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- Member of: Theses and Dissertations
Description
DNA nanotechnology is one of the most flourishing interdisciplinary research fields. Through the features of programmability and predictability, DNA nanostructures can be designed to self-assemble into a variety of periodic or aperiodic patterns of different shapes and length scales, and more importantly, they can be used as scaffolds for organizing other nanoparticles, proteins and chemical groups. By leveraging these molecules, DNA nanostructures can be used to direct the organization of complex bio-inspired materials that may serve as smart drug delivery systems and in vitro or in vivo bio-molecular computing and diagnostic devices. In this dissertation I describe a systematic study of the thermodynamic properties of complex DNA nanostructures, including 2D and 3D DNA origami, in order to understand their assembly, stability and functionality and inform future design endeavors. It is conceivable that a more thorough understanding of DNA self-assembly can be used to guide the structural design process and optimize the conditions for assembly, manipulation, and functionalization, thus benefiting both upstream design and downstream applications. As a biocompatible nanoscale motif, the successful integration, stabilization and separation of DNA nanostructures from cells/cell lysate suggests its potential to serve as a diagnostic platform at the cellular level. Here, DNA origami was used to capture and identify multiple T cell receptor mRNA species from single cells within a mixed cell population. This demonstrates the potential of DNA nanostructure as an ideal nano scale tool for biological applications.
ContributorsWei, Xixi (Author) / Liu, Yan (Thesis advisor) / Yan, Hao (Thesis advisor) / Chen, Julian (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Created2014
Description
Bridging semantic gap is one of the fundamental problems in multimedia computing and pattern recognition. The challenge of associating low-level signal with their high-level semantic interpretation is mainly due to the fact that semantics are often conveyed implicitly in a context, relying on interactions among multiple levels of concepts or low-level data entities. Also, additional domain knowledge may often be indispensable for uncovering the underlying semantics, but in most cases such domain knowledge is not readily available from the acquired media streams. Thus, making use of various types of contextual information and leveraging corresponding domain knowledge are vital for effectively associating high-level semantics with low-level signals with higher accuracies in multimedia computing problems. In this work, novel computational methods are explored and developed for incorporating contextual information/domain knowledge in different forms for multimedia computing and pattern recognition problems. Specifically, a novel Bayesian approach with statistical-sampling-based inference is proposed for incorporating a special type of domain knowledge, spatial prior for the underlying shapes; cross-modality correlations via Kernel Canonical Correlation Analysis is explored and the learnt space is then used for associating multimedia contents in different forms; model contextual information as a graph is leveraged for regulating interactions among high-level semantic concepts (e.g., category labels), low-level input signal (e.g., spatial/temporal structure). Four real-world applications, including visual-to-tactile face conversion, photo tag recommendation, wild web video classification and unconstrained consumer video summarization, are selected to demonstrate the effectiveness of the approaches. These applications range from classic research challenges to emerging tasks in multimedia computing. Results from experiments on large-scale real-world data with comparisons to other state-of-the-art methods and subjective evaluations with end users confirmed that the developed approaches exhibit salient advantages, suggesting that they are promising for leveraging contextual information/domain knowledge for a wide range of multimedia computing and pattern recognition problems.
ContributorsWang, Zhesheng (Author) / Li, Baoxin (Thesis advisor) / Sundaram, Hari (Committee member) / Qian, Gang (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2011
Description
The world of healthcare can be seen as dynamic, often an area where technology and science meet to consummate a greater good for humanity. This relationship has been working well for the last century as evident by the average life expectancy change. For the greater of the last five decades the average life expectancy at birth increased globally by almost 20 years. In the United States specifically, life expectancy has grown from 50 years in 1900 to 78 years in 2009. That is a 76% increase in just over a century. As great as this increase sounds for humanity it means there are soon to be real issues in the healthcare world. A larger older population will need more healthcare services but have fewer young professionals to provide those services. Technology and science will need to continue to push the boundaries in order to develop and provide the solutions needed to continue providing the aging world population sufficient healthcare. One solution sure to help provide a brighter future for healthcare is mobile health (m-health). M-health can help provide a means for healthcare professionals to treat more patients with less work expenditure and do so with more personalized healthcare advice which will lead to better treatments. This paper discusses one area of m-health devices specifically; human breath analysis devices. The current laboratory methods of breath analysis and why these methods are not adequate for common healthcare practices will be discussed in more detail. Then more specifically, mobile breath analysis devices are discussed. The topic will encompass the challenges that need to be met in developing such devices, possible solutions to these challenges, two real examples of mobile breath analysis devices and finally possible future directions for m-health technologies.
ContributorsLester, Bryan (Author) / Forzani, Erica (Thesis advisor) / Xian, Xiaojun (Committee member) / Trimble, Steve (Committee member) / Arizona State University (Publisher)
Created2012
Description
Businesses stand to face many uncertainties from the moment they start up to every moment in between. A business can try to recognize them and plan ahead, react to them as they occur, or be rocked by a black swan they never saw coming. How a business deals with unforeseen events can increase its potential for success or failure. With this in mind, there is no better bridge between the here and now and the future than planning for change in order to move a company toward preparing for change, adapting to change and achieving optimal results. Interested in taking a step toward the digital age, Alpha Homes Management, Inc. (Alpha Homes) sought our help to explore ideas and options to take their company to a new level. This Barrett Creative Project was centered on designing a system for Alpha Homes that will replace their outdated paper-based system with a more digital one. This aligns with the project also featured as a capstone project as required by the information technology degree expectations. In supplement to the capstone, and for the Barrett Creative Project, the final product was presented to the owners of Alpha Homes Management, Inc. to be utilized by the business. The end goal is to provide a platform which provides a paperless environment for documentation and bring the company a step closer to having a robust internet presence. Now that the web-based application product has been created and presented, the testing phase can now begin to evaluate its efficacy.
ContributorsBrice-Nash, Tristan (Co-author) / Alfawzan, Mohammad (Co-author) / Doheny, Damien (Thesis director) / Rodriguez, Carlos (Committee member) / Information Technology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Multiple sclerosis is a neurological disease that attacks the nerves in the central nervous system of the brain and spinal cord. Multiple sclerosis is a neurological disease that attacks the nerves in the central nervous system of the brain and spinal cord. The severity of multiple sclerosis varies based on the each person and the progression of the disease. There are roughly 2.5 million people that suffer from this disease that life is changed dramatically from being diagnosed with no main way to ease into adjusting to a new lifestyle. The increase of people that are diagnosed with multiple sclerosis, and with a majority of those people being diagnosed in their early 20’s, there is a need for an application that will help patients manage their health. Multiple sclerosis leads to a lifestyle change, which includes various treatment options as well as routine doctor appointments. The creation of the myMS Specialist application will allow patients with multiple sclerosis to live a more comfortable lifestyle while they easily track and manage their health through their mobile devices. Our application has seven components that all play an important role in adjusting to the new everyday lifestyle for a patient with multiple sclerosis. All seven components are largely intertwined with each other to help patients realize patterns in their diet, sleep, exercise and the weather that causes their symptoms to worsen. Our application not only connects to a patient’s doctor so that there is full access of information at all time to the doctor but provides beneficial research to help further the understanding of multiple sclerosis. This application will be marketed and available for purchase to not only patients but doctors. It is our goal to lessen the burden of a new lifestyle to a patient, create constant communication with one’s doctor and provide beneficial data to researchers.
ContributorsSaenz, Devon (Co-author) / Peterson, Tyler (Co-author) / Chomina-Chavez, Aram (Thesis director) / Staats, Cody (Committee member) / W. P. Carey School of Business (Contributor) / Herberger Institute for Design and the Arts (Contributor) / School of Accountancy (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Mental illness has always been a stark fact of life, whether it affects people directly or indirectly. More and more research is now showing that mental illness is becoming increasingly more widespread in the U.S. This poses a serious problem to our society in terms of treatment of mental illness, as well as the costs that are involved with treating those who are affected with different disorders. According to the CDC's (Centers for Disease Control and Prevention) Autism and Developmental Disabilities Monitoring (ADDM) Network, about 1 in 68 children have been identified with autism spectrum disorder (ASD). A large number of these children are given psychotropic medications when there is no real proof of their efficacy. Our children are our society's future, so how can we aide parents of these young children to ultimately benefit their future? As a result of my research in the gut-brain connection, I have developed an application called Portal. Portal will serve the parents of children with autism in assisting with their daily lives and teaching them about the most up to date research. This application will work in conjunction with thesis material developed in the Visual Communication Design program to create a well-rounded approach to incorporating knowledge of the gut-brain connection in everyday life. Portal will have a variety of capabilities including that of autism related news, diet plans, schedules, community resources, and medication planning. There will be a daily tip or reminder to incorporate knowledge of the gut-brain connection in daily life. This can be something as simple as a reminder to eat vegetables to a fact about the research. The main goal of Portal is to assist parents in adapting to a lifestyle with ASD easier and healthier for both parents and children alike.
ContributorsChen, Cynthia Yue (Author) / Sanft, Alfred (Thesis director) / Heywood, William (Committee member) / Barrett, The Honors College (Contributor) / The Design School (Contributor)
Created2014-05
Description
I have created a business plan for the idea of the development of an iOS mobile application called MoveGroove. MoveGroove plans to be a simple, yet engaging application that is designed to maintain a runner's desired pace through music modulation. MoveGroove will allow an individual to set his or her appropriate desired running or jogging pace, and will adjust (speed up or slow down) the music to match their desired pace. It will not be focused on direct competition, but rather, progress. MoveGroove is catered to all ages and types of individuals, whether the individual is a marathon runner or a power-walker through the neighborhood. This iOS application will allow individuals to remain focused, entertained, and engaged. This business plan will allow the reader to understand the foundation of the different types of operating systems resulting in the reasons for creating the application, MoveGroove; how to use the application to provide the mode effective results; and how MoveGroove will contribute to the mobile market. Additionally, within the business plan are categories that allow an individual to determine and compare its growth and marketability against other competitors in the market system. Ultimately, within the current mobile application market, there are over one million applications \u2014 the number of applications is continuing to increase each year. Applications are becoming a large part of the mobile phone. This particular application, MoveGroove, will provide a new way in the mobile market that will increase the productivity of individuals while producing a unique blend of recreational and goal-setting values as they exercise.
ContributorsTon, Victoria Marie (Co-author) / Goyette, Steven (Co-author) / Peck, Sidnee (Thesis director) / Faucon, Christophe (Committee member) / School of Life Sciences (Contributor) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The Wish List is a website that allows users to input URLs of products that they like into a wish list, much like Amazon's Wish List. The website also connects users to their Facebook friends who also use the application, so that users can view their friends' wish lists and "claim" products that they've purchased. This makes the Wish List like a registry as well. This report documents the functionality and the structure of the website, but the website itself is not yet released to the general public.
ContributorsChesley, Bryana Renee (Author) / Ahmad, Altaf (Thesis director) / Prince, Linda (Committee member) / Barrett, The Honors College (Contributor) / WPC Graduate Programs (Contributor) / Department of Information Systems (Contributor) / School of Accountancy (Contributor)
Created2014-05
Description
Smartphones have become increasingly common over the past few years, and mobile games continue to be the most common type of application (Apple, Inc., 2013). For many people, the social aspect of gaming is very important, and thus most mobile games include support for playing with multiple players. However, there is a lack of common knowledge about which implementation of this functionality is most favorable from a development standpoint. In this study, we evaluate three different types of multiplayer gameplay (pass-and-play, Bluetooth, and GameCenter) via development cost and user interviews. We find that pass-and-play, the most easily-implemented mode, is not favored by players due to its inconvenience. We also find that GameCenter is not as well favored as expected due to latency of GameCenter's servers, and that Bluetooth multiplayer is the most well favored for social play due to its similarity to real-life play. Despite there being a large overhead in developing and testing Bluetooth and GameCenter multiplayer due to Apple's development process, this is irrelevant since professional developers must enroll in this process anyway. Therefore, the most effective multiplayer mode to develop is mostly determined by whether Internet play is desirable: Bluetooth if not, GameCenter if so. Future studies involving more complete development work and more types of multiplayer modes could yield more promising results.
ContributorsBradley, Michael Robert (Author) / Collofello, James (Thesis director) / Wilkerson, Kelly (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Computer Science and Engineering Program (Contributor)
Created2013-12
Description
In this thesis a community-based ride sharing mobile application, Ride Devil, will be introduced and created to provide services for communities such as Arizona State University and its students, faculty, and other affiliates to find safe rides around campus because campus population problem exists. This causes increased transportation costs, decreased parking space availability, and more transportation issues. The Ride Devil application itself is based off on the ride-sharing concept of transportation as introduced, above. Students, faculty, and other university affiliates will drive their own vehicles and use the Ride Devil services in order to coordinate pick-ups with members of its community. Not only is this form of transportation more cost effective than competing transportation models, taxis, but it also promotes safety, community, and educational assistance.
ContributorsVan Hook, Ryan Leo (Author) / Lin, Elva (Thesis director) / Peck, Sidnee (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / W. P. Carey School of Business (Contributor) / Department of Management (Contributor)
Created2014-05