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- All Subjects: Bexarotene
- Creators: Marshall, Pamela
- Creators: Polidoro, Beth
- Creators: Yang, Joanna
- Status: Published
Silicone wristbands consist of a porous surface with the potential to sequester organic contaminants in the environment. Their properties allow for them to be used as a novel sampling approach to assessing personal human exposure to environmental contaminants. The purpose of the study was to understand the effectiveness of silicone wristbands as sampling devices. This was addressed by identifying and quantifying pesticide recovery from exposed wristbands. Triplicate groups of wristbands were dosed with 37 persistent organochlorine or organophosphate pesticides and then extracted to estimate human exposure through recovery. Results suggest that silicone wristbands have the potential to absorb a number of pesticides and organic contaminants, although at varying rates and quantities. As more uptake and sequestration rates can be established, wristbands have the potential to serve as indicators of human exposure to a variety of pesticides and other chemical groups at trace amounts.
The ever-increasing importance of cancer and neurodegenerative diseases continues to grow as populations across the world are affected by death and aging. The vitamin A (RXR) and vitamin D (VDR) receptor pathways offer promising potential to aid in treatment of cancer and Alzheimer’s disease. This thesis discusses the potential application of novel analogs of Bexarotene (RXR agonist), MeTC7 (a new potent VDR antagonist), and vitamin D as possible therapeutics for cancer and Alzheimer’s disease.