Matching Items (976)

Filtering by

Clear all filters

129184-Thumbnail Image.png

The U.S. Rebalance and Southeast Asia: A Work in Progress

Description

This article assesses Southeast Asian views of the US “rebalance,” examining reactions to US military deployments, military assistance to partners, and support for Southeast Asian diplomacy on South China Sea conflicts. Although not ostensibly designed to contain China, the rebalance

This article assesses Southeast Asian views of the US “rebalance,” examining reactions to US military deployments, military assistance to partners, and support for Southeast Asian diplomacy on South China Sea conflicts. Although not ostensibly designed to contain China, the rebalance provides Southeast Asia with hedging options against more assertive PRC actions in the South China Sea.

Contributors

Created

Date Created
2015-05-01

Revival

Description

Although bipolar disorder affects millions of Americans, it is not widely discussed topic. Therefore many misconceptions remain about the disorder, which is partially due to its misrepresentation in the media. However with television producers and writers such as Julie Plec,

Although bipolar disorder affects millions of Americans, it is not widely discussed topic. Therefore many misconceptions remain about the disorder, which is partially due to its misrepresentation in the media. However with television producers and writers such as Julie Plec, co-creator of The Vampire Diaries, The Originals and Legacies, creating a humanistic characters with bipolar disorder, this is slowly changing. Inspired by these writers, I also decided to create my own video about my experience with bipolar disorder.

Contributors

Agent

Created

Date Created
2019-05

132583-Thumbnail Image.png

CXCL10-Induced Migration of Triple-Negative Breast Cancer Cells

Description

Inhibitor of growth factor 4 (ING4) is a tumor suppressor of which low expression has been associated with poor patient survival and aggressive tumor progression in breast cancer. ING4 is characterized as a transcription regulator of inflammatory genes. Among the

Inhibitor of growth factor 4 (ING4) is a tumor suppressor of which low expression has been associated with poor patient survival and aggressive tumor progression in breast cancer. ING4 is characterized as a transcription regulator of inflammatory genes. Among the ING4-regulated genes is CXCL10, a chemokine secreted by endothelial cells during normal inflammation response, which induces chemotactic migration of immune cells to the site. High expression of CXCL10 has been implicated in aggressive breast cancer, but the mechanism is not well understood. A potential signaling molecule downstream of Cxcl10 is Janus Kinase 2 (Jak2), a kinase activated in normal immune response. Deregulation of Jak2 is associated with metastasis, immune evasion, and tumor progression in breast cancer. Thus, we hypothesized that the Ing4/Cxcl10/Jak2 axis plays a key role in breast cancer progression. We first investigated whether Cxcl10 affected breast cancer cell migration. We also investigated whether Cxcl10-mediated migration is dependent on ING4 expression levels. We utilized genetically engineered MDAmb231 breast cancer cells with a CRISPR/Cas9 ING4-knockout construct or a viral ING4 overexpression construct. We performed Western blot analysis to confirm Ing4 expression. Cell migration was assessed using Boyden Chamber assay with or without exogenous Cxcl10 treatment. The results showed that in the presence of Cxcl10, ING4-deficient cells had a two-fold increase in migration as compared to the vector controls, suggesting Ing4 inhibits Cxcl10-induced migration. These findings support our hypothesis that ING4-deficient tumor cells have increased migration when Cxcl10 signaling is present in breast cancer. These results implicate Ing4 is a key regulator of a chemokine-induced tumor migration. Our future plan includes evaluation of Jak2 as an intermediate signaling molecule in Cxcl10/Ing4 pathway. Therapeutic implications of these findings are targeting Cxcl10 and/or Jak2 may be effective in treating ING4-deficient aggressive breast cancer.

Contributors

Agent

Created

Date Created
2019-05

128948-Thumbnail Image.png

Validity of the Australian Recommended Food Score as a Diet Quality Index for Pre-Schoolers

Description

Background: Diet quality tools provide researchers with brief methods to assess the nutrient adequacy of usual dietary intake. This study describes the development and validation of a pediatric diet quality index, the Australian Recommended Food Scores for Pre-schoolers (ARFS-P), for

Background: Diet quality tools provide researchers with brief methods to assess the nutrient adequacy of usual dietary intake. This study describes the development and validation of a pediatric diet quality index, the Australian Recommended Food Scores for Pre-schoolers (ARFS-P), for use with children aged two to five years.

Methods: The ARFS-P was derived from a 120-item food frequency questionnaire, with eight sub-scales, and was scored from zero to 73. Linear regressions were used to estimate the relationship between diet quality score and nutrient intakes, in 142 children (mean age 4 years) in rural localities in New South Wales, Australia.

Results: Total ARFS-P and component scores were highly related to dietary intake of the majority of macronutrients and micronutrients including protein, β-carotene, vitamin C, vitamin A. Total ARFS-P was also positively related to total consumption of nutrient dense foods, such as fruits and vegetables, and negatively related to total consumption of discretionary choices, such as sugar sweetened drinks and packaged snacks.

Conclusion: ARFS-P is a valid measure that can be used to characterize nutrient intakes for children aged two to five years. Further research could assess the utility of the ARFS-P for monitoring of usual dietary intake over time or as part of clinical management.

Contributors

Agent

Created

Date Created
2014-08-29

128462-Thumbnail Image.png

Variable Autosomal and X Divergence Near and Far From Genes Affects Estimates of Male Mutation Bias in Great Apes

Description

Male mutation bias, when more mutations are passed on via the male germline than via the female germline, is observed across mammals. One common way to infer the magnitude of male mutation bias, α, is to compare levels of neutral

Male mutation bias, when more mutations are passed on via the male germline than via the female germline, is observed across mammals. One common way to infer the magnitude of male mutation bias, α, is to compare levels of neutral sequence divergence between genomic regions that spend different amounts of time in the male and female germline. For great apes, including human, we show that estimates of divergence are reduced in putatively unconstrained regions near genes relative to unconstrained regions far from genes. Divergence increases with increasing distance from genes on both the X chromosome and autosomes, but increases faster on the X chromosome than autosomes. As a result, ratios of X/A divergence increase with increasing distance from genes and corresponding estimates of male mutation bias are significantly higher in intergenic regions near genes versus far from genes. Future studies in other species will need to carefully consider the effect that genomic location will have on estimates of male mutation bias.

Contributors

Created

Date Created
2016-11-09

129202-Thumbnail Image.png

Variations in the Influence of Parental Socialization of Anxiety Among Clinic Referred Children

Description

This study examined the relations between parental socialization of child anxious behaviors (i.e., reinforcement, punishment, modeling, transmission of information) and child anxiety and related problems at varying child sensitivity levels. Data corresponding to 70 clinic-referred children (M age = 9.86

This study examined the relations between parental socialization of child anxious behaviors (i.e., reinforcement, punishment, modeling, transmission of information) and child anxiety and related problems at varying child sensitivity levels. Data corresponding to 70 clinic-referred children (M age = 9.86 years; 50% girls; 49% Hispanic/Latino, 51% Caucasian) showed that for children with low (but not high) anxiety sensitivity, anxiety-related parental socialization behaviors were associated with more child anxiety and depression symptoms. Findings also indicated that parental socialization of anxious behaviors and anxiety sensitivity functioned similarly in the prediction of anxiety and depression across Caucasian and Hispanic/Latino children. There were no significant mean level variations across child sociodemographic characteristics in general, but anxiety-promoting parenting behaviors were twice as high in Hispanic/Latino compared to Caucasian families.

Contributors

Agent

Created

Date Created
2015-06-01

133588-Thumbnail Image.png

Assessing Practices and Perceptions of Supplements Among College Students

Description

With the new independence of adulthood, college students are a group susceptible to adopting unsupported, if not harmful, health practices. A survey of Arizona State University undergraduate students (N=200) was conducted to evaluate supplement use, trust in information sources, and

With the new independence of adulthood, college students are a group susceptible to adopting unsupported, if not harmful, health practices. A survey of Arizona State University undergraduate students (N=200) was conducted to evaluate supplement use, trust in information sources, and beliefs about supplement regulation. Of those who reported using supplements, college students most frequently received information from friends and family. STEM majors in fields unrelated to health who were taking a supplement were found to be less likely to receive information about the supplement from a medical practitioner than those in health fields or those in non-STEM majors (-26.9%, p=0.018). STEM majors in health-related fields were 15.0% more likely to treat colds and/or cold symptoms with research-supported methods identified from reliable sources, while non-health STEM and non-STEM majors were more likely to take unsupported cold treatments (p=0.010). Surveyed students, regardless of major, also stated they would trust a medical practitioner for supplement advice above other sources (88.0%), and the majority expressed a belief that dietary supplements are approved/regulated by the government (59.8%).

Contributors

Agent

Created

Date Created
2018-05

128159-Thumbnail Image.png

Urban Impacts on Oxidative Balance and Animal Signals

Description

Though many animal ornaments and signals are sensitive to and encode information about the oxidative balance (OB) of individuals (e.g., antioxidant supplies/activity, reactive oxygen species, cellular oxidative damage/repair), often the environmental and/or physiological sources of such OB are unknown. Urban

Though many animal ornaments and signals are sensitive to and encode information about the oxidative balance (OB) of individuals (e.g., antioxidant supplies/activity, reactive oxygen species, cellular oxidative damage/repair), often the environmental and/or physiological sources of such OB are unknown. Urban development is among the most recent, pervasive, and persistent human stressors on the planet and impacts many environmental and physiological parameters of animals. Here we review the mechanistic underpinnings and functional consequences of how human urbanization drives antioxidant/oxidative status in animals and how this affects signal expression and use. Although we find that urbanization has strong negative effects on signal quality (e.g., visual, auditory, chemical) and OB across a range of taxa, few urban ecophysiological studies address signals and oxidative stress in unison, and even fewer in a fitness context. We also highlight particular signal types, taxa, life-histories, and anthropogenic environmental modifications on which future work integrating OB, signals, and urbanization could be centered. Last, we examine the conceptual and empirical framework behind the idea that urban conditions may disentangle signal expression from honesty and affect plasticity and adaptedness of sexually selected traits and preferences in the city.

Contributors

Agent

Created

Date Created
2016-05-19

128151-Thumbnail Image.png

Web-Scale Multidimensional Visualization of Big Spatial Data to Support Earth Sciences - A Case Study With Visualizing Climate Simulation Data

Description

The world is undergoing rapid changes in its climate, environment, and ecosystems due to increasing population growth, urbanization, and industrialization. Numerical simulation is becoming an important vehicle to enhance the understanding of these changes and their impacts, with regional and

The world is undergoing rapid changes in its climate, environment, and ecosystems due to increasing population growth, urbanization, and industrialization. Numerical simulation is becoming an important vehicle to enhance the understanding of these changes and their impacts, with regional and global simulation models producing vast amounts of data. Comprehending these multidimensional data and fostering collaborative scientific discovery requires the development of new visualization techniques. In this paper, we present a cyberinfrastructure solution - PolarGlobe - that enables comprehensive analysis and collaboration. PolarGlobe is implemented upon an emerging web graphics library, WebGL, and an open source virtual globe system Cesium, which has the ability to map spatial data onto a virtual Earth. We have also integrated volume rendering techniques, value and spatial filters, and vertical profile visualization to improve rendered images and support a comprehensive exploration of multi-dimensional spatial data. In this study, the climate simulation dataset produced by the extended polar version of the well-known Weather Research and Forecasting Model (WRF) is used to test the proposed techniques. PolarGlobe is also easily extendable to enable data visualization for other Earth Science domains, such as oceanography, weather, or geology.

Contributors

Agent

Created

Date Created
2017-06-26

128739-Thumbnail Image.png

What’s in a Name? Effect of Breed Perceptions & Labeling on Attractiveness, Adoptions, & Length of Stay for Pit-Bull-Type Dogs

Description

Previous research has indicated that certain breeds of dogs stay longer in shelters than others. However, exactly how breed perception and identification influences potential adopters' decisions remains unclear. Current dog breed identification practices in animal shelters are often based upon

Previous research has indicated that certain breeds of dogs stay longer in shelters than others. However, exactly how breed perception and identification influences potential adopters' decisions remains unclear. Current dog breed identification practices in animal shelters are often based upon information supplied by the relinquishing owner, or staff determination based on the dog's phenotype. However, discrepancies have been found between breed identification as typically assessed by welfare agencies and the outcome of DNA analysis. In Study 1, the perceived behavioral and adoptability characteristics of a pit-bull-type dog were compared with those of a Labrador Retriever and Border Collie. How the addition of a human handler influenced those perceptions was also assessed. In Study 2, lengths of stay and perceived attractiveness of dogs that were labeled as pit bull breeds were compared to dogs that were phenotypically similar but were labeled as another breed at an animal shelter. The latter dogs were called "lookalikes." In Study 3, we compared perceived attractiveness in video recordings of pit-bull-type dogs and lookalikes with and without breed labels. Lastly, data from an animal shelter that ceased applying breed labeling on kennels were analyzed, and lengths of stay and outcomes for all dog breeds, including pit bulls, before and after the change in labeling practice were compared. In total, these findings suggest that breed labeling influences potential adopters' perceptions and decision-making. Given the inherent complexity of breed assignment based on morphology coupled with negative breed perceptions, removing breed labels is a relatively low-cost strategy that will likely improve outcomes for dogs in animal shelters.

Contributors

Agent

Created

Date Created
2016-03-23