Filtering by
- Status: Published
The ex vivo glycation of human serum albumin was also investigated showing that P/S samples stored above their freezing point leads to significant increases in glycated albumin. These increases were found to occur within hours at room temperature, and within days at -20 °C. These increases continued over a period of 1-2 weeks at room temperature and over 200 days at -20 °C, ultimately resulting in a doubling of glycated albumin in both healthy and diabetic patients. It was also shown that samples stored at lower surface area-to-volume ratios or incubated under a nitrogen atmosphere experienced less rapid glucose adduction of albumin—suggesting a role for oxidative glycation in the ex vivo glycation of albumin.
in particle physics, where it explains the origin of pion and hadron mass hierarchy
among other things.
Despite its microscopic origin chirality may also lead to observable effects
in macroscopic physical systems -- relativistic plasmas made of chiral
(spin-$\frac{1}{2}$) particles.
Such plasmas are called \textit{chiral}.
The effects include non-dissipative currents in external fields that could be present
even in quasi-equilibrium, such as the chiral magnetic (CME) and separation (CSE)
effects, as well as a number of inherently chiral collective modes
called the chiral magnetic (CMW) and vortical (CVW) waves.
Applications of chiral plasmas are truly interdisciplinary, ranging from
hot plasma filling the early Universe, to dense matter in neutron stars,
to electronic band structures in Dirac and Weyl semimetals, to quark-gluon plasma
produced in heavy-ion collisions.
The main focus of this dissertation is a search for traces of chiral physics
in the spectrum of collective modes in chiral plasmas.
I start from relativistic chiral kinetic theory and derive
first- and second-order chiral hydrodynamics.
Then I establish key features of an equilibrium state that describes many
physical chiral systems and use it to find the full spectrum of collective modes
in high-temperature and high-density cases.
Finally, I consider in detail the fate of the two inherently chiral waves, namely
the CMW and the CVW, and determine their detection prospects.
The main results of this dissertation are the formulation of a fully covariant
dissipative chiral hydrodynamics and the calculation of the spectrum of collective
modes in chiral plasmas.
It is found that the dissipative effects and dynamical electromagnetism play
an important role in most cases.
In particular, it is found that both the CMW and the CVW are heavily damped by the usual
Ohmic dissipation in charged plasmas and the diffusion effects in neutral plasmas.
These findings prompt a search for new physical observables in heavy-ion collisions,
as well as a revision of potential applications of chiral theories in
cosmology and solid-state physics.
In 2007, Dennis Lo and his colleagues used digital polymerase chain reaction or PCR to detect trisomy 21 in maternal blood, validating the method as a means to detect fetal chromosomal aneuploidies, or an abnormal number of chromosomes in a cell. The team conducted their research at the Chinese University of Hong Kong in Hong Kong, Hong Kong, and at the Boston University in Boston, Massachusetts. Because small amounts of fetal DNA appear in maternal blood during pregnancy, Lo and his team hypothesized that they could detect fetal chromosomal aneuploidy trisomy 21, or Down’s syndrome, in a sample of maternal blood. The group diagnosed Down’s syndrome in unborn fetuses by first taking a maternal blood sample, then amplifying the small amounts of fetal DNA in the maternal blood using digital PCR, and applying two genetic methods to that sample. Lo and his colleagues’ experiment demonstrated the accuracy of a novel, noninvasive method for fetal chromosomal aneuploidy testing that can enable people to make informed decisions about their pregnancies.