The ability of Neandertals to cope with the oscillating climate of the late Pleistocene and the extent to which these climate changes affected local Neandertal habitats remain unanswered anthropological topics of considerable scientific interest. Understanding the impact of climatic instability on Neandertals is critical for reconstructing the behaviors of our closest fossil relatives and possibly identifying factors that contributed to their extinction. My work aimed to test the hypotheses that 1) cold climates stressed Neandertal populations, and 2) that global climate changes affected local Neandertal habitats. An analysis of Neandertal butchering on Cervus elaphus, Rangifer tarandus, and Capreolus capreolus skeletal material deposited during global warm and cold phases from two French sites - Pech de l'Azé IV and Roc de Marsal - was conducted to assess the impact of climate change on butchering strategies and resource extraction. Results from a statistical analysis of surface modification on all marrow yielding long bones, including the 1st phalanx, demonstrated that specimens excavated from the cold levels at each cave have more cut marks (Wald χ2= 51.33, p= <0.001) and percussion marks (Wald χ2= 4.92, p= 0.02) than specimens from the warm levels after controlling for fragment size. These results support the hypothesis that Neandertals were nutritionally stressed during glacial cycles. The hypothesis that global climates affected local habitats was tested through radiogenic strontium isotopic reconstruction of large herbivore mobility patterns (e.g., Bison, Equus, Cervus and Rangifer), because it is known that in the northern hemisphere, mammals migrate less in warm, well-vegetated environments, but more in cold, open environments. Identifying isotopic variation in mammalian fossils enables mobility patterns to be inferred, providing an indication of whether environments at Pech de l'Azé IV and Roc de Marsal tracked global climates. Results from this study indicate that Neandertal prey species within the Dordogne Valley of France did not undertake long distance round-trip migrations in glacial or interglacial cycles, maintaining the possibility that local habitats did not change in differing climatic cycles. However, because Neandertals were nutritionally stressed the most likely conclusion is that glacial cycles decreased herbivore populations, thus stressing Neandertals.