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- Creators: Barrett, The Honors College
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
- Status: Published
Heart disease is the leading cause of death in the developed world and often occurs following myocardial infarction. Apelin is an endogenous prepropeptide that has been studied for its role in improving cardiac contractility and vasodilation but suffers from a short half-life in the body. By encasing apelin in a nanoparticle patch, we were able to slowly release apelin to cardiac tissue and observe its effects for one month following induced myocardial infarction surgery in mice. This study demonstrates that the apelin nanoparticles can protect the heart from myocardial-induced heart failure, observing overall improved cardiac function and reduction of fibrotic scarring associated with post-myocardial infarction compared to a nontreated group.
Alginate microspheres have recently become increasingly popular in the realm of drug delivery for their biocompatibility, nontoxicity, inexpensiveness, among other factors. Recent strict regulations on microsphere size have drastically increased manufacturing cost and waste, even though the effect of size variance on drug delivery and subsequent performance is unclear. If sphere size variance does not significantly affect drug release profiles, it is possible that future ordinances may loosen tolerances in manufacturing to limit waste produced and expenditures. We use a mathematical model developed by Nickel et al. [12], to theoretically predict drug delivery profiles based on sphere size, and correlate the expected release with experimental data. This model considers diffusion as the key component for drug delivery, which is defined by Fick’s Laws of Diffusion. Alginate, chosen for its simple fabrication method and biocompatibility, was formed into microspheres with a modified extrusion technique and characterized by size. Size variance was introduced in batches and delivery patterns were compared to control groups of identical size. Release patterns for brilliant blue dye, the mock drug chosen, were examined for both groups via UV spectrometry. The absorbance values were then converted to concentration value using a calibration curve done prior to experimentation. The concentration values were then converted to mass values. These values then produced curves representing the mass of the drug released over time. Although the control and experimental values were statistically significantly different, the curves were rather similar to each other. However, when compared to the predicted release pattern, the curves were not the same. Unexpected degradation caused this dissimilarity between the curves. The predictive model was then adjusted to account for degradation by changing the diffusion coefficient in the code to a reciprocal first order exponent. The similarity between the control and experimental curves can insinuate the notion that size tolerances for microsphere production can be somewhat lenient, as a batch containing fifteen beads of the same size and one with three different sizes yields similar release patterns.
This is a primer on the mathematic foundation of quantum mechanics. It seeks to introduce the topic in such a way that it is useful to both mathematicians and physicists by providing an extended example of abstract math concepts to work through and by going more in-depth in the math formalism than would normally be covered in a quantum mechanics class. The thesis begins by investigating functional analysis topics such as the Hilbert space and operators acting on them. Then it goes on to the postulates of quantum mechanics which extends the math formalism covered before to physics and works as the foundation for the rest of quantum mechanics.
The purpose of this project was to develop a student-led holistic nurses chapter as a space where students can learn to apply mind-body based modalities into their routine, accommodating their unique lifestyle. This paper aims to discuss the process of implementing a student-led holistic chapter. From this project further discussion can be completed in regards to policy, practice, research, and inclusion. Policy can be developed in regards to student-driven processes and procedures of the new chapter. This experience can translate to nurses who develop policy in the practice setting. Practice focus can be implemented within the chapter as self-care application and how to bring knowledge to patients in the clinical setting. Research studies can measure the effectiveness of the chapter in regards to student stress levels and academic improvement. Inclusion is a unique part of this initiative as the goal is to grow the student-led organization by inviting nursing students from all schools in the state. Inclusion of leaders from the American Holistic Nurses Association in mentoring and supporting the initiatives is critical.