Matching Items (29)
Description
How early life is experienced and perceived can greatly affect mental and physical health outcomes. An individual is greatly influenced by their first models of what social relationships look and feel like, and with time also learn how to survive when less favorable social experiences occur. The lessons learned may lead to healthy problem solving and resilience, or it may lead to unhealthy problem-solving habits that hinder well-being. Anxious thoughts and other mental health symptoms may accompany an individual long-term and hinder an essential need for a healthy life. The first main purpose of this thesis is to examine the impact of Adverse Childhood Experiences (ACEs) on mental health (anxiety symptoms), and on sleep quality (an essential need). The second purpose of my thesis is to investigate the impact of genetics on resilience, specifically, the mu-opioid receptor gene. The first hypothesis proposed ACEs that were perceived as more traumatic and occurred more frequently would be associated with more poor sleep quality symptoms. The second hypothesis predicted that anxiety symptoms would mediate the association. The third hypothesis (exploratory) suggested that an individual’s alleles for the mu-opioid receptor gene would moderate the mediation pathway. The study was conducted with 318 participants between the ages of 18 and 35 years old. The study demonstrated a direct effect for ACEs and sleep. Anxiety mediated the association between ACEs (exposure and severity) and sleep (insomnia, quality, sleepiness), suggesting that ACEs possibly increase feelings of anxiety which, in turn, lead to worse sleep outcomes. Finally, the moderated-mediation model with OPRM1 as the moderator, was not significant for the mediation pathway A; however, there was a significant interaction with anxiety and sleep symptoms.
ContributorsBailey, Elise (Author) / Mickelson, Kristin (Thesis advisor) / Burleson, Mary (Committee member) / Petrov, Megan (Committee member) / Arizona State University (Publisher)
Created2022
Description
More than a century of research has investigated the etiology of dyslexia, coalescing around ‘phonological awareness’ – the ability to recognize and manipulate phonemes – as a trait typically deficient in reading disorders. Meanwhile, the last few decades of research in neuroscience have highlighted the brain as a predictive organ, which subliminally calibrates sensory expectations according to experience. Do the brains of adults with dyslexia respond differently than those of matched controls to expected tones and unexpected omissions? While auditory oddball paradigms have previously been used to study dyslexia, these studies often interpret group differences to indicate deficit auditory discrimination rather than deficit auditory prediction. The current study takes a step toward fusing theories of predictive coding and dyslexia, finding that event-related potentials related to auditory prediction are attenuated in adults with dyslexia compared with typical controls. It further suggests that understanding dyslexia, and perhaps other psychiatric disorders, in terms of contributory neural systems will elucidate shared and distinct etiologies.
ContributorsBennett, Augustin (Author) / Peter, Beate (Thesis advisor) / Daliri, Ayoub (Committee member) / Goldinger, Stephen (Committee member) / Arizona State University (Publisher)
Created2023
Description
This thesis illustrates that Kanner held an explicitly descriptive frame of reference toward his eleven child patients, their parents, and autism. Adolf Meyer, his mentor at Johns Hopkins, trained him to make detailed life-charts under a clinical framework called psychobiology. By understanding that Kanner was a psychobiologist by training, I revisit the original definition of autism as a category of mental disorder and restate its terms. This history illuminates the theoretical context of autism's discovery and has important implications for the first definition of autism amidst shifting theories of childhood mental disorders and the place of the natural sciences in defining them.
ContributorsCohmer, Sean (Author) / Tuoti, Whitney Alexandra (Editor) / Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia. (Publisher) / Arizona Board of Regents (Publisher)
Created2020-11-03
Description
Computer-based environments provide a window into the complex and multifaceted learning process. These systems often collect a vast amount of information concerning how users choose to engage and behave within the interface (i.e., click streams, language input, and choices). Researchers have begun to use this information to gain a deeper understanding of users’ cognition, attitudes, and abilities. This dissertation is comprised of two published articles that describe how post-hoc and real-time analyses of trace data provides fine-grained details about how users regulate, process, and approach various learning tasks within computer-based environments. This work aims to go beyond simply understanding users’ skills and abilities, and instead focuses on understanding how users approach various tasks and subsequently using this information in real-time to enhance and personalize the user’s learning experience.
ContributorsSnow, Erica L (Author) / McNamara, Danielle S. (Thesis advisor) / Connor, Carol (Committee member) / Winne, Phillip (Committee member) / Duran, Nicholas (Committee member) / Arizona State University (Publisher)
Created2015
Description
Schizophrenia, a debilitating neuropsychiatric disorder, affects 1% of the population. This multifaceted disorder is comprised of positive (hallucinations/psychosis), negative (social withdrawal/anhedonia) and cognitive symptoms. While treatments for schizophrenia have advanced over the past few years, high economic burdens are still conferred to society, totaling more than $34 billion in direct annual costs to the United States of America. Thus, a critical need exists to identify the factors that contribute towards the etiology of schizophrenia. This research aimed to determine the interactions between environmental factors and genetics in the etiology of schizophrenia. Specifically, this research shows that the immediate early gene, early growth response 3 (EGR3), which is upregulated in response to neuronal activity, resides at the center of a biological pathway to confer risk for schizophrenia. While schizophrenia-risk proteins including neuregulin 1 (NRG1) and N-methyl-D-aspartate receptors (NMDAR’s) have been identified upstream of EGR3, the downstream targets of EGR3 remain relatively unknown. This research demonstrates that early growth response 3 regulates the expression of the serotonin 2A-receptor (5HT2AR) in the frontal cortex following the physiologic stimulus, sleep deprivation. This effect is translated to the level of protein as 8 hours of sleep-deprivation results in the upregulation of 5HT2ARs, a target of antipsychotic medications. Additional downstream targets were identified following maximal upregulation of EGR3 through electroconvulsive stimulation (ECS). Both brain-derived neurotrophic factor (BDNF) and its epigenetic regulator, growth arrest DNA-damage-inducible 45 beta (GADD45B) are upregulated one-hour following ECS in the hippocampus and require the presence of EGR3. These proteins play important roles in both cellular proliferation and dendritic structural changes. Next, the effects of ECS on downstream neurobiological processes, hippocampal cellular proliferation and dendritic structural changes were examined. Following ECS, hippocampal cellular proliferationwas increased, and dendritic structural changes were observed in both wild-type and early growth response 3 knock-out (Egr3-/-) mice. Effects in the number of dendritic spines and dendritic complexity following ECS were not found to require EGR3. Collectively, these results demonstrate that neuronal activity leads to the regulation of schizophrenia risk proteins by EGR3 and point to a possible molecular mechanism contributing risk for schizophrenia.
ContributorsMeyers, Kimberly (Author) / Gallitano, Amelia L (Thesis advisor) / Newbern, Jason (Thesis advisor) / Mangone, Marco (Committee member) / Nikulina, Ella (Committee member) / Qiu, Shenfeng (Committee member) / Ferguson, Deveroux (Committee member) / Arizona State University (Publisher)
Created2020
Description
This study provides insights into expanding the concepts of community arts in general and more specifically community-based art practices (CAP); highlights the participatory characteristics in the processes of CAP, and seeks to discern the mechanism that contributes to the formation of community collective identity. Revolving around Bhattacharyya’s (1995, 2004) conceptualization of community development, this study found it essential for exploring the fundamental concept of community in relation to community identity. To examine the concept of community identity, this research anchors the inquiry by studying how community-based art practice contributes to community identification and seeks to discover the connection between identity process and social change. The research also discusses the emergent concepts that serve as influential factors to the formation of community identity and proposes an alternative identification mechanism, ‘jen-tung’ process, which provides a needed new dimension to the existing theories of social identity formation and community efficacy development.
ContributorsHsia, Chiamei (Author) / Knopf, Richard C. (Thesis advisor) / Buzinde, Christine (Committee member) / de la Garza, Sarah Amira (Committee member) / Shockley, Gordon (Committee member) / Arizona State University (Publisher)
Created2020
Description
Post-Traumatic Stress Disorder (PTSD) is characterized by intrusive memories from a traumatic event. Current therapies rarely lead to complete remission. PTSD can be modeled in rodents using chronic stress (creating vulnerable phenotype) combined with fear conditioning (modeling a traumatic experience), resulting in attenuated extinction learning and impaired recall of extinction. Studies typically investigate cognition soon after chronic stress ends; however, as days and weeks pass (“rest” period) some cognitive functions may improve compared to soon after stress. Whether a rest period between chronic stress and fear conditioning/extinction would lead to improvements is unclear. In Chapter 2, male rats were chronically stressed by restraint (6hr/d/21d), a reliable method to produce cognitive changes, or assigned to a non-stressed control group (CON). After chronic stress ended, fear conditioning occurred within a day (STR-IMM), or after three (STR-R3) or six weeks (STR-R6). During the first three extinction trials, differences emerged in fear to the non-shock context: STR-R3/R6 showed significantly less fear to the context than did STR-IMM or CON. Differences were unlikely attributable to generalization or to second-order conditioning. Therefore, a rest period following chronic stress may lead to improved fear extinction and discrimination between the conditioned stimulus and environment. In Chapter 3, the infralimbic cortex (IL) was investigated due to the IL’s importance in fear extinction. Rats were infused with chemogenetics to target IL glutamatergic neurons and then assigned to CON, STR-IMM or STR-R3. During the rest period of STR-R3 and the restraint for STR-IMM, the IL was inhibited using CNO (1mg/kg BW, i.p., daily), which ended before behavioral testing. STR-R3 with IL inhibition failed to demonstrate a tone-shock association as spontaneous recovery was not observed. CON with IL inhibition behaved somewhat like STR-IMM; freezing to the extinction context was enhanced. Consequently, inhibiting IL function during the rest period following chronic stress was particularly disruptive for learning in STR-R3, impaired freezing to a safe context for CON, and had no effect in STR-IMM. These studies show that time since the end of chronic stress (recently ended or with a delay) can interact with IL functioning to modify fear learning and response.
ContributorsJudd, Jessica Michelle (Author) / Conrad, Cheryl D. (Thesis advisor) / Sanabria, Federico (Committee member) / Olive, Michael F (Committee member) / Bimonte-Nelson, Heather A. (Committee member) / Arizona State University (Publisher)
Created2020
Description
Activity in the sympathetic branch of the autonomic nervous system tends tocovary amongst romantic partners. Studies of interpersonal physiology suggest that
romantic partners possess the ability to influence each other’s physiological states, which
may be observable through systematic covariation in partners’ physiological activity (i.e.,
physiological synchrony). However, very few studies have directly tested physiological
synchrony across conversation contexts, which is a notable gap in the literature given that
social context may modulate the implications of physiological synchrony on relational
functioning. Using electrodermal skin conductance as a measure of autonomic activity,
this study used multilevel vector autoregressive modeling to test for time-lagged
physiological synchrony across different-gender romantic partners while they discuss 1) a
mutual stress and 2) a topic of mutual enjoyment. Strong carryover (i.e., autoregressive)
effects were observed in both female and male partners in both conversations.
Unidirectional time-lagged synchrony was observed in the mutual stress conversation,
with female skin conductance preceding and predicting male skin conductance, on
average. No time-lagged synchrony effects were observed in the enjoyment conversation,
on average. Across both conversations, physiological synchrony varied greatly between
each couple. Findings prompt future studies to further explore physiological synchrony
using multiple physiological indicators to identity couple-specific dynamics.
ContributorsLeon, Gabriel Aaron (Author) / Randall, Ashley K (Thesis advisor) / Bludworth, James (Committee member) / Burleson, Mary H (Committee member) / Duran, Nicholas D (Committee member) / Arizona State University (Publisher)
Created2021
Description
The hypothalamic pituitary adrenal (HPA) axis is a primary neuroendocrine system posited to mediate the associations between early life stress and long-term deleterious psychological and physical health outcomes. The effects of early life adversity on HPA axis functioning have been well-documented in primarily White samples, with statistical advances allowing researchers to isolate latent trait cortisol as a stable indicator of HPA axis functioning to account for day-to-day influences on diurnal cortisol patterns. However, directional associations have been mixed depending on developmental stage, demographic composition, and methodological differences across studies. The few studies of early adversity and HPA axis functioning in Hispanic/Latino/a/x samples demonstrate complex interactions between cultural processes and adversity in predicting HPA axis output. Further, nascent literature has isolated the cognitive, meaning-making, and prosocial skills involved in ethnic racial identity (ERI) and its subconstructs of exploration, resolution, and affirmation as promotive during the adolescent stage of development in Latinx youth. Such skills might better prepare youth for neurobiological stress regulation after adversity. To my knowledge, no study has examined whether ERI plays a protective role against the effects of early adversity on trait-level indicators of the HPA axis during adolescence, despite the particularly high rates of cumulative exposure to early life adversity in Latinx youth as compared to White counterparts. Guided by adaptive cultural resilience theories, this study of 197 socioeconomically diverse Latinx older-adolescents aimed to leverage recent findings of stable trait indicators of cortisol output to 1) identify consistent directional markers of the effects of early life adversity on latent trait cortisol in a Latinx sample and 2) elucidate the degree to which ERI might act as a promotive feature for HPA axis levels and protective factor against cumulative early life adversity. Confirmatory factor analyses identified a theory-driven model as an adequate measure of latent trait cortisol. Greater exposure to early adversity predicted lower latent trait cortisol, but ERI demonstrated neither protective nor promotive effects. The present study reifies that early adversity exposure has deleterious effects on trait-level HPA axis functioning, but identifying sources of cultural resilience among Latinx youth remains critical for the future of health equity.
ContributorsGusman, Michaela S. (Author) / Doane, Leah D (Thesis advisor) / Causadias, José M (Committee member) / Grimm, Kevin J (Committee member) / Wolchik, Sharlene A (Committee member) / Arizona State University (Publisher)
Created2022