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- All Subjects: Songs (High voice) with piano
ContributorsWasbotten, Leia (Performer) / ASU Library. Music Library (Publisher)
Created2018-03-30
Description
Libby Larsen is one of the most performed and acclaimed composers today. She is a spirited, compelling, and sensitive composer whose music enhances the poetry of America's most prominent authors. Notable among her works are song cycles for soprano based on the poetry of female writers, among them novelist and poet Willa Cather (1873-1947). Larsen has produced two song cycles on works from Cather's substantial output of fiction: one based on Cather's short story, "Eric Hermannson's Soul," titled Margaret Songs: Three Songs from Willa Cather (1996); and later, My Antonia (2000), based on Cather's novel of the same title. In Margaret Songs, Cather's poetry and short stories--specifically the character of Margaret Elliot--combine with Larsen's unique compositional style to create a surprising collaboration. This study explores how Larsen in these songs delves into the emotional and psychological depths of Margaret's character, not fully formed by Cather. It is only through Larsen's music and Cather's poetry that Margaret's journey through self-discovery and love become fully realized. This song cycle is a glimpse through the eyes of two prominent female artists on the societal pressures placed upon Margaret's character, many of which still resonate with women in today's culture. This study examines the work Margaret Songs by discussing Willa Cather, her musical influences, and the conditions surrounding the writing of "Eric Hermannson's Soul." It looks also into Cather's influence on Libby Larsen and the commission leading to Margaret Songs. Finally, a description of the musical, dramatic, and textual content of the songs completes this interpretation of the interactions of Willa Cather, Libby Larsen, and the character of Margaret Elliot.
ContributorsMcLain, Christi Marie (Author) / FitzPatrick, Carole (Thesis advisor) / Dreyfoos, Dale (Committee member) / Holbrook, Amy (Committee member) / Ryan, Russell (Committee member) / Arizona State University (Publisher)
Created2013
Discovering Puerto Rican art song: a research project on four art song works by Héctor Campos Parsi
Description
Puerto Rico has produced many important composers who have contributed to the musical culture of the nation during the last 200 years. However, a considerable amount of their music has proven to be difficult to access and may contain numerous errors. This research project intends to contribute to the accessibility of such music and to encourage similar studies of Puerto Rican music. This study focuses on the music of Héctor Campos Parsi (1922-1998), one of the most prominent composers of the 20th century in Puerto Rico. After an overview of the historical background of music on the island and the biography of the composer, four works from his art song repertoire are given for detailed examination. A product of this study is the first corrected edition of his cycles Canciones de Cielo y Agua, Tres Poemas de Corretjer, Los Paréntesis, and the song Majestad Negra. These compositions date from 1947 to 1959, and reflect both the European and nationalistic writing styles of the composer during this time. Data for these corrections have been obtained from the composer's manuscripts, published and unpublished editions, and published recordings. The corrected scores are ready for publication and a compact disc of this repertoire, performed by soprano Melliangee Pérez and the author, has been recorded to bring to life these revisions. Despite the best intentions of the author, the various copyright issues have yet to be resolved. It is hoped that this document will provide the foundation for a resolution and that these important works will be available for public performance and study in the near future.
ContributorsRodríguez Morales, Luis F., 1980- (Author) / Campbell, Andrew (Thesis advisor) / Buck, Elizabeth (Committee member) / Holbrook, Amy (Committee member) / Kopta, Anne (Committee member) / Ryan, Russell (Committee member) / Arizona State University (Publisher)
Created2013
ContributorsYi, Joyce (Performer) / ASU Library. Music Library (Publisher)
Created2018-03-22
ContributorsCummiskey, Hannah (Performer) / Kim, Olga (Performer) / ASU Library. Music Library (Publisher)
Created2018-03-23
ContributorsEvans, Emily (Performer) / Sherrill, Amanda (Performer) / ASU Library. Music Library (Publisher)
Created2018-03-02
Description
Exposure of blood plasma/serum (P/S) to thawed conditions, greater than -30°C, can produce biomolecular changes that misleadingly impact measurements of clinical markers within archived samples. Reported here is a low sample-volume, dilute-and-shoot, intact protein mass spectrometric assay of albumin proteoforms called “ΔS-Cys-Albumin” that quantifies cumulative exposure of archived P/S samples to thawed conditions. The assay uses the fact that S-cysteinylation (oxidation) of albumin in P/S increases to a maximum value when exposed to temperatures greater than -30°C. The multi-reaction rate law that governs this albumin S-cysteinylation formation in P/S was determined and was shown to predict the rate of formation of S-cysteinylated albumin in P/S samples—a step that enables back-calculation of the time at which unknown P/S specimens have been exposed to room temperature. To emphasize the capability of this assay, a blind challenge demonstrated the ability of ΔS-Cys-Albumin to detect exposure of individual and grouped P/S samples to unfavorable storage conditions. The assay was also capable of detecting an anomaly in a case study of nominally pristine serum samples collected under NIH-sponsorship, demonstrating that empirical evidence is required to guarantee accurate knowledge of archived P/S biospecimen storage history.
The ex vivo glycation of human serum albumin was also investigated showing that P/S samples stored above their freezing point leads to significant increases in glycated albumin. These increases were found to occur within hours at room temperature, and within days at -20 °C. These increases continued over a period of 1-2 weeks at room temperature and over 200 days at -20 °C, ultimately resulting in a doubling of glycated albumin in both healthy and diabetic patients. It was also shown that samples stored at lower surface area-to-volume ratios or incubated under a nitrogen atmosphere experienced less rapid glucose adduction of albumin—suggesting a role for oxidative glycation in the ex vivo glycation of albumin.
The ex vivo glycation of human serum albumin was also investigated showing that P/S samples stored above their freezing point leads to significant increases in glycated albumin. These increases were found to occur within hours at room temperature, and within days at -20 °C. These increases continued over a period of 1-2 weeks at room temperature and over 200 days at -20 °C, ultimately resulting in a doubling of glycated albumin in both healthy and diabetic patients. It was also shown that samples stored at lower surface area-to-volume ratios or incubated under a nitrogen atmosphere experienced less rapid glucose adduction of albumin—suggesting a role for oxidative glycation in the ex vivo glycation of albumin.
ContributorsJeffs, Joshua W (Author) / Borges, Chad R (Thesis advisor) / Van Horn, Wade (Committee member) / Williams, Peter (Committee member) / Arizona State University (Publisher)
Created2018
Description
Extracellular vesicles (EVs) represent a heterogeneous population of small vesicles, consisting of a phospholipidic bilayer surrounding a soluble interior cargo. These vesicles play an important role in cellular communication by virtue of their protein, RNA, and lipid content, which can be transferred among cells. Peripheral blood is a rich source of circulating EVs. An analysis of EVs in peripheral blood could provide access to unparalleled amounts of biomarkers of great diagnostic, prognostic as well as therapeutic value. In the current study, a plasma EV enrichment method based on pluronic co-polymer was first established and characterized. Plasma EVs from breast cancer patients were then enriched, profiled and compared to non-cancer controls. Proteins signatures that contributed to the prediction of cancer samples from non-cancer controls were created by a random-forest based cross-validation approach. We found that a large portion of these signatures were related to breast cancer aggression. To verify such findings, KIAA0100, one of the features identified, was chosen for in vitro molecular and cellular studies in the breast cancer cell line MDA-MB-231. We found that KIAA0100 regulates cancer cell aggression in MDA-MB-231 in an anchorage-independent manner and is particularly associated with anoikis resistance through its interaction with HSPA1A. Lastly, plasma EVs contain not only individual proteins, but also numerous molecular complexes. In order to measure millions of proteins, isoforms, and complexes simultaneously, Adaptive Dynamic Artificial Poly-ligand Targeting (ADAPT) platform was applied. ADAPT employs an enriched library of single-stranded oligodeoxynucleotides to profile complex biological samples, thus achieving a deep coverage of system-wide, native biomolecules. Profiling of EVs from breast cancer patients was able to obtain a prediction AUC performance of 0.73 when compared biopsy-positive cancer patient to healthy controls and 0.64 compared to biopsy-negative controls and such performance was not associated with the physical breast condition indicated by BIRAD scores. Taken together, current research demonstrated the potential of profiling plasma EVs in searching for therapeutic targets as well as diagnostic signatures.
ContributorsZhong, Zhenyu (Author) / Spetzler, David (Thesis advisor) / Yan, Hao (Thesis advisor) / Lake, Douglas (Committee member) / Mangone, Marco (Committee member) / Arizona State University (Publisher)
Created2018
Description
Chiral symmetry and its anomalous and spontaneous breaking play an important role
in particle physics, where it explains the origin of pion and hadron mass hierarchy
among other things.
Despite its microscopic origin chirality may also lead to observable effects
in macroscopic physical systems -- relativistic plasmas made of chiral
(spin-$\frac{1}{2}$) particles.
Such plasmas are called \textit{chiral}.
The effects include non-dissipative currents in external fields that could be present
even in quasi-equilibrium, such as the chiral magnetic (CME) and separation (CSE)
effects, as well as a number of inherently chiral collective modes
called the chiral magnetic (CMW) and vortical (CVW) waves.
Applications of chiral plasmas are truly interdisciplinary, ranging from
hot plasma filling the early Universe, to dense matter in neutron stars,
to electronic band structures in Dirac and Weyl semimetals, to quark-gluon plasma
produced in heavy-ion collisions.
The main focus of this dissertation is a search for traces of chiral physics
in the spectrum of collective modes in chiral plasmas.
I start from relativistic chiral kinetic theory and derive
first- and second-order chiral hydrodynamics.
Then I establish key features of an equilibrium state that describes many
physical chiral systems and use it to find the full spectrum of collective modes
in high-temperature and high-density cases.
Finally, I consider in detail the fate of the two inherently chiral waves, namely
the CMW and the CVW, and determine their detection prospects.
The main results of this dissertation are the formulation of a fully covariant
dissipative chiral hydrodynamics and the calculation of the spectrum of collective
modes in chiral plasmas.
It is found that the dissipative effects and dynamical electromagnetism play
an important role in most cases.
In particular, it is found that both the CMW and the CVW are heavily damped by the usual
Ohmic dissipation in charged plasmas and the diffusion effects in neutral plasmas.
These findings prompt a search for new physical observables in heavy-ion collisions,
as well as a revision of potential applications of chiral theories in
cosmology and solid-state physics.
in particle physics, where it explains the origin of pion and hadron mass hierarchy
among other things.
Despite its microscopic origin chirality may also lead to observable effects
in macroscopic physical systems -- relativistic plasmas made of chiral
(spin-$\frac{1}{2}$) particles.
Such plasmas are called \textit{chiral}.
The effects include non-dissipative currents in external fields that could be present
even in quasi-equilibrium, such as the chiral magnetic (CME) and separation (CSE)
effects, as well as a number of inherently chiral collective modes
called the chiral magnetic (CMW) and vortical (CVW) waves.
Applications of chiral plasmas are truly interdisciplinary, ranging from
hot plasma filling the early Universe, to dense matter in neutron stars,
to electronic band structures in Dirac and Weyl semimetals, to quark-gluon plasma
produced in heavy-ion collisions.
The main focus of this dissertation is a search for traces of chiral physics
in the spectrum of collective modes in chiral plasmas.
I start from relativistic chiral kinetic theory and derive
first- and second-order chiral hydrodynamics.
Then I establish key features of an equilibrium state that describes many
physical chiral systems and use it to find the full spectrum of collective modes
in high-temperature and high-density cases.
Finally, I consider in detail the fate of the two inherently chiral waves, namely
the CMW and the CVW, and determine their detection prospects.
The main results of this dissertation are the formulation of a fully covariant
dissipative chiral hydrodynamics and the calculation of the spectrum of collective
modes in chiral plasmas.
It is found that the dissipative effects and dynamical electromagnetism play
an important role in most cases.
In particular, it is found that both the CMW and the CVW are heavily damped by the usual
Ohmic dissipation in charged plasmas and the diffusion effects in neutral plasmas.
These findings prompt a search for new physical observables in heavy-ion collisions,
as well as a revision of potential applications of chiral theories in
cosmology and solid-state physics.
ContributorsRybalka, Denys (Author) / Shovkovy, Igor (Thesis advisor) / Lunardini, Cecilia (Committee member) / Timmes, Francis (Committee member) / Vachaspati, Tanmay (Committee member) / Arizona State University (Publisher)
Created2019