Classroom communication is imperative in the creation of a classroom environment that encourages participation and inter-student relationships. Several factors that may influence these variables, such as female-to-male sex ratio, have not been studied in depth. This study examined the impact of class size, female-to-male ratio, and teaching method on individual participation and class interactions. Class size was negatively related to individual verbal participation, classroom connection, classroom animation, and classroom intimacy and positively related to classroom nonimmediacy. Female-to-male sex ratio was positively associated with classroom connection, animation, and intimacy. Class activities were positively related to individual verbal participation, classroom connection, classroom animation, and classroom intimacy and positively related to classroom nonimmediacy. The use of videos in the classroom was positively associated with classroom animation and intimacy while other technologies were not significantly correlated with any variables. These findings suggest that the ideal classroom should have a small number of students and utilize interactive class activities. Furthermore, women should be encouraged to take classes that are traditionally dominated by men and future research should focus on how gender is connected to the variables in this study.