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Sustaining Depression Remission: Integrating Mindfulness-Based Modalities and Ketamine Infusion Therapy

Description
Major depressive disorder contributes to a growing disease burden globally, with limiting or inadequate treatment options available to patients and healthcare providers. Traditional medications to treat the disorder demonstrate modest efficacy while best outcomes are seen when psychotherapy is implemented adjunctively. Barriers to delivering optimal treatment can lead to relapse, diminished psychosocial functioning, and…

Major depressive disorder contributes to a growing disease burden globally, with limiting or inadequate treatment options available to patients and healthcare providers. Traditional medications to treat the disorder demonstrate modest efficacy while best outcomes are seen when psychotherapy is implemented adjunctively. Barriers to delivering optimal treatment can lead to relapse, diminished psychosocial functioning, and suicide, a leading cause of death in the United States. The purpose of this paper is to examine the rapid antidepressant effects of ketamine combined with nurse-delivered mindfulness-based cognitive therapy to help reduce depression severity and support remission. Research differentiating ketamine’s mechanism of action from traditional anti-depressants and the efficacy of mindfulness-based interventions to reduce depression, have led this evidence-based project integrating these modalities.
ContributorsYuhas, John V. (Author) / McIntosh, Wayne (Thesis advisor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor)
Created2021-04-20