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Increasing interest in individualized treatment strategies for prevention and treatment of health disorders has created a new application domain for dynamic modeling and control. Standard population-level clinical trials, while useful, are not the most suitable vehicle for understanding the dynamics of dosage changes to patient response. A secondary analysis of

Increasing interest in individualized treatment strategies for prevention and treatment of health disorders has created a new application domain for dynamic modeling and control. Standard population-level clinical trials, while useful, are not the most suitable vehicle for understanding the dynamics of dosage changes to patient response. A secondary analysis of intensive longitudinal data from a naltrexone intervention for fibromyalgia examined in this dissertation shows the promise of system identification and control. This includes datacentric identification methods such as Model-on-Demand, which are attractive techniques for estimating nonlinear dynamical systems from noisy data. These methods rely on generating a local function approximation using a database of regressors at the current operating point, with this process repeated at every new operating condition. This dissertation examines generating input signals for data-centric system identification by developing a novel framework of geometric distribution of regressors and time-indexed output points, in the finite dimensional space, to generate sufficient support for the estimator. The input signals are generated while imposing “patient-friendly” constraints on the design as a means to operationalize single-subject clinical trials. These optimization-based problem formulations are examined for linear time-invariant systems and block-structured Hammerstein systems, and the results are contrasted with alternative designs based on Weyl's criterion. Numerical solution to the resulting nonconvex optimization problems is proposed through semidefinite programming approaches for polynomial optimization and nonlinear programming methods. It is shown that useful bounds on the objective function can be calculated through relaxation procedures, and that the data-centric formulations are amenable to sparse polynomial optimization. In addition, input design formulations are formulated for achieving a desired output and specified input spectrum. Numerical examples illustrate the benefits of the input signal design formulations including an example of a hypothetical clinical trial using the drug gabapentin. In the final part of the dissertation, the mixed logical dynamical framework for hybrid model predictive control is extended to incorporate a switching time strategy, where decisions are made at some integer multiple of the sample time, and manipulation of only one input at a given sample time among multiple inputs. These are considerations important for clinical use of the algorithm.
ContributorsDeśapāṇḍe, Sunīla (Author) / Rivera, Daniel E. (Thesis advisor) / Peet, Matthew M. (Committee member) / Si, Jennie (Committee member) / Tsakalis, Konstantinos S. (Committee member) / Arizona State University (Publisher)
Created2014
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Description
There is increasing interest in the medical and behavioral health communities towards developing effective strategies for the treatment of chronic diseases. Among these lie adaptive interventions, which consider adjusting treatment dosages over time based on participant response. Control engineering offers a broad-based solution framework for optimizing the effectiveness of such

There is increasing interest in the medical and behavioral health communities towards developing effective strategies for the treatment of chronic diseases. Among these lie adaptive interventions, which consider adjusting treatment dosages over time based on participant response. Control engineering offers a broad-based solution framework for optimizing the effectiveness of such interventions. In this thesis, an approach is proposed to develop dynamical models and subsequently, hybrid model predictive control schemes for assigning optimal dosages of naltrexone, an opioid antagonist, as treatment for a chronic pain condition known as fibromyalgia. System identification techniques are employed to model the dynamics from the daily diary reports completed by participants of a blind naltrexone intervention trial. These self-reports include assessments of outcomes of interest (e.g., general pain symptoms, sleep quality) and additional external variables (disturbances) that affect these outcomes (e.g., stress, anxiety, and mood). Using prediction-error methods, a multi-input model describing the effect of drug, placebo and other disturbances on outcomes of interest is developed. This discrete time model is approximated by a continuous second order model with zero, which was found to be adequate to capture the dynamics of this intervention. Data from 40 participants in two clinical trials were analyzed and participants were classified as responders and non-responders based on the models obtained from system identification. The dynamical models can be used by a model predictive controller for automated dosage selection of naltrexone using feedback/feedforward control actions in the presence of external disturbances. The clinical requirement for categorical (i.e., discrete-valued) drug dosage levels creates a need for hybrid model predictive control (HMPC). The controller features a multiple degree-of-freedom formulation that enables the user to adjust the speed of setpoint tracking, measured disturbance rejection and unmeasured disturbance rejection independently in the closed loop system. The nominal and robust performance of the proposed control scheme is examined via simulation using system identification models from a representative participant in the naltrexone intervention trial. The controller evaluation described in this thesis gives credibility to the promise and applicability of control engineering principles for optimizing adaptive interventions.
ContributorsDeśapāṇḍe, Sunīla (Author) / Rivera, Daniel E. (Thesis advisor) / Si, Jennie (Committee member) / Tsakalis, Konstantinos (Committee member) / Arizona State University (Publisher)
Created2011
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Description
The purpose of this dissertation is to develop a design technique for fractional PID controllers to achieve a closed loop sensitivity bandwidth approximately equal to a desired bandwidth using frequency loop shaping techniques. This dissertation analyzes the effect of the order of a fractional integrator which is used as a

The purpose of this dissertation is to develop a design technique for fractional PID controllers to achieve a closed loop sensitivity bandwidth approximately equal to a desired bandwidth using frequency loop shaping techniques. This dissertation analyzes the effect of the order of a fractional integrator which is used as a target on loop shaping, on stability and performance robustness. A comparison between classical PID controllers and fractional PID controllers is presented. Case studies where fractional PID controllers have an advantage over classical PID controllers are discussed. A frequency-domain loop shaping algorithm is developed, extending past results from classical PID’s that have been successful in tuning controllers for a variety of practical systems.
ContributorsSaleh, Khalid M (Author) / Tsakalis, Konstantinos (Thesis advisor) / Rodriguez, Armando (Committee member) / Si, Jennie (Committee member) / Artemiadis, Panagiotis (Committee member) / Arizona State University (Publisher)
Created2017
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Description
This thesis addresses control design for fixed-wing air-breathing aircraft. Four aircraft with distinct dynamical properties are considered: a scram-jet powered hypersonic (100foot long, X-43 like, wedge shaped) aircraft with flexible modes operating near Mach 8, 85k ft, a NASA HiMAT (Highly Maneuverable Aircraft Technology) F-18 aircraft,

a McDonnell Douglas AV-8A

This thesis addresses control design for fixed-wing air-breathing aircraft. Four aircraft with distinct dynamical properties are considered: a scram-jet powered hypersonic (100foot long, X-43 like, wedge shaped) aircraft with flexible modes operating near Mach 8, 85k ft, a NASA HiMAT (Highly Maneuverable Aircraft Technology) F-18 aircraft,

a McDonnell Douglas AV-8A Harrier aircraft, and a Vought F-8 Crusader aircraft. A two-input two-output (TITO) longitudinal LTI (linear time invariant) dynamical model is used for each aircraft. Control design trade studies are conducted for each of the aircraft. Emphasis is placed on the hypersonic vehicle because of its complex nonlinear (unstable, non-minimum phase, flexible) dynamics and uncertainty associated with hypersonic flight (Mach $>$ 5, shocks and high temperatures on leading edges). Two plume models are used for the hypersonic vehicle – an old plume model and a new plume model. The old plume model is simple and assumes a typical decaying pressure distribution for aft nozzle. The new plume model uses Newtonian impact theory and a nonlinear solver to compute the aft nozzle pressure distribution. Multivariable controllers were generated using standard weighted $H_{\inf}$ mixed-sensitivity optimization as well as a new input disturbance weighted mixed-sensitivity framework that attempts to achieve good multivariable properties at both the controls (plant inputs) as well as the errors (plant outputs). Classical inner-outer (PD-PI) structures (partially centralized and decentralized) were also used. It is shown that while these classical (sometimes partially centralized PD-PI) structures could be used to generate comparable results to the multivariable controllers (e.g. for the hypersonic vehicle, Harrier, F-8), considerable tuning (iterative optimization) is often essential. This is especially true for the highly coupled hypersonic vehicle – thus justifying the need for a good multivariable control design tool. Fundamental control design tradeoffs for each aircraft are presented – comprehensively for the hypersonic aircraft. In short, the thesis attempts to shed light on when complex controllers are essential and when simple structures are sufficient for achieving control designs with good multivariable loop properties at both the errors (plant outputs) and the controls (plant inputs).
ContributorsMondal, Kaustav (Author) / Rodriguez, Armando Antonio (Thesis advisor) / Tsakalis, Kostas (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Created2015
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Description
This dissertation discusses continuous-time reinforcement learning (CT-RL) for control of affine nonlinear systems. Continuous-time nonlinear optimal control problems hold great promise in real-world applications. After decades of development, reinforcement learning (RL) has achieved some of the greatest successes as a general nonlinear control design method. Yet as RL control has

This dissertation discusses continuous-time reinforcement learning (CT-RL) for control of affine nonlinear systems. Continuous-time nonlinear optimal control problems hold great promise in real-world applications. After decades of development, reinforcement learning (RL) has achieved some of the greatest successes as a general nonlinear control design method. Yet as RL control has developed, CT-RL results have greatly lagged their discrete-time RL (DT-RL) counterparts, especially in regards to real-world applications. Current CT-RL algorithms generally fall into two classes: adaptive dynamic programming (ADP), and actor-critic deep RL (DRL). The first school of ADP methods features elegant theoretical results stemming from adaptive and optimal control. Yet, they have not been shown effectively synthesizing meaningful controllers. The second school of DRL has shown impressive learning solutions, yet theoretical guarantees are still to be developed. A substantive analysis uncovering the quantitative causes of the fundamental gap between CT and DT remains to be conducted. Thus, this work develops a first-of-its kind quantitative evaluation framework to diagnose the performance limitations of the leading CT-RL methods. This dissertation also introduces a suite of new CT-RL algorithms which offers both theoretical and synthesis guarantees. The proposed design approach relies on three important factors. First, for physical systems that feature physically-motivated dynamical partitions into distinct loops, the proposed decentralization method breaks the optimal control problem into smaller subproblems. Second, the work introduces a new excitation framework to improve persistence of excitation (PE) and numerical conditioning via classical input/output insights. Third, the method scales the learning problem via design-motivated invertible transformations of the system state variables in order to modulate the algorithm learning regression for further increases in numerical stability. This dissertation introduces a suite of (decentralized) excitable integral reinforcement learning (EIRL) algorithms implementing these paradigms. It rigorously proves convergence, optimality, and closed-loop stability guarantees of the proposed methods, which are demonstrated in comprehensive comparative studies with the leading methods in ADP on a significant application problem of controlling an unstable, nonminimum phase hypersonic vehicle (HSV). It also conducts comprehensive comparative studies with the leading DRL methods on three state-of-the-art (SOTA) environments, revealing new performance/design insights.
ContributorsWallace, Brent Abraham (Author) / Si, Jennie (Thesis advisor) / Berman, Spring M (Committee member) / Bertsekas, Dimitri P (Committee member) / Tsakalis, Konstantinos S (Committee member) / Arizona State University (Publisher)
Created2024
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Description
The Inverted Pendulum on a Cart is a classical control theory problem that helps understand the importance of feedback control systems for a coupled plant. In this study, a custom built pendulum system is coupled with a linearly actuated cart and a control system is designed to show the stability

The Inverted Pendulum on a Cart is a classical control theory problem that helps understand the importance of feedback control systems for a coupled plant. In this study, a custom built pendulum system is coupled with a linearly actuated cart and a control system is designed to show the stability of the pendulum. The three major objectives of this control system are to swing up the pendulum, balance the pendulum in the inverted position (i.e. $180^\circ$), and maintain the position of the cart. The input to this system is the translational force applied to the cart using the rotation of the tires. The main objective of this thesis is to design a control system that will help in balancing the pendulum while maintaining the position of the cart and implement it in a robot. The pendulum is made free rotating with the help of ball bearings and the angle of the pendulum is measured using an Inertial Measurement Unit (IMU) sensor. The cart is actuated by two Direct Current (DC) motors and the position of the cart is measured using encoders that generate pulse signals based on the wheel rotation. The control is implemented in a cascade format where an inner loop controller is used to stabilize and balance the pendulum in the inverted position and an outer loop controller is used to control the position of the cart. Both the inner loop and outer loop controllers follow the Proportional-Integral-Derivative (PID) control scheme with some modifications for the inner loop. The system is first mathematically modeled using the Newton-Euler first principles method and based on this model, a controller is designed for specific closed-loop parameters. All of this is implemented on hardware with the help of an Arduino Due microcontroller which serves as the main processing unit for the system.
ContributorsNamasivayam, Vignesh (Author) / Tsakalis, Konstantinos (Thesis advisor) / Rodriguez, Armando (Committee member) / Si, Jennie (Committee member) / Shafique, Md. Ashfaque Bin (Committee member) / Arizona State University (Publisher)
Created2021