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- Creators: Arizona State University
- Creators: Brian, Jennifer
Description
Today in the U.S. the narrative of the “bad drug” has become quite a familiar account. There is an ever-growing collection of pharmaceutical products whose safety and efficacy has been debunked through the scandalous exposure of violations of integrity on the part of researchers, lapses in procedure and judgment on the part of the FDA, and reckless profiteering on the part of big pharma. However, a closer look reveals that the oversights and loopholes depicted in the bad drug narrative are not incidental failures of an otherwise intact, effective system. Rather, bad drugs, like good drugs, are a product of normal operations of the system; the same processes, actors, and influences manifest in both. The aim of this project is to shed light on these processes, actors, and influences at work in drug normalization by interrogating the peculiar case of the drug Lupron. Lupron exhibits all of the controversial features of the “bad drug” narrative but has remained an endorsed and embraced staple of the infertility industry. This contradiction situates Lupron to expose a number of the contingencies on which drug normalization rests more generally. In order to put forth an explanatory model for drug normalization, three such contingencies are described in detail for the case at hand: the nature of drug regulation, the structures and value that underpin the medical categorization of diseases, and the inextricability of post-medicine from the forces of industry. These contingencies provide some explanatory power for understanding not only the retention of Lupron but the ways in which all drugs are produced, validated, and perpetuated in a society.
ContributorsStevenson, Christine, M.S (Author) / Brian, Jennifer (Thesis advisor) / Hurlbut, Benjamin (Thesis advisor) / Maienschein, Jane (Committee member) / Arizona State University (Publisher)
Created2015
Description
Glucose sensors have had many paradigm shifts, beginning with using urine, to point of care blood, now being approved for implant. This review covers various aspects of the sensors, ranging from the types of surface chemistry, and electron transduction. All the way to the algorithms, and filters used to alter and understand the signal being transduced. Focus is given to Dr. Hellerâ’s work using redox mediators, as well as Dr. Sode in his advances for direct electron transfer. Simple process of designing sensors are described, as well as the possible errors that may come with glucose sensor use. Finally, a small window into the future trends of glucose sensors is described both from a device view point, as well as organic viewpoint. Using this history the initial point of care sensor for insulin published through LaBelle’s lab is reevaluated critically. In addition, the modeling of the possibility of continuously measuring insulin is researched. To better understand the design for a continuous glucose sensor, the basic kinetic model is set up, and ran through a design of experiments to then optimized what the binding kinetics for an ideal insulin molecular recognition element would be. In addition, the phenomena of two electrochemical impedance spectroscopy peaks is analyzed, and two theories are suggests, and demonstrated to a modest level.
ContributorsProbst, David L (Author) / LaBelle, Jeffery (Thesis advisor) / Caplan, Micheal (Committee member) / Cook, Curtiss (Committee member) / Arizona State University (Publisher)
Created2018
Description
Endocrine disruptors are chemicals that interact with the hormone system to negative effect. They ‘disrupt’ normal processes to cause diseases like vaginal cancer and obesity, reproductive issues like t-shaped uteri and infertility, and developmental abnormalities like spina bifida and cleft palate. These chemicals are ubiquitous in our daily lives, components in everything from toothpaste to microwave popcorn to plastic water bottles. My dissertation looks at the history, science, and regulation of these impactful substances in order to answer the question of how endocrine disruptors appeared, got interpreted by different groups, and what role science played in the process. My analysis reveals that endocrine disruptors followed a unique science policy trajectory in the US, rapidly going from their proposal in 1991 to their federal regulation in 1996, even amid intense and majority scientific disagreement over whether the substances existed at all. That trajectory resulted from the work of a small number of scientist-activists who constructed a concept and category as scientific, social, and regulatory. By playing actors from each sphere against each other and advancing a very specific scientific narrative that fit into a regulatory and social window of opportunity in the 1990s, those scientist-activists made endocrine disruptors a national issue that few could ignore. Those actions resulted in the Endocrine Disruptor Screening Program, a heavily-criticized and ineffective regulatory program. My dissertation tells a story of the past that informs the present. In 2018, the work of researchers, public media, and policymakers in the 1990s continues to play out, evident in the deep scientific division over endocrine disrupting effects and the inability of the European Union to settle on even a definition of endocrine disruptors for regulation purposes.
ContributorsAbboud, Alexis J (Author) / Maienschein, Jane A (Thesis advisor) / Crow, Michael M. (Committee member) / Hurlbut, J. Benjamin (Committee member) / Marchant, Gary E (Committee member) / Arizona State University (Publisher)
Created2018
Description
While there is extensive information available about organizations that receive donated organs for transplant, much less is known about those that accept tissue and whole bodies for medical education and research. Throughout the United States, nontransplant anatomical donation organizations exist within an ambiguous sector of the donation industry, unencumbered by federal regulations. Although these companies adhere to the Uniform Anatomical Gift Act, the lack of a single entity responsible for overseeing their operations has led to public skepticism and animosity among competing businesses. Legislation has the potential to legitimize the industry. For it to be successful, however, the intricacies of a complex market that deals directly with the movement of human remains and intangible issues of human integrity and morality, must be thoroughly understood.
ContributorsGlynn, Emily Sanders (Author) / Brian, Jennifer (Thesis director) / Fisher, Rebecca (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / Department of English (Contributor)
Created2015-05
Description
Scientific and Cultural Interpretations of Volcanoes, 1766-1901 analyzes nineteenth-century conceptions of volcanoes through interdisciplinary literature and science studies. The project considers how people in the nineteenth century used science, aesthetics, and other ways of knowing to understand volcanoes and their operations. In the mid-eighteenth century, volcanoes were seen as singular, unique features of the planet that lacked temporal and terrestrial reach. By the end of the nineteenth century, volcanoes were seen as networked, environmental phenomena that stretched through geological time and geographic space. Scientific and Cultural Interpretations of Volcanoes, 1766-1901 offers a new historical understanding of volcanoes and their environmental connections, using literature and science to show how perceptions of volcanic time and space changed over 135 years.
The first chapter, using texts by Sir William Hamilton, Hester Piozzi, and Priscilla Wakefield, argues that in the late eighteenth century important aspects of volcanoes, like their impact upon human life and their existence through time, were beginning to be defined in texts ranging from the scientific to the educational. The second chapter focuses on works by Sir Edward Bulwer-Lytton and Charles Lyell to demonstrate the ways that volcanoes were stripped of metaphysical or symbolic meaning as the nineteenth century progressed. The third chapter contrasts the 1883 eruption of Krakatoa with Constance Gordon-Cumming’s travels to Kīlauea. The chapter shows how even towards the end of the century, trying to connect human minds with the process of volcanic phenomenon was a substantial challenge, but that volcanoes like Kīlauea allowed for new conceptions of volcanic action. The last chapter, through a post-apocalyptic novel by M. P. Shiel, shows how volcanoes were finally beginning to be categorized as a primary agent within the environment, shaping all life including humanity. Ultimately, I argue that the change in thinking about volcanoes parallels today’s shift in thinking about global climate change. My work provides insight into how we imagine ecological catastrophes like volcanic eruptions or climate change in the past and present and what that means for their impact on people.
The first chapter, using texts by Sir William Hamilton, Hester Piozzi, and Priscilla Wakefield, argues that in the late eighteenth century important aspects of volcanoes, like their impact upon human life and their existence through time, were beginning to be defined in texts ranging from the scientific to the educational. The second chapter focuses on works by Sir Edward Bulwer-Lytton and Charles Lyell to demonstrate the ways that volcanoes were stripped of metaphysical or symbolic meaning as the nineteenth century progressed. The third chapter contrasts the 1883 eruption of Krakatoa with Constance Gordon-Cumming’s travels to Kīlauea. The chapter shows how even towards the end of the century, trying to connect human minds with the process of volcanic phenomenon was a substantial challenge, but that volcanoes like Kīlauea allowed for new conceptions of volcanic action. The last chapter, through a post-apocalyptic novel by M. P. Shiel, shows how volcanoes were finally beginning to be categorized as a primary agent within the environment, shaping all life including humanity. Ultimately, I argue that the change in thinking about volcanoes parallels today’s shift in thinking about global climate change. My work provides insight into how we imagine ecological catastrophes like volcanic eruptions or climate change in the past and present and what that means for their impact on people.
ContributorsLinthicum, Kent Robert (Author) / Lussier, Mark (Thesis advisor) / Bivona, Daniel (Committee member) / Looser, Devoney (Committee member) / Tromp, Marlene (Committee member) / Arizona State University (Publisher)
Created2016
Description
This is a project about medicine and the history of a condition called premenstrual syndrome (PMS), its “discovery” and conceptual development at both scientific and socio-cultural levels. Since it was first mentioned in medical literature, PMS has been explored empirically as a medical condition and conceptually as non-somatic cultural phenomenon. Many attempts have been made to produce scientific, empirical evidence to bolster the theory of PMS as a biological disease. Some non-medical perspectives argue that invoking biology as the cause of PMS medicalizes a natural function of the female reproductive system and shallowly interrogates what is actually a complex bio-psycho-social phenomenon. This thesis questions both sides of this debate in order to reveal how criteria for PMS were categorized despite disagreement surrounding its etiology.
This thesis illustrates how the concept of PMS developed and was informed by the discovery of hormones and the resulting field of endocrinology that provided a framework for conceptualizing PMS. It displays how the development of the medical diagnostic category of PMS developed in tandem with the emergence of the field of endocrinology and was legitimized and effectively medicalized through this connection. The diagnosis of PMS became established though the diagnostic techniques like questionnaires in spite of persistent disagreement over its definition. The thesis shows how these medical concepts and practices legitimated the category of PMS, and how it has become ubiquitous in contemporary culture.
This thesis illustrates how the concept of PMS developed and was informed by the discovery of hormones and the resulting field of endocrinology that provided a framework for conceptualizing PMS. It displays how the development of the medical diagnostic category of PMS developed in tandem with the emergence of the field of endocrinology and was legitimized and effectively medicalized through this connection. The diagnosis of PMS became established though the diagnostic techniques like questionnaires in spite of persistent disagreement over its definition. The thesis shows how these medical concepts and practices legitimated the category of PMS, and how it has become ubiquitous in contemporary culture.
ContributorsZietal, Bianca (Author) / Hurlbut, James (Thesis advisor) / Robert, Jason (Committee member) / Brian, Jennifer (Committee member) / Arizona State University (Publisher)
Created2016
Description
Systems biology studies complex biological systems. It is an interdisciplinary field, with biologists working with non-biologists such as computer scientists, engineers, chemists, and mathematicians to address research problems applying systems’ perspectives. How these different researchers and their disciplines differently contributed to the advancement of this field over time is a question worth examining. Did systems biology become a systems-oriented science or a biology-oriented science from 1992 to 2013?
This project utilized computational tools to analyze large data sets and interpreted the results from historical and philosophical perspectives. Tools deployed were derived from scientometrics, corpus linguistics, text-based analysis, network analysis, and GIS analysis to analyze more than 9000 articles (metadata and text) on systems biology. The application of these tools to a HPS project represents a novel approach.
The dissertation shows that systems biology has transitioned from a more mathematical, computational, and engineering-oriented discipline focusing on modeling to a more biology-oriented discipline that uses modeling as a means to address real biological problems. Also, the results show that bioengineering and medical research has increased within systems biology. This is reflected in the increase of the centrality of biology-related concepts such as cancer, over time. The dissertation also compares the development of systems biology in China with some other parts of the world, and reveals regional differences, such as a unique trajectory of systems biology in China related to a focus on traditional Chinese medicine.
This dissertation adds to the historiography of modern biology where few studies have focused on systems biology compared with the history of molecular biology and evolutionary biology.
This project utilized computational tools to analyze large data sets and interpreted the results from historical and philosophical perspectives. Tools deployed were derived from scientometrics, corpus linguistics, text-based analysis, network analysis, and GIS analysis to analyze more than 9000 articles (metadata and text) on systems biology. The application of these tools to a HPS project represents a novel approach.
The dissertation shows that systems biology has transitioned from a more mathematical, computational, and engineering-oriented discipline focusing on modeling to a more biology-oriented discipline that uses modeling as a means to address real biological problems. Also, the results show that bioengineering and medical research has increased within systems biology. This is reflected in the increase of the centrality of biology-related concepts such as cancer, over time. The dissertation also compares the development of systems biology in China with some other parts of the world, and reveals regional differences, such as a unique trajectory of systems biology in China related to a focus on traditional Chinese medicine.
This dissertation adds to the historiography of modern biology where few studies have focused on systems biology compared with the history of molecular biology and evolutionary biology.
ContributorsZou, Yawen (Author) / Laubichler, Manfred (Thesis advisor) / Maienschein, Jane (Thesis advisor) / Creath, Richard (Committee member) / Ellison, Karin (Committee member) / Newfeld, Stuart (Committee member) / Arizona State University (Publisher)
Created2016
Description
In the fifteen years between the discovery of fetal alcohol syndrome (FAS) in 1973 and the passage of alcohol beverage warning labels in 1988, FAS transformed from a medical diagnosis between practitioner and pregnant women to a broader societal risk imbued with political and cultural meaning. I examine how scientific, social, moral, and political narratives dynamically interacted to construct the risk of drinking during pregnancy and the public health response of health warning labels on alcohol. To situate such phenomena I first observe the closest regulatory precedents, the public health responses to thalidomide and cigarettes, which established a federal response to fetal risk. I then examine the history of how the US defined and responded to the social problem of alcoholism, paying particular attention to the role of women in that process. Those chapters inform my discussion of how the US reengaged with alcohol control at the federal level in the last quarter of the twentieth century. In the 1970s, FAS allowed federal agencies to carve out disciplinary authority, but robust public health measures were tempered by uncertainty surrounding issues of bureaucratic authority over labeling, and the mechanism and extent of alcohol’s impact on development. A socially conservative presidency, dramatic budgetary cuts, and increased industry funding reshaped the public health approach to alcoholism in the 1980s. The passage of labeling in 1988 required several conditions: a groundswell of other labeling initiatives that normalized the practice; the classification of other high profile, socially unacceptable alcohol-related behaviors such as drunk driving and youth drinking; and the creation of a dual public health population that faced increased medical, social, and political scrutiny, the pregnant woman and her developing fetus.
ContributorsO'Neil, Erica (Author) / Maienschein, Jane (Thesis advisor) / Hurlbut, James (Committee member) / Ellison, Karin (Committee member) / Wetmore, Jameson (Committee member) / Arizona State University (Publisher)
Created2016
Description
This dissertation begins to lay out a small slice of the history of morphological research, and how it has changed, from the late 19th through the close of the 20th century. Investigators using different methods, addressing different questions, holding different assumptions, and coming from different research fields have pursued morphological research programs, i.e. research programs that explore the process of changing form. Subsequently, the way in which investigators have pursued and understood morphology has witnessed significant changes from the 19th century to modern day research. In order to trace this shifting history of morphology, I have selected a particular organ, teeth, and traced a tendril of research on the dentition beginning in the late 19th century and ending at the year 2000. But even focusing on teeth would be impossible; the scope of research on this organ is far too vast. Instead, I narrow this dissertation to investigation of research on a particular problem: explaining mammalian tooth morphology. How researchers have investigated mammalian tooth morphology and what counts as an explanation changed dramatically during this period.
ContributorsMacCord, Katherine (Author) / Maienschein, Jane (Thesis advisor) / Laubichler, Manfred (Thesis advisor) / Laplane, Lucie (Committee member) / Kimbel, William (Committee member) / Creath, Richard (Committee member) / Hurlbut, Benjamin (Committee member) / Arizona State University (Publisher)
Created2017
Description
This dissertation examines the efforts of the Carnegie Image Tube Committee (CITC), a group created by Vannevar Bush and composed of astronomers and physicists, who sought to develop a photoelectric imaging device, generally called an image tube, to aid astronomical observations. The Carnegie Institution of Washington’s Department of Terrestrial Magnetism coordinated the CITC, but the committee included members from observatories and laboratories across the United States. The CITC, which operated from 1954 to 1976, sought to replace direct photography as the primary means of astronomical imaging.
Physicists, who gained training in electronics during World War II, led the early push for the development of image tubes in astronomy. Vannevar Bush’s concern for scientific prestige led him to form a committee to investigate image tube technology, and postwar federal funding for the sciences helped the CITC sustain development efforts for a decade. During those development years, the CITC acted as a mediator between the astronomical community and the image tube producers but failed to engage astronomers concerning various development paths, resulting in a user group without real buy-in on the final product.
After a decade of development efforts, the CITC designed an image tube, which Radio Corporation of American manufactured, and, with additional funding from the National Science Foundation, the committee distributed to observatories around the world. While excited about the potential of electronic imaging, few astronomers used the Carnegie-developed device regularly. Although the CITC’s efforts did not result in an overwhelming adoption of image tubes by the astronomical community, examining the design, funding, production, and marketing of the Carnegie image tube shows the many and varied processes through which astronomers have acquired new tools. Astronomers’ use of the Carnegie image tube to acquire useful scientific data illustrates factors that contribute to astronomers’ adoption or non-adoption of those new tools.
Physicists, who gained training in electronics during World War II, led the early push for the development of image tubes in astronomy. Vannevar Bush’s concern for scientific prestige led him to form a committee to investigate image tube technology, and postwar federal funding for the sciences helped the CITC sustain development efforts for a decade. During those development years, the CITC acted as a mediator between the astronomical community and the image tube producers but failed to engage astronomers concerning various development paths, resulting in a user group without real buy-in on the final product.
After a decade of development efforts, the CITC designed an image tube, which Radio Corporation of American manufactured, and, with additional funding from the National Science Foundation, the committee distributed to observatories around the world. While excited about the potential of electronic imaging, few astronomers used the Carnegie-developed device regularly. Although the CITC’s efforts did not result in an overwhelming adoption of image tubes by the astronomical community, examining the design, funding, production, and marketing of the Carnegie image tube shows the many and varied processes through which astronomers have acquired new tools. Astronomers’ use of the Carnegie image tube to acquire useful scientific data illustrates factors that contribute to astronomers’ adoption or non-adoption of those new tools.
ContributorsThompson, Samantha Michelle (Author) / Ellison, Karin (Thesis advisor) / Wetmore, Jameson (Thesis advisor) / Maienschein, Jane (Committee member) / Creath, Richard (Committee member) / DeVorkin, David (Committee member) / Arizona State University (Publisher)
Created2019