands upon current literature by focusing on how children's academic experiences simultaneously influence children's academic performance through behavioral engagement. Specifically, study one examined the mediating role of first-grade behavioral engagement between first-grade academic experiences (i.e. parental involvement, positive peer interactions, student-teacher relationship, and instructional support) and second-grade academic performance. Using a panel model, results showed that behavioral engagement mediates relations between peer interactions and academic performance and relations between instructional support and academic performance. Implications for interventions focusing on children's positive peer interactions and teacher's high-quality instructional support in order to promote behavioral engagement during early elementary school are discussed.
The second study expands the current literature regarding instructional quality thresholds. Limited research has addressed the question of whether there is a minimum level of instructional quality that must be experienced in order to see significant changes in children's academic performance, and the limited research has focused primarily on preschoolers. The goal of study two was to determine if high-quality first-grade instructional support predicted children's first-, third-, and fifth-grade academic performance. Using piecewise regression analyses, results did not show evidence of a relation between first-grade instructional support quality and children's academic performance at any grade. Possible reasons for inconsistencies in findings from this study and previous research are discussed, including differences in sample characteristics and measurement tools. Because instructional quality remains at the forefront of discussions by educators and policy makers, the inconsistencies in research findings argue for further research that may clarify thresholds of instructional support quality that must be met in order for various subgroups of children to gain the skills needed for long-term academic success.
The second study expands the current literature regarding instructional quality thresholds. Limited research has addressed the question of whether there is a minimum level of instructional quality that must be experienced in order to see significant changes in children's academic performance, and the limited research has focused primarily on preschoolers. The goal of study two was to determine if high-quality first-grade instructional support predicted children's first-, third-, and fifth-grade academic performance. Using piecewise regression analyses, results did not show evidence of a relation between first-grade instructional support quality and children's academic performance at any grade. Possible reasons for inconsistencies in findings from this study and previous research are discussed, including differences in sample characteristics and measurement tools. Because instructional quality remains at the forefront of discussions by educators and policy makers, the inconsistencies in research findings argue for further research that may clarify thresholds of instructional support quality that must be met in order for various subgroups of children to gain the skills needed for long-term academic success.
ContributorsBryce, Crystal I (Author) / Bradley, Robert H (Thesis advisor) / Abry, Tashia (Committee member) / Swanson, Jodi (Committee member) / Thompson, Marilyn S (Committee member) / Arizona State University (Publisher)
Created2015
Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
Externalizing behaviors are pervasive, widespread, and disruptive across a multitude of settings and developmental contexts. While the conventional diathesis-stress model typically measures the disordered end of the spectrum, studies that span the range of behavior, from externalizing to competence behaviors, are necessary to see the full picture. To that end, this study examined the additive and nonadditive relations of a dimension of parenting (ranging from warm to rejecting), and variants in dopamine, vasopressin, and neuropeptide-y receptor genes on externalizing/competence in a large sample of predominantly Caucasian twin children in toddlerhood, middle childhood, and early adolescence. Variants within each gene were hypothesized to increase biological susceptibility to both negative and positive environments. Consistent with prediction, warmth related to lower externalizing/higher competence at all ages. Earlier levels of externalizing/competence washed out the effect of parental warmth on future externalizing/competence with the exception of father warmth in toddlerhood marginally predicting change in externalizing/competence from toddlerhood to middle childhood. Warmth was a significant moderator of the heritability of behavior in middle childhood and early adolescence such that behavior was less heritable (mother report) and more heritable (father report) in low warmth environments. Interactions with warmth and the dopamine and vasopressin genes in middle childhood and early adolescence emphasize the moderational role gene variants play in relations between the rearing environment and child behavior. For dopamine, the long variant related to increased sensitivity to parent warmth such that the children displayed more externalizing behaviors when exposed to rejection but they also displayed more competence behaviors when exposed to high warmth. Vasopressin moderation was only present under conditions of parental warmth, not rejection. Interactions with neuropeptide-y and warmth were not significant. The picture that emerges is one of gene-environment interplay, wherein the influence of both parenting and child genotype each depend on the level of the other. As genetic research moves forward, gene variants previously implicated as conferring risk for disorder should be reexamined in conjunction with salient aspects of the environment on the full range of the behavioral outcome of interest.
ContributorsO'Brien, T. Caitlin (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Eisenberg, Nancy (Committee member) / Enders, Craig (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2011
Description
The interplay of genes and environment on children's development is a complex dynamic process. As behavior geneticists begin to model protective as well as risk factors, and interactive as well as main effect influences, development is elucidated. It was hypothesized that positive parenting, a quality home environment, and high family cohesion would moderate the heritability of three components of temperament: Effortful Control, Negative Affectivity, and Extraversion/Surgency. Participants were drawn from the Wisconsin Twin Project and consisted of 1573 twins (51% boys), 88.5% Caucasian, M=7.93 years (SD=0.87). Higher order composites for the parenting and family environment moderators were formed from mother and father reports of Behavior Management Self-Assessment, Child Rearing Practices Report, Family Assessment Device, and Family Conflict Scale. Measures of the home environment (LEOS Living Environment Observation Scale and CHAOS Confusion, Hubbub, and Order Scale) were not composited due to the nature of the variables. Correlational analyses showed a majority of the temperament and environmental measures to be correlated (rs = -.49-.57). For Effortful Control, Negative Affectivity, and Extraversion/Surgency, estimates for the heritability and nonshared environment were 0.60 and 0.40, 0.80 and 0.20, and 0.59 and 0.41, respectively, with no significant main effects of the shared environment. Models incorporating environmental moderation of these estimates yielded parenting as a significant moderator for Negative Affectivity, LEOS for Effortful Control and Extraversion/Surgency, and CHAOS for Effortful Control and Extraversion/Surgency. Results suggest that the quality of the family environment may act as a permissive or determinative influence on the heritability and expression of temperament. Future analyses include the examination of interactive genetic influences. These findings underscore the importance of shared environment, and support the recent literature on the benefits of positive influences on children's development.
ContributorsKao, Karen (Author) / Bradley, Robert H. (Thesis advisor) / Lemery-Chalfant, Kathryn (Thesis advisor) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2011