Matching Items (4)
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- All Subjects: Physical anthropology
- Creators: Stojanowski, Christopher
- Member of: ASU Electronic Theses and Dissertations
Description
Within the primate lineage, skeletal traits that contribute to inter-specific anatomical variation and enable varied niche occupations and forms of locomotion are often described as the result of environmental adaptations. However, skeletal phenotypes are more accurately defined as complex traits, and environmental, genetic, and epigenetic mechanisms, such as DNA methylation which regulates gene expression, all contribute to these phenotypes. Nevertheless, skeletal complexity in relation to epigenetic variation has not been assessed across the primate order. In order to gain a complete understanding of the evolution of skeletal phenotypes across primates, it is necessary to study skeletal epigenetics in primates. This study attempts to fill this gap by identifying intra- and inter-specific variation in primate skeletal tissue methylation in order to test whether specific features of skeletal form are related to specific variations in methylation. Specifically, methylation arrays and gene-specific methylation sequencing are used to identify DNA methylation patterns in femoral trabecular bone and cartilage of several nonhuman primate species. Samples include baboons (Papio spp.), macaques (Macaca mulatta), vervets (Chlorocebus aethiops), chimpanzees (Pan troglodytes), and marmosets (Callithrix jacchus), and the efficiencies of these methods are validated in each taxon. Within one nonhuman primate species (baboons), intra-specific variations in methylation patterns are identified across a range of comparative levels, including skeletal tissue differences (bone vs. cartilage), age cohort differences (adults vs. juveniles), and skeletal disease state differences (osteoarthritic vs. healthy), and some of the identified patterns are evolutionarily conserved with those known in humans. Additionally, in all nonhuman primate species, intra-specific methylation variation in association with nonpathological femur morphologies is assessed. Lastly, inter-specific changes in methylation are evaluated among all nonhuman primate taxa and used to provide a phylogenetic framework for methylation changes previously identified in the hominin lineage. Overall, findings from this work reveal how skeletal DNA methylation patterns vary within and among primate species and relate to skeletal phenotypes, and together they inform our understanding of epigenetic regulation and complex skeletal trait evolution in primates.
ContributorsHousman, Genevieve (Author) / Stone, Anne (Thesis advisor) / Quillen, Ellen (Committee member) / Kusumi, Kenro (Committee member) / Stojanowski, Christopher (Committee member) / Arizona State University (Publisher)
Created2017
Description
This dissertation research employs biological distance and mortuary analyses in tandem with historical sources to investigate the degree to which conversion, as opposed to migration, contributed to the spread of Islam in southern Iberia. The dynamics of the 8th century conquest of Iberia by Muslim Arab and Berber forces from North Africa, and the subsequent 800-year period of religious, political, and social change, remain contested and poorly understood. Migration of Islamic peoples to the peninsula once was invoked as the primary vehicle of Islamic influence, but religious conversion, whether true or nominal, increasingly is regarded as a key component of those changes. This dissertation proposes that conversion, whether a prelude to or a component of Islamization, altered social group affiliations and interactions among those living in southern Iberia. Such changes in social relations and the resultant patterns of mate exchange will be recognizable by means of altered biological patterns of phenotypic variation. Through the examination of ~900 individuals from both Iberian and North African skeletal collections, this study concludes that conquest resulted in a great increase in phenotypic variability in the peninsula from the 8th-11th centuries. The data further indicate that males contributed this phenotypic variability to the samples in the Early Conquest period. Females, most frequently from Hispano-Roman Christian groups, appear to have ‘intermarried’ with these early conquerors and with the Muwallads, male Islamic converts, and are included in the early Muslim burial programs. From the 11th to the 14th centuries, the data presented here demonstrate a stasis and even a slight decrease in phenotypic variability in southern Iberia, which may be explained by endogamy among religious groups in this region.
ContributorsBolhofner, Katelyn L (Author) / Buikstra, Jane E. (Thesis advisor) / Stojanowski, Christopher (Committee member) / Curta, Florin (Committee member) / Arizona State University (Publisher)
Created2017
Description
Although the Caribbean has been continuously inhabited for the last 7,000 years, European contact in the last 500 years dramatically reshaped the cultural and genetic makeup of island populations. Several recent studies have explored the genetic diversity of Caribbean Latinos and have characterized Native American variation present within their genomes. However, the difficulty of obtaining ancient DNA from pre-contact populations and the underrepresentation of non-Latino Caribbean islanders in current research have prevented a complete understanding of genetic variation over time and space in the Caribbean basin. This dissertation uses two approaches to characterize the role of migration and admixture in the demographic history of Caribbean islanders. First, autosomal variants were genotyped in a sample of 55 Afro-Caribbeans from five islands in the Lesser Antilles: Grenada, St. Kitts, St. Lucia, Trinidad, and St. Vincent. These data were used to characterize genetic structure, ancestry and signatures of selection in these populations. The results demonstrate a complex pattern of admixture since European contact, including a strong signature of sex-biased mating and inputs from at least five continental populations to the autosomal ancestry of Afro-Caribbean peoples. Second, ancient mitochondrial and nuclear DNA were obtained from 60 skeletal remains, dated between A.D. 500–1300, from three archaeological sites in Puerto Rico: Paso del Indio, Punta Candelero and Tibes. The ancient data were used to reassesses existing models for the peopling of Puerto Rico and the Caribbean and to examine the extent of genetic continuity between ancient and modern populations. Project findings support a largely South American origin for Ceramic Age Caribbean populations and identify some genetic continuity between pre and post contact islanders. The above study was aided by development and testing of extraction methods optimized for recovery of ancient DNA from tropical contexts. Overall, project findings characterize how ancient indigenous groups, European colonial regimes, the African Slave Trade and modern labor movements have shaped the genomic diversity of Caribbean islanders. In addition to its anthropological and historical importance, such knowledge is also essential for informing the identification of medically relevant genetic variation in these populations.
ContributorsNieves Colón, Maria (Author) / Stone, Anne C (Thesis advisor) / Pestle, William J. (Committee member) / Benn-Torres, Jada (Committee member) / Stojanowski, Christopher (Committee member) / Arizona State University (Publisher)
Created2017
Description
This dissertation examines microevolutionary changes in the Eastern Adriatic and hinterland during Roman imperialism, evaluating changing patterns of variation among indigenous groups with varying histories of acceptance or defiance to Roman rule. Despite the prevalence of Roman influence, trade, and the accommodating nature of Roman political authority administered through existing local leaders, Eastern Adriatic and hinterland peoples underwent significant cultural transformations. Unlike the Roman-allied Liburnians, Romanization was not a voluntary and amicable process for the resisting Delmatae, Histri, Japodes, and Pannonians. The violent experiences of locals during the late Republican Period and early Roman Empire, including death, enslavement, conscription, and displacement, contrast with the eventual integration of the region by the end of the Roman Empire, when their descendants were Roman citizens. These complex histories make it challenging to understand local identities and the impact of Romanization. Biological distance analyses of dental morphology from Liburnian, Delmatae, Japodes, and Pannonian samples representing 313 individuals dating to the Iron Age (c. 700- 400 BCE), and Roman Period (Roman Republic c. 200- 0 BCE; Roman Empire c. 1- 500 CE), were contextualized with archaeological data and classical research. Results indicated no significant differences within Eastern Adriatic and hinterland populations across the time periods. However, interpretations of the results for Roman Period Liburnians, descendants of Roman allies, suggest differentiation from contemporaneous Italic Romans. Conversely, the descendants of resisting populations were not statistically different from Roman Empire Italics, potentially influenced by their ancestors’ experiences of war affecting subsequent admixture, community formation, and adherence to prevailing norms.
Roman laws that managed access to advantageous status identities through marriage and citizenship may also explain the findings that all surveyed local populations demonstrate continuity between ancestors and descendants. The dynamic of being identified as Roman, and yet descending from the people who fought against Rome, is further discussed as a form of biological imperialism, consequentially shaping indigenous ancestral ties within a pan-regional Roman citizenry. While Roman multiculturalism is often considered exemplary of Antique Period diversity, Roman values prioritized diversity when it was advantageous and used pluralism to encourage cultural assimilation and define outsiders.
ContributorsLoewen, Tisa Nicolette (Author) / Stojanowski, Christopher (Thesis advisor) / Buikstra, Jane (Committee member) / Novak, Mario (Committee member) / Knudson, Kelly (Committee member) / Arizona State University (Publisher)
Created2024