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- All Subjects: Electroencephalography
- Creators: Papandreou-Suppappola, Antonia
Description
Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart of these algorithms is particle filtering (PF), a sequential Monte Carlo technique used to estimate the unknown parameters of dynamic systems. First, we analyze the bottlenecks in existing PF algorithms, and we propose a new parallel PF (PPF) algorithm based on the independent Metropolis-Hastings (IMH) algorithm. We show that the proposed PPF-IMH algorithm improves the root mean-squared error (RMSE) estimation performance, and we demonstrate that a parallel implementation of the algorithm results in significant reduction in inter-processor communication. We apply our implementation on a Xilinx Virtex-5 field programmable gate array (FPGA) platform to demonstrate that, for a one-dimensional problem, the PPF-IMH architecture with four processing elements and 1,000 particles can process input samples at 170 kHz by using less than 5% FPGA resources. We also apply the proposed PPF-IMH to waveform-agile sensing to achieve real-time tracking of dynamic targets with high RMSE tracking performance. We next integrate the PPF-IMH algorithm to track the dynamic parameters in neural sensing when the number of neural dipole sources is known. We analyze the computational complexity of a PF based method and propose the use of multiple particle filtering (MPF) to reduce the complexity. We demonstrate the improved performance of MPF using numerical simulations with both synthetic and real data. We also propose an FPGA implementation of the MPF algorithm and show that the implementation supports real-time tracking. For the more realistic scenario of automatically estimating an unknown number of time-varying neural dipole sources, we propose a new approach based on the probability hypothesis density filtering (PHDF) algorithm. The PHDF is implemented using particle filtering (PF-PHDF), and it is applied in a closed-loop to first estimate the number of dipole sources and then their corresponding amplitude, location and orientation parameters. We demonstrate the improved tracking performance of the proposed PF-PHDF algorithm and map it onto a Xilinx Virtex-5 FPGA platform to show its real-time implementation potential. Finally, we propose the use of sensor scheduling and compressive sensing techniques to reduce the number of active sensors, and thus overall power consumption, of electroencephalography (EEG) systems. We propose an efficient sensor scheduling algorithm which adaptively configures EEG sensors at each measurement time interval to reduce the number of sensors needed for accurate tracking. We combine the sensor scheduling method with PF-PHDF and implement the system on an FPGA platform to achieve real-time tracking. We also investigate the sparsity of EEG signals and integrate compressive sensing with PF to estimate neural activity. Simulation results show that both sensor scheduling and compressive sensing based methods achieve comparable tracking performance with significantly reduced number of sensors.
ContributorsMiao, Lifeng (Author) / Chakrabarti, Chaitali (Thesis advisor) / Papandreou-Suppappola, Antonia (Thesis advisor) / Zhang, Junshan (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2013
Description
Neural activity tracking using electroencephalography (EEG) and magnetoencephalography (MEG) brain scanning methods has been widely used in the field of neuroscience to provide insight into the nervous system. However, the tracking accuracy depends on the presence of artifacts in the EEG/MEG recordings. Artifacts include any signals that do not originate from neural activity, including physiological artifacts such as eye movement and non-physiological activity caused by the environment.
This work proposes an integrated method for simultaneously tracking multiple neural sources using the probability hypothesis density particle filter (PPHDF) and reducing the effect of artifacts using feature extraction and stochastic modeling. Unique time-frequency features are first extracted using matching pursuit decomposition for both neural activity and artifact signals.
The features are used to model probability density functions for each signal type using Gaussian mixture modeling for use in the PPHDF neural tracking algorithm. The probability density function of the artifacts provides information to the tracking algorithm that can help reduce the probability of incorrectly estimating the dynamically varying number of current dipole sources and their corresponding neural activity localization parameters. Simulation results demonstrate the effectiveness of the proposed algorithm in increasing the tracking accuracy performance for multiple dipole sources using recordings that have been contaminated by artifacts.
This work proposes an integrated method for simultaneously tracking multiple neural sources using the probability hypothesis density particle filter (PPHDF) and reducing the effect of artifacts using feature extraction and stochastic modeling. Unique time-frequency features are first extracted using matching pursuit decomposition for both neural activity and artifact signals.
The features are used to model probability density functions for each signal type using Gaussian mixture modeling for use in the PPHDF neural tracking algorithm. The probability density function of the artifacts provides information to the tracking algorithm that can help reduce the probability of incorrectly estimating the dynamically varying number of current dipole sources and their corresponding neural activity localization parameters. Simulation results demonstrate the effectiveness of the proposed algorithm in increasing the tracking accuracy performance for multiple dipole sources using recordings that have been contaminated by artifacts.
ContributorsJiang, Jiewei (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Arizona State University (Publisher)
Created2014
Description
Parkinson's disease is a neurodegenerative condition diagnosed on patients with
clinical history and motor signs of tremor, rigidity and bradykinesia, and the estimated
number of patients living with Parkinson's disease around the world is seven
to ten million. Deep brain stimulation (DBS) provides substantial relief of the motor
signs of Parkinson's disease patients. It is an advanced surgical technique that is used
when drug therapy is no longer sufficient for Parkinson's disease patients. DBS alleviates the motor symptoms of Parkinson's disease by targeting the subthalamic nucleus using high-frequency electrical stimulation.
This work proposes a behavior recognition model for patients with Parkinson's
disease. In particular, an adaptive learning method is proposed to classify behavioral
tasks of Parkinson's disease patients using local field potential and electrocorticography
signals that are collected during DBS implantation surgeries. Unique patterns
exhibited between these signals in a matched feature space would lead to distinction
between motor and language behavioral tasks. Unique features are first extracted
from deep brain signals in the time-frequency space using the matching pursuit decomposition
algorithm. The Dirichlet process Gaussian mixture model uses the extracted
features to cluster the different behavioral signal patterns, without training or
any prior information. The performance of the method is then compared with other
machine learning methods and the advantages of each method is discussed under
different conditions.
clinical history and motor signs of tremor, rigidity and bradykinesia, and the estimated
number of patients living with Parkinson's disease around the world is seven
to ten million. Deep brain stimulation (DBS) provides substantial relief of the motor
signs of Parkinson's disease patients. It is an advanced surgical technique that is used
when drug therapy is no longer sufficient for Parkinson's disease patients. DBS alleviates the motor symptoms of Parkinson's disease by targeting the subthalamic nucleus using high-frequency electrical stimulation.
This work proposes a behavior recognition model for patients with Parkinson's
disease. In particular, an adaptive learning method is proposed to classify behavioral
tasks of Parkinson's disease patients using local field potential and electrocorticography
signals that are collected during DBS implantation surgeries. Unique patterns
exhibited between these signals in a matched feature space would lead to distinction
between motor and language behavioral tasks. Unique features are first extracted
from deep brain signals in the time-frequency space using the matching pursuit decomposition
algorithm. The Dirichlet process Gaussian mixture model uses the extracted
features to cluster the different behavioral signal patterns, without training or
any prior information. The performance of the method is then compared with other
machine learning methods and the advantages of each method is discussed under
different conditions.
ContributorsDutta, Arindam (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Holbert, Keith E. (Committee member) / Bliss, Daniel W. (Committee member) / Arizona State University (Publisher)
Created2015
Description
Research on developing new algorithms to improve information on brain functionality and structure is ongoing. Studying neural activity through dipole source localization with electroencephalography (EEG) and magnetoencephalography (MEG) sensor measurements can lead to diagnosis and treatment of a brain disorder and can also identify the area of the brain from where the disorder has originated. Designing advanced localization algorithms that can adapt to environmental changes is considered a significant shift from manual diagnosis which is based on the knowledge and observation of the doctor, to an adaptive and improved brain disorder diagnosis as these algorithms can track activities that might not be noticed by the human eye. An important consideration of these localization algorithms, however, is to try and minimize the overall power consumption in order to improve the study and treatment of brain disorders. This thesis considers the problem of estimating dynamic parameters of neural dipole sources while minimizing the system's overall power consumption; this is achieved by minimizing the number of EEG/MEG measurements sensors without a loss in estimation performance accuracy. As the EEG/MEG measurements models are related non-linearity to the dipole source locations and moments, these dynamic parameters can be estimated using sequential Monte Carlo methods such as particle filtering. Due to the large number of sensors required to record EEG/MEG Measurements for use in the particle filter, over long period recordings, a large amounts of power is required for storage and transmission. In order to reduce the overall power consumption, two methods are proposed. The first method used the predicted mean square estimation error as the performance metric under the constraint of a maximum power consumption. The performance metric of the second method uses the distance between the location of the sensors and the location estimate of the dipole source at the previous time step; this sensor scheduling scheme results in maximizing the overall signal-to-noise ratio. The performance of both methods is demonstrated using simulated data, and both methods show that they can provide good estimation results with significant reduction in the number of activated sensors at each time step.
ContributorsMichael, Stefanos (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2012
Description
Brain Computer Interfaces are becoming the next generation controllers not only in the medical devices for disabled individuals but also in the gaming and entertainment industries. In order to build an effective Brain Computer Interface, which accurately translates the user thoughts into machine commands, it is important to have robust and fail proof signal processing and machine learning modules which operate on the raw EEG signals and estimate the current thought of the user.
In this thesis, several techniques used to perform EEG signal pre-processing, feature extraction and signal classification have been discussed, implemented, validated and verified; efficient supervised machine learning models, for the EEG motor imagery signal classification are identified. To further improve the performance of system unsupervised feature learning techniques have been investigated by pre-training the Deep Learning models. Use of pre-training stacked autoencoders have been proposed to solve the problems caused by random initialization of weights in neural networks.
Motor Imagery (imaginary hand and leg movements) signals are acquire using the Emotiv EEG headset. Different kinds of features like mean signal, band powers, RMS of the signal have been extracted and supplied to the machine learning (ML) stage, wherein, several ML techniques like LDA, KNN, SVM, Logistic regression and Neural Networks are applied and validated. During the validation phase the performances of various techniques are compared and some important observations are reported. Further, deep Learning techniques like autoencoding have been used to perform unsupervised feature learning. The reliability of the features is analyzed by performing classification by using the ML techniques mentioned earlier. The performance of the neural networks has been further improved by pre-training the network in an unsupervised fashion using stacked autoencoders and supplying the stacked autoencoders’ network parameters as initial parameters to the neural network. All the findings in this research, during each phase (pre-processing, feature extraction, classification) are directly relevant and can be used by the BCI research community for building motor imagery based BCI applications.
Additionally, this thesis attempts to develop, test, and compare the performance of an alternative method for classifying human driving behavior. This thesis proposes the use of driver affective states to know the driving behavior. The purpose of this part of the thesis was to classify the EEG data collected from several subjects while driving simulated vehicle and compare the classification results with those obtained by classifying the driving behavior using vehicle parameters collected simultaneously from all the subjects. The objective here is to see if the drivers’ mental state is reflected in his driving behavior.
In this thesis, several techniques used to perform EEG signal pre-processing, feature extraction and signal classification have been discussed, implemented, validated and verified; efficient supervised machine learning models, for the EEG motor imagery signal classification are identified. To further improve the performance of system unsupervised feature learning techniques have been investigated by pre-training the Deep Learning models. Use of pre-training stacked autoencoders have been proposed to solve the problems caused by random initialization of weights in neural networks.
Motor Imagery (imaginary hand and leg movements) signals are acquire using the Emotiv EEG headset. Different kinds of features like mean signal, band powers, RMS of the signal have been extracted and supplied to the machine learning (ML) stage, wherein, several ML techniques like LDA, KNN, SVM, Logistic regression and Neural Networks are applied and validated. During the validation phase the performances of various techniques are compared and some important observations are reported. Further, deep Learning techniques like autoencoding have been used to perform unsupervised feature learning. The reliability of the features is analyzed by performing classification by using the ML techniques mentioned earlier. The performance of the neural networks has been further improved by pre-training the network in an unsupervised fashion using stacked autoencoders and supplying the stacked autoencoders’ network parameters as initial parameters to the neural network. All the findings in this research, during each phase (pre-processing, feature extraction, classification) are directly relevant and can be used by the BCI research community for building motor imagery based BCI applications.
Additionally, this thesis attempts to develop, test, and compare the performance of an alternative method for classifying human driving behavior. This thesis proposes the use of driver affective states to know the driving behavior. The purpose of this part of the thesis was to classify the EEG data collected from several subjects while driving simulated vehicle and compare the classification results with those obtained by classifying the driving behavior using vehicle parameters collected simultaneously from all the subjects. The objective here is to see if the drivers’ mental state is reflected in his driving behavior.
ContributorsManchala, Vamsi Krishna (Author) / Redkar, Sangram (Thesis advisor) / Rogers, Bradley (Committee member) / Sugar, Thomas (Committee member) / Arizona State University (Publisher)
Created2015