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Evaluating the viability of a DNA-based chip targeted for C. trachomatis, N. gonorrhoeae, and other pathogens of interest

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Sexually transmitted diseases like gonorrhea and chlamydia, standardly treated with antibiotics, produce over 1.2 million cases annually in the emergency department (Jenkins et al., 2013). To determine a need for antibiotics, hospital labs utilize bacterial cultures to isolate and identify possible pathogens. Unfortunately, this technique can take up to 72…

Sexually transmitted diseases like gonorrhea and chlamydia, standardly treated with antibiotics, produce over 1.2 million cases annually in the emergency department (Jenkins et al., 2013). To determine a need for antibiotics, hospital labs utilize bacterial cultures to isolate and identify possible pathogens. Unfortunately, this technique can take up to 72 hours, leading to several physicians presumptively treating patients based solely on history and physical presentation. With vague standards for diagnosis and a high percentage of asymptomatic carriers, several patients undergo two scenarios; over- or under-treatment. These two scenarios can lead to consequences like unnecessary exposure to antibiotics and development of secondary conditions (for example: pelvic inflammatory disease, infertility, etc.). This presents a need for a laboratory technique that can provide reliable results in an efficient matter. The viability of DNA-based chip targeted for C. trachomatis, N. gonorrhoeae, and other pathogens of interest were evaluated. The DNA-based chip presented several advantages as it can be easily integrated as a routine test given the process is already well-known, is customizable and able to target multiple pathogens within a single test and has the potential to return results within a few hours as opposed to days. As such, implementation of a DNA-based chip as a diagnostic tool is a timely and potentially impactful investigation.
ContributorsCharoenmins, Patherica (Author) / Penton, Christopher (Thesis director) / Moore, Marianne (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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Quantifying the Preference of Corynorhinus townsendii to Hibernate in Highly Ventilated Areas in Arizona Caves

Description

Corynorhinus townsendii, a bat species residing in north-central Arizona, has historically been observed hibernating in highly ventilated areas within caves and abandoned mines, but there is little to no specific data regarding this tendency. Understanding how air movement may influence hibernacula selection is critical in bettering conservation efforts for Arizona…

Corynorhinus townsendii, a bat species residing in north-central Arizona, has historically been observed hibernating in highly ventilated areas within caves and abandoned mines, but there is little to no specific data regarding this tendency. Understanding how air movement may influence hibernacula selection is critical in bettering conservation efforts for Arizona bats, especially with white-nose syndrome continuing to devastate bat species populations throughout the United States. My study aimed to begin filling in this knowledge gap. I measured wind speed in three known Arizona hibernacula during the winter hibernation season and combined this data with the locations of bats observed throughout each of the three survey locations. I modeled our findings using a generalized linear model, which confirmed that wind speed is indeed a predictor of C. townsendii roost selection.
ContributorsKitchel, Heidi (Author) / Moore, Marianne (Thesis director) / Saul, Steven (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2022-05