Transhumanist concepts and themes increasingly occupy a prominent place in contemporary visions of the future, particularly with regard to technology. A growing number of scholars, including some self-described transhumanists, see transhumanism as functioning like a religion for secular people, in that it fulfills many of the same desires and impulses without reference to any supernatural forces. For this reason there is a growing discussion of transhumanism in comparison with major religious traditions, but one which has heretofore been underappreciated is Protestant pietism. Pietism grew out of a need among Protestants after the Reformation to realize a better Christian community and better prepare individual believers for the afterlife. It had a significant influence over the European Enlightenment, of which transhumanists claim to be the successors. In its understanding of human improvement, human nature, and ultimate human destiny in death and the end-point of history, pietism has multiple interesting points of comparison with transhumanism. Both ideologies begin by improving individual human beings as the primary means to the end of eliminating suffering, especially death and disease, and building the ideal human community. Transhumanism accomplishes its goals for humanity through the use of advanced technologies which enable human beings to transcend their natural limitations. Pietism focuses, as its name suggests, on moral and spiritual improvement according to practical guidelines that lead a Christian believer to take an active role in his or her own sanctification. This essay concludes that pietism reveals certain key limitations in transhumanism as a comprehensive life philosophy, especially in its ability to organize society according to its system of values.