Matching Items (3)
Filtering by
- All Subjects: Affect
- Creators: Davis, Mary
- Creators: Aizura, Aren
- Status: Published
Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
There is currently a proliferation of images of transgender youth in popular discourse, many of which reflect the threat to capitalist heteronormativity that transgender young people pose to contemporary U.S. society. This veritable explosion in media visibility of transgender youth must be critically examined. This dissertation explores media economies of transgender youth visibility by examining media and self-represented narratives by and about transgender young people in contemporary U.S. popular discourse to uncover where, and how, certain young transgender bodies become endowed with value in the service of the neoliberal multicultural U.S. nation-state. As normative transgender youth become increasingly visible as signifiers of the progress of the tolerant U.S. nation, transgender youth who are positioned further from the intelligible field of U.S. citizenship are erased.
Utilizing frameworks from critical transgender studies, youth studies, and media studies, this project illustrates how value is distributed, and at the expense of whom this process of assigning value occurs, in media economies of transgender youth visibility. Discursive analyses of online self-representations, as well as of online representations of media narratives, facilitate this investigation into how transgender youth negotiate the terms of those narratives circulating about them in U.S. contemporary media. This project demonstrates that increases in visibility do not always translate into political power; at best, they distract from the need for political interventions for marginalized groups, and at worst, they erase those stories already far from view in popular discourse: of non-normative transgender youth who are already positioned outside the realm of intelligibility to a national body structured by a heteronormative binary gender system.
Utilizing frameworks from critical transgender studies, youth studies, and media studies, this project illustrates how value is distributed, and at the expense of whom this process of assigning value occurs, in media economies of transgender youth visibility. Discursive analyses of online self-representations, as well as of online representations of media narratives, facilitate this investigation into how transgender youth negotiate the terms of those narratives circulating about them in U.S. contemporary media. This project demonstrates that increases in visibility do not always translate into political power; at best, they distract from the need for political interventions for marginalized groups, and at worst, they erase those stories already far from view in popular discourse: of non-normative transgender youth who are already positioned outside the realm of intelligibility to a national body structured by a heteronormative binary gender system.
ContributorsReinke, Rachel Anne (Author) / Switzer, Heather D. (Thesis advisor) / Aizura, Aren (Committee member) / Anderson, Lisa (Committee member) / Himberg, Julia (Committee member) / Arizona State University (Publisher)
Created2016
Description
Experiencing poor, unrefreshing sleep is a common occurrence for individuals with chronic pain. Sleep disturbance predicts not only greater pain and disability, but also heightened negative affect and reduced positive affect in individuals with chronic pain. Such fluctuations in affect have been linked with more negative and fewer positive social events. For those with chronic pain, negative social relations can exacerbate pain, whereas positive social interactions can help decrease disability. Thus, exploring the sleep‒social functioning process in chronic pain may be one way to improve daily functioning and quality of life. The current study examined positive and negative affect as two parallel mediators of the within-day relations between sleep quality and positive and negative social events in individuals with chronic pain. For 21 days, electronic daily diary reports were collected from 220 individuals with fibromyalgia, a condition characterized by widespread chronic pain. Within-person relations among reports of last night’s sleep quality, afternoon affects and pain, and evening social events were estimated via multilevel structural equation modeling. Findings showed that positive affect mediated both the sleep quality‒positive social events and sleep quality‒negative social events relations. That is, greater than usual sleep disturbance last night predicted afternoon reports of lower than usual positive affect. Low positive affect, in turn, predicted evening reports of fewer than usual positive social events and more than usual negative social events that day, controlling for the effects of afternoon pain. In addition, negative affect mediated the sleep quality‒negative social events link. That is, greater than usual sleep disturbance last night predicted afternoon reports of higher than usual negative affect, which, in turn, predicted evening reports of more than usual negative social events that day, controlling for the effects of afternoon pain. Of the three significant mediated paths, the sleep quality‒positive affect‒positive social events path was the strongest in magnitude. Thus, a night of poor sleep can have an impact on social events the next day in those with chronic pain by dysregulating affect. Further, findings highlight the key role of positive affect in the sleep‒social functioning process and potential socio-affective benefits of sleep interventions in chronic pain.
ContributorsKothari, Dhwani J. (Author) / Davis, Mary (Thesis advisor) / Luecken, Linda (Committee member) / Karoly, Paul (Committee member) / Infurna, Frank (Committee member) / Arizona State University (Publisher)
Created2019