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- Genre: Doctoral Dissertation
Description
Once perceived as an unimportant occurrence in living organisms, cell degeneration was reconfigured as an important biological phenomenon in development, aging, health, and diseases in the twentieth century. This dissertation tells a twentieth-century history of scientific investigations on cell degeneration, including cell death and aging. By describing four central developments in cell degeneration research with the four major chapters, I trace the emergence of the degenerating cell as a scientific object, describe the generations of a variety of concepts, interpretations and usages associated with cell death and aging, and analyze the transforming influences of the rising cell degeneration research. Particularly, the four chapters show how the changing scientific practices about cellular life in embryology, cell culture, aging research, and molecular biology of Caenorhabditis elegans shaped the interpretations about cell degeneration in the twentieth-century as life-shaping, limit-setting, complex, yet regulated. These events created and consolidated important concepts in life sciences such as programmed cell death, the Hayflick limit, apoptosis, and death genes. These cases also transformed the material and epistemic practices about the end of cellular life subsequently and led to the formations of new research communities. The four cases together show the ways cell degeneration became a shared subject between molecular cell biology, developmental biology, gerontology, oncology, and pathology of degenerative diseases. These practices and perspectives created a special kind of interconnectivity between different fields and led to a level of interdisciplinarity within cell degeneration research by the early 1990s.
ContributorsJiang, Lijing (Author) / Maienschein, Jane (Thesis advisor) / Laubichler, Manfred (Thesis advisor) / Hurlbut, James (Committee member) / Creath, Richard (Committee member) / White, Michael (Committee member) / Arizona State University (Publisher)
Created2013
Description
In the United States, approximately 400,000 youth are in out-of-home care in the custody of child protection systems (CPS). They are incarcerated, but not as punishment for a crime. States place youth in CPS custody for many different reasons, centered around legal determinations of families’ failure to provide adequate care. Such youth are forcibly separated from their biological (“bio”) families and required to live in shelters, group homes, and foster households at the threat of arrest. Through the socio-legal concept of parens patriae, the government assumes responsibility for their safety and development. In other words, the state assumes the role of parents to children it places in CPS. Still, despite years of social work research, three fundamental questions remain about CPS for criminology. First, criminologists are beginning to recognize the overlap between criminology and CPS but lack a theoretical framework for analyzing that intersection. Second, the proper role of the state in youth development and the measurement of its relative success are of central importance to criminal justice, but at best loosely defined. Finally, this dissertation asks: how do entering CPS custody, growing up in state care, and (someday) exiting CPS shape the experiences and perceptions of CPS youth? Given the attenuated social processes associated with CPS, criminologists might expect youth to experience significant barriers to transitioning successfully to adulthood. At the same time, therapeutic assessment and treatment in CPS should ameliorate those barriers. This dissertation addresses that theoretical paradox in eight chapters. After an introductory overview, Chapter Two posits social control, social support, and agency over the life course as a theoretical framework for understanding the implications of growing up in CPS. Chapter Three details the phronetic and ethnographic approach of the study, designed to encounter the perspectives of youth themselves in their “natural” setting. Chapters Four through Seven present findings from interviews with participants in an arts-based therapy program for youth in CPS (n=33). Chapter Eight concludes the study with a discussion of the implications of this work for criminological research, juvenile justice policy, and youth who grow up in CPS.
ContributorsCesar, Gabriel T Gilberto (Author) / Decker, Scott (Thesis advisor) / Wallace, Danielle (Committee member) / White, Michael (Committee member) / Arizona State University (Publisher)
Created2018