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- Genre: Masters Thesis
Description
Adapting to one novel condition of a motor task has been shown to generalize to other naïve conditions (i.e., motor generalization). In contrast, learning one task affects the proficiency of another task that is altogether different (i.e. motor transfer). Much more is known about motor generalization than about motor transfer, despite of decades of behavioral evidence. Moreover, motor generalization is studied as a probe to understanding how movements in any novel situations are affected by previous experiences. Thus, one could assume that mechanisms underlying transfer from trained to untrained tasks may be same as the ones known to be underlying motor generalization. However, the direct relationship between transfer and generalization has not yet been shown, thereby limiting the assumption that transfer and generalization rely on the same mechanisms. The purpose of this study was to test whether there is a relationship between motor generalization and motor transfer. To date, ten healthy young adult subjects were scored on their motor generalization ability and motor transfer ability on various upper extremity tasks. Although our current sample size is too small to clearly identify whether there is a relationship between generalization and transfer, Pearson product-moment correlation results and a priori power analysis suggest that a significant relationship will be observed with an increased sample size by 30%. If so, this would suggest that the mechanisms of transfer may be similar to those of motor generalization.
ContributorsSohani, Priyanka (Author) / Schaefer, Sydney (Thesis advisor) / Daliri, Ayoub (Committee member) / Honeycutt, Claire (Committee member) / Arizona State University (Publisher)
Created2018
Description
More than a century of research has investigated the etiology of dyslexia, coalescing around ‘phonological awareness’ – the ability to recognize and manipulate phonemes – as a trait typically deficient in reading disorders. Meanwhile, the last few decades of research in neuroscience have highlighted the brain as a predictive organ, which subliminally calibrates sensory expectations according to experience. Do the brains of adults with dyslexia respond differently than those of matched controls to expected tones and unexpected omissions? While auditory oddball paradigms have previously been used to study dyslexia, these studies often interpret group differences to indicate deficit auditory discrimination rather than deficit auditory prediction. The current study takes a step toward fusing theories of predictive coding and dyslexia, finding that event-related potentials related to auditory prediction are attenuated in adults with dyslexia compared with typical controls. It further suggests that understanding dyslexia, and perhaps other psychiatric disorders, in terms of contributory neural systems will elucidate shared and distinct etiologies.
ContributorsBennett, Augustin (Author) / Peter, Beate (Thesis advisor) / Daliri, Ayoub (Committee member) / Goldinger, Stephen (Committee member) / Arizona State University (Publisher)
Created2023
Description
Prosodic features such as fundamental frequency (F0), intensity, and duration convey important information of speech intonation (i.e., is it a statement or a question?). Because cochlear implants (CIs) do not adequately encode pitch-related F0 cues, pre-lignually deaf pediatric CI users have poorer speech intonation perception and production than normal-hearing (NH) children. In contrast, post-lingually deaf adult CI users have developed speech production skills via normal hearing before deafness and implantation. Further, combined electric hearing (via CI) and acoustic hearing (via hearing aid, HA) may improve CI users’ perception of pitch cues in speech intonation. Therefore, this study tested (1) whether post-lingually deaf adult CI users have similar speech intonation production to NH adults and (2) whether their speech intonation production improves with auditory feedback via CI+HA (i.e., bimodal hearing). Eight post-lingually deaf adult bimodal CI users and nine NH adults participated in this study. 10 question-and-answer dialogues with an experimenter were used to elicit 10 pairs of syntactically matched questions and statements from each participant. Bimodal CI users were tested under four hearing conditions: no-device (ND), HA, CI, and CI+HA. F0 change, intensity change, and duration ratio between the last two syllables of each utterance were analyzed to evaluate the quality of speech intonation production. The results showed no significant differences between CI and NH participants in any of the acoustic features of questions and statements. For CI participants, the CI+HA condition led to significantly greater F0 decreases of statements than the ND condition, while the ND condition led to significantly greater duration ratios of questions and statements. These results suggest that bimodal CI users change the use of prosodic cues for speech intonation production in different hearing conditions and access to auditory feedback via CI+HA may improve their voice pitch control to produce more salient statement intonation contours.
ContributorsAi, Chang (Author) / Luo, Xin (Thesis advisor) / Daliri, Ayoub (Committee member) / Davidson, Lisa (Committee member) / Arizona State University (Publisher)
Created2022
Description
Studies using transcranial direct current stimulation (tDCS) to enhance motor training areoften irreproducible. This may be partly due to differences in stimulation parameters across
studies, but it is also plausible that uncontrolled placebo effects may interact with the true
‘treatment’ effect of tDCS. Thus, the purpose of this study was to test whether there was a
placebo effect of tDCS on motor training and to identify possible mechanisms of such an effect.
Fifty-one participants (age: 22.2 ± 4.16; 26 F) were randomly assigned to one of three groups:
active anodal tDCS (n=18), sham tDCS (n=18), or no stimulation control (n=15). Participant
expectations about how much tDCS could enhance motor function and their general suggestibility
were assessed. Participants then completed 30 trials of functional upper extremity motor training
with or without online tDCS. Stimulation (20-min, 2mA) was applied to the right primary motor
cortex (C4) in a double-blind, sham-controlled fashion, while the control group was unblinded and
not exposed to any stimulation. Following motor training, expectations about how much tDCS
could enhance motor function were assessed again for participants in the sham and active tDCS
groups only. Results showed no effect of active tDCS on motor training (p=.67). However, there
was a significant placebo effect, such that the collapsed sham and active tDCS groups improved
more during motor training than the control group (p=.02). This placebo effect was significantly
influenced by post-training expectations about tDCS (p=.0004). Thus, this exploratory study
showed that there is a measurable placebo effect of tDCS on motor training, likely driven by
participants’ perceptions of whether they received stimulation. Future studies should consider
placebo effects of tDCS and identify their underlying mechanisms in order to leverage them in
clinical care.
ContributorsHAIKALIS, NICOLE (Author) / Schaefer, Sydney Y (Thesis advisor) / Honeycutt, Claire (Committee member) / Daliri, Ayoub (Committee member) / Arizona State University (Publisher)
Created2022
Description
Parkinson’s Disease is one of the most complicated and abundantneurodegenerative diseases in the world. Previous analysis of Parkinson’s disease has
identified both speech and gait deficits throughout progression of the disease. There has
been minimal research looking into the correlation between both the speech and gait
deficits in those diagnosed with Parkinson’s. There is high indication that there is a
correlation between the two given the similar pathology and origins of both deficits. This
exploratory study aims to establish correlation between both the gait and speech deficits
in those diagnosed with Parkinson’s disease. Using previously identified motor and
speech measurements and tasks, I conducted a correlational study of individuals with
Parkinson’s disease at baseline. There were correlations between multiple speech and gait
variability outcomes. The expected correlations ranged from average harmonics-to-noise
ratio values against anticipatory postural adjustments-lateral peak distance to average
shimmer values against anticipatory postural adjustments-lateral peak distance. There
were also unexpected outcomes that ranged from F2 variability against the average
number of steps in a turn to intensity variability against step duration variability. I also
analyzed the speech changes over 1 year as a secondary outcome of the study. Finally, I
found that averages and variabilities increased over 1 year regarding speech primary
outcomes. This study serves as a basis for further treatment that may be able to
simultaneously treat both speech and gait deficits in those diagnosed with Parkinson’s.
The exploratory study also indicates multiple targets for further investigation to better
understand cohesive and compensatory mechanisms.
ContributorsBelnavis, Alexander Salvador (Author) / Peterson, Daniel (Thesis advisor) / Daliri, Ayoub (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2022
Description
Speech and music are traditionally thought to be primarily supported by different hemispheres. A growing body of evidence suggests that speech and music often rely on shared resources in bilateral brain networks, though the right and left hemispheres exhibit some domain-specific specialization. While there is ample research investigating speech deficits in individuals with right hemisphere lesions and amusia, fewer investigate amusia in individuals with left hemisphere lesions and aphasia. Many of the fronto-temporal-parietal regions in the left hemisphere commonly associated with speech processing and production are also implicated in bilateral music processing networks. The current study investigates the relationship between damage to specific regions of interest within these networks, and an individual’s ability to successfully match the pitch and rhythm of a presented melody. Twenty-seven participants with chronic-stroke lesions were given a melody repetition task to hum short novel piano melodies. Participants underwent structural MRI acquisition and were administered an extensive speech and cognitive battery. Pitch and rhythm scores were calculated by correlating participant responses and target piano notes. Production errors were calculated by counting trials with responses that don’t match the target melody’s note count. Overall, performance varied widely, and rhythm scores were significantly correlated. Working memory scores were significantly correlated with rhythm scores and production errors, but not pitch scores. Broca’s area lesions were not associated with significant differences in any of the melody repetition measures, while left Heschl’s gyrus lesions were associated with worse performance on pitch, rhythm, and production errors. Lower rhythm scores were associated with lesions including both the left anterior and posterior superior temporal gyrus, and in participants with damage to the left planum temporale. The other regions of interest were not consistently associated with poorer pitch scores or production errors. Although the present study does have limitations, the current study suggests lesions to left hemisphere regions thought to only affect speech also affect musical pitch and rhythm processing. Therefore, amusia should not be characterized solely as a right hemisphere disorder. Instead, musical abilities of individuals with left hemisphere stroke and aphasia should be characterized to better understand their deficits and mechanisms of impairment.
ContributorsWojtaszek, Mallory (Author) / Rogalsky, Corianne (Thesis advisor) / Daliri, Ayoub (Committee member) / Patten, Kristopher (Committee member) / Arizona State University (Publisher)
Created2022
Description
The brain uses the somatosensory system to interact with the environment and control movements. Additionally, many movement disorders are associated with deficits in the somatosensory sensory system. Thus, understanding the somatosensory system is essential for developing treatments for movement disorders. Previous studies have extensively examined the role of the somatosensory system in controlling the lower and upper extremities; however, little is known about the contributions of the orofacial somatosensory system. The overall goal of this study was to determine factors that influence the sensitivity of the orofacial somatosensory system. To measure the somatosensory system's sensitivity, transcutaneous electrical current stimulation was applied to the skin overlaying the trigeminal nerve on the lower portion of the face. After applying stimulation, participants' sensitivity was determined through the detection of the electrical stimuli (i.e., perceptual threshold). The data analysis focused on the impact of (1) stimulation parameters, (2) electrode placement, and (3) motor tasks on the perceptual threshold. The results showed that, as expected, stimulation parameters (such as stimulation frequency and duration) influenced perceptual thresholds. However, electrode placement (left vs. right side of the face) and motor tasks (lip contraction vs. rest) did not influence perceptual thresholds. Overall, these findings have important implications for designing and developing therapeutic neuromodulation techniques based on trigeminal nerve stimulation.
ContributorsKhoury, Maya Elie (Author) / Daliri, Ayoub (Thesis advisor) / Patten, Jake (Committee member) / Liss, Julie (Committee member) / Arizona State University (Publisher)
Created2022