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Description
For most of human history hunting has been the primary economic activity of men. Hunted animals are valued for their food energy and nutrients, however, hunting is associated with a high risk of failure. Additionally, large animals cannot be consumed entirely by the nuclear family, so much of the harvest

For most of human history hunting has been the primary economic activity of men. Hunted animals are valued for their food energy and nutrients, however, hunting is associated with a high risk of failure. Additionally, large animals cannot be consumed entirely by the nuclear family, so much of the harvest may be shared to others. This has led some researchers to ask why men hunt large and difficult game. The “costly signaling” and “show-off” hypotheses propose that large prey are hunted because the difficulty of finding and killing them is a reliable costly signal of the phenotypic quality of the hunter.

These hypotheses were tested using original interview data from Aché (hunter gatherer; n=52, age range 50-76, 46% female) and Tsimané (horticulturalist; n=40, age range 15-77, 45% female) informants. Ranking tasks and paired comparison tasks were used to determine the association between the costs of killing an animal and its value as a signal of hunter phenotypic quality for attracting mates and allies. Additional tasks compared individual large animals to groups of smaller animals to determine whether assessments of hunters’ phenotypes and preferred status were more impacted by the signal value of the species or by the weight and number of animals killed.

Aché informants perceived hunters who killed larger or harder to kill animals as having greater provisioning ability, strength, fighting ability, and disease susceptibility, and preferred them as mates and allies. Tsimané informants held a similar preference for hunters who killed large game, but not for hunters targeting hard to kill species. When total biomass harvested was controlled, both populations considered harvesting more animals in a given time period to be a better signal of preferred phenotypes than killing a single large and impressive species. Male and female informants both preferred hunters who consistently brought back small game over hunters who sometimes killed large animals and sometimes killed nothing. No evidence was found that hunters should forgo overall food return rates in order to signal phenotypic qualities by specializing on large game. Nutrient provisioning rather than costly phenotypic signaling was the strategy preferred by potential mates and allies.
ContributorsBishop, Andrew Phillip Carson (Author) / Hill, Kim (Thesis advisor) / Boyd, Robert (Committee member) / Trumble, Benjamin (Committee member) / Arizona State University (Publisher)
Created2019
Description
This study aims to address the deficiencies of the Marcus model of electron transfer

(ET) and then provide modifications to the model. A confirmation of the inverted energy

gap law, which is the cleanest verification so far, is presented for donor-acceptor complexes.

In addition to the macroscopic properties of the solvent, the physical

This study aims to address the deficiencies of the Marcus model of electron transfer

(ET) and then provide modifications to the model. A confirmation of the inverted energy

gap law, which is the cleanest verification so far, is presented for donor-acceptor complexes.

In addition to the macroscopic properties of the solvent, the physical properties of the solvent

are incorporated in the model via the microscopic solvation model. For the molecules

studied in this dissertation, the rate constant first increases with cooling, in contrast to the

prediction of the Arrhenius law, and then decreases at lower temperatures. Additionally,

the polarizability of solute, which was not considered in the original Marcus theory, is included

by the Q-model of ET. Through accounting for the polarizability of the reactants, the

Q-model offers an important design principle for achieving high performance solar energy

conversion materials. By means of the analytical Q-model of ET, it is shown that including

molecular polarizability of C60 affects the reorganization energy and the activation barrier

of ET reaction.

The theory and Electrochemistry of Ferredoxin and Cytochrome c are also investigated.

By providing a new formulation for reaction reorganization energy, a long-standing disconnect

between the results of atomistic simulations and cyclic voltametery experiments is

resolved. The significant role of polarizability of enzymes in reducing the activation energy

of ET is discussed. The binding/unbinding of waters to the active site of Ferredoxin leads

to non-Gaussian statistics of energy gap and result in a smaller activation energy of ET.

Furthermore, the dielectric constant of water at the interface of neutral and charged

C60 is studied. The dielectric constant is found to be in the range of 10 to 22 which is

remarkably smaller compared to bulk water( 80). Moreover, the interfacial structural

crossover and hydration thermodynamic of charged C60 in water is studied. Increasing the

charge of the C60 molecule result in a dramatic structural transition in the hydration shell,

which lead to increase in the population of dangling O-H bonds at the interface.
ContributorsWaskasi, Morteza M (Author) / Matyushov, Dmitry (Thesis advisor) / Richert, Ranko (Committee member) / Heyden, Matthias (Committee member) / Beckstein, Oliver (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Calcium imaging is a well-established, non-invasive or minimally technique designed to study the electrical signaling neurons. Calcium regulates the release of gliotransmitters in astrocytes. Analyzing astrocytic calcium transients can provide significant insights into mechanisms such as neuroplasticity and neural signal modulation.

In the past decade, numerous methods have been developed

Calcium imaging is a well-established, non-invasive or minimally technique designed to study the electrical signaling neurons. Calcium regulates the release of gliotransmitters in astrocytes. Analyzing astrocytic calcium transients can provide significant insights into mechanisms such as neuroplasticity and neural signal modulation.

In the past decade, numerous methods have been developed to analyze in-vivo calcium imaging data that involves complex techniques such as overlapping signals segregation and motion artifact correction. The hypothesis used to detect calcium signal is the spatiotemporal sparsity of calcium signal, and these methods are unable to identify the passive cells that are not actively firing during the time frame in the video. Statistics regarding the percentage of cells in each frame of view can be critical for the analysis of calcium imaging data for human induced pluripotent stem cells derived neurons and astrocytes.

The objective of this research is to develop a simple and efficient semi-automated pipeline for analysis of in-vitro calcium imaging data. The region of interest (ROI) based image segmentation is used to extract the data regarding intensity fluctuation caused by calcium concentration changes in each cell. It is achieved by using two approaches: basic image segmentation approach and a machine learning approach. The intensity data is evaluated using a custom-made MATLAB that generates statistical information and graphical representation of the number of spiking cells in each field of view, the number of spikes per cell and spike height.
ContributorsBhandarkar, Siddhi Umesh (Author) / Brafman, David (Thesis advisor) / Stabenfeldt, Sarah (Committee member) / Tian, Xiaojun (Committee member) / Arizona State University (Publisher)
Created2019
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Description
In 2016, the United Nations reported a historical high of 65.6 million globally displaced people. Within the current protectionist and isolationist climate, the U.S is accepting a fewer number of refugees for resettlement than ever before and less governmental funding is being allocated to resettlement organizations, which provide support services

In 2016, the United Nations reported a historical high of 65.6 million globally displaced people. Within the current protectionist and isolationist climate, the U.S is accepting a fewer number of refugees for resettlement than ever before and less governmental funding is being allocated to resettlement organizations, which provide support services for refugee resettlement and integration.

Increased migration and the advancement of communication technologies with affordable access to these technologies have produced extensive communication networks and complex relational ties across the globe. While this is certainly true of all migrants, building and maintaining relational ties has added complexity for refugees whose journey to resettlement, economic insecurity, political disenfranchisement, and vulnerability impact the motivating factors for digital engagement.

This dissertation seeks to understand to what extent Diminescu’s (2008) concept of the connected migrant addresses the lived experience of resettled refugees in Phoenix, Arizona. The connected migrant through Information Communication Technology (ICT) use maintains transnational and local networks that produce mobility and belonging. Connected migrants are able to produce and maintain socio-technical sociality abroad and in the country of settlement to create and access social capital and resources. Using a grounded theory approach and qualitative methods, this research project explores concepts of mobility, connectivity, and belonging in relation to resettled refugees. The research indicates that age, imagined affordances, digital literacy, language, and time moderate connectivity, belonging, and mobility for resettled refugees. Finally, I offer the concept of transnational contextual relationality to understand refugee communication strategies with the transnational and local network.
ContributorsSabnis, Nandita Nishant (Author) / Cheong, Pauline (Thesis advisor) / Adame, Elissa (Committee member) / Tsuda, Takeyuki 'Gaku' (Committee member) / Arizona State University (Publisher)
Created2019
Description
There is an ongoing debate around the extent that anthropogenic processes influence both plant species distribution dynamics and plant biodiversity patterns. Past human food use may leave a strong legacy on not only the extent that food plants are dispersed and fill their potential geographic ranges, but also on food

There is an ongoing debate around the extent that anthropogenic processes influence both plant species distribution dynamics and plant biodiversity patterns. Past human food use may leave a strong legacy on not only the extent that food plants are dispersed and fill their potential geographic ranges, but also on food plant species richness in areas that have been densely populated by humans through time. The persistent legacy of plant domestication on contemporary species composition has been suggested to be significant in some regions. However, little is known about the effects that past human food use has had on the biogeography of the Sonoran Desert despite its rich cultural diversity and species richness. I used a combination of ecoinformatics, ethnobotanical, and archaeological data sources to quantitatively assess the impacts of pre-Columbian, and in some cases, more recent, human-mediated dispersal of food plants on the Sonoran Desert landscape. I found that (i) food plants do fill more of their potential geographic ranges than their un-used congeners, and that polyploidy, growth form, and life form are correlated with range filling and past food usage. I also found that (ii) both pre-Columbian and contemporary human population presence are correlated with relative food plant species richness. Thus, both past human food use and contemporary human activities may have influenced the geographic distribution of food plants at regional scales as well as species richness patterns. My research emphasizes that there is an interplay between ecological and anthropogenic processes, and that, therefore, humans must be considered as part of the landscape and included in ecological models.
ContributorsFlower, Carolyn (Author) / Blonder, Benjamin (Thesis advisor) / Hodgson, Wendy (Committee member) / Peeples, Matthew (Committee member) / Salywon, Andrew (Committee member) / Arizona State University (Publisher)
Created2019
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Description
This thesis explores the possibility of fabricating superconducting tunnel junctions (STJ) using double angle evaporation using an E-beam system. The traditional method of making STJs use a shadow mask to deposit two films requires the breaking of the vacuum of the main chamber. This technique has given bad results and

This thesis explores the possibility of fabricating superconducting tunnel junctions (STJ) using double angle evaporation using an E-beam system. The traditional method of making STJs use a shadow mask to deposit two films requires the breaking of the vacuum of the main chamber. This technique has given bad results and proven to be a tedious process. To improve on this technique, the E-beam system was modified by adding a load lock and transfer line to perform the multi-angle deposition and in situ oxidation in the load lock without breaking the vacuum of the main chamber. Bilayer photolithography process was used to prepare a pattern for double angle deposition for the STJ. The overlap length could be easily controlled by varying the deposition angles. The low-temperature resistivity measurement and scanning electron microscope (SEM) characterization showed that the deposited films were good. However, I-V measurement for tunnel junction did not give expected results for the quality of the fabricated STJs. The main objective of modifying the E-beam system for multiple angle deposition was achieved. It can be used for any application that requires angular deposition. The motivation for the project was to set up a system that can fabricate a device that can be used as a phonon spectrometer for phononic crystals. Future work will include improving the quality of the STJ and fabricating an STJs on both sides of a silicon substrate using a 4-angle deposition.
ContributorsRana, Ashish (Author) / Wang, Robert Y (Thesis advisor) / Newman, Nathan (Committee member) / Wang, Liping (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Mental health disparities in the U.S. among racial and ethnic minorities are a serious public health issue associated with substantial ethical and economic costs as well as negative health outcomes. Compared with Whites, racial/ethnic minorities have been found to have greater mental disorder symptomatology, however, very little research exists on

Mental health disparities in the U.S. among racial and ethnic minorities are a serious public health issue associated with substantial ethical and economic costs as well as negative health outcomes. Compared with Whites, racial/ethnic minorities have been found to have greater mental disorder symptomatology, however, very little research exists on how this impacts functional outcomes and quality of life. Additionally, research addressing the impact of bias on symptomatology and functional outcomes, especially across racial/ethnic groups, is lacking. Using the International Classification of Functioning, Disability, and Health (ICF) Biopsychosocial Model of Disability as a conceptual framework, the current study aims to address the relationship between mental disorder symptomatology and functional impairment across racial/ethnic groups, as well as evaluate the influence of perceived bias on this association. These relationships were examined using data from the Collaborative Psychiatric Epidemiological Surveys (CPES) among White, Black, Latinx, and Asian American individuals (N = 10,276). Variables include past-30-day functional impairment, past-year mental disorder symptomatology, and lifetime perceived bias. One-way analyses of variance were conducted to compare mental disorder symptomatology and perceived bias across racial/ethnic groups. Pearson correlation analyses were conducted to assess the relationship between mental disorder symptomatology and functional impairment across racial/ethnic groups. Zero-inflated negative binomial regressions were conducted to evaluate the moderating effect of perceived bias on the relationship between mental disorder symptomatology and functional impairment across racial/ethnic groups. Additional exploratory analyses were conducted to assess the relationships between mental disorder symptomatology, perceived bias, and various domains of functional impairment across racial/ethnic groups. Findings speak to the need for additional research on predictors and correlates of mental health outcomes, such as social support, community, and other resiliency factors. Additionally, the need for broader conceptualizations of how bias, prejudice, stigma, and intersectional identity may impact health and wellbeing across diverse populations is illustrated in this work. Overall, findings indicate the continued existence of disparities in mental health across racial/ethnic groups and reify the need for additional work to address this public health problem.
ContributorsYu, Kimberly (Author) / Perez, Marisol (Thesis advisor) / Edwards, Michael (Committee member) / Ha, Thao (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Optimal design theory provides a general framework for the construction of experimental designs for categorical responses. For a binary response, where the possible result is one of two outcomes, the logistic regression model is widely used to relate a set of experimental factors with the probability of a positive

Optimal design theory provides a general framework for the construction of experimental designs for categorical responses. For a binary response, where the possible result is one of two outcomes, the logistic regression model is widely used to relate a set of experimental factors with the probability of a positive (or negative) outcome. This research investigates and proposes alternative designs to alleviate the problem of separation in small-sample D-optimal designs for the logistic regression model. Separation causes the non-existence of maximum likelihood parameter estimates and presents a serious problem for model fitting purposes.

First, it is shown that exact, multi-factor D-optimal designs for the logistic regression model can be susceptible to separation. Several logistic regression models are specified, and exact D-optimal designs of fixed sizes are constructed for each model. Sets of simulated response data are generated to estimate the probability of separation in each design. This study proves through simulation that small-sample D-optimal designs are prone to separation and that separation risk is dependent on the specified model. Additionally, it is demonstrated that exact designs of equal size constructed for the same models may have significantly different chances of encountering separation.

The second portion of this research establishes an effective strategy for augmentation, where additional design runs are judiciously added to eliminate separation that has occurred in an initial design. A simulation study is used to demonstrate that augmenting runs in regions of maximum prediction variance (MPV), where the predicted probability of either response category is 50%, most reliably eliminates separation. However, it is also shown that MPV augmentation tends to yield augmented designs with lower D-efficiencies.

The final portion of this research proposes a novel compound optimality criterion, DMP, that is used to construct locally optimal and robust compromise designs. A two-phase coordinate exchange algorithm is implemented to construct exact locally DMP-optimal designs. To address design dependence issues, a maximin strategy is proposed for designating a robust DMP-optimal design. A case study demonstrates that the maximin DMP-optimal design maintains comparable D-efficiencies to a corresponding Bayesian D-optimal design while offering significantly improved separation performance.
ContributorsPark, Anson Robert (Author) / Montgomery, Douglas C. (Thesis advisor) / Mancenido, Michelle V (Thesis advisor) / Escobedo, Adolfo R. (Committee member) / Pan, Rong (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Healthy lifestyle behaviors including quality nutrition have been shown to successfully prevent chronic disease or minimize symptoms. However, many physicians lack the knowledge and skills to provide adequate nutrition counseling and education for their patients. A major component of this problem is that medical schools are not required to

Healthy lifestyle behaviors including quality nutrition have been shown to successfully prevent chronic disease or minimize symptoms. However, many physicians lack the knowledge and skills to provide adequate nutrition counseling and education for their patients. A major component of this problem is that medical schools are not required to teach nutrition education. The purpose of this feasibility study was to compare the changes in the perceived importance of nutrition in the medical field in medical students before and after participating in a week-long interactive nutrition course in order to determine if a week-long course can positively influence students’ perceptions of nutrition. Ultimately by changing these perceptions, medical students may be able to better help patients prevent chronic disease. The participants were first year medical students at the Mayo Clinic School of Medicine (Scottsdale, AZ) who chose to participate in this medical school “Selective”. The study included a five-day curriculum of case-studies, lectures from specialized health professionals, and a cooking class led by a chef who trained in France. An anonymous pre- and post-study questionnaire with five-point Likert scale questions was used to measure changes in attitudes. The data suggest that students’ perceptions regarding the importance and relevance of nutrition in the medical shifted slightly more positive after attending this Selective, although these shifts in attitude were not statistically significant. Limitations of this study include a small sample size and selection bias, which may have decreased the potential of having significant results. Both of these factors also make the results of this study less generalizable to all medical students. This study supports the need for a larger experimental study of a similar design to verify that an interactive, evidence-based nutrition class and culinary experience increases medical students’ positive perceptions of nutrition in the medical field.
ContributorsBaum, Makenna (Author) / Johnston, Carol (Thesis advisor) / Levinson, Simin (Committee member) / Sears, Dorothy (Committee member) / Arizona State University (Publisher)
Created2020
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Description
Geochronology and thermochronology are valuable tools for investigating the synergy between the deformational and erosional processes that shape mountainous terrains. Though numerous techniques have been developed to probe the rate and timing of events within these settings, the research presented here explores how scientists can use fewer samples to produce

Geochronology and thermochronology are valuable tools for investigating the synergy between the deformational and erosional processes that shape mountainous terrains. Though numerous techniques have been developed to probe the rate and timing of events within these settings, the research presented here explores how scientists can use fewer samples to produce richer data products with broader contextual importance.

The beginning of this compilation focuses on establishing laboratory techniques to facilitate this goal. I developed a novel laser ablation ‘double dating’ (LADD) technique that rapidly yields paired U/Pb and (U-Th)/He dates for the accessory minerals zircon, titanite, and apatite. The technique obviates the need for geometric corrections typically applied during (U-Th)/He data reduction, enables the analysis of a broader spectrum of detrital crystals, and provides the opportunity for additional mapping and isotopic analyses that are traditionally challenging to procure and/or fraught with assumptions. Despite the technique’s promise, I also found it essential to weigh several considerations of relevance when attempting to date young (≤ Miocene) accessory minerals with low concentrations of U + Th. Consequently, I discuss the impact that such variables have on the magnitude of analytical imprecision and the data’s flexibility for geologic interpretation.

Beyond the lab, I collected a suite of bedrock and detrital samples from small catchments draining the southeastern Sierra Nevada mountains of California. Using the techniques described above as well as conventional methods for (U-Th)/He zircon dating, I compared the utility of both bedrock and detrital approaches for extrapolating local exhumation histories. I additionally tested the ability to employ detrital datasets to extrapolate cooling histories that span from mineral crystallization to rock exhumation through the upper crust. Employing principal mode dates from a combination of zircon and apatite LADD dates and detrital hornblende 40Ar/39Ar dates, I was able to derive thermal models that demonstrate the existence of significant variability in the cooling histories of various intrusive units along the eastern Sierra Nevada. While these results only scratch the surface of what’s possible within the realm of detrital-based research, this contribution demonstrates the utility of expanding the temporal and spatial scope of traditional detrital methodologies.
ContributorsHorne, Alexandra Michelle (Author) / Hodges, Kip V. (Thesis advisor) / van Soest, Matthijs C. (Committee member) / Whipple, Kelin X (Committee member) / Heimsath, Arjun M. (Committee member) / Reynolds, Stephen J. (Committee member) / Arizona State University (Publisher)
Created2019