Matching Items (6)
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Description
For many adolescents, high school is a critical period of self-awareness, peer-influence, and identity construction. During this volatile period, young people explore how to express themselves in ways that range from conformity to non-conformity and transgression. This is particularly true when it comes to young people's understanding and expression of

For many adolescents, high school is a critical period of self-awareness, peer-influence, and identity construction. During this volatile period, young people explore how to express themselves in ways that range from conformity to non-conformity and transgression. This is particularly true when it comes to young people's understanding and expression of gender identity. For some youth, their personal form(s) of gender expression align neatly with social expectations; for others, it does not. When gender expression does not align with social expectations, students may be vulnerable to bullying or harassment by peers or adults. Often, youth who are policed and regulated by their classmates through bullying (or harassment, depending upon the relevant or implemented policy) are targeted based on their perceived identity, be that racial, ethnic, citizenship, or, most frequently, gender and sexuality. This project advances the need for research done from a critical youth studies perspective (both methodologically and ethically) and provides new insight into the types of language and practices used by youth to express, perform and "do" gender. Utilizing qualitative methodology, including participant observation, focus group and individual interviews, surveys, and the collection and content analysis of school ephemera, this research investigated how high school students navigate gender identity amidst other intersecting identities. This project examined how youth both "do" and "perform" gender in their everyday lives as high school students. Their gender identity is frequently understood amidst other intersecting identities, particularly sexual orientation, religion and race. These youth also pointed to several important influences in how they understand their own gender, and the gender identity of those around them, including media and peer groups. Because this research took place at two charter art schools, the findings also provided a framework for understanding how these two schools, and charter art schools more generally, provide alternative spaces for young people to experiment and play with their identity construction. Findings indicate that youth are forced to navigate and construct their gender identity amidst many conflicting and contradictory ideologies. Schools, media, and peer groups all heavily influence the way young people understand themselves.
ContributorsPrior, Sarah (Author) / Cavender, Gray (Thesis advisor) / Adelman, Madelaine (Thesis advisor) / Swadener, Beth Blue (Committee member) / Katsulis, Yasmina (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Laboratory animals represent an invaluable, yet controversial, resource in the field of biomedical research. Animal research has been behind many influential discoveries in the field of emerging therapeutics. They provide the link between the theory of the lab bench and the functional application of medicine to influence human health. The

Laboratory animals represent an invaluable, yet controversial, resource in the field of biomedical research. Animal research has been behind many influential discoveries in the field of emerging therapeutics. They provide the link between the theory of the lab bench and the functional application of medicine to influence human health. The use of animals in research is a consideration which must be heavily weighed, and the implementation must be carried out at a very high standard in order to retain research integrity and responsibility. We are in the process of conducting an experiment using laboratory mice to demonstrate cancer treatment using vaccinia (VACV) mutants as a possible oncolytic therapy for certain strains of melanoma. VACV is a double-stranded DNA poxvirus with a large and easily altered genome. This virus contains many genes dedicated to immune evasion, but has shown sensitivity to cell death by necroptosis in mouse studies (5). We have identified the absence of the kinase RIP3 which is vital in the necroptosis pathway as a potential target for oncolytic therapy using VACV mutants in specific strains of melanoma. Multiple groups of SCID Beige mice were inoculated with different melanoma cell lines and observed for tumor growth. Upon reaching 1 cm3 in volume, tumors were injected with either VACV- Δ83N, VACV- Δ54N, or PBS, and observed for regression. It was hypothesized that melanoma tumors that are RIP3-/- such as the MDA5 cell line will show regression, but melanoma tumors that are RIP3-positive and capable of necroptosis, such as the 2427 cell line, will resist viral replication and continue to proliferate. Our results so far tentatively support this hypothesis, but the data collection is ongoing. Strict and specific protocols with regard to the ethical and responsible use of mice have been implemented and upheld throughout the experiment. Animals are closely monitored, and if their quality of life becomes too poor to justify their continued use in the experiment, they are humanely euthanized, even at the expense of valuable data. The importance of commitment to a high ethical standard is pervasive throughout our work. Animals represent an invaluable contribution to research, and it is important to maintain high standards and transparency with regard to their use. Education and engagement in critical discussions about the use and care of animals in the laboratory contribute to the overall merit and legitimacy of biomedical research in the public and professional eye as a whole, and give legitimacy to the continued use of animals as models to advance science and health.
ContributorsBergamaschi, Julia (Author) / Kibler, Karen (Thesis director) / Jacobs, Bertram (Committee member) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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The problem of whether women should be involved in drug research is a question of who can assume risk and who is responsible for disseminating what specific kinds of information. The problem tends to be framed as one that juxtaposes the health of women and fetuses and sets their health

The problem of whether women should be involved in drug research is a question of who can assume risk and who is responsible for disseminating what specific kinds of information. The problem tends to be framed as one that juxtaposes the health of women and fetuses and sets their health as in opposition. That opposition, coupled with the inherent uncertainty in testing drugs, provides for a complex set of issues surrounding consent and access to information.

Created2021-03-01
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On 9 July 1990, in Moore v. Regents of the University of California, the Supreme Court of California ruled in a four-to-three decision that individuals do not have rights to a share in profits earned from research performed on their bodily materials. In its decision, the Supreme Court of California

On 9 July 1990, in Moore v. Regents of the University of California, the Supreme Court of California ruled in a four-to-three decision that individuals do not have rights to a share in profits earned from research performed on their bodily materials. In its decision, the Supreme Court of California ruled that cancer patient John L. Moore did not have personal property rights to samples or fluids that his physicians took from his body for research purposes. Moore created the precedent in California that although physicians are required to disclose their research interests to their patients, patients do not have property-related claims to any samples that their physicians take from their body. The Supreme Court of California’s decision in Moore v. Regents of the University of California enabled physicians and researchers to retain legal ownership on samples taken from their patients’ bodies so that they can conduct what the court describes as socially important medical research, such as work on reproductive cancers or developmental disorders.

Created2020-11-18
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The HeLa cell line was the first immortal human cell line that George Otto Gey, Margaret Gey, and Mary Kucibek first isolated from Henrietta Lacks and developed at The Johns Hopkins Hospital in Baltimore, Maryland, in 1951. An immortal human cell line is a cluster of cells that continuously multiply

The HeLa cell line was the first immortal human cell line that George Otto Gey, Margaret Gey, and Mary Kucibek first isolated from Henrietta Lacks and developed at The Johns Hopkins Hospital in Baltimore, Maryland, in 1951. An immortal human cell line is a cluster of cells that continuously multiply on their own outside of the human from which they originated. Scientists use immortal human cell lines in their research to investigate how cells function in humans. Though the HeLa cell line has contributed to many advancements in biomedical research since the twentieth century, its usage in medical research has been controversial because Lacks did not consent to having her cells used for such purposes. As of 2020, scientists continue to use the HeLa cell line for numerous scientific advancements, such as the development of vaccines and the identification of many underlying disease mechanisms.

Created2020-09-18
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Description

With over a century of culturally established associations for different musical sounds, the narrative properties of film scoring powerfully influence how societies and cultures perceive themselves through film. Film scoring in mainstream culture functions as a form of social practice in which consumers dictate the market that producers create for,

With over a century of culturally established associations for different musical sounds, the narrative properties of film scoring powerfully influence how societies and cultures perceive themselves through film. Film scoring in mainstream culture functions as a form of social practice in which consumers dictate the market that producers create for, while the ideas and philosophies portrayed in film shape consumer audiences’ perceptions of what their societies look like. A surge of discourse in the 21st century surrounds issues of representation and inclusivity in mainstream media, including what constitutes appropriation versus appreciation in film scores using non-Western music traditions. Recent postcolonial ethnomusicological theory demonstrates that collaboration and co-authorship are inclusive ways that can both avoid the pitfalls of colonialist power structures and also create autonomy for participating marginalized groups. My research examines four contemporary films of the 21st century--Kung Fu Panda 3, Moana, Black Panther, and The Breadwinner--and the collaborations between film composers and source musicians that establish cultural and racial musical narratives. I analyze various musical techniques these composers learned through the collaboration process with contributing source musicians and the resulting musical space each film’s soundtrack created for the representative demographic. This discourse opens other avenues of exploration into how mainstream media and the “global imagination” informs cultural music identities. I conclude my research with examples of film scores appearing outside cinema in social musicality; these examples demonstrate the impact that inclusivity in film scoring has on many areas of mainstream culture, especially in racial representation discourse.

ContributorsArcher, Madison (Author) / Solís, Ted (Thesis advisor) / Feisst, Sabine M (Thesis advisor) / Fossum, Dave (Committee member) / Bhattacharjya, Nilanjana (Committee member) / Arizona State University (Publisher)
Created2021