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Random Forests is a statistical learning method which has been proposed for propensity score estimation models that involve complex interactions, nonlinear relationships, or both of the covariates. In this dissertation I conducted a simulation study to examine the effects of three Random Forests model specifications in propensity score analysis. The

Random Forests is a statistical learning method which has been proposed for propensity score estimation models that involve complex interactions, nonlinear relationships, or both of the covariates. In this dissertation I conducted a simulation study to examine the effects of three Random Forests model specifications in propensity score analysis. The results suggested that, depending on the nature of data, optimal specification of (1) decision rules to select the covariate and its split value in a Classification Tree, (2) the number of covariates randomly sampled for selection, and (3) methods of estimating Random Forests propensity scores could potentially produce an unbiased average treatment effect estimate after propensity scores weighting by the odds adjustment. Compared to the logistic regression estimation model using the true propensity score model, Random Forests had an additional advantage in producing unbiased estimated standard error and correct statistical inference of the average treatment effect. The relationship between the balance on the covariates' means and the bias of average treatment effect estimate was examined both within and between conditions of the simulation. Within conditions, across repeated samples there was no noticeable correlation between the covariates' mean differences and the magnitude of bias of average treatment effect estimate for the covariates that were imbalanced before adjustment. Between conditions, small mean differences of covariates after propensity score adjustment were not sensitive enough to identify the optimal Random Forests model specification for propensity score analysis.
ContributorsCham, Hei Ning (Author) / Tein, Jenn-Yun (Thesis advisor) / Enders, Stephen G (Thesis advisor) / Enders, Craig K. (Committee member) / Mackinnon, David P (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Methods to test hypotheses of mediated effects in the pretest-posttest control group design are understudied in the behavioral sciences (MacKinnon, 2008). Because many studies aim to answer questions about mediating processes in the pretest-posttest control group design, there is a need to determine which model is most appropriate to

Methods to test hypotheses of mediated effects in the pretest-posttest control group design are understudied in the behavioral sciences (MacKinnon, 2008). Because many studies aim to answer questions about mediating processes in the pretest-posttest control group design, there is a need to determine which model is most appropriate to test hypotheses about mediating processes and what happens to estimates of the mediated effect when model assumptions are violated in this design. The goal of this project was to outline estimator characteristics of four longitudinal mediation models and the cross-sectional mediation model. Models were compared on type 1 error rates, statistical power, accuracy of confidence interval coverage, and bias of parameter estimates. Four traditional longitudinal models and the cross-sectional model were assessed. The four longitudinal models were analysis of covariance (ANCOVA) using pretest scores as a covariate, path analysis, difference scores, and residualized change scores. A Monte Carlo simulation study was conducted to evaluate the different models across a wide range of sample sizes and effect sizes. All models performed well in terms of type 1 error rates and the ANCOVA and path analysis models performed best in terms of bias and empirical power. The difference score, residualized change score, and cross-sectional models all performed well given certain conditions held about the pretest measures. These conditions and future directions are discussed.
ContributorsValente, Matthew John (Author) / MacKinnon, David (Thesis advisor) / West, Stephen (Committee member) / Aiken, Leona (Committee member) / Enders, Craig (Committee member) / Arizona State University (Publisher)
Created2015
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Description
This dissertation examines a planned missing data design in the context of mediational analysis. The study considered a scenario in which the high cost of an expensive mediator limited sample size, but in which less expensive mediators could be gathered on a larger sample size. Simulated multivariate normal data were

This dissertation examines a planned missing data design in the context of mediational analysis. The study considered a scenario in which the high cost of an expensive mediator limited sample size, but in which less expensive mediators could be gathered on a larger sample size. Simulated multivariate normal data were generated from a latent variable mediation model with three observed indicator variables, M1, M2, and M3. Planned missingness was implemented on M1 under the missing completely at random mechanism. Five analysis methods were employed: latent variable mediation model with all three mediators as indicators of a latent construct (Method 1), auxiliary variable model with M1 as the mediator and M2 and M3 as auxiliary variables (Method 2), auxiliary variable model with M1 as the mediator and M2 as a single auxiliary variable (Method 3), maximum likelihood estimation including all available data but incorporating only mediator M1 (Method 4), and listwise deletion (Method 5).

The main outcome of interest was empirical power to detect the mediated effect. The main effects of mediation effect size, sample size, and missing data rate performed as expected with power increasing for increasing mediation effect sizes, increasing sample sizes, and decreasing missing data rates. Consistent with expectations, power was the greatest for analysis methods that included all three mediators, and power decreased with analysis methods that included less information. Across all design cells relative to the complete data condition, Method 1 with 20% missingness on M1 produced only 2.06% loss in power for the mediated effect; with 50% missingness, 6.02% loss; and 80% missingess, only 11.86% loss. Method 2 exhibited 20.72% power loss at 80% missingness, even though the total amount of data utilized was the same as Method 1. Methods 3 – 5 exhibited greater power loss. Compared to an average power loss of 11.55% across all levels of missingness for Method 1, average power losses for Methods 3, 4, and 5 were 23.87%, 29.35%, and 32.40%, respectively. In conclusion, planned missingness in a multiple mediator design may permit higher quality characterization of the mediator construct at feasible cost.
ContributorsBaraldi, Amanda N (Author) / Enders, Craig K. (Thesis advisor) / Mackinnon, David P (Thesis advisor) / Aiken, Leona S. (Committee member) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Researchers who conduct longitudinal studies are inherently interested in studying individual and population changes over time (e.g., mathematics achievement, subjective well-being). To answer such research questions, models of change (e.g., growth models) make the assumption of longitudinal measurement invariance. In many applied situations, key constructs are measured by a collection

Researchers who conduct longitudinal studies are inherently interested in studying individual and population changes over time (e.g., mathematics achievement, subjective well-being). To answer such research questions, models of change (e.g., growth models) make the assumption of longitudinal measurement invariance. In many applied situations, key constructs are measured by a collection of ordered-categorical indicators (e.g., Likert scale items). To evaluate longitudinal measurement invariance with ordered-categorical indicators, a set of hierarchical models can be sequentially tested and compared. If the statistical tests of measurement invariance fail to be supported for one of the models, it is useful to have a method with which to gauge the practical significance of the differences in measurement model parameters over time. Drawing on studies of latent growth models and second-order latent growth models with continuous indicators (e.g., Kim & Willson, 2014a; 2014b; Leite, 2007; Wirth, 2008), this study examined the performance of a potential sensitivity analysis to gauge the practical significance of violations of longitudinal measurement invariance for ordered-categorical indicators using second-order latent growth models. The change in the estimate of the second-order growth parameters following the addition of an incorrect level of measurement invariance constraints at the first-order level was used as an effect size for measurement non-invariance. This study investigated how sensitive the proposed sensitivity analysis was to different locations of non-invariance (i.e., non-invariance in the factor loadings, the thresholds, and the unique factor variances) given a sufficient sample size. This study also examined whether the sensitivity of the proposed sensitivity analysis depended on a number of other factors including the magnitude of non-invariance, the number of non-invariant indicators, the number of non-invariant occasions, and the number of response categories in the indicators.
ContributorsLiu, Yu, Ph.D (Author) / West, Stephen G. (Thesis advisor) / Tein, Jenn-Yun (Thesis advisor) / Green, Samuel (Committee member) / Grimm, Kevin J. (Committee member) / Arizona State University (Publisher)
Created2016
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Description
This paper investigates a relatively new analysis method for longitudinal data in the framework of functional data analysis. This approach treats longitudinal data as so-called sparse functional data. The first section of the paper introduces functional data and the general ideas of functional data analysis. The second section discusses the

This paper investigates a relatively new analysis method for longitudinal data in the framework of functional data analysis. This approach treats longitudinal data as so-called sparse functional data. The first section of the paper introduces functional data and the general ideas of functional data analysis. The second section discusses the analysis of longitudinal data in the context of functional data analysis, while considering the unique characteristics of longitudinal data such, in particular sparseness and missing data. The third section introduces functional mixed-effects models that can handle these unique characteristics of sparseness and missingness. The next section discusses a preliminary simulation study conducted to examine the performance of a functional mixed-effects model under various conditions. An extended simulation study was carried out to evaluate the estimation accuracy of a functional mixed-effects model. Specifically, the accuracy of the estimated trajectories was examined under various conditions including different types of missing data and varying levels of sparseness.
ContributorsWard, Kimberly l (Author) / Suk, Hye Won (Thesis advisor) / Aiken, Leona (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2016
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Description
In investigating mediating processes, researchers usually use randomized experiments and linear regression or structural equation modeling to determine if the treatment affects the hypothesized mediator and if the mediator affects the targeted outcome. However, randomizing the treatment will not yield accurate causal path estimates unless certain assumptions are satisfied. Since

In investigating mediating processes, researchers usually use randomized experiments and linear regression or structural equation modeling to determine if the treatment affects the hypothesized mediator and if the mediator affects the targeted outcome. However, randomizing the treatment will not yield accurate causal path estimates unless certain assumptions are satisfied. Since randomization of the mediator may not be plausible for most studies (i.e., the mediator status is not randomly assigned, but self-selected by participants), both the direct and indirect effects may be biased by confounding variables. The purpose of this dissertation is (1) to investigate the extent to which traditional mediation methods are affected by confounding variables and (2) to assess the statistical performance of several modern methods to address confounding variable effects in mediation analysis. This dissertation first reviewed the theoretical foundations of causal inference in statistical mediation analysis, modern statistical analysis for causal inference, and then described different methods to estimate causal direct and indirect effects in the presence of two post-treatment confounders. A large simulation study was designed to evaluate the extent to which ordinary regression and modern causal inference methods are able to obtain correct estimates of the direct and indirect effects when confounding variables that are present in the population are not included in the analysis. Five methods were compared in terms of bias, relative bias, mean square error, statistical power, Type I error rates, and confidence interval coverage to test how robust the methods are to the violation of the no unmeasured confounders assumption and confounder effect sizes. The methods explored were linear regression with adjustment, inverse propensity weighting, inverse propensity weighting with truncated weights, sequential g-estimation, and a doubly robust sequential g-estimation. Results showed that in estimating the direct and indirect effects, in general, sequential g-estimation performed the best in terms of bias, Type I error rates, power, and coverage across different confounder effect, direct effect, and sample sizes when all confounders were included in the estimation. When one of the two confounders were omitted from the estimation process, in general, none of the methods had acceptable relative bias in the simulation study. Omitting one of the confounders from estimation corresponded to the common case in mediation studies where no measure of a confounder is available but a confounder may affect the analysis. Failing to measure potential post-treatment confounder variables in a mediation model leads to biased estimates regardless of the analysis method used and emphasizes the importance of sensitivity analysis for causal mediation analysis.
ContributorsKisbu Sakarya, Yasemin (Author) / Mackinnon, David Peter (Thesis advisor) / Aiken, Leona (Committee member) / West, Stephen (Committee member) / Millsap, Roger (Committee member) / Arizona State University (Publisher)
Created2013