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- Creators: School of Life Sciences
Description
Natural resource depletion and environmental degradation are the stark realities of the times we live in. As awareness about these issues increases globally, industries and businesses are becoming interested in understanding and minimizing the ecological footprints of their activities. Evaluating the environmental impacts of products and processes has become a key issue, and the first step towards addressing and eventually curbing climate change. Additionally, companies are finding it beneficial and are interested in going beyond compliance using pollution prevention strategies and environmental management systems to improve their environmental performance. Life-cycle Assessment (LCA) is an evaluative method to assess the environmental impacts associated with a products' life-cycle from cradle-to-grave (i.e. from raw material extraction through to material processing, manufacturing, distribution, use, repair and maintenance, and finally, disposal or recycling). This study focuses on evaluating building envelopes on the basis of their life-cycle analysis. In order to facilitate this analysis, a small-scale office building, the University Services Building (USB), with a built-up area of 148,101 ft2 situated on ASU campus in Tempe, Arizona was studied. The building's exterior envelope is the highlight of this study. The current exterior envelope is made of tilt-up concrete construction, a type of construction in which the concrete elements are constructed horizontally and tilted up, after they are cured, using cranes and are braced until other structural elements are secured. This building envelope is compared to five other building envelope systems (i.e. concrete block, insulated concrete form, cast-in-place concrete, steel studs and curtain wall constructions) evaluating them on the basis of least environmental impact. The research methodology involved developing energy models, simulating them and generating changes in energy consumption due to the above mentioned envelope types. Energy consumption data, along with various other details, such as building floor area, areas of walls, columns, beams etc. and their material types were imported into Life-Cycle Assessment software called ATHENA impact estimator for buildings. Using this four-stepped LCA methodology, the results showed that the Steel Stud envelope performed the best and less environmental impact compared to other envelope types. This research methodology can be applied to other building typologies.
ContributorsRamachandran, Sriranjani (Author) / Bryan, Harvey (Thesis advisor) / Reddy T, Agami (Committee member) / White, Philip (Committee member) / Arizona State University (Publisher)
Created2013
Description
Random peptide microarrays are a powerful tool for both the treatment and diagnostics of infectious diseases. On the treatment side, selected random peptides on the microarray have either binding or lytic potency against certain pathogens cells, thus they can be synthesized into new antimicrobial agents, denoted as synbodies (synthetic antibodies). On the diagnostic side, serum containing specific infection-related antibodies create unique and distinct "pathogen-immunosignatures" on the random peptide microarray distinct from the healthy control serum, and this different mode of binding can be used as a more precise measurement than traditional ELISA tests. My thesis project is separated into these two parts: the first part falls into the treatment side and the second one focuses on the diagnostic side. My first chapter shows that a substitution amino acid peptide library helps to improve the activity of a recently reported synthetic antimicrobial peptide selected by the random peptide microarray. By substituting one or two amino acids of the original lead peptide, the new substitutes show changed hemolytic effects against mouse red blood cells and changed potency against two pathogens: Staphylococcus aureus and Pseudomonas aeruginosa. Two new substitutes are then combined together to form the synbody, which shows a significantly antimicrobial potency against Staphylococcus aureus (<0.5uM). In the second chapter, I explore the possibility of using the 10K Ver.2 random peptide microarray to monitor the humoral immune response of dengue. Over 2.5 billion people (40% of the world's population) live in dengue transmitting areas. However, currently there is no efficient dengue treatment or vaccine. Here, with limited dengue patient serum samples, we show that the immunosignature has the potential to not only distinguish the dengue infection from non-infected people, but also the primary dengue infection from the secondary dengue infections, dengue infection from West Nile Virus (WNV) infection, and even between different dengue serotypes. By further bioinformatic analysis, we demonstrate that the significant peptides selected to distinguish dengue infected and normal samples may indicate the epitopes responsible for the immune response.
ContributorsWang, Xiao (Author) / Johnston, Stephen Albert (Thesis advisor) / Blattman, Joseph (Committee member) / Arntzen, Charles (Committee member) / Arizona State University (Publisher)
Created2013
Description
Life Cycle Assessment (LCA) quantifies environmental impacts of products in raw material extraction, processing, manufacturing, distribution, use and final disposal. The findings of an LCA can be used to improve industry practices, to aid in product development, and guide public policy. Unfortunately, existing approaches to LCA are unreliable in the cases of emerging technologies, where data is unavailable and rapid technological advances outstrip environmental knowledge. Previous studies have demonstrated several shortcomings to existing practices, including the masking of environmental impacts, the difficulty of selecting appropriate weight sets for multi-stakeholder problems, and difficulties in exploration of variability and uncertainty. In particular, there is an acute need for decision-driven interpretation methods that can guide decision makers towards making balanced, environmentally sound decisions in instances of high uncertainty. We propose the first major methodological innovation in LCA since early establishment of LCA as the analytical perspective of choice in problems of environmental management. We propose to couple stochastic multi-criteria decision analytic tools with existing approaches to inventory building and characterization to create a robust approach to comparative technology assessment in the context of high uncertainty, rapid technological change, and evolving stakeholder values. Namely, this study introduces a novel method known as Stochastic Multi-attribute Analysis for Life Cycle Impact Assessment (SMAA-LCIA) that uses internal normalization by means of outranking and exploration of feasible weight spaces.
ContributorsPrado, Valentina (Author) / Seager, Thomas P (Thesis advisor) / Landis, Amy E. (Committee member) / Chester, Mikhail (Committee member) / White, Philip (Committee member) / Arizona State University (Publisher)
Created2013
Description
Industrial activities have damaged the natural environment at an unprecedented scale. A number of approaches to environmentally responsible design and sustainability have been developed that are aimed at minimizing negative impacts derived from products on the environment. Environmental assessment methods exist as well to measure these impacts. Major environmentally responsible approaches to design and sustainability were analyzed using content analysis techniques. The results show several recommendations to minimize product impacts through design, and dimensions to which they belong. Two products made by a manufacturing firm with exceptional commitment to environmental responsibility were studied to understand how design approaches and assessment methods were used in their development. The results showed that the company used several strategies for environmentally responsible design as well as assessment methods in product and process machine design, both of which resulted in reduced environmental impacts of their products. Factors that contributed positively to reduce impacts are the use of measurement systems alongside environmentally responsible design, as well as inspiring innovations by observing how natural systems work. From a managerial perspective, positive influencing factors included a commitment to environmental responsibility from the executive level of the company and a clear vision about sustainability that has been instilled from the top through every level of employees. Additionally, a high degree of collaboration between the company and its suppliers and customers was instrumental in making the success possible.
ContributorsHuerta Gajardo, Oscar André (Author) / Giard, Jacques (Thesis advisor) / White, Philip (Committee member) / Dooley, Kevin (Committee member) / Arizona State University (Publisher)
Created2014
Description
Currently, consumers throw away products every day, turning those materials into waste. Electronic waste poses special problems when it is not recycled because it may contain toxic components that can leach into landfill surroundings and reach groundwater sources or contaminate soil, and its plastic, metal, and electronic materials do not biodegrade and are lost rather than recycled. This study analyzes a system that attempts to solve the electronic post-consumer-waste problem by shifting the economic burden of disposal from local municipalities to producers, reducing its environmental impacts while promoting economic development. The system was created in British Columbia, Canada after the province enacted a recycling regulation based on Extended Producer Responsibility (EPR), a policy strategy that is fast growing globally. The BC recycling regulation requires all e-toy corporations in BC to comply with a government-approved product-stewardship program to recover and dispose of e-toys after they have been discarded by consumers. In response to the regulation, e-toy corporations joined a Canadian non-profit entity that recycles regulated waste. I conducted a case study using in-depth interviews with the stakeholders to identify the outcomes of this program and its potential for replication in other industries. I derived lessons from which corporations can learn to implement stewardship programs based on EPR regulations. The e-toy program demonstrated that creating exclusive programs is neither efficient nor economically feasible. Corporations should expect low recycling rates in the first phases of the program implementation because EPR regulations are long-term strategies. In order to reach any conclusions about the demand of consumers for recycling programs, we need to measure the program's return rates during at least three years. I also derived lessons that apply to the expansion of EPR regulations to a broader scope of product categories. The optimal way to expand EPR policy is to do it by gradually adding new product categories to the regulation on a long-term schedule. By doing so, new categories can take advantage of existing stewardship programs and their infrastructure to recover and recycle the post-consumer products. EPR proved to be an effective option to make corporations start thinking about the end of life of their products.
ContributorsNemer Soto, Andrea (Author) / Dooley, Kevin (Thesis advisor) / Basile, George (Committee member) / White, Philip (Committee member) / Arizona State University (Publisher)
Created2014
Description
The majority of non-small cell lung cancer (NSCLC) patients (70%) are diagnosed with adenocarcinoma versus other histological subtypes. These patients often present with advanced, metastatic disease and frequently relapse after treatment. The tumor suppressor, Liver Kinase B1, is frequently inactivated in adenocarcinomas and loss of function is associated with a highly aggressive, metastatic tumor (1). Identification of the mechanisms deregulated with LKB1 inactivation could yield targeted therapeutic options for adenocarcinoma patients. Re-purposing the immune system to support tumor growth and aid in metastasis has been shown to be a feature in cancer progression (2). Tumor associated macrophages (TAMs) differentiate from monocytes, which are recruited to the tumor microenvironment via secretion of chemotaxic factors by cancer cells. We find that NSCLC cells deficient in LKB1 display increased secretion of C-C motif ligand 2 (CCL2), a chemokine involved in monocyte recruitment. To elucidate the molecular pathway regulating CCL2 up-regulation, we investigated inhibitors of substrates downstream of LKB1 signaling in A549, H23, H2030 and H838 cell lines. Noticeably, BAY-11-7082 (NF-κB inhibitor) reduced CCL2 secretion by an average 92%. We further demonstrate that a CCR2 antagonist and neutralizing CCL2 antibody substantially reduce monocyte migration to NSCLC (H23) cell line conditioned media. Using an in vivo model of NSCLC, we find that LKB1 deleted tumors demonstrate a discernible increase in CCL2 levels compared to normal lung. Moreover, tumors display an increase in the M2:M1 macrophage ratio and increase in tumor associated neutrophil (TAN) infiltrate compared to normal lung. This M2 shift was significantly reduced in mice treated with anti-CCL2 or a CCR2 antagonist and the TAN infiltrate was significantly reduced with the CCR2 antagonist. These data suggest that deregulation of the CCL2/CCR2 signaling axis could play a role in cancer progression in LKB1 deficient tumors.
ContributorsFriel, Jacqueline (Author) / Inge, Landon (Thesis advisor) / Lake, Douglas (Thesis advisor) / Blattman, Joseph (Committee member) / Arizona State University (Publisher)
Created2015
Description
ABSTRACT In an attempt to advocate body-conscious design and healing work environments, this research study of holistic health in the workplace explores cognitive, social and physical well-being in four small US offices that are between 1000 and 4000 square feet and employ three to twelve employees. Holistic health, as pursued in this research, includes social health, emotional health and physical health. These three factors of holistic health have been identified and investigated in this study: biophilia: peoples' love and affiliation with other species and the natural environment; ergonomics: the relationship between the human body, movement, the immediate environment and productivity; and exercise: exertion of the body to obtain physical fitness. This research study proposes that employees and employers of these four participating workplaces desire mobility and resources in the workplace that support holistic health practices involving biophilia, ergonomics, and exercise. Literature review of holistic health and the holistic health factors of this research topic support the idea that interaction with other species can be healing, ergonomic body-conscious furniture and equipment increase productivity, limit body aches, pains and health costs; and exercise stimulates the mind and body, increasing productivity. This study has been conducted primarily with qualitative and flexible research approaches using observation, survey, interview and pedometer readings as methods for data collection. Two small corporate franchise financial institutions and two small private healthcare providers from both Arizona and Georgia participated in this study. Each office volunteered one employer and two employee participants. Of the holistic health factors considered in these four case studies, this study found that a majority of participants equally valued emotional health, social health and physical health. A majority of participants declared a preference for workplace environments with serene natural environments with outdoor spaces and interaction with other species, work environments with body-conscious furniture, equipment and workstations, as well as exercise space and equipment. As these particular workplace environments affirmed value for elements of the factors biophilia, ergonomics and exercise, all three factors are considered valueable within the workplaces of these case studies. Furthermore, factors that were said to contribute to personal productivity in participating workplaces were found as well as sacrifices that participants stated they would be willing to make in order to implement their preferred work environment(s). In addition, this study recorded and calculated average miles walked by participants in each workplace as well as existing incentives and descriptions of ideal work environments. Implications of this research study involve interior design, industrial design and fashion design that can accommodate the desires of the four participating workplaces. Major design implications involve accommodating these particular workplaces to provide personnel with opportunities for holistic health in working environments. More specific implications of office related design involve providing access to natural environments, body-conscious equipment and spaces, as well as opportunities for exercise and social interaction. These elements of the factors biophilia, ergonomics and exercise were found to be said to contribute to cognitive, social and physical health.
ContributorsMcEwan, April (Author) / White, Philip (Thesis advisor) / Shraiky, James (Committee member) / Barry, Rebecca (Committee member) / Arizona State University (Publisher)
Created2011
Description
In recent years, the length of time people use and keep belongings has decreased. With the acceptance of short-lived furniture and inexpensive replacements, the American mentality has shifted to thinking that discarding furniture is normal, often in the guise of recycling. Americans are addicted to landfills. The high cost of landfill real estate and other considerable ecological impacts created by the manufacturing of furniture should persuade people to give their belongings a longer life, but in reality, furniture is often prematurely discarded. This grounded theory study takes a multi-method approach to analyze why some types of furniture are kept longer and to theorize about new ways to design and sell furniture that lasts well past its warranty. Case studies bring new insight into designer intention, manufacturer intent, the world of auction-worthy collectables and heirlooms, why there is a booming second-hand furniture market and the growing importance of informed interior designers and architects who specify or help clients choose interior furnishings. An environmental life cycle assessment compares how the length of furniture life affects environmental impacts. A product's life could continue for generations if properly maintained. Designers and manufacturers hoping to promote longevity can apply the conclusions of this report in bringing new pieces to the market that have a much longer life span. This study finds areas of opportunity that promote user attachment, anticipate future repurposing, and provide services. This thinking envisions a paradigm for furniture that can re-invent itself over multiple generations of users, and ultimately lead to a new wave of desirable heirloom furniture.
ContributorsIngham, Sarah (Author) / White, Philip (Thesis advisor) / Wolf, Peter (Committee member) / Underhill, Michael (Committee member) / Arizona State University (Publisher)
Created2011
Description
Environmental changes are occurring at an unprecedented rate, and these changes will undoubtedly lead to alterations in resource availability for many organisms. To effectively predict the implications of such changes, it is critical to better understand how organisms have adapted to coping with seasonally limited resources. The vast majority of previous work has focused on energy balance as the driver of changes in organismal physiology. While energy is clearly a vital currency, other resources can also be limited and impact physiological functions. Water is essential for life as it is the main constituent of cells, tissues, and organs. Yet, water has received little consideration for its role as a currency that impacts physiological functions. Given the importance of water to most major physiological systems, I investigated how water limitations interact with immune function, metabolism, and reproductive investment, an almost entirely unexplored area. Using multiple species and life stages, I demonstrated that dehydrated animals typically have enhanced innate immunity, regardless of whether the dehydration is a result of seasonal water constraints, water deprivation in the lab, or high physiological demand for water. My work contributed greatly to the understanding of immune function dynamics and lays a foundation for the study of hydration immunology as a component of the burgeoning field of ecoimmunology. While a large portion of my dissertation focused on the interaction between water balance and immune function, there are many other physiological processes that may be impacted by water restrictions. Accordingly, I recently expanded the understanding of how reproductive females can alter metabolic substrates to reallocate internal water during times of water scarcity, an important development in our knowledge of reproductive investments. Overall, by thoroughly evaluating implications and responses to water limitations, my dissertation, when combined previous acquired knowledge on food limitation, will enable scientists to better predict the impacts of future climate change, where, in many regions, rainfall events are forecasted to be less reliable, resulting in more frequent drought.
ContributorsBrusch, George, IV (Author) / DeNardo, Dale F (Thesis advisor) / Blattman, Joseph (Committee member) / French, Susannah (Committee member) / Sabo, John (Committee member) / Taylor, Emily (Committee member) / Arizona State University (Publisher)
Created2019
Description
The inherent risk in testing drugs has been hotly debated since the government first started regulating the drug industry in the early 1900s. Who can assume the risks associated with trying new pharmaceuticals is unclear when looked at through society's lens. In the mid twentieth century, the US Food and Drug Administration (FDA) published several guidance documents encouraging researchers to exclude women from early clinical drug research. The motivation to publish those documents and the subsequent guidance documents in which the FDA and other regulatory offices established their standpoints on women in drug research may have been connected to current events at the time. The problem of whether women should be involved in drug research is a question of who can assume risk and who is responsible for disseminating what specific kinds of information. The problem tends to be framed as one that juxtaposes the health of women and fetuses and sets their health as in opposition. That opposition, coupled with the inherent uncertainty in testing drugs, provides for a complex set of issues surrounding consent and access to information.
ContributorsMeek, Caroline Jane (Author) / Maienschein, Jane (Thesis director) / Brian, Jennifer (Committee member) / School of Life Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05