Matching Items (2)
Filtering by

Clear all filters

135840-Thumbnail Image.png
Description
Arizona State University experienced some of its most explosive growth in the 1960s—doubling its enrollment in just seven years, expanding many programs and adding a college of law, and significantly augmenting its physical plant. This work examines the architectural and planning development of ASU in this decade and the surrounding

Arizona State University experienced some of its most explosive growth in the 1960s—doubling its enrollment in just seven years, expanding many programs and adding a college of law, and significantly augmenting its physical plant. This work examines the architectural and planning development of ASU in this decade and the surrounding years, coinciding with the presidency of Dr. G. Homer Durham, in various facets. Topics covered include the pedestrianization of the university campus, land acquisition and street realignment; the construction of newer and taller buildings to accommodate and expanded student population and educational program; and efforts to improve the university’s prestige through the use of modern architecture. ASU’s physical and human growth is compared to selected peer institutions. The legacy of the 1960s at ASU is also discussed within a historic preservation context.
ContributorsHumbert, Raymond Eugene (Author) / Zygas, K. Paul (Thesis director) / Spindler, Robert (Committee member) / School of International Letters and Cultures (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
137656-Thumbnail Image.png
Description
Cancer is one of the leading causes of death in the world and represents a tremendous burden on patients, families and societies. S. Typhimurium strains are specifically attracted to compounds produced by cancer cells and could overcome the traditional therapeutic barrier. However, a major problem with using live attenuated Salmonella

Cancer is one of the leading causes of death in the world and represents a tremendous burden on patients, families and societies. S. Typhimurium strains are specifically attracted to compounds produced by cancer cells and could overcome the traditional therapeutic barrier. However, a major problem with using live attenuated Salmonella as anti-cancer agents is their toxicity at the dose required for therapeutic efficacy, but reducing the dose results in diminished efficacy. In this project, we explored novel means to reduce the toxicity of the recombinant attenuated Salmonella by genetically engineering those virulence factors to facilitate maximal colonization of tumor tissues and reduced fitness in normal tissues. We have constructed two sets of Salmonella strains. In the first set, each targeted gene was knocked out by deletion of the gene. In the second set, the predicted promoter region of each gene was replaced with a rhamnose-regulated promoter, which will cease the synthesis of these genes in vivo, a rhamnose-free environment.
ContributorsBenson, Lee Samuel (Author) / Kong, Wei (Thesis director) / Martin, Thomas (Committee member) / Lake, Douglas (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Center for Infectious Diseases and Vaccinology (Contributor) / School of Life Sciences (Contributor)
Created2013-05