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Description
In recent years, machine learning and data mining technologies have received growing attention in several areas such as recommendation systems, natural language processing, speech and handwriting recognition, image processing and biomedical domain. Many of these applications which deal with physiological and biomedical data require person specific or person adaptive systems. The greatest challenge in developing such systems is the subject-dependent data variations or subject-based variability in physiological and biomedical data, which leads to difference in data distributions making the task of modeling these data, using traditional machine learning algorithms, complex and challenging. As a result, despite the wide application of machine learning, efficient deployment of its principles to model real-world data is still a challenge. This dissertation addresses the problem of subject based variability in physiological and biomedical data and proposes person adaptive prediction models based on novel transfer and active learning algorithms, an emerging field in machine learning. One of the significant contributions of this dissertation is a person adaptive method, for early detection of muscle fatigue using Surface Electromyogram signals, based on a new multi-source transfer learning algorithm. This dissertation also proposes a subject-independent algorithm for grading the progression of muscle fatigue from 0 to 1 level in a test subject, during isometric or dynamic contractions, at real-time. Besides subject based variability, biomedical image data also varies due to variations in their imaging techniques, leading to distribution differences between the image databases. Hence a classifier learned on one database may perform poorly on the other database. Another significant contribution of this dissertation has been the design and development of an efficient biomedical image data annotation framework, based on a novel combination of transfer learning and a new batch-mode active learning method, capable of addressing the distribution differences across databases. The methodologies developed in this dissertation are relevant and applicable to a large set of computing problems where there is a high variation of data between subjects or sources, such as face detection, pose detection and speech recognition. From a broader perspective, these frameworks can be viewed as a first step towards design of automated adaptive systems for real world data.
ContributorsChattopadhyay, Rita (Author) / Panchanathan, Sethuraman (Thesis advisor) / Ye, Jieping (Thesis advisor) / Li, Baoxin (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2013
Description
Real-world environments are characterized by non-stationary and continuously evolving data. Learning a classification model on this data would require a framework that is able to adapt itself to newer circumstances. Under such circumstances, transfer learning has come to be a dependable methodology for improving classification performance with reduced training costs and without the need for explicit relearning from scratch. In this thesis, a novel instance transfer technique that adapts a "Cost-sensitive" variation of AdaBoost is presented. The method capitalizes on the theoretical and functional properties of AdaBoost to selectively reuse outdated training instances obtained from a "source" domain to effectively classify unseen instances occurring in a different, but related "target" domain. The algorithm is evaluated on real-world classification problems namely accelerometer based 3D gesture recognition, smart home activity recognition and text categorization. The performance on these datasets is analyzed and evaluated against popular boosting-based instance transfer techniques. In addition, supporting empirical studies, that investigate some of the less explored bottlenecks of boosting based instance transfer methods, are presented, to understand the suitability and effectiveness of this form of knowledge transfer.
ContributorsVenkatesan, Ashok (Author) / Panchanathan, Sethuraman (Thesis advisor) / Li, Baoxin (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2011
Description
Discriminative learning when training and test data belong to different distributions is a challenging and complex task. Often times we have very few or no labeled data from the test or target distribution, but we may have plenty of labeled data from one or multiple related sources with different distributions. Due to its capability of migrating knowledge from related domains, transfer learning has shown to be effective for cross-domain learning problems. In this dissertation, I carry out research along this direction with a particular focus on designing efficient and effective algorithms for BioImaging and Bilingual applications. Specifically, I propose deep transfer learning algorithms which combine transfer learning and deep learning to improve image annotation performance. Firstly, I propose to generate the deep features for the Drosophila embryo images via pretrained deep models and build linear classifiers on top of the deep features. Secondly, I propose to fine-tune the pretrained model with a small amount of labeled images. The time complexity and performance of deep transfer learning methodologies are investigated. Promising results have demonstrated the knowledge transfer ability of proposed deep transfer algorithms. Moreover, I propose a novel Robust Principal Component Analysis (RPCA) approach to process the noisy images in advance. In addition, I also present a two-stage re-weighting framework for general domain adaptation problems. The distribution of source domain is mapped towards the target domain in the first stage, and an adaptive learning model is proposed in the second stage to incorporate label information from the target domain if it is available. Then the proposed model is applied to tackle cross lingual spam detection problem at LinkedIn’s website. Our experimental results on real data demonstrate the efficiency and effectiveness of the proposed algorithms.
ContributorsSun, Qian (Author) / Ye, Jieping (Committee member) / Xue, Guoliang (Committee member) / Liu, Huan (Committee member) / Li, Jing (Committee member) / Arizona State University (Publisher)
Created2015
Description
Machine learning models convert raw data in the form of video, images, audio,
text, etc. into feature representations that are convenient for computational process-
ing. Deep neural networks have proven to be very efficient feature extractors for a
variety of machine learning tasks. Generative models based on deep neural networks
introduce constraints on the feature space to learn transferable and disentangled rep-
resentations. Transferable feature representations help in training machine learning
models that are robust across different distributions of data. For example, with the
application of transferable features in domain adaptation, models trained on a source
distribution can be applied to a data from a target distribution even though the dis-
tributions may be different. In style transfer and image-to-image translation, disen-
tangled representations allow for the separation of style and content when translating
images.
This thesis examines learning transferable data representations in novel deep gen-
erative models. The Semi-Supervised Adversarial Translator (SAT) utilizes adversar-
ial methods and cross-domain weight sharing in a neural network to extract trans-
ferable representations. These transferable interpretations can then be decoded into
the original image or a similar image in another domain. The Explicit Disentangling
Network (EDN) utilizes generative methods to disentangle images into their core at-
tributes and then segments sets of related attributes. The EDN can separate these
attributes by controlling the ow of information using a novel combination of losses
and network architecture. This separation of attributes allows precise modi_cations
to speci_c components of the data representation, boosting the performance of ma-
chine learning tasks. The effectiveness of these models is evaluated across domain
adaptation, style transfer, and image-to-image translation tasks.
text, etc. into feature representations that are convenient for computational process-
ing. Deep neural networks have proven to be very efficient feature extractors for a
variety of machine learning tasks. Generative models based on deep neural networks
introduce constraints on the feature space to learn transferable and disentangled rep-
resentations. Transferable feature representations help in training machine learning
models that are robust across different distributions of data. For example, with the
application of transferable features in domain adaptation, models trained on a source
distribution can be applied to a data from a target distribution even though the dis-
tributions may be different. In style transfer and image-to-image translation, disen-
tangled representations allow for the separation of style and content when translating
images.
This thesis examines learning transferable data representations in novel deep gen-
erative models. The Semi-Supervised Adversarial Translator (SAT) utilizes adversar-
ial methods and cross-domain weight sharing in a neural network to extract trans-
ferable representations. These transferable interpretations can then be decoded into
the original image or a similar image in another domain. The Explicit Disentangling
Network (EDN) utilizes generative methods to disentangle images into their core at-
tributes and then segments sets of related attributes. The EDN can separate these
attributes by controlling the ow of information using a novel combination of losses
and network architecture. This separation of attributes allows precise modi_cations
to speci_c components of the data representation, boosting the performance of ma-
chine learning tasks. The effectiveness of these models is evaluated across domain
adaptation, style transfer, and image-to-image translation tasks.
ContributorsEusebio, Jose Miguel Ang (Author) / Panchanathan, Sethuraman (Thesis advisor) / Davulcu, Hasan (Committee member) / Venkateswara, Hemanth (Committee member) / Arizona State University (Publisher)
Created2018
Description
Transfer learning is a sub-field of statistical modeling and machine learning. It refers to methods that integrate the knowledge of other domains (called source domains) and the data of the target domain in a mathematically rigorous and intelligent way, to develop a better model for the target domain than a model using the data of the target domain alone. While transfer learning is a promising approach in various application domains, my dissertation research focuses on the particular application in health care, including telemonitoring of Parkinson’s Disease (PD) and radiomics for glioblastoma.
The first topic is a Mixed Effects Transfer Learning (METL) model that can flexibly incorporate mixed effects and a general-form covariance matrix to better account for similarity and heterogeneity across subjects. I further develop computationally efficient procedures to handle unknown parameters and large covariance structures. Domain relations, such as domain similarity and domain covariance structure, are automatically quantified in the estimation steps. I demonstrate METL in an application of smartphone-based telemonitoring of PD.
The second topic focuses on an MRI-based transfer learning algorithm for non-invasive surgical guidance of glioblastoma patients. Limited biopsy samples per patient create a challenge to build a patient-specific model for glioblastoma. A transfer learning framework helps to leverage other patient’s knowledge for building a better predictive model. When modeling a target patient, not every patient’s information is helpful. Deciding the subset of other patients from which to transfer information to the modeling of the target patient is an important task to build an accurate predictive model. I define the subset of “transferrable” patients as those who have a positive rCBV-cell density correlation, because a positive correlation is confirmed by imaging theory and the its respective literature.
The last topic is a Privacy-Preserving Positive Transfer Learning (P3TL) model. Although negative transfer has been recognized as an important issue by the transfer learning research community, there is a lack of theoretical studies in evaluating the risk of negative transfer for a transfer learning method and identifying what causes the negative transfer. My work addresses this issue. Driven by the theoretical insights, I extend Bayesian Parameter Transfer (BPT) to a new method, i.e., P3TL. The unique features of P3TL include intelligent selection of patients to transfer in order to avoid negative transfer and maintain patient privacy. These features make P3TL an excellent model for telemonitoring of PD using an At-Home Testing Device.
The first topic is a Mixed Effects Transfer Learning (METL) model that can flexibly incorporate mixed effects and a general-form covariance matrix to better account for similarity and heterogeneity across subjects. I further develop computationally efficient procedures to handle unknown parameters and large covariance structures. Domain relations, such as domain similarity and domain covariance structure, are automatically quantified in the estimation steps. I demonstrate METL in an application of smartphone-based telemonitoring of PD.
The second topic focuses on an MRI-based transfer learning algorithm for non-invasive surgical guidance of glioblastoma patients. Limited biopsy samples per patient create a challenge to build a patient-specific model for glioblastoma. A transfer learning framework helps to leverage other patient’s knowledge for building a better predictive model. When modeling a target patient, not every patient’s information is helpful. Deciding the subset of other patients from which to transfer information to the modeling of the target patient is an important task to build an accurate predictive model. I define the subset of “transferrable” patients as those who have a positive rCBV-cell density correlation, because a positive correlation is confirmed by imaging theory and the its respective literature.
The last topic is a Privacy-Preserving Positive Transfer Learning (P3TL) model. Although negative transfer has been recognized as an important issue by the transfer learning research community, there is a lack of theoretical studies in evaluating the risk of negative transfer for a transfer learning method and identifying what causes the negative transfer. My work addresses this issue. Driven by the theoretical insights, I extend Bayesian Parameter Transfer (BPT) to a new method, i.e., P3TL. The unique features of P3TL include intelligent selection of patients to transfer in order to avoid negative transfer and maintain patient privacy. These features make P3TL an excellent model for telemonitoring of PD using an At-Home Testing Device.
ContributorsYoon, Hyunsoo (Author) / Li, Jing (Thesis advisor) / Wu, Teresa (Committee member) / Yan, Hao (Committee member) / Hu, Leland S. (Committee member) / Arizona State University (Publisher)
Created2018
Description
Transfer learning refers to statistical machine learning methods that integrate the knowledge of one domain (source domain) and the data of another domain (target domain) in an appropriate way, in order to develop a model for the target domain that is better than a model using the data of the target domain alone. Transfer learning emerged because classic machine learning, when used to model different domains, has to take on one of two mechanical approaches. That is, it will either assume the data distributions of the different domains to be the same and thereby developing one model that fits all, or develop one model for each domain independently. Transfer learning, on the other hand, aims to mitigate the limitations of the two approaches by accounting for both the similarity and specificity of related domains. The objective of my dissertation research is to develop new transfer learning methods and demonstrate the utility of the methods in real-world applications. Specifically, in my methodological development, I focus on two different transfer learning scenarios: spatial transfer learning across different domains and temporal transfer learning along time in the same domain. Furthermore, I apply the proposed spatial transfer learning approach to modeling of degenerate biological systems.Degeneracy is a well-known characteristic, widely-existing in many biological systems, and contributes to the heterogeneity, complexity, and robustness of biological systems. In particular, I study the application of one degenerate biological system which is to use transcription factor (TF) binding sites to predict gene expression across multiple cell lines. Also, I apply the proposed temporal transfer learning approach to change detection of dynamic network data. Change detection is a classic research area in Statistical Process Control (SPC), but change detection in network data has been limited studied. I integrate the temporal transfer learning method called the Network State Space Model (NSSM) and SPC and formulate the problem of change detection from dynamic networks into a covariance monitoring problem. I demonstrate the performance of the NSSM in change detection of dynamic social networks.
ContributorsZou, Na (Author) / Li, Jing (Thesis advisor) / Baydogan, Mustafa (Committee member) / Borror, Connie (Committee member) / Montgomery, Douglas C. (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2015
Description
Large datasets of sub-meter aerial imagery represented as orthophoto mosaics are widely available today, and these data sets may hold a great deal of untapped information. This imagery has a potential to locate several types of features; for example, forests, parking lots, airports, residential areas, or freeways in the imagery. However, the appearances of these things vary based on many things including the time that the image is captured, the sensor settings, processing done to rectify the image, and the geographical and cultural context of the region captured by the image. This thesis explores the use of deep convolutional neural networks to classify land use from very high spatial resolution (VHR), orthorectified, visible band multispectral imagery. Recent technological and commercial applications have driven the collection a massive amount of VHR images in the visible red, green, blue (RGB) spectral bands, this work explores the potential for deep learning algorithms to exploit this imagery for automatic land use/ land cover (LULC) classification. The benefits of automatic visible band VHR LULC classifications may include applications such as automatic change detection or mapping. Recent work has shown the potential of Deep Learning approaches for land use classification; however, this thesis improves on the state-of-the-art by applying additional dataset augmenting approaches that are well suited for geospatial data. Furthermore, the generalizability of the classifiers is tested by extensively evaluating the classifiers on unseen datasets and we present the accuracy levels of the classifier in order to show that the results actually generalize beyond the small benchmarks used in training. Deep networks have many parameters, and therefore they are often built with very large sets of labeled data. Suitably large datasets for LULC are not easy to come by, but techniques such as refinement learning allow networks trained for one task to be retrained to perform another recognition task. Contributions of this thesis include demonstrating that deep networks trained for image recognition in one task (ImageNet) can be efficiently transferred to remote sensing applications and perform as well or better than manually crafted classifiers without requiring massive training data sets. This is demonstrated on the UC Merced dataset, where 96% mean accuracy is achieved using a CNN (Convolutional Neural Network) and 5-fold cross validation. These results are further tested on unrelated VHR images at the same resolution as the training set.
ContributorsUba, Nagesh Kumar (Author) / Femiani, John (Thesis advisor) / Razdan, Anshuman (Committee member) / Amresh, Ashish (Committee member) / Arizona State University (Publisher)
Created2016
Description
The widespread adoption of computer vision models is often constrained by the issue of domain mismatch. Models that are trained with data belonging to one distribution, perform poorly when tested with data from a different distribution. Variations in vision based data can be attributed to the following reasons, viz., differences in image quality (resolution, brightness, occlusion and color), changes in camera perspective, dissimilar backgrounds and an inherent diversity of the samples themselves. Machine learning techniques like transfer learning are employed to adapt computational models across distributions. Domain adaptation is a special case of transfer learning, where knowledge from a source domain is transferred to a target domain in the form of learned models and efficient feature representations.
The dissertation outlines novel domain adaptation approaches across different feature spaces; (i) a linear Support Vector Machine model for domain alignment; (ii) a nonlinear kernel based approach that embeds domain-aligned data for enhanced classification; (iii) a hierarchical model implemented using deep learning, that estimates domain-aligned hash values for the source and target data, and (iv) a proposal for a feature selection technique to reduce cross-domain disparity. These adaptation procedures are tested and validated across a range of computer vision applications like object classification, facial expression recognition, digit recognition, and activity recognition. The dissertation also provides a unique perspective of domain adaptation literature from the point-of-view of linear, nonlinear and hierarchical feature spaces. The dissertation concludes with a discussion on the future directions for research that highlight the role of domain adaptation in an era of rapid advancements in artificial intelligence.
The dissertation outlines novel domain adaptation approaches across different feature spaces; (i) a linear Support Vector Machine model for domain alignment; (ii) a nonlinear kernel based approach that embeds domain-aligned data for enhanced classification; (iii) a hierarchical model implemented using deep learning, that estimates domain-aligned hash values for the source and target data, and (iv) a proposal for a feature selection technique to reduce cross-domain disparity. These adaptation procedures are tested and validated across a range of computer vision applications like object classification, facial expression recognition, digit recognition, and activity recognition. The dissertation also provides a unique perspective of domain adaptation literature from the point-of-view of linear, nonlinear and hierarchical feature spaces. The dissertation concludes with a discussion on the future directions for research that highlight the role of domain adaptation in an era of rapid advancements in artificial intelligence.
ContributorsDemakethepalli Venkateswara, Hemanth (Author) / Panchanathan, Sethuraman (Thesis advisor) / Li, Baoxin (Committee member) / Davulcu, Hasan (Committee member) / Ye, Jieping (Committee member) / Chakraborty, Shayok (Committee member) / Arizona State University (Publisher)
Created2017
Description
In this thesis, the applications of deep learning in the analysis, detection and classification of medical imaging datasets were studied, with a focus on datasets having a limited sample size. A combined machine learning-deep learning model was designed to classify one small dataset, prostate cancer provided by Mayo Clinic, Arizona. Deep learning model was implemented to extract imaging features followed by machine learning classifier for prostate cancer diagnosis. The results were compared against models trained on texture-based features, namely gray level co-occurrence matrix (GLCM) and Gabor. Some of the challenges of performing diagnosis on medical imaging datasets with limited sample sizes, have been identified. Lastly, a set of future works have been proposed. Keywords: Deep learning, radiology, transfer learning, convolutional neural network.
ContributorsSarkar, Suryadipto (Author) / Wu, Teresa (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Silva, Alvin (Committee member) / Arizona State University (Publisher)
Created2021
Description
Deep learning is a sub-field of machine learning in which models are developed to imitate the workings of the human brain in processing data and creating patterns for decision making. This dissertation is focused on developing deep learning models for medical imaging analysis of different modalities for different tasks including detection, segmentation and classification. Imaging modalities including digital mammography (DM), magnetic resonance imaging (MRI), positron emission tomography (PET) and computed tomography (CT) are studied in the dissertation for various medical applications. The first phase of the research is to develop a novel shallow-deep convolutional neural network (SD-CNN) model for improved breast cancer diagnosis. This model takes one type of medical image as input and synthesizes different modalities for additional feature sources; both original image and synthetic image are used for feature generation. This proposed architecture is validated in the application of breast cancer diagnosis and proved to be outperforming the competing models. Motivated by the success from the first phase, the second phase focuses on improving medical imaging synthesis performance with advanced deep learning architecture. A new architecture named deep residual inception encoder-decoder network (RIED-Net) is proposed. RIED-Net has the advantages of preserving pixel-level information and cross-modality feature transferring. The applicability of RIED-Net is validated in breast cancer diagnosis and Alzheimer’s disease (AD) staging. Recognizing medical imaging research often has multiples inter-related tasks, namely, detection, segmentation and classification, my third phase of the research is to develop a multi-task deep learning model. Specifically, a feature transfer enabled multi-task deep learning model (FT-MTL-Net) is proposed to transfer high-resolution features from segmentation task to low-resolution feature-based classification task. The application of FT-MTL-Net on breast cancer detection, segmentation and classification using DM images is studied. As a continuing effort on exploring the transfer learning in deep models for medical application, the last phase is to develop a deep learning model for both feature transfer and knowledge from pre-training age prediction task to new domain of Mild cognitive impairment (MCI) to AD conversion prediction task. It is validated in the application of predicting MCI patients’ conversion to AD with 3D MRI images.
ContributorsGao, Fei (Author) / Wu, Teresa (Thesis advisor) / Li, Jing (Committee member) / Yan, Hao (Committee member) / Patel, Bhavika (Committee member) / Arizona State University (Publisher)
Created2019