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- Creators: Barrett, The Honors College
- Creators: School of Life Sciences
- Resource Type: Text
Description
Immunology, the study of the immune system and its ability to distinguish self from non-self, is a rapidly advancing sector of molecular biology. Cancer, being host derived, provides a difficult challenge for immune cells to distinguish it from normal tissue. The historic treatment of cancer has had three main methods: radiation, chemotherapy, and surgery (1). Due to recent advancements in understanding the regulatory role of adaptive immunity against cancer, researchers have been attempting to engineer therapies to enhance patients’ immunities against their cancer. Immunotherapies, both passive and active, demonstrate potential for combating many diseases. Passive immunization provides temporary protection against a pathogen, whereas active immunization teaches the patient’s system to respond to the antigen independently, giving life-long immunity. Passive immunization, generally, is a much more expensive method of providing immunity and is commonly used in emergency situations. Anti-venom, for example, uses antibodies grown in lab to neutralize venom. Examples of active immunization are vaccines, which mimic the wild-type pathogen in a way that elicits an immune response, specifically naïve lymphocyte activation and maturation into memory lymphocytes. In terms of cancer therapy, both passive and active immunization are being tested for efficacy (2).
ContributorsMarquardt, Charles Andrew (Author) / Anderson, Karen S. (Thesis director) / Mason, Hugh S. (Committee member) / Lake, Douglas F. (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The current observable universe is made of matter due to baryon/antibaryon asymmetry. The Deep Underground Neutrino Experiment is an international experiment through the Fermi National Accelerator Laboratory that will study neutrinos. In this study, the detection efficiency for low energy supernova neutrinos was examined in order to improve energy reconstruction for neutrino energies less than 40 MeV. To do this, supernova neutrino events were simulated using the LarSoft simulation package with and without background. The ratios between the true data and reconstructed data were compared to identify the deficiencies of the detector, which were found to be low energies and high drift times. The ratio between the true and reconstructed data was improved by applying the physical limits of the detector. The efficiency of the improved ratio of the clean data was found to be 93.2% and the efficiency of the improved ratio with the data with background was 82.6%. The study suggests that a second photon detector at the far wall of the detector would help improve the resolutions at high drift times and low neutrino energies.
ContributorsProcter-Murphy, Rachel Grace (Co-author) / Procter-Murphy, Rachel (Co-author) / Ritchie, Barry (Thesis director) / LoSecco, John (Committee member) / School of Earth and Space Exploration (Contributor) / Department of Physics (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Background: Despite a multitude of health initiatives, obesity rates in America have continued to increase yearly, with obese or overweight people making up two-thirds of the population. Due to a lack of significant results from diet and weight-loss medication, new methods of weight-loss are increasingly considered. This paper looks beyond traditional Western treatments for weight loss and will analyze views and treatments for overweight and obesity in traditional Chinese medicine (TCM).
Methods: Three databases were used to search for papers published after 2010 until October 2019 discussing obesity, overweight and TCM. No forms of Chinese medicine were excluded from the search. Studies were excluded if they did not meet the date criteria or if they overlapped with papers found in other databases.
Results: Six of the selected papers covered acupuncture (electro, balance or catgut embedding acupuncture methods) either jointly with other treatments or alone, one exclusively on moxibustion and three studies on three different types of TCM herbal medicine. Each study showed a statistically significant effect on body mass index (BMI) value decrease or total weight loss (TWL). The six acupuncture papers all showed statistical significance at the 95% CI against control groups (sham acupuncture or no acupuncture) and against before-treatment BMI values or TWL values.
Conclusion: Of the treatments reviewed, almost all acupuncture studies were shown to be consistently effective in treating overweight or obese individuals within this selection of studies, as well as in another meta-analysis. This may be due to acupuncture’s ties to a neuroendocrine mechanism. Future studies should further explore the neuroendocrine connection between acupuncture and weight loss. Herbal medication was also shown to have a significant effect in reducing weight in each study; however, two studies used mice or rats as subjects, therefore understanding the effects on human subjects is limited.
Methods: Three databases were used to search for papers published after 2010 until October 2019 discussing obesity, overweight and TCM. No forms of Chinese medicine were excluded from the search. Studies were excluded if they did not meet the date criteria or if they overlapped with papers found in other databases.
Results: Six of the selected papers covered acupuncture (electro, balance or catgut embedding acupuncture methods) either jointly with other treatments or alone, one exclusively on moxibustion and three studies on three different types of TCM herbal medicine. Each study showed a statistically significant effect on body mass index (BMI) value decrease or total weight loss (TWL). The six acupuncture papers all showed statistical significance at the 95% CI against control groups (sham acupuncture or no acupuncture) and against before-treatment BMI values or TWL values.
Conclusion: Of the treatments reviewed, almost all acupuncture studies were shown to be consistently effective in treating overweight or obese individuals within this selection of studies, as well as in another meta-analysis. This may be due to acupuncture’s ties to a neuroendocrine mechanism. Future studies should further explore the neuroendocrine connection between acupuncture and weight loss. Herbal medication was also shown to have a significant effect in reducing weight in each study; however, two studies used mice or rats as subjects, therefore understanding the effects on human subjects is limited.
ContributorsTung, Kiram Yeo (Author) / Lateef, Dalya (Thesis director) / Capco, David (Committee member) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The purpose of this creative project was to create a forensic science program that accommodated Diné Philosophy and Culture. Indigenous representation is a key factor in promoting the advancement of the native ways of life. This thesis provides a culturally aware program that assists students to learn about taboo fields within the restrictions of the cultural teachings and traditions. This thesis developed a week-long forensics program targeted to Navajo middle school students with the cultural restriction in mind. During this process, the most difficult was integrating not only the taboos but also the foundations. At the end of this project, the most significant way to create an outreach program for Navajo students is by utilizing the Diné philosophy teaching models. This project is important because to create an effective science community there has to be equal representation for it to grow.
ContributorsJohnson, Elisabeth (Author) / Kobojek, Kimberly (Thesis director) / Chadwick, Deborah (Committee member) / School of Mathematical and Natural Sciences (Contributor) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The goal of this was to identify the most important characteristic for racquetball players to consider when purchasing a new racquet to maximize satisfaction. Currently companies showcase their special patented technology without addressing the specifics individual players are looking for. Looking past the patents this thesis wanted to find a single racquet property by which players can base their purchase decisions on according to their preferences. This quality was determined by which differed the most between different racquets. Racquets tested were taken from the Arizona State University Club Racquetball team as well as a lower quality racquet from the fitness center storage. In the end swing weight was determined to be the most varied property in the racquet which is developed from using balance and total mass.
ContributorsNorton, Zachary E (Author) / Wiezel, Avi (Thesis director) / Kosaraju, Srinivas (Committee member) / Mechanical and Aerospace Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Abiotic stresses, such as heat, can drive protein misfolding and aggregation, leading to inhibition of cellular function and ultimately cell death. Unexpectedly, a thermotolerant Escherichia coli was identified from a pool of antibiotic resistant RNA polymerase β subunit (rpoB) mutants. This stress tolerant phenotype was characterized through exposure to high temperature and ethanol. After 30-minute exposure of cells to 55°C or 25% ethanol, the mutant displayed 100 times greater viability than the wild-type, indicating that the rpoB mutation may have broadly affected the cellular environment to reduce protein misfolding and/or prevent protein aggregation. To further test this hypothesis, we examined thermotolerance of cells lacking heat shock chaperone DnaJ (Hsp40), which is a cochaperone of one of the most abundant and conserved chaperones, DnaK (Hsp70). The deletion of dnaJ led to severe growth defects in the wild-type, namely a slower growth rate and extreme filamentation at 42°C. The severity of the growth defects increased after additionally deleting DnaJ analog, CbpA. However, these defects were significantly ameliorated by the rpoB mutation. Finally, the rpoB mutant was found to be minimally affected by the simultaneous depletion of DnaK and DnaJ compared to the wild-type, which failed to form single colonies at 37°C and 42°C. Based on these observations, it is proposed that the rpoB mutant’s robust thermotolerant phenotype results from a cellular environment protective against protein aggregation or improper folding. The folding environment of the rpoB mutants should be further examined to elucidate the mechanism by which both antibiotic resistance and thermotolerance can be conferred.
ContributorsYeh, Melody (Author) / Misra, Rajeev (Thesis director) / Wang, Xuan (Committee member) / Kelly, Keilen (Committee member) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The non-native mosquito Aedes aegypti has become a common nuisance in Maricopa county. Associated with human settlement, Ae. aegypti is known to reproduce in standing water sources both indoors and outdoors, within vessels such as tires, flowerpots, and neglected swimming pools (Jansen & Beebe, 2010). Ae. aegypti and the related Ae. albopictus are the primary vectors of the arboviral diseases chikungunya, Zika, yellow fever and dengue. Ae. aegypti tends to blood feed multiple times per gonotrophic cycle (cycle of feeding and egg laying) which, alongside a preference for human blood and close association with human habitation, contributes to an increased risk of Ae. aegypti borne virus transmission (Scott & Takken, 2012). Between 2010-2017, 153 travel-associated cases of dengue were reported in the whole of Arizona (Rivera et al., 2020); while there have been no documented locally transmitted cases of Aedes borne diseases in Maricopa county, there are no apparent reasons why local transmission can’t occur in the future via local Aedes aegypti mosquitoes infected after feeding from travelling viremic hosts. Incidents of local dengue transmission in New York (Rivera et al., 2020) and Barcelona (European Center for Disease Control [ECDC], 2019) suggest that outbreaks of Aedes borne arbovirus’ can occur in regions more temperate than the current endemic range of Aedes borne diseases. Further, while the fact that Ae. aegypti eggs have a high mortality rate when exposed to cold temperatures limits the ability for Ae aegypti to establish stable breeding populations in temperate climates (Thomas, Obermayr, Fischer, Kreyling, & Beierkuhnlein, 2012), global increases in temperature will expand the possible ranges of Ae aegypti and Aedes borne diseases.
ContributorsHon, Ruiheng (Author) / Paaijmans, Krijn (Thesis director) / Bond, Angela (Committee member) / Angilletta, Michael (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This thesis outlines the creation of an excel tool designed to utilize public flight data for a given flight and determine further information such as general flight properties, weight estimation, and aerodynamic and stability characteristics. In depth analyses is done for a TV Relay flight of a Beechcraft Super King Air 200 to display the data processing and accuracy of the values. From this analyses it is displayed that the aircraft is flown safely and well within its performance parameters for the entire mission. The usefulness of this tool comes from its ability to successfully analyze critical properties and perform pilot and crash reconstruction analysis.
ContributorsSchierbrock, Aaron James (Author) / Takahashi, Timothy (Thesis director) / Niemczyk, Mary (Committee member) / Mechanical and Aerospace Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Accessible STEAM (Science, Technology, Engineering, Art, and Mathematics) education is imperative in creating the future innovators of the world. This business proposal is for a K-8 STEAM Museum to be built in the Novus Innovation Corridor on Arizona State University (ASU)’s Tempe campus. The museum will host dynamic spaces that are constantly growing and evolving as exhibits are built by interdisciplinary capstone student groups- creating an internal capstone project pipeline. The intention of the museum is to create an interactive environment that fosters curiosity and creativity while acting as supplemental learning material to Arizona K-8 curriculum. The space intends to serve the greater Phoenix area community and will cater to underrepresented audiences through the development of accessible education rooted in equality and inclusivity.
ContributorsPeters, Abigail J (Author) / McCarville, Daniel R. (Thesis director) / Juarez, Joseph (Committee member) / Industrial, Systems & Operations Engineering Prgm (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The tendon-bone junction is essential for allowing humans to transfer mechanical loads during activities. When injury does occur to this important area, current surgical techniques improperly bypass important physical and chemical gradients and do not restore proper function. It is essential to create tissue engineered scaffolds that create proper models for the region and induce healing responses for repair. To advance research into these scaffolds, electrospinning fibers and hydrogels made of norbornene functionalized hyaluronic acid (NorHA) were used to promote bone growth by adhering calcium to the material. To further improve calcium adherence, which is indicative of bone regions, a mineralization peptide was allowed to soak through the fibers. NorHA proved to be a suitable material for biomineralization experiments, showing slow calcium adherence within the first hour before accelerating in adherence over 24 hours in both fibers and hydrogels. When the mineralization peptide was implemented calcium adherence on fibers increased nearly eight times within the first 15 minutes of experimentation.
ContributorsCasey, Nathan Robert (Author) / Holloway, Julianne (Thesis director) / Tindell, Raymond (Committee member) / Fumasi, Fallon (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05