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Accumulating evidence implicates exposure to adverse childhood experiences in the development of hypocortisolism in the long-term, and researchers are increasingly examining individual-level mechanisms that may underlie, exacerbate or attenuate this relation among at-risk populations. The current study takes a developmentally and theoretically informed approach to examining episodic childhood stressors, inherent

Accumulating evidence implicates exposure to adverse childhood experiences in the development of hypocortisolism in the long-term, and researchers are increasingly examining individual-level mechanisms that may underlie, exacerbate or attenuate this relation among at-risk populations. The current study takes a developmentally and theoretically informed approach to examining episodic childhood stressors, inherent and voluntary self-regulation, and physiological reactivity among a longitudinal sample of youth who experienced parental divorce. Participants were drawn from a larger randomized controlled trial of a preventive intervention for children of divorce between the ages of 9 and 12. The current sample included 159 young adults (mean age = 25.5 years; 53% male; 94% Caucasian) who participated in six waves of data collection, including a 15-year follow-up study. Participants reported on exposure to negative life events (four times over a 9-month period) during childhood, and mothers rated child temperament. Six years later, youth reported on the use of active and avoidant coping strategies, and 15 years later, they participated in a standardized psychosocial stress task and provided salivary cortisol samples prior to and following the task. Path analyses within a structural equation framework revealed that a multiple mediation model best fit the data. It was found that children with better mother-rated self-regulation (i.e. low impulsivity, low negative emotionality, and high attentional focus) exhibited lower total cortisol output 15 years later. In addition, greater self-regulation in childhood predicted greater use of active coping in adolescence, whereas a greater number of negative life events predicted increased use of avoidant coping in adolescence. Finally, a greater number of negative events in childhood predicted marginally lower total cortisol output, and higher levels of active coping in adolescence were associated with greater total cortisol output in young adulthood. Findings suggest that children of divorce who exhibit better self-regulation evidence lower cortisol output during a standardized psychosocial stress task relative to those who have higher impulsivity, lower attentional focus, and/or higher negative emotionality. The conceptual significance of the current findings, including the lack of evidence for hypothesized relations, methodological issues that arose, and issues in need of future research are discussed.
ContributorsHagan, Melissa (Author) / Luecken, Linda (Thesis advisor) / MacKinnon, David (Committee member) / Wolchik, Sharlene (Committee member) / Doane, Leah (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Type 1 Diabetes Mellitus (T1DM) is a chronic disease that requires maintaining tight metabolic control through complex behavioral and pharmaceutical regimens. Subtle cognitive impairments and stress response dysregulation may partially account for problems negotiating life changes and maintaining treatment adherence among emerging adults. The current study examined whether young adults

Type 1 Diabetes Mellitus (T1DM) is a chronic disease that requires maintaining tight metabolic control through complex behavioral and pharmaceutical regimens. Subtle cognitive impairments and stress response dysregulation may partially account for problems negotiating life changes and maintaining treatment adherence among emerging adults. The current study examined whether young adults with T1DM physiologically respond to psychological stress in a dysregulated manner compared to non-diabetic peers, and if such individuals also demonstrated greater cognitive declines following psychological stress. Participants included 23 young adults with T1DM and 52 non-diabetic controls yoked to T1DM participants based on age, gender, ethnicity, participant education, and maternal education. Participants completed a laboratory-based social stressor, pre- and post-stressor neurocognitive testing, provided fingerstick blood spots (for glucose levels) and salivary samples (for cortisol levels) at five points across the protocol, and completed psychosocial questionnaires. Related measures ANOVAs were conducted to assess differences between T1DM participants and the average of yoked controls on cortisol and cognitive outcomes. Results demonstrated that differences in cortisol reactivity were dependent on T1DM participants' use of insulin pump therapy (IPT). T1DM participants not using IPT demonstrated elevated cortisol reactivity compared to matched controls. There was no difference in cortisol reactivity between the T1DM participants on IPT and matched controls. On the Stroop task, performance patterns did not differ between participants with T1DM not on IPT and matched controls. The performance of participants with T1DM on IPT slightly improved following the stressor and matched controls slightly worsened. On the Trail Making Test, the performance of participants with T1DM was not different following the stressor whereas participants without T1DM demonstrated a decline following the stressor. Participants with and without T1DM did not differ in patterns of performance on the Rey Verbal Learning Task, Sustained Attention Allocation Task, Controlled Oral Word Association Task, or overall cortisol output across participation. The results of this study are suggestive of an exaggerated cortisol response to psychological stress in T1DM and indicate potential direct and indirect protective influences of IPT.
ContributorsMarreiro, Catherine (Author) / Luecken, Linda (Thesis advisor) / Doane, Leah (Thesis advisor) / Barrera, Manuel (Committee member) / Aiken, Leona (Committee member) / Arizona State University (Publisher)
Created2013
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Description
The main objective of this study was to use a genetically-informative design to examine the putative influences of maternal perceived prenatal stress, obstetrical complications, and gestational age on infant dysregulation, competence, and developmental maturity. Specifically, whether or not prenatal and obstetrical environmental conditions modified the heritability of infant outcomes was

The main objective of this study was to use a genetically-informative design to examine the putative influences of maternal perceived prenatal stress, obstetrical complications, and gestational age on infant dysregulation, competence, and developmental maturity. Specifically, whether or not prenatal and obstetrical environmental conditions modified the heritability of infant outcomes was examined. A total of 291 mothers were interviewed when their twin infants were 12 months of age. Pregnancy and twin birth medical records were obtained to code obstetrical data. Utilizing behavioral genetic models, results indicated maternal perceived prenatal stress moderated genetic and environmental influences on developmental maturity whereas obstetrical complications moderated shared environmental influences on infant competence and nonshared environmental influences on developmental maturity. Gestational age moderated the heritability and nonshared environment of infant dysregulation, shared and nonshared environmental influences on competence, and nonshared environmental influences on developmental maturity. Taken together, prenatal and obstetric conditions were important nonlinear influences on infant outcomes. An evolutionary perspective may provide a framework for these findings, such that the prenatal environment programs the fetus to be adaptive to current environmental contexts. Specifically, prenatal stress governs gene expression through epigenetic processes. Findings highlight the utility of a genetically informative design for elucidating the role of prenatal and obstetric conditions in the etiology of infant developmental outcomes.
ContributorsMcDonald, Kristy (Author) / Lemery-Chalfant, Kathryn S (Thesis advisor) / Fabricius, William (Committee member) / Luecken, Linda (Committee member) / Spinrad, Tracy (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Cognitive reappraisal, or redefining the meaning of a stressful circumstance, is useful in regulating emotional responses to acute stressors and may be mobilized to up- or down- regulate the stressors’ emotional salience. A conceptually-related but more targeted emotion regulation strategy to that offered by cognitive reappraisal, termed positive cognitive shift,

Cognitive reappraisal, or redefining the meaning of a stressful circumstance, is useful in regulating emotional responses to acute stressors and may be mobilized to up- or down- regulate the stressors’ emotional salience. A conceptually-related but more targeted emotion regulation strategy to that offered by cognitive reappraisal, termed positive cognitive shift, was examined in the current study. Positive cognitive shift (“PCS”) is defined as a point of cognitive transformation during a chronic, stressful situation that alters the meaning and emotional salience of the situation for the individual. Key aspects of the PCS that differentiate it from the broader reappraisal construct are that it 1) is relevant to responses to chronic (versus acute) aversive events, 2) is deployed when there is a mismatch between coping and stressors, and 3) involves insight together with redefinition in meaning of the situation generating stress. The current study used qualitative and quantitative analyses to 1) examine whether PCS is an observable, reliable, and valid experience in response to a stressful event that occurred in the past year, and 2) test whether PCS moderates the relations between the number of past-year stressful life circumstances and subsequent emotional well-being and functional health. A community sample of 175 middle-aged individuals were interviewed regarded a past chronic stressor and completed questionnaires regarding number of past year stressors and health outcomes. Theory-based coding of interviews was conducted to derive reliable scores for PCS, and findings indicated that PCS was evident in 37.7 % of participant responses. Furthermore, PCS scores were related positively to openness, personal growth from one’s most difficult lifetime event, and affect intensity-calm, in line with predictions. Also in line with prediction, PCS moderated the relations between number of past-year life events and health outcomes, such that the deleterious relations between past year stressful events and cognitive functioning, wellbeing, positive affect, and negative affect were weaker among individuals higher versus lower in PCS. Of note, PCS moderation effects diminished as the number of stressful events increased.
ContributorsRivers, Crystal (Author) / Davis, Mary (Thesis advisor) / Luecken, Linda (Committee member) / Infurna, Frank (Committee member) / Robinson Kurpius, Sharon (Committee member) / Arizona State University (Publisher)
Created2018
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Longitudinal data from European-American (EA) and Mexican-American (MA) families (n = 179 mothers, fathers, and youth; 41% MA) was used to test a bio-psycho-cultural model of the effect of non-responsive parenting on externalizing problems in young adult offspring through the effect on the stress response system. Parenting behavior (acceptance, rejection,

Longitudinal data from European-American (EA) and Mexican-American (MA) families (n = 179 mothers, fathers, and youth; 41% MA) was used to test a bio-psycho-cultural model of the effect of non-responsive parenting on externalizing problems in young adult offspring through the effect on the stress response system. Parenting behavior (acceptance, rejection, harsh discipline) was assessed when children were in late childhood (12-13 years), cortisol samples were collected during late adolescence (18-19 years), and externalizing problems were measured in young adulthood (21-22 years). Latent profile analyses were used to examine patterns of parenting behavior in EA and MA families. A path analysis framework was used to examine how non-responsive parenting interacted with acceptance to predict adolescent stress response and subsequent externalizing problems in EA and MA young adults. Results showed different patterns of parenting behavior in EA versus MA families, with MA families demonstrating a profile of high acceptance and high non-responsiveness at higher rates than EA families. In MA families, youth adherence to the traditional cultural value of familismo related to more positive perceptions of parenting behavior. Across ethnic groups, parent rejection only predicted higher externalizing problems in young adults when acceptance was high. The effect of parent harsh discipline on offspring stress response differed by ethnicity. In MA families, harsh discipline predicted dysregulated stress response in youth when acceptance was low. In EA families, harsh discipline did not relate to youth stress response. Overall, results increase the understanding of normative and adaptive parenting behaviors in MA families. Findings inform the development of culturally-competent parenting-focused interventions that can better prevent dysregulated stress response and externalizing behavior problems in ethnically diverse youth.
ContributorsMahrer, Nicole Eva (Author) / Luecken, Linda (Thesis advisor) / Wolchik, Sharlene (Thesis advisor) / Tein, Jenn-Yun (Committee member) / Pina, Armando (Committee member) / Arizona State University (Publisher)
Created2015
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Research suggests that early family relationships have critical influences on later physical and psychological health, but most studies have focused on the influence of mothers ignoring the unique impacts of fathers. One mechanism by which families may transmit risk is by repeated activation of the hypothalamic-pituitary-adrenal (HPA) axis in the

Research suggests that early family relationships have critical influences on later physical and psychological health, but most studies have focused on the influence of mothers ignoring the unique impacts of fathers. One mechanism by which families may transmit risk is by repeated activation of the hypothalamic-pituitary-adrenal (HPA) axis in the short-term that leads to adult neurobiological dysregulaton, evident in hyper- or hypo-cortisol levels. Using 218 father-child dyads from the Parent and Youth Study (PAYS), the current study investigated whether father involvement in adolescence predicted youth cortisol AUCg and reactivity to a stress task in young adulthood, and whether this relation was mediated by youth perceptions of mattering to their fathers in adolescence. Results revealed that higher father-reported father involvement predicted lower cortisol AUCg in youth when mattering was included in the model, although father involvement was not a statistically significant predictor of AUCg or cortisol reactivity when mattering was not included. Additionally, children who reported higher father involvement also reported higher feelings of mattering, but this association was only statistically significant for girls and European American youth. Youth feelings of mattering did not predict their cortisol reactivity or AUCg in young adulthood. Results suggest that future research should include fathers when investigating the effects of family relationships on youth psychophysiological development.
ContributorsHanna, Mariam A (Author) / Luecken, Linda (Thesis advisor) / Wolchik, Sharlene (Committee member) / Fabricius, William (Committee member) / Arizona State University (Publisher)
Created2015
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Childhood obesity is associated with many well established health risks as well as high annual public health costs. Because of this, the childhood obesity literature has highlighted the need to detect at-risk groups in order to implement targeted preventions. Emotional eating has been identified as an unhealthy behavior and a

Childhood obesity is associated with many well established health risks as well as high annual public health costs. Because of this, the childhood obesity literature has highlighted the need to detect at-risk groups in order to implement targeted preventions. Emotional eating has been identified as an unhealthy behavior and a risk factor for overweight status among children though very little is known about what predisposes children to emotionally eat. Stress has often been found to elicit emotional eating but most studies looking at this relationship have relied on self-reports in adult and clinical samples. Thus, the current study seeks to investigate the relationship between stress reactivity (measured using heart rate variability) and emotional eating in a sample of 247 children between the ages of 4-6. Furthermore, levels of control may moderate the relationship between stress reactivity (HRV) and emotional eating. Linear regression analysis was used to explore these relationships. It was expected that higher levels of reactivity to stress would predict an increased likelihood of emotional eating. This association was expected to be attenuated among children with higher levels of inhibitory control and attentional focusing as well as lower levels of impulsivity. However, the hypothesized findings were not supported by the data. Despite these null findings, and in light of several limitations, it is still hypothesized that emotional eating involves physiological and impulsivity/effortful control processes. Implications of future research are discussed.
ContributorsOhrt, Tara K (Author) / Perez La Mar, Marisol (Thesis advisor) / Luecken, Linda (Committee member) / Lemery, Kathryn (Committee member) / Arizona State University (Publisher)
Created2016
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Description
The theory of biological sensitivity to context (BSC; Boyce & Ellis, 2005) posits that specific biological characteristics, such as vagal tone, may confer risk for physical and mental health outcomes for some children but promote health for others. High levels of resting respiratory sinus arrhythmia (RSA), an index of vagal

The theory of biological sensitivity to context (BSC; Boyce & Ellis, 2005) posits that specific biological characteristics, such as vagal tone, may confer risk for physical and mental health outcomes for some children but promote health for others. High levels of resting respiratory sinus arrhythmia (RSA), an index of vagal tone, may confer susceptibility to the effects of the caregiving environment on child development. Consistent with BSC, I expected that, relative to infants with lower RSA, infants with higher RSA would demonstrate fewer behavior problems if their mothers reported fewer postpartum depressive symptoms, but more behavior problems if their mothers reported more postpartum depressive symptoms. I also evaluated whether observed child social engagement with their mothers mediated children's biological sensitivity to the effects of postpartum depressive symptoms on behavior problems in early childhood. I evaluated a mediated moderation model among a sample of 322 low-income Mexican American mother-infant dyads. As expected, the RSA x maternal depressive symptoms interaction, controlling for covariates, was a significant predictor of internalizing, externalizing and total behavior problems, and high vagal tone conferred susceptibility for externalizing behavior problems. Contrary to my hypothesis, children with low RSA may be more susceptible to the effects of maternal postpartum depressive symptoms on children's internalizing and total behavior problems, and child social engagement did not account for these effects. Among infants in economically disadvantaged families, lower RSA and fewer maternal depressive symptoms may promote resilience, and more research is needed to understand behavioral mediators of biological sensitivity.
ContributorsSomers, Jennifer (Author) / Luecken, Linda (Thesis advisor) / Crnic, Keith (Committee member) / Spinrad, Tracy (Committee member) / Arizona State University (Publisher)
Created2017
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Description
The current study examined effects of representations of relationships with parents on young adults’ representations of romantic relationships and self-esteem, with particular attention paid to the role of fathers, instability of representations, and bidirectional effects. Data were obtained from two waves (Waves 4 and 5) of a five-wave study. At

The current study examined effects of representations of relationships with parents on young adults’ representations of romantic relationships and self-esteem, with particular attention paid to the role of fathers, instability of representations, and bidirectional effects. Data were obtained from two waves (Waves 4 and 5) of a five-wave study. At wave 4, 287 young adults (mean age = 20) participated, and at Wave 5, 276 young adults (mean age = 22) participated. One-time interviews (Behavioral Systems Questionnaires; BSQ) were conducted to measure the level of representations of relationships with parents. Nightly diary checklists (7 nights at Wave 4, and 5 nights at Wave 5) were used to measure the level and instability of representations of romantic relationships (BSQ) and self-esteem (Rosenberg Self Esteem Scale). Two styles of representations, including secure versus dismissing (e.g., relying on parents or romantic partners when distressed versus not relying on them) and preoccupied (e.g., worrying about rejection and excessive dependency) were measured for relationships with parents and romantic partners. The results showed evidence for unique roles of fathers, instability of representations, and bidirectional effects. Relationships with fathers affected young adults’ self-esteem. More nightly fluctuations in security with romantic partners predicted higher levels of security with romantic partners, but only in the context of more secure relationships. More nightly fluctuations in self-esteem predicted more dismissive representations of fathers. Bidirectional effects involved young adults’ representations of both romantic relationships and self-esteem, and their representations of relationships with parents. The relation between instability of representations of romantic relationships and later security in romantic relationships might represent learning about romantic relationships. The relation between instability of self-esteem and later dismissive styles with fathers (e.g., not relying on fathers when distressed) at this age might be an indication of learning to become autonomous from fathers. Finally, I also hypothesize that during emerging adulthood, fathers tend to encourage children to solve their stress or problems by themselves, while mothers tend to still provide help when children are distressed. These suggested hypotheses should be examined in future research.
ContributorsSuh, Go Woon (Author) / Fabricius, William (Thesis advisor) / Cookston, Jeffrey (Committee member) / Suk, Hye Won (Committee member) / Luecken, Linda (Committee member) / Arizona State University (Publisher)
Created2016
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Description
Dysregulated cortisol has been linked to a variety of adverse physical and psychological consequences. Stressors in the childhood family environment can influence cortisol activity throughout development. For example, research has shown that both infants and children of depressed mothers exhibit altered levels of cortisol compared to infants and children of

Dysregulated cortisol has been linked to a variety of adverse physical and psychological consequences. Stressors in the childhood family environment can influence cortisol activity throughout development. For example, research has shown that both infants and children of depressed mothers exhibit altered levels of cortisol compared to infants and children of non-depressed mothers. It is unclear, however, whether exposure to maternal depression in childhood and adolescence is related to cortisol activity at later stages of development. The current study examined the longitudinal relation between maternal depressive symptoms during late childhood (9-12 years old) and adolescence (15-19 years old) and cortisol activity in offspring in young adulthood (24- 28 years old) in a sample of 40 young adults and their mothers. Maternal depressive symptoms were prospectively assessed at four time points across the 15 year study. Cortisol samples were collected from young adult offspring at the final time point. Findings revealed that higher levels of maternal depressive symptoms during late childhood were associated with lower total cortisol output in young adulthood. Results suggest that attenuated cortisol levels, which put these young adults at risk for a variety of stress-related physical and psychological illnesses, may be a long-term consequence of exposure to maternal depression,. Depressive symptoms in mothers during their child's adolescence, however, did not relate to cortisol output. These findings suggest a sensitive period in late childhood during which the development of HPA activity may be susceptible to the environmental stressor of maternal depression.
ContributorsMahrer, Nicole Eva (Author) / Wolchik, Sharlene (Thesis advisor) / Luecken, Linda (Thesis advisor) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2011