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- Genre: Doctoral Dissertation
- Creators: Papandreou-Suppappola, Antonia
- Creators: Tepedelenlioğlu, Cihan
Description
Analysis of social networks has the potential to provide insights into wide range of applications. As datasets continue to grow, a key challenge is the lack of a widely applicable algorithmic framework for detection of statistically anomalous networks and network properties. Unlike traditional signal processing, where models of truth or empirical verification and background data exist and are often well defined, these features are commonly lacking in social and other networks. Here, a novel algorithmic framework for statistical signal processing for graphs is presented. The framework is based on the analysis of spectral properties of the residuals matrix. The framework is applied to the detection of innovation patterns in publication networks, leveraging well-studied empirical knowledge from the history of science. Both the framework itself and the application constitute novel contributions, while advancing algorithmic and mathematical techniques for graph-based data and understanding of the patterns of emergence of novel scientific research. Results indicate the efficacy of the approach and highlight a number of fruitful future directions.
ContributorsBliss, Nadya Travinin (Author) / Laubichler, Manfred (Thesis advisor) / Castillo-Chavez, Carlos (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2015
Description
The healthcare system in this country is currently unacceptable. New technologies may contribute to reducing cost and improving outcomes. Early diagnosis and treatment represents the least risky option for addressing this issue. Such a technology needs to be inexpensive, highly sensitive, highly specific, and amenable to adoption in a clinic. This thesis explores an immunodiagnostic technology based on highly scalable, non-natural sequence peptide microarrays designed to profile the humoral immune response and address the healthcare problem. The primary aim of this thesis is to explore the ability of these arrays to map continuous (linear) epitopes. I discovered that using a technique termed subsequence analysis where epitopes could be decisively mapped to an eliciting protein with high success rate. This led to the discovery of novel linear epitopes from Plasmodium falciparum (Malaria) and Treponema palladium (Syphilis), as well as validation of previously discovered epitopes in Dengue and monoclonal antibodies. Next, I developed and tested a classification scheme based on Support Vector Machines for development of a Dengue Fever diagnostic, achieving higher sensitivity and specificity than current FDA approved techniques. The software underlying this method is available for download under the BSD license. Following this, I developed a kinetic model for immunosignatures and tested it against existing data driven by previously unexplained phenomena. This model provides a framework and informs ways to optimize the platform for maximum stability and efficiency. I also explored the role of sequence composition in explaining an immunosignature binding profile, determining a strong role for charged residues that seems to have some predictive ability for disease. Finally, I developed a database, software and indexing strategy based on Apache Lucene for searching motif patterns (regular expressions) in large biological databases. These projects as a whole have advanced knowledge of how to approach high throughput immunodiagnostics and provide an example of how technology can be fused with biology in order to affect scientific and health outcomes.
ContributorsRicher, Joshua Amos (Author) / Johnston, Stephen A. (Thesis advisor) / Woodbury, Neal (Committee member) / Stafford, Phillip (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2014
Description
Horn antennas have been used for over a hundred years. They have a wide variety of uses where they are a basic and popular microwave antenna for many practical applications, such as feed elements for communication reflector dishes on satellite or point-to-point relay antennas. They are also widely utilized as gain standards for calibration and gain measurement of other antennas.
The gain and loss factor of conical horns are revisited in this dissertation based on
spherical and quadratic aperture phase distributions. The gain is compared with published classical data in an attempt to confirm their validity and accuracy and to determine whether they were derived based on spherical or quadratic aperture phase distributions. In this work, it is demonstrated that the gain of a conical horn antenna obtained by using a spherical phase distribution is in close agreement with published classical data. Moreover, more accurate expressions for the loss factor, to account for amplitude and phase tapers over the horn aperture, are derived. New formulas for the design of optimum gain conical horns, based on the more accurate spherical aperture phase distribution, are derived.
To better understand the impact of edge diffractions on aperture antenna performance, an extensive investigation of the edge diffractions impact is undertaken in this dissertation for commercial aperture antennas. The impact of finite uncoated and coated PEC ground plane edge diffractions on the amplitude patterns in the principal planes of circular apertures is intensively examined. Similarly, aperture edge diffractions of aperture antennas without ground planes are examined. Computational results obtained by the analytical model are compared with experimental and HFSS-simulated results for all cases studied. In addition, the impact of the ground plane size, coating thickness, and relative permittivity of the dielectric layer on the radiation amplitude in the back region has been examined.
This investigation indicates that the edge diffractions do impact the main forward lobe pattern, especially in the E plane. Their most significant contribution appears in far side and back lobes. This work demonstrates that the finite edge contributors must be considered to obtain more accurate amplitude patterns of aperture antennas.
The gain and loss factor of conical horns are revisited in this dissertation based on
spherical and quadratic aperture phase distributions. The gain is compared with published classical data in an attempt to confirm their validity and accuracy and to determine whether they were derived based on spherical or quadratic aperture phase distributions. In this work, it is demonstrated that the gain of a conical horn antenna obtained by using a spherical phase distribution is in close agreement with published classical data. Moreover, more accurate expressions for the loss factor, to account for amplitude and phase tapers over the horn aperture, are derived. New formulas for the design of optimum gain conical horns, based on the more accurate spherical aperture phase distribution, are derived.
To better understand the impact of edge diffractions on aperture antenna performance, an extensive investigation of the edge diffractions impact is undertaken in this dissertation for commercial aperture antennas. The impact of finite uncoated and coated PEC ground plane edge diffractions on the amplitude patterns in the principal planes of circular apertures is intensively examined. Similarly, aperture edge diffractions of aperture antennas without ground planes are examined. Computational results obtained by the analytical model are compared with experimental and HFSS-simulated results for all cases studied. In addition, the impact of the ground plane size, coating thickness, and relative permittivity of the dielectric layer on the radiation amplitude in the back region has been examined.
This investigation indicates that the edge diffractions do impact the main forward lobe pattern, especially in the E plane. Their most significant contribution appears in far side and back lobes. This work demonstrates that the finite edge contributors must be considered to obtain more accurate amplitude patterns of aperture antennas.
ContributorsAboserwal, Nafati Abdasallam (Author) / Balanis, Constantine A (Thesis advisor) / Aberle, James T (Committee member) / Pan, George (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014
Description
Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate epitope antigen subsequences as well as identify mimotope antigen subsequences that mimic the structure of epitopes from random-sequence peptide microarrays. The method first maps peptide sequences to linear expansions of highly-localized one-dimensional (1-D) time-varying signals and uses a time-frequency processing technique to detect recurring patterns in subsequences. This technique is matched to the aforementioned mapping scheme, and it allows for an inherent analysis on how substitutions in the subsequences can affect antibody binding strength. The performance of the proposed method is demonstrated by estimating epitopes and identifying potential mimotopes for eight monoclonal antibody samples.
The proposed mapping is generalized to express information on a protein's sequence location, structure and function onto a highly localized three-dimensional (3-D) Gaussian waveform. In particular, as analysis of protein homology has shown that incorporating different kinds of information into an alignment process can yield more robust alignment results, a pairwise protein structure alignment method is proposed based on a joint similarity measure of multiple mapped protein attributes. The 3-D mapping allocates protein properties into distinct regions in the time-frequency plane in order to simplify the alignment process by including all relevant information into a single, highly customizable waveform. Simulations demonstrate the improved performance of the joint alignment approach to infer relationships between proteins, and they provide information on mutations that cause changes to both the sequence and structure of a protein.
In addition to the biology-based signal processing methods, a statistical method is considered that uses a physics-based model to improve processing performance. In particular, an externally developed physics-based model for sea clutter is examined when detecting a low radar cross-section target in heavy sea clutter. This novel model includes a process that generates random dynamic sea clutter based on the governing physics of water gravity and capillary waves and a finite-difference time-domain electromagnetics simulation process based on Maxwell's equations propagating the radar signal. A subspace clutter suppression detector is applied to remove dominant clutter eigenmodes, and its improved performance over matched filtering is demonstrated using simulations.
The proposed mapping is generalized to express information on a protein's sequence location, structure and function onto a highly localized three-dimensional (3-D) Gaussian waveform. In particular, as analysis of protein homology has shown that incorporating different kinds of information into an alignment process can yield more robust alignment results, a pairwise protein structure alignment method is proposed based on a joint similarity measure of multiple mapped protein attributes. The 3-D mapping allocates protein properties into distinct regions in the time-frequency plane in order to simplify the alignment process by including all relevant information into a single, highly customizable waveform. Simulations demonstrate the improved performance of the joint alignment approach to infer relationships between proteins, and they provide information on mutations that cause changes to both the sequence and structure of a protein.
In addition to the biology-based signal processing methods, a statistical method is considered that uses a physics-based model to improve processing performance. In particular, an externally developed physics-based model for sea clutter is examined when detecting a low radar cross-section target in heavy sea clutter. This novel model includes a process that generates random dynamic sea clutter based on the governing physics of water gravity and capillary waves and a finite-difference time-domain electromagnetics simulation process based on Maxwell's equations propagating the radar signal. A subspace clutter suppression detector is applied to remove dominant clutter eigenmodes, and its improved performance over matched filtering is demonstrated using simulations.
ContributorsO'Donnell, Brian (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Johnston, Stephen A. (Committee member) / Kovvali, Narayan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014
Description
Thousands of high-resolution images are generated each day. Detecting and analyzing variations in these images are key steps in image understanding. This work focuses on spatial and multitemporal
visual change detection and its applications in multi-temporal synthetic aperture radar (SAR) images.
The Canny edge detector is one of the most widely-used edge detection algorithms due to its superior performance in terms of SNR and edge localization and only one response to a single edge. In this work, we propose a mechanism to implement the Canny algorithm at the block level without any loss in edge detection performance as compared to the original frame-level Canny algorithm. The resulting block-based algorithm has significantly reduced memory requirements and can achieve a significantly reduced latency. Furthermore, the proposed algorithm can be easily integrated with other block-based image processing systems. In addition, quantitative evaluations and subjective tests show that the edge detection performance of the proposed algorithm is better than the original frame-based algorithm, especially when noise is present in the images.
In the context of multi-temporal SAR images for earth monitoring applications, one critical issue is the detection of changes occurring after a natural or anthropic disaster. In this work, we propose a novel similarity measure for automatic change detection using a pair of SAR images
acquired at different times and apply it in both the spatial and wavelet domains. This measure is based on the evolution of the local statistics of the image between two dates. The local statistics are modeled as a Gaussian Mixture Model (GMM), which is more suitable and flexible to approximate the local distribution of the SAR image with distinct land-cover typologies. Tests on real datasets show that the proposed detectors outperform existing methods in terms of the quality of the similarity maps, which are assessed using the receiver operating characteristic (ROC) curves, and in terms of the total error rates of the final change detection maps. Furthermore, we proposed a new
similarity measure for automatic change detection based on a divisive normalization transform in order to reduce the computation complexity. Tests show that our proposed DNT-based change detector
exhibits competitive detection performance while achieving lower computational complexity as compared to previously suggested methods.
visual change detection and its applications in multi-temporal synthetic aperture radar (SAR) images.
The Canny edge detector is one of the most widely-used edge detection algorithms due to its superior performance in terms of SNR and edge localization and only one response to a single edge. In this work, we propose a mechanism to implement the Canny algorithm at the block level without any loss in edge detection performance as compared to the original frame-level Canny algorithm. The resulting block-based algorithm has significantly reduced memory requirements and can achieve a significantly reduced latency. Furthermore, the proposed algorithm can be easily integrated with other block-based image processing systems. In addition, quantitative evaluations and subjective tests show that the edge detection performance of the proposed algorithm is better than the original frame-based algorithm, especially when noise is present in the images.
In the context of multi-temporal SAR images for earth monitoring applications, one critical issue is the detection of changes occurring after a natural or anthropic disaster. In this work, we propose a novel similarity measure for automatic change detection using a pair of SAR images
acquired at different times and apply it in both the spatial and wavelet domains. This measure is based on the evolution of the local statistics of the image between two dates. The local statistics are modeled as a Gaussian Mixture Model (GMM), which is more suitable and flexible to approximate the local distribution of the SAR image with distinct land-cover typologies. Tests on real datasets show that the proposed detectors outperform existing methods in terms of the quality of the similarity maps, which are assessed using the receiver operating characteristic (ROC) curves, and in terms of the total error rates of the final change detection maps. Furthermore, we proposed a new
similarity measure for automatic change detection based on a divisive normalization transform in order to reduce the computation complexity. Tests show that our proposed DNT-based change detector
exhibits competitive detection performance while achieving lower computational complexity as compared to previously suggested methods.
ContributorsXu, Qian (Author) / Karam, Lina J (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Bliss, Daniel (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014
Description
Underwater acoustic communications face significant challenges unprecedented in radio terrestrial communications including long multipath delay spreads, strong Doppler effects, and stringent bandwidth requirements. Recently, multi-carrier communications based on orthogonal frequency division multiplexing (OFDM) have seen significant growth in underwater acoustic (UWA) communications, thanks to their well well-known robustness against severely time-dispersive channels. However, the performance of OFDM systems over UWA channels significantly deteriorates due to severe intercarrier interference (ICI) resulting from rapid time variations of the channel. With the motivation of developing enabling techniques for OFDM over UWA channels, the major contributions of this thesis include (1) two effective frequencydomain equalizers that provide general means to counteract the ICI; (2) a family of multiple-resampling receiver designs dealing with distortions caused by user and/or path specific Doppler scaling effects; (3) proposal of using orthogonal frequency division multiple access (OFDMA) as an effective multiple access scheme for UWA communications; (4) the capacity evaluation for single-resampling versus multiple-resampling receiver designs. All of the proposed receiver designs have been verified both through simulations and emulations based on data collected in real-life UWA communications experiments. Particularly, the frequency domain equalizers are shown to be effective with significantly reduced pilot overhead and offer robustness against Doppler and timing estimation errors. The multiple-resampling designs, where each branch is tasked with the Doppler distortion of different paths and/or users, overcome the disadvantages of the commonly-used single-resampling receivers and yield significant performance gains. Multiple-resampling receivers are also demonstrated to be necessary for UWA OFDMA systems. The unique design effectively mitigates interuser interference (IUI), opening up the possibility to exploit advanced user subcarrier assignment schemes. Finally, the benefits of the multiple-resampling receivers are further demonstrated through channel capacity evaluation results.
ContributorsTu, Kai (Author) / Duman, Tolga M. (Thesis advisor) / Zhang, Junshan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2011
Description
There are many wireless communication and networking applications that require high transmission rates and reliability with only limited resources in terms of bandwidth, power, hardware complexity etc.. Real-time video streaming, gaming and social networking are a few such examples. Over the years many problems have been addressed towards the goal of enabling such applications; however, significant challenges still remain, particularly, in the context of multi-user communications. With the motivation of addressing some of these challenges, the main focus of this dissertation is the design and analysis of capacity approaching coding schemes for several (wireless) multi-user communication scenarios. Specifically, three main themes are studied: superposition coding over broadcast channels, practical coding for binary-input binary-output broadcast channels, and signalling schemes for two-way relay channels. As the first contribution, we propose an analytical tool that allows for reliable comparison of different practical codes and decoding strategies over degraded broadcast channels, even for very low error rates for which simulations are impractical. The second contribution deals with binary-input binary-output degraded broadcast channels, for which an optimal encoding scheme that achieves the capacity boundary is found, and a practical coding scheme is given by concatenation of an outer low density parity check code and an inner (non-linear) mapper that induces desired distribution of "one" in a codeword. The third contribution considers two-way relay channels where the information exchange between two nodes takes place in two transmission phases using a coding scheme called physical-layer network coding. At the relay, a near optimal decoding strategy is derived using a list decoding algorithm, and an approximation is obtained by a joint decoding approach. For the latter scheme, an analytical approximation of the word error rate based on a union bounding technique is computed under the assumption that linear codes are employed at the two nodes exchanging data. Further, when the wireless channel is frequency selective, two decoding strategies at the relay are developed, namely, a near optimal decoding scheme implemented using list decoding, and a reduced complexity detection/decoding scheme utilizing a linear minimum mean squared error based detector followed by a network coded sequence decoder.
ContributorsBhat, Uttam (Author) / Duman, Tolga M. (Thesis advisor) / Tepedelenlioğlu, Cihan (Committee member) / Li, Baoxin (Committee member) / Zhang, Junshan (Committee member) / Arizona State University (Publisher)
Created2011
Description
Following the success in incorporating perceptual models in audio coding algorithms, their application in other speech/audio processing systems is expanding. In general, all perceptual speech/audio processing algorithms involve minimization of an objective function that directly/indirectly incorporates properties of human perception. This dissertation primarily investigates the problems associated with directly embedding an auditory model in the objective function formulation and proposes possible solutions to overcome high complexity issues for use in real-time speech/audio algorithms. Specific problems addressed in this dissertation include: 1) the development of approximate but computationally efficient auditory model implementations that are consistent with the principles of psychoacoustics, 2) the development of a mapping scheme that allows synthesizing a time/frequency domain representation from its equivalent auditory model output. The first problem is aimed at addressing the high computational complexity involved in solving perceptual objective functions that require repeated application of auditory model for evaluation of different candidate solutions. In this dissertation, a frequency pruning and a detector pruning algorithm is developed that efficiently implements the various auditory model stages. The performance of the pruned model is compared to that of the original auditory model for different types of test signals in the SQAM database. Experimental results indicate only a 4-7% relative error in loudness while attaining up to 80-90 % reduction in computational complexity. Similarly, a hybrid algorithm is developed specifically for use with sinusoidal signals and employs the proposed auditory pattern combining technique together with a look-up table to store representative auditory patterns. The second problem obtains an estimate of the auditory representation that minimizes a perceptual objective function and transforms the auditory pattern back to its equivalent time/frequency representation. This avoids the repeated application of auditory model stages to test different candidate time/frequency vectors in minimizing perceptual objective functions. In this dissertation, a constrained mapping scheme is developed by linearizing certain auditory model stages that ensures obtaining a time/frequency mapping corresponding to the estimated auditory representation. This paradigm was successfully incorporated in a perceptual speech enhancement algorithm and a sinusoidal component selection task.
ContributorsKrishnamoorthi, Harish (Author) / Spanias, Andreas (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Tsakalis, Konstantinos (Committee member) / Arizona State University (Publisher)
Created2011
Description
Structural health management (SHM) is emerging as a vital methodology to help engineers improve the safety and maintainability of critical structures. SHM systems are designed to reliably monitor and test the health and performance of structures in aerospace, civil, and mechanical engineering applications. SHM combines multidisciplinary technologies including sensing, signal processing, pattern recognition, data mining, high fidelity probabilistic progressive damage models, physics based damage models, and regression analysis. Due to the wide application of carbon fiber reinforced composites and their multiscale failure mechanisms, it is necessary to emphasize the research of SHM on composite structures. This research develops a comprehensive framework for the damage detection, localization, quantification, and prediction of the remaining useful life of complex composite structures. To interrogate a composite structure, guided wave propagation is applied to thin structures such as beams and plates. Piezoelectric transducers are selected because of their versatility, which allows them to be used as sensors and actuators. Feature extraction from guided wave signals is critical to demonstrate the presence of damage and estimate the damage locations. Advanced signal processing techniques are employed to extract robust features and information. To provide a better estimate of the damage for accurate life estimation, probabilistic regression analysis is used to obtain a prediction model for the prognosis of complex structures subject to fatigue loading. Special efforts have been applied to the extension of SHM techniques on aerospace and spacecraft structures, such as UAV composite wings and deployable composite boom structures. Necessary modifications of the developed SHM techniques were conducted to meet the unique requirements of the aerospace structures. The developed SHM algorithms are able to accurately detect and quantify impact damages as well as matrix cracking introduced.
ContributorsLiu, Yingtao (Author) / Chattopadhyay, Aditi (Thesis advisor) / Rajadas, John (Committee member) / Dai, Lenore (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Jiang, Hanqing (Committee member) / Arizona State University (Publisher)
Created2012
Description
Damage assessment and residual useful life estimation (RULE) are essential for aerospace, civil and naval structures. Structural Health Monitoring (SHM) attempts to automate the process of damage detection and identification. Multiscale modeling is a key element in SHM. It not only provides important information on the physics of failure, such as damage initiation and growth, the output can be used as "virtual sensing" data for detection and prognosis. The current research is part of an ongoing multidisciplinary effort to develop an integrated SHM framework for metallic aerospace components. In this thesis a multiscale model has been developed by bridging the relevant length scales, micro, meso and macro (or structural scale). Micro structural representations obtained from material characterization studies are used to define the length scales and to capture the size and orientation of the grains at the micro level. Parametric studies are conducted to estimate material parameters used in this constitutive model. Numerical and experimental simulations are performed to investigate the effects of Representative Volume Element (RVE) size, defect area fraction and distribution. A multiscale damage criterion accounting for crystal orientation effect is developed. This criterion is applied for fatigue crack initial stage prediction. A damage evolution rule based on strain energy density is modified to incorporate crystal plasticity at the microscale (local). Optimization approaches are used to calculate global damage index which is used for the RVE failure prediciton. Potential cracking directions are provided from the damage criterion simultaneously. A wave propagation model is incorporated with the damage model to detect changes in sensing signals due to plastic deformation and damage growth.
ContributorsLuo, Chuntao (Author) / Chattopadhyay, Aditi (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Jiang, Hanqing (Committee member) / Dai, Lenore (Committee member) / Li, Jian (Committee member) / Arizona State University (Publisher)
Created2011